Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming
Open accessAbstract
Cardiovascular disease is a leading cause of death worldwide. The limited capability of heart tissue to regenerate has prompted methodological developments for creating de novo cardiomyocytes, both in vitro and in vivo. Beyond uses in cell replacement therapy, patient-specific cardiomyocytes may find applications in drug testing, drug discovery, and disease modeling. Recently, approaches for generating cardiomyocytes have expanded to encompass three major sources of starting cells: human pluripotent stem cells (hPSCs), adult heart-derived cardiac progenitor cells (CPCs), and reprogrammed fibroblasts. We discuss state-of-the-art methods for generating de novo cardiomyocytes from hPSCs and reprogrammed fibroblasts, highlighting potential applications and future challenges.
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iPSC-CMs have become the most appropriate cell source for fabricating functional cardiac tissues.
“iPSC-CMs have become the most appropriate cell source for fabricating functional cardiac tissues [161].”
From Cardiovascular disease models: A game changing paradigm in drug discovery and screening (2019) · cites this paper as [161]
Enhanced differentiation at lower CHIR concentrations can be attributed to endogenous morphogen production due to the self-assembling conditions.
“We believe enhanced differentiation at lower CHIR concentrations can be attributed to endogenous morphogen production due to the self-assembling conditions provided28–32.”
From Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease (2021) · cites this paper as [29]
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- Authors
- Burridge, P. W., Keller, G., Gold, J. D., & Wu, J. C.
- Affiliations
- Stanford Medicine (US)
- University Health Network (CA)
- Geron (United States) (US)
- Corresponding author
- Wu, Joseph C.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 10
- Issue
- 1
- Pages
- 16-28
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC3255078
- OpenAlex
- W2062298134
- Cited by
- 670
- References
- 132
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 28 · 2023: 38 · 2022: 32 · 2021: 54 · 2020: 38 · 2019: 46 · 2018: 45 · 2017: 57 · 2016: 68 · 2015: 65 · 2014: 69 · 2013: 49 · 2012: 33
- FWCI
- 25.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1dp2od004437-01)
- National Institute on Aging (RC1AG036142)
- National Heart, Lung, and Blood Institute (R33HL089027)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Keywords
- human pluripotent stem cells, direct reprogramming, fibroblast reprogramming, cardiac progenitor cells, cardiomyocyte differentiation, cardiac regeneration, cell replacement therapy, drug testing, disease modeling
- MeSH terms
- Adult, Cardiovascular Diseases, Cell Differentiation, Fibroblasts, Humans, Myocytes, Cardiac, Pluripotent Stem Cells, Cell Dedifferentiation
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