Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237

Regeneration beyond the glial scar

Silver, J., & Miller, J. H. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1326 · Cited by 3,151

A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function

Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

Srinivas, S., Watanabe, T., Lin, C.-S., William, C. M., Tanabe, Y., Jessell, T. M., & Costantini, F. (2001) · BMC Developmental Biology · doi:10.1186/1471-213x-1-4 · Cited by 3,121

Mechanisms and Functional Implications of Adult Neurogenesis

Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007

Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation

Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219

Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

Johansson, C. B., Momma, S., Clarke, D. L., Risling, M., Lendahl, U., & Frisén, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80956-3 · Cited by 1,875

Reactive Astrocytes Protect Tissue and Preserve Function after Spinal Cord Injury

Faulkner, J. R., Herrmann, J. E., Woo, M. J., Tansey, K. E., Doan, N., & Sofroniew, M. V. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3547-03.2004 · Cited by 1,652

Remyelination in the CNS: from biology to therapy

Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544

Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

Ito, M., Liu, Y., Yang, Z., Nguyen, J., Liang, F., Morris, R. J., & Cotsarelis, G. (2005) · Nature Medicine · doi:10.1038/nm1328 · Cited by 1,317

Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination

Lohrberg, M., Winkler, A., Franz, J., van der Meer, F., Ruhwedel, T., Sirmpilatze, N., Dadarwal, R., Löber-Handwerker, R., Esser, D. S., Wiegand, K., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01105-2 · Cited by 25

Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A

Han, T., Song, P., Wu, Z., Wang, C., Liu, Y., Wang, Y., Li, K., & Shen, C. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03284-w · Cited by 24

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected by Caudal Regression Syndrome

Devesa, J., Alonso, A., López, N., García, J., Puell, C. I., Pablos, T., & Devesa, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010230 · Cited by 22

Neural stem cell heterogeneity in the mammalian forebrain

Adams, K. V., & Morshead, C. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.005 · Cited by 26

Melatonin promotes proliferation of neural stem cells from adult mouse spinal cord via the PI3K/AKT signaling pathway

Yu, S., Zhang, X., Xu, Z., & Hu, C. (2019) · FEBS Letters · doi:10.1002/1873-3468.13458 · Cited by 23

Activation of Neurogenesis in Multipotent Stem Cells Cultured In Vitro and in the Spinal Cord Tissue After Severe Injury by Inhibition of Glycogen Synthase Kinase-3

Rodríguez-Jiménez, F. J., Vilches, A., Aragó, M. A. P., Clemente, E., Román, R., Leal, J., Artero‐Castro, A., Fustero, S., Moreno‐Manzano, V., Jendelová, P., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00928-0 · Cited by 23

Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish

Saraswathy, V. M., Zhou, L., McAdow, A. R., Burris, B., Dogra, D., Reischauer, S., & Mokalled, M. H. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111705 · Cited by 23

Activating Endogenous Neurogenesis for Spinal Cord Injury Repair: Recent Advances and Future Prospects

Yu, H., Yang, S., Li, H., Wu, R., Lai, B., & Zheng, Q. (2023) · Neurospine · doi:10.14245/ns.2245184.296 · Cited by 23

Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury

Han, T., Song, P., Wu, Z., Liu, Y., Ying, W., & Shen, C. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10560-y · Cited by 24

Thoracic Rat Spinal Cord Contusion Injury Induces Remote Spinal Gliogenesis but Not Neurogenesis or Gliogenesis in the Brain

Franz, S., Ciatipis, M., Pfeifer, K., Kierdorf, B., Sandner, B., Bogdahn, U., Blesch, A., Winner, B., & Weidner, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102896 · Cited by 22

Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury

Fukuoka, T., Kato, A., Hirano, M., Ohka, F., Aoki, K., Awaya, T., Adilijiang, A., Maeda, S., Tanahashi, K., Yamaguchi, J., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102074 · Cited by 21

Interleukin-17A regulates ependymal cell proliferation and functional recovery after spinal cord injury in mice

Miyajima, H., Itokazu, T., Tanabe, S., & Yamashita, T. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04064-1 · Cited by 23

Proper wiring of newborn neurons to control bladder function after complete spinal cord injury

Hao, F., Jia, F., Hao, P., Duan, H., Wang, Z., Fan, Y., Zhao, W., Gao, Y., Fan, O. R., Xu, F., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121919 · Cited by 21

Restoration of spinal cord injury: From endogenous repairing process to cellular therapy

