Linking functional decline of telomeres, mitochondria and stem cells during ageing
Open accessAbstract
The study of human genetic disorders and mutant mouse models has provided evidence that genome maintenance mechanisms, DNA damage signalling and metabolic regulation cooperate to drive the ageing process. In particular, age-associated telomere damage, diminution of telomere 'capping' function and associated p53 activation have emerged as prime instigators of a functional decline of tissue stem cells and of mitochondrial dysfunction that adversely affect renewal and bioenergetic support in diverse tissues. Constructing a model of how telomeres, stem cells and mitochondria interact with key molecules governing genome integrity, 'stemness' and metabolism provides a framework for how diverse factors contribute to ageing and age-related disorders.
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Telomerase activity and recombination-based processes that maintain telomere length are critical for tissue homeostasis.
“telomerase activity and recombination‐based processes that maintain telomere length are critical for tissue homeostasis (Sahin & Depinho, 2010).”
From P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan (2016) · cites this paper as Sahin & Depinho, 2010
The ‘Telomeres and ageing’ section says telomerase maintains telomeres and links adequate telomerase activity and telomere length to ageing; it also describes organ dysfunction associated with telomere-maintenance defects. But the paper does not identify recombination-based telomere-length maintenance as critical for tissue homeostasis. Its References annotation instead describes telomerase as preventing end-to-end recombination. (LLM, conf=0.87)
Experimental — accuracy not yet measuredAge-progressive loss of telomere function in mice provokes widespread p53 activation resulting in activation of cellular checkpoints of apoptosis, impaired proliferation and senescence, compromised tissue stem cell and progenitor function, marked tissue atrophy and physiological impairment in many organ systems.
“Of particular relevance to this study, age-progressive loss of telomere function in mice has been shown to provoke widespread p53 activation resulting in activation of cellular checkpoints of apoptosis, impaired proliferation and senescence, compromised tissue stem cell and progenitor function, marked tissue atrophy and physiological impairment in many organ systems 1 , 6 .”
From Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice (2011) · cites this paper as [1]
Telomere loss and uncapping provokes progressive tissue atrophy, stem cell depletion, organ system failure, and impaired tissue injury responses.
“Telomere loss and uncapping provokes progressive tissue atrophy, stem cell depletion, organ system failure, and impaired tissue injury responses 1 .”
From Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice (2011) · cites this paper as [1]
Immune ageing involves fewer stem cells, changed T-cell production, weaker B-cell antibody responses, and less phagocytosis by neutrophils, macrophages and natural killer cells.
“The ageing immune system is characterised by a decline in stem cells, alterations in T-lymphocyte production, blunting of the B-cell led antibody response and reduced phagocytic activity of neutrophils, macrophages and natural killer cells (50, 51).”
From Frailty in elderly people (2013) · cites this paper as [50]
An aged immune system may work well at rest but respond poorly to acute inflammatory stress.
“This senescent immune system may function adequately in the quiescent state but fail to respond appropriately to the stress of acute inflammation (50).”
From Frailty in elderly people (2013) · cites this paper as [50]
DNA damage in association with telomere dysfunction and shortening precipitates premature aging and shortened lifespan, leading to depletion of almost all tissue stem cell reserves and dysfunction of stem cells, including self-renewal and repair capacity of epidermal stem cells and melanocytes of the follicle during hair growth.
“DNA damage in association with telomere dysfunction and shortening precipitates premature aging and shortened lifespan, leading to depletion of almost all tissue stem cell reserves and dysfunction of stem cells, including self-renewal and repair capacity of ESCs and melanocytes of the follicle during the hair growth process [113, 114].”
From Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging (2016) · cites this paper as [113]
Repeated cell division may cause progressive telomere shortening, leading to DNA damage that cannot be repaired efficiently because of age-related defects in DNA repair.
“Thus, repeated cell division may result in progressive telomere shortening that in turn results in DNA damage that can no longer be repaired efficiently due to agerelated defects in DNA repair mechanisms (75).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [75]
Aging often dysregulates similar molecular pathways in stem and progenitor cells from various tissues.
“The analysis of stem and progenitor cells from various tissues has revealed that aging often results in the dysregulation of similar molecular pathways (75).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [75]
In mouse HSCs and neural stem cells, excessive cellular ROS concentrations cause abnormal proliferation, malignancy, and compromised self-renewal.