Wu, Y., Tang, Z., Zhang, J., Wang, Y., & Liu, S. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1077441 · Cited by 21

Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration

Xing, J., Rheaume, B. A., Kim, J., Łukomska, A., Sajid, M. S., Damania, A., & Trakhtenberg, E. F. (2023) · Development · doi:10.1242/dev.201311 · Cited by 22

Transplanting Human Neural Stem Cells with ≈50% Reduction of SOX9 Gene Dosage Promotes Tissue Repair and Functional Recovery from Severe Spinal Cord Injury

Liu, J. A., Tam, K. W., Chen, Y. L., Feng, X., Chan, C. W. L., Lo, A. L. H., Wu, K. L., Hui, M., Wu, M., Chan, K. K., et al. (2023) · Advanced Science · doi:10.1002/advs.202205804 · Cited by 20

UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury

Ding, L.-L., Chu, W., Xia, Y., Ming, S., Li, T., Zhou, F., & Deng, D. Y. B. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06003-8 · Cited by 21

FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury

Alastrue‐Agudo, A., Rodríguez-Jiménez, F. J., Mocholi, E. L., Giorgio, F. D., Erceg, S., & Moreno‐Manzano, V. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19010200 · Cited by 21

Wheel Running Improves Motor Function and Spinal Cord Plasticity in Mice With Genetic Absence of the Corticospinal Tract

Zhang, W., Yang, B., Weng, H., Liu, T., Shi, L., Yu, P., So, K., Qu, Y., & Zhou, L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00106 · Cited by 21

Acute upregulation of bone morphogenetic protein-4 regulates endogenous cell response and promotes cell death in spinal cord injury

Hart, C. G., Dyck, S. M., Kataria, H., Alizadeh, A., Nagakannan, P., Thliveris, J. A., Eftekharpour, E., & Karimi‐Abdolrezaee, S. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113163 · Cited by 22

Substance P enhances endogenous neurogenesis to improve functional recovery after spinal cord injury

Yang, L., Li, G., Ye, J., Lu, D., Chen, Z., Xiang, A. P., & Jiang, M. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.030 · Cited by 21

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

Dias, D. O., Kalkitsas, J., Kelahmetoglu, Y., Estrada, C. P., Tatarishvili, J., Ernst, A., Huttner, H. B., Kokaia, Z., Lindvall, O., Brundin, L., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.04.30.068965

Immature spinal cord neurons are dynamic regulators of adult nociceptive sensitivity

Rusanescu, G., & Mao, J. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12648 · Cited by 20

Oligodendrogliogenesis and Axon Remyelination after Traumatic Spinal Cord Injuries in Animal Studies: A Systematic Review

Hassannejad, Z., Shakouri‐Motlagh, A., Mokhatab, M., Zadegan, S. A., Sharif-Alhoseini, M., Shokraneh, F., & Rahimi‐Movaghar, V. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.019 · Cited by 20

Neurogenesis as a Tool for Spinal Cord Injury

Haveliková, K., Šmejkalová, B., & Jendelová, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073728 · Cited by 20

Neurogenesis in the Adult Mammalian Brain: How Much Do We Need, How Much Do We Have?

Kazanis, I. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_227 · Cited by 20

Purinergic signalling in a latent stem cell niche of the rat spinal cord

Marichal, N., Fabbiani, G., Trujillo-Cenóz, O., & Russo, R. E. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9507-6 · Cited by 20

Lymphotoxin β receptor-mediated NFκB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells

Xiao, X., Putatunda, R., Zhang, Y., Soni, P. V., Li, F., Zhang, T., Xin, M., Luo, J. J., Bethea, J. R., Cheng, Y. Z., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1074-z · Cited by 20

Nasal Delivery of Engineered Exosomes via a Thermo‐Sensitive Hydrogel Depot Reprograms Glial Cells for Spinal Cord Repair

Wang, Y., Liu, J., Li, P., Peng, Z., Zhang, Y., Liu, Y., Li, M., Gong, X., Liu, D., Xu, E., et al. (2025) · Advanced Science · doi:10.1002/advs.202504486 · Cited by 20

A cell population that strongly expresses the CB1 cannabinoid receptor in the ependyma of the rat spinal cord

García‐Ovejero, D., Arévalo‐Martín, Á., Paniagua‐Torija, B., Sierra‐Palomares, Y., & Molina‐Holgado, E. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23184 · Cited by 19

IFN-γ-STAT1-mediated CD8+ T-cell-neural stem cell cross talk controls astrogliogenesis after spinal cord injury

Wang, J., Xu, L., Peng, D., Zhu, Y., Gu, Z., Yao, Y., Li, H., Cao, X., Fu, C., Zheng, M., et al. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00263-9 · Cited by 19

Ectopic ependymal cells in striatum accompany neurogenesis in a rat model of stroke

Danilov, A. I., Kokaia, Z., & Lindvall, O. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.062 · Cited by 19

Functional Recovery, Serotonergic Sprouting, and Endogenous Progenitor Fates in Response to Delayed Environmental Enrichment after Spinal Cord Injury

Koopmans, G. C., Deumens, R., Honig, W. M. M., Hamers, F. P. T., Mey, J., van Kleef, M., & Joosten, E. A. J. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.1949 · Cited by 19

GABAergic responses of mammalian ependymal cells in the central canal neurogenic niche of the postnatal spinal cord

Corns, L. F., Deuchars, J., & Deuchars, S. A. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.07.007 · Cited by 19

Leptin sustains spontaneous remyelination in the adult central nervous system

Matoba, K., Muramatsu, R., & Yamashita, T. (2017) · Scientific Reports · doi:10.1038/srep40397 · Cited by 19

An ex vivo spinal cord injury model to study ependymal cells in adult mouse tissue

Fernández-Zafra, T., Codeluppi, S., & Uhlén, P. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.06.002 · Cited by 18

Reactivity of microglia and astrocytes after an excitotoxic injury induced by kainic acid in the rat spinal cord

Zanuzzi, C. N., Nishida, F., Sisti, M. S., Barbeito, C. G., & Portiansky, E. L. (2018) · Tissue and Cell · doi:10.1016/j.tice.2018.11.007 · Cited by 19

Binary scaffold facilitates in situ regeneration of axons and neurons for complete spinal cord injury repair

Liu, D., Shu, M., Liu, W., Shen, Y., Long, G., Zhao, Y., Hou, X., Xiao, Z., Dai, J., & Li, X. (2021) · Biomaterials Science · doi:10.1039/d0bm02212h · Cited by 19

Effects of mesenchymal stem cell transplantation on spinal cord injury patients

Tahmasebi, F., & Barati, S. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03648-3 · Cited by 20

Stem cell-derived exosomes for traumatic spinal cord injury: a systematic review and network meta-analysis based on a rat model

Shang, Z., Wanyan, P., Wang, M., Zhang, B., Cui, X., & Wang, X. (2023) · Cytotherapy · doi:10.1016/j.jcyt.2023.09.002 · Cited by 20

Functional Hydrogel Co‐Remolding Migration and Differentiation Microenvironment for Severe Spinal Cord Injury Repair

Liu, D., Shen, H., Zhang, K., Shen, Y., Wen, R., He, X., Long, G., & Li, X. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301662 · Cited by 18

Gene Therapy Strategies for the Treatment of Spinal Cord Injury

Uchida, K., Nakajima, H., Guerrero, A. R., Johnson, W. E., Masri, W. E., & Baba, H. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.20 · Cited by 18

How sympathetic are your spinal cord circuits?

Deuchars, S. A. (2015) · Experimental Physiology · doi:10.1113/ep085031 · Cited by 18

Distribution and Characterization of Progenitor Cells within the Human Filum Terminale

Arvidsson, L., Fagerlund, M., Jaff, N., Ossoinak, A., Jansson, K., Hägerstrand, A., Johansson, C. B., Brundin, L., & Svensson, M. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027393 · Cited by 18

Regeneration strategies after the adult mammalian central nervous system injury—biomaterials

Gao, Y., Yang, Z., & Li, X. (2016) · Regenerative Biomaterials · doi:10.1093/rb/rbw004 · Cited by 18

Temporal Response of Endogenous Neural Progenitor Cells Following Injury to the Adult Rat Spinal Cord

Mao, Y., Mathews, K. J., & Gorrie, C. A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00058 · Cited by 19

Methods of reactivation and reprogramming of neural stem cells for neural repair

Tian, Z., Zhao, Q., Biswas, S., & Deng, W. (2017) · Methods · doi:10.1016/j.ymeth.2017.08.014 · Cited by 18

Combinatorial lentiviral gene delivery of pro‐oligodendrogenic factors for improving myelination of regenerating axons after spinal cord injury

Smith, D. R., Margul, D. J., Dumont, C. M., Carlson, M. A., Munsell, M. K., Johnson, M. A., Cummings, B. J., Anderson, A. J., & Shea, L. D. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26838 · Cited by 18