“in HSCs and neural stem cells (NSCs) of mice, excessive cellular ROS concentrations lead to abnormal proliferation, malignancy and compromised stem cell self-renewal11–14”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [12]
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Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
Identification of a specific telomere terminal transferase activity in tetrahymena extracts
Greider, C. W., & Blackburn, E. H. (1985) · Cell · doi:10.1016/0092-8674(85)90170-9 · Cited by 3,400 · see citing works
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007 · see citing works
Accelerated telomere shortening in response to life stress
Epel, E. S., Blackburn, E. H., Lin, J., Dhabhar, F. S., Adler, N. E., Morrow, J. D., & Cawthon, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407162101 · Cited by 3,002 · see citing works
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 2,744 · see citing works
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734 · see citing works
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works
Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,274 · see citing works
St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works
Self-citationSwitching and Signaling at the Telomere
Blackburn, E. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00492-5 · Cited by 2,097 · see citing works
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works
Association between telomere length in blood and mortality in people aged 60 years or older
Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761 · see citing works
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Mostoslavsky, R., Chua, K. F., Lombard, D. B., Pang, W. W., Fischer, M. R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M. M., et al. (2006) · Cell · doi:10.1016/j.cell.2005.11.044 · Cited by 1,637 · see citing works
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
Tothova, Z., Kollipara, R., Huntly, B. J., Lee, B. H., Castrillon, D. H., Cullen, D. E., McDowell, E. P., Lazo-Kallanian, S., Williams, I. R., Sears, C., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.003 · Cited by 1,562 · see citing works
Self-citationRecent progress in the biology and physiology of sirtuins
Finkel, T., Deng, C., & Mostoslavsky, R. (2009) · Nature · doi:10.1038/nature08197 · Cited by 1,484 · see citing works
p53 mutant mice that display early ageing-associated phenotypes
Tyner, S. D., Venkatachalam, S., Choi, J., Jones, S., Ghebranious, N., Igelmann, H., Lu, X., Soron, G., Cooper, B., Brayton, C., et al. (2002) · Nature · doi:10.1038/415045a · Cited by 1,459 · see citing works
DNA Damage Foci at Dysfunctional Telomeres
Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409 · see citing works
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis
Armanios, M. Y., Chen, J. J.-L., Cogan, J. D., Alder, J. K., Ingersoll, R. G., Markin, C., Lawson, W. E., Xie, M., Vulto, I., Phillips, J. A., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066157 · Cited by 1,357 · see citing works
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works
Self-citationThe plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338 · see citing works
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Yilmaz, Ö. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature04703 · Cited by 1,272 · see citing works
Essential role of mouse telomerase in highly proliferative organs
Lee, H.-W., Blasco, M. A., Gottlieb, G. J., Horner, J. W., Greider, C. W., & DePinho, R. A. (1998) · Nature · doi:10.1038/33345 · Cited by 1,270 · cited 1× · see citing works
“Coincident with cytogenetic evidence of telomere dysfunction (signal-free ends and end-to-end fusions), late-generation (G 3 and beyond) Terc −/− mice had a shortened lifespan, overall frailty, decreased fecundity and tissue atrophy with impaired organ functio”
Self-citationAge-related changes in lymphocyte development and function
Linton, P. J., & Dorshkind, K. A. (2004) · Nature Immunology · doi:10.1038/ni1033 · Cited by 1,180 · see citing works
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · see citing works
Greider, C. W., & Blackburn, E. H. (1987) · Cell · doi:10.1016/0092-8674(87)90576-9 · Cited by 1,150 · see citing works
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115 · see citing works
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
Michishita, E., McCord, R. A., Berber, E., Kioi, M., Padilla-Nash, H., Damian, M., Cheung, P., Kusumoto, R., Kawahara, T. L. A., Barrett, J. C., et al. (2008) · Nature · doi:10.1038/nature06736 · Cited by 1,111 · see citing works
The antioxidant function of the p53 tumor suppressor
Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,110 · see citing works
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Artandi, S. E., Chang, S., Lee, S.-L., Alson, S., Gottlieb, G. J., Chin, L., & DePinho, R. A. (2000) · Nature · doi:10.1038/35020592 · Cited by 1,085 · see citing works