Adult spinal cord neurogenesis: A regulator of nociception

Rusanescu, G. (2016) · Neurogenesis · doi:10.1080/23262133.2016.1256853 · Cited by 18

Endogenous opioid signalling regulates spinal ependymal cell proliferation

Yue, W. W. S., Touhara, K. K., Toma, K., Duan, X., & Julius, D. J. (2024) · Nature · doi:10.1038/s41586-024-07889-w · Cited by 17

EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury

Tsenkina, Y., Ricard, J., Runko, E., Acosta, M. M. Q., Mier, J., & Liebl, D. J. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.262 · Cited by 17

Metformin Improves Functional Outcomes, Activates Neural Precursor Cells, and Modulates Microglia in a Sex-Dependent Manner After Spinal Cord Injury

Gilbert, E. A. B., Livingston, J. M., Flores, E. G., Kehtari, T., & Morshead, C. M. (2023) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szad030 · Cited by 17

Nicotine modulates neurogenesis in the central canal during experimental autoimmune encephalomyelitis

Gao, Z., Nissen, J. C., Legakis, L. P., & Tsirka, S. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.031 · Cited by 17

A mouse model of complete-crush transection spinal cord injury made by two operations

Li, C., Zhu, X., Lee, C.-M. J., Wu, Z., & Cheng, L. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.01.58 · Cited by 16

Spinal Cord Injury — Healing from Within

Monje, M. (2021) · New England Journal of Medicine · doi:10.1056/nejmcibr2030836 · Cited by 17

Evidence that the central canal lining of the spinal cord contributes to oligodendrogenesis during postnatal development and adulthood in intact rats

Ševc, J., Matiašová, A. A., Kútna, V., & Daxnerová, Z. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23590 · Cited by 17

Connexin 50 modulates Sox2 expression in spinal-cord-derived ependymal stem/progenitor cells

Rodríguez-Jiménez, F. J., Alastrue‐Agudo, A., Stojković, M., Erceg, S., & Moreno‐Manzano, V. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2421-y · Cited by 17

Bazedoxifene, a Selective Estrogen Receptor Modulator, Promotes Functional Recovery in a Spinal Cord Injury Rat Model

Kim, Y., Roh, E. J., Joshi, H. P., Shin, H. E., Choi, H., Kwon, S. Y., Sohn, S., & Han, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011012 · Cited by 16

The origins and dynamic changes of C3- and S100A10-positive reactive astrocytes after spinal cord injury

Zhao, Q., Ren, Y.-L., Zhu, Y.-J., Huang, R.-Q., Zhu, R.-R., Cheng, L.-M., & Xie, N. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1276506 · Cited by 15

Reshaping the chromatin landscape after spinal cord injury

Wong, J. K., & Zou, H. (2014) · Frontiers in Biology · doi:10.1007/s11515-014-1329-8 · Cited by 16

Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord

Zhang, M., Barde, S. S., Szodorai, E., Josephson, A., Mitsios, N., Watanabe, M., Attems, J., Lübec, G., Kovács, G. G., Uhlén, M., et al. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1191-3 · Cited by 17

Wnts Are Expressed in the Ependymal Region of the Adult Spinal Cord

González‐Fernández, C., Arévalo‐Martín, Á., Paniagua‐Torija, B., Ferrer, I., Rodríguez, F. J., & García‐Ovejero, D. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0132-8 · Cited by 16

Induction of Endogenous Neural Stem Cells By Extracorporeal Shock Waves After Spinal Cord Injury

Shin, D.-C., Ha, K.-Y., Kim, Y.-H., Kim, J.-W., Cho, Y., & Kim, S.-I. (2017) · Spine · doi:10.1097/brs.0000000000002302 · Cited by 16

The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals

la Cal, A. T.-D., Paniagua‐Torija, B., Arévalo‐Martín, Á., Faulkes, C. G., Jimenez, A. J., Ferrer, I., Molina‐Holgado, E., & García‐Ovejero, D. (2021) · Cells · doi:10.3390/cells10092235 · Cited by 16

Sodium hyaluronate-CNTF gelatinous particles promote axonal growth, neurogenesis and functional recovery after spinal cord injury

Wang, N., Zhang, S., Zhang, A., Yang, Z., & Li, X. (2014) · Spinal Cord · doi:10.1038/sc.2014.54 · Cited by 16