Self-citationThe Regulation of INK4/ARF in Cancer and Aging
Kim, W. Y., & Sharpless, N. E. (2006) · Cell · doi:10.1016/j.cell.2006.10.003 · Cited by 1,009 · see citing works
The common biology of cancer and ageing
Finkel, T., Serrano, M., & Blasco, M. A. (2007) · Nature · doi:10.1038/nature05985 · Cited by 988 · see citing works
Chin, L., Artandi, S. E., Shen, Q., Tam, A., Lee, S.-L., Gottlieb, G. J., Greider, C. W., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80762-x · Cited by 979 · see citing works
Self-citationIncreasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972 · see citing works
DePinho, R. A. (2000) · Nature · doi:10.1038/35041694 · Cited by 959 · see citing works
Self-citationStems Cells and the Pathways to Aging and Cancer
Rossi, D. J., Jamieson, C. H. M., & Weissman, I. L. (2008) · Cell · doi:10.1016/j.cell.2008.01.036 · Cited by 895 · see citing works
How stem cells age and why this makes us grow old
Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 843 · see citing works
Self-citationAging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
Chambers, S. M., Shaw, C. A., Gatza, C. E., Fisk, C. J., Donehower, L. A., & Goodell, M. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050201 · Cited by 799 · see citing works
Ruzankina, Y., Pinzon‐Guzman, C., Asare, A., Ong, T., Pontano, L. L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A., & Brown, E. J. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.03.002 · Cited by 780 · see citing works
Mutations in <i>TERT,</i> the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia
Yamaguchi, H., Calado, R. T., Ly, H., Kajigaya, S., Baerlocher, G. M., Chanock, S. J., Lansdorp, P. M., & Young, N. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042980 · Cited by 723 · see citing works
Kollman, C., Howe, C. W. S., Anasetti, C., Antin, J. H., Davies, S. M., Filipovich, A. H., Hegland, J., Kamani, N. R., Kernan, N. A., King, R., et al. (2001) · Blood · doi:10.1182/blood.v98.7.2043 · Cited by 703 · see citing works
Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14723 · Cited by 649 · see citing works
Cloning yeast telomeres on linear plasmid vectors
Szostak, J. W., & Blackburn, E. H. (1982) · Cell · doi:10.1016/0092-8674(82)90109-x · Cited by 629 · see citing works
Modulation of mammalian life span by the short isoform of p53
Maier, B., Gluba, W., Bernier, B., Turner, T., Mohammad, K., Guise, T., Sutherland, A., Thorner, M., & Scrable, H. (2004) · Genes & Development · doi:10.1101/gad.1162404 · Cited by 586 · see citing works
Connecting Chromosomes, Crisis, and Cancer
Maser, R. S., & DePinho, R. A. (2002) · Science · doi:10.1126/science.297.5581.565 · Cited by 561 · see citing works
Self-citationThe Behavior in Successive Nuclear Divisions of a Chromosome Broken at Meiosis
McClintock, B. (1939) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.25.8.405 · Cited by 559 · see citing works
DNA sequences of telomeres maintained in yeast
Shampay, J., Szostak, J. W., & Blackburn, E. H. (1984) · Nature · doi:10.1038/310154a0 · Cited by 551 · see citing works
Enwere, E. K., Shingo, T., Gregg, C., Fujikawa, H., Ohta, S., & Weiss, S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2751-04.2004 · Cited by 549 · see citing works
Maslov, A. Y., Barone, T. A., Plunkett, R. J., & Pruitt, S. C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4608-03.2004 · Cited by 522 · see citing works
Simon, N. M., Smoller, J. W., McNamara, K. L., Maser, R. S., Zalta, A. K., Pollack, M. H., Nierenberg, A. A., Fava, M., & Wong, K.-K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.004 · Cited by 516 · see citing works
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513 · see citing works
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.034 · Cited by 484 · see citing works
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Liu, J., Cao, L., Chen, J., Song, S., Lee, I. H., Quijano, C., Liu, H., Keyvanfar, K., Chen, H., Cao, L.-Y., et al. (2009) · Nature · doi:10.1038/nature08040 · Cited by 474 · see citing works
Delayed ageing through damage protection by the Arf/p53 pathway
Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466 · see citing works
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
Chang, S., Multani, A. S., Cabrera, N. G., Naylor, M. L., Laud, P., Lombard, D., Pathak, S., Guarente, L., & DePinho, R. A. (2004) · Nature Genetics · doi:10.1038/ng1389 · Cited by 462 · see citing works
Self-citationFoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis
Paik, J.-H., Ding, Z., Narurkar, R., Ramkissoon, S., Muller, F., Kamoun, W. S., Chae, S.-S., Zheng, H., Ying, H., Mahoney, J., et al. (2009) · Cell Stem Cell · doi:10.1016/j.stem.2009.09.013 · Cited by 459 · see citing works
Self-citationCell aging in relation to stress arousal and cardiovascular disease risk factors