The astrocytic lineage marker calmodulin‐regulated spectrin‐associated protein 1 (Camsap1): Phenotypic heterogeneity of newly born Camsap1‐expressing cells in injured mouse brain

Yoshioka, N., Asou, H., Hisanaga, S., & Kawano, H. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22788 · Cited by 16

Progenitors in the Ependyma of the Spinal Cord: A Potential Resource for Self-Repair After Injury

Marichal, N., Reali, C., Rehermann, M. I., Trujillo-Cenóz, O., & Russo, R. E. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-62817-2_13 · Cited by 16

Bridging the gap: a translational perspective in spinal cord injury

Hassan, O. I., Takamiya, S., Asgarihafshejani, A., & Fehlings, M. G. (2024) · Experimental Biology and Medicine · doi:10.3389/ebm.2024.10266 · Cited by 16

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Xu, W., Wang, F., Stein, J., Wang, S., Jiang, P., Yang, L., Cheng, L., & Lee, K. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202508435 · Cited by 15

Analysis of the early response to spinal cord injury identified a key role for mTORC1 signaling in the activation of neural stem progenitor cells

Peñailillo, J., Palacios, M., Mounieres, C., Muñoz, R., Slater, P. G., Domenico, E. D., Patrushev, I., Gilchrist, M. J., & Larraı́n, J. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00179-3 · Cited by 15

The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via NF ‐ κB / MMP9

Li, D., Liu, S., Lu, X., Gong, Z., Wang, H., Xia, X., Lu, F., Jiang, J., Zhang, Y., Xu, G., et al. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70130 · Cited by 15

Organized Neurogenic-Niche-Like Pinwheel Structures Discovered in Spinal Cord Tissue-Derived Neurospheres

Rodríguez-Jiménez, F. J., Clemente, E., Moreno‐Manzano, V., & Erceg, S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00334 · Cited by 15

Baicalein-functionalized collagen scaffolds direct neuronal differentiation toward enhancing spinal cord injury repair

Qian, L., Yang, K., Liu, X., Zhang, L., Zhao, H., Qiu, L., Chu, Y., Zhao, Y., Zhuang, Y., Chen, Y., et al. (2022) · Biomaterials Science · doi:10.1039/d2bm01467j · Cited by 15

Persistence of FoxJ1+ Pax6+ Sox2+ ependymal cells throughout life in the human spinal cord

Ripoll, C., Poulen, G., Chevreau, R., Lonjon, N., Vachiéry-Lahaye, F., Bauchet, L., & Hugnot, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04811-x · Cited by 15

In the presence of danger: the extracellular matrix defensive response to central nervous system injury

Jakeman, L. B., Williams, K., & Brautigam, B. A. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.128238 · Cited by 15

Research progress on the mechanisms of endogenous neural stem cell differentiation in spinal cord injury repair

Wang, T., Han, Q., Lv, S., Zhang, L.-P., Li, H., Liu, J., Kuang, J., Sun, B., & Sun, J. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1592297 · Cited by 15

A core scientific problem in the treatment of central nervous system diseases: newborn neurons

Hao, P., Yang, Z., So, K., & Li, X. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01775 · Cited by 16

Can Adult Neural Stem Cells Create New Brains? Plasticity in the Adult Mammalian Neurogenic Niches

Kazanis, I. (2011) · The Neuroscientist · doi:10.1177/1073858410390379 · Cited by 14

Musashi and Plasticity of Xenopus and Axolotl Spinal Cord Ependymal Cells

Chernoff, E. A. G., Sato, K., Salfity, H., Sarria, D. A., & Belecky‐Adams, T. L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00045 · Cited by 14

Remyelination in PNS and CNS: current and upcoming cellular and molecular strategies to treat disabling neuropathies

Momenzadeh, S., & Jami, M. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06755-6 · Cited by 14

Finding degrees of separation: Experimental approaches for astroglial and oligodendroglial cell isolation and genetic targeting

Chew, L., DeBoy, C. A., & Senatorov, V. V. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.08.017 · Cited by 13

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Iacobucci, S., Padilla, N., Gabrielli, M., Navarro, C., Lombardi, M., Vicioso‐Mantis, M., Verderio, C., de la Cruz, X., & Martínez‐Balbás, M. A. (2021) · Development · doi:10.1242/dev.194951 · Cited by 12

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Meletis, K., Barnabé‐Heider, F., Carlén, M., Evergren, E., Tomilin, N. V., Shupliakov, O., & Frisén, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060182 · Cited by 685

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Sabelström, H. (2014) · Figshare

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