Epel, E. S., Lin, J., Wilhelm, F. H., Wolkowitz, O. M., Cawthon, R., Adler, N. E., Dolbier, C., Mendes, W. B., & Blackburn, E. H. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.08.011 · Cited by 450 · see citing works
Effects of Telomerase and Telomere Length on Epidermal Stem Cell Behavior
Flores, I., Cayuela, M. L., & Blasco, M. A. (2005) · Science · doi:10.1126/science.1115025 · Cited by 448 · see citing works
Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1937 · Cited by 426 · see citing works
Conditional telomerase induction causes proliferation of hair follicle stem cells
Sarin, K. Y., Cheung, P., Gilison, D., Lee, E., Tennen, R. I., Wang, E., Artandi, M. K., Oro, A. E., & Artandi, S. E. (2005) · Nature · doi:10.1038/nature03836 · Cited by 425 · see citing works
Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery
Rudolph, K. L., Chang, S., Millard, M., Schreiber-Agus, N., & DePinho, R. A. (2000) · Science · doi:10.1126/science.287.5456.1253 · Cited by 424 · see citing works
Self-citationAn RNA-dependent RNA polymerase formed by TERT and the RMRP RNA
Maida, Y., Yasukawa, M., Furuuchi, M., Lassmann, T., Possemato, R., Okamoto, N., Kasim, V., Hayashizaki, Y., Hahn, W. C., & Masutomi, K. (2009) · Nature · doi:10.1038/nature08283 · Cited by 384 · see citing works
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
Wong, K.-K., Maser, R. S., Bachoo, R. M., Menon, J., Carrasco, D. R., Gu, Y., Alt, F. W., & DePinho, R. A. (2003) · Nature · doi:10.1038/nature01385 · Cited by 375 · see citing works
Self-citationGenotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
Inomata, K., Aoto, T., Binh, N. T., Okamoto, N., Tanimura, S., Wakayama, T., Iseki, S., Hara, E., Masunaga, T., Shimizu, H., et al. (2009) · Cell · doi:10.1016/j.cell.2009.03.037 · Cited by 368 · see citing works
The longest telomeres: a general signature of adult stem cell compartments
Flores, I., Canela, A., Vera, E., Tejera, A., Cotsarelis, G., & Blasco, M. A. (2008) · Genes & Development · doi:10.1101/gad.451008 · Cited by 352 · see citing works
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
Passos, J. F., Saretzki, G., & von Zglinicki, T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm893 · Cited by 344 · see citing works
FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System
Tothova, Z., & Gilliland, D. G. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.017 · Cited by 331 · see citing works
Leri, A., Franco, S., Zacheo, A., Barlucchi, L., Chimenti, S., Limana, F., Nadal‐Ginard, B., Kajstura, J., Anversa, P., & Blasco, M. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg013 · Cited by 313 · see citing works
Telomere Length Dynamics and Chromosomal Instability in Cells Derived from Telomerase Null Mice
Hande, M. P., Samper, E., Lansdorp, P., & Blasco, M. A. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.4.589 · Cited by 313 · cited 1× · see citing works
“The severity of these degenerative phenotypes parallels the degree of telomere dysfunction in successive Terc −/− generations, as measured by the number of chromosomal fusions and anaphase bridges and, in a more recent study, the number of DNA damage foci at telomere”
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
Hao, L.-Y., Armanios, M., Strong, M. A., Karim, B., Feldser, D. M., Huso, D., & Greider, C. W. (2005) · Cell · doi:10.1016/j.cell.2005.11.020 · Cited by 302 · see citing works
Stem Cell Review Series: Aging of the skeletal muscle stem cell niche
Gopinath, S. D., & Rando, T. A. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00399.x · Cited by 262 · see citing works
Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging
Armanios, M., Alder, J. K., Parry, E. M., Karim, B., Strong, M. A., & Greider, C. W. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.10.028 · Cited by 257 · see citing works
Njajou, O. T., Hsueh, W.-C., Blackburn, E. H., Newman, A. B., Wu, S.-H., Li, R., Simonsick, E. M., Harris, T. B., Cummings, S., & Cawthon, R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp061 · Cited by 249 · see citing works
Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians
Atzmon, G., Cho, M., Cawthon, R., Budagov, T., Katz, M., Yang, X., Siegel, G., Bergman, A., Huffman, D. M., Schechter, C. B., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906191106 · Cited by 247 · see citing works
Tumor suppression and normal aging in mice with constitutively high p53 activity
Mendrysa, S. M., O'Leary, K. A., McElwee, M. K., Michalowski, J., Eisenman, R. N., Powell, D. A., & Perry, M. E. (2006) · Genes & Development · doi:10.1101/gad.1378506 · Cited by 210 · see citing works
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization
Gan, B., Sahin, E., Jiang, S., Sánchez‐Aguilera, A., Scott, K. L., Chin, L., Williams, D. A., Kwiatkowski, D. J., & DePinho, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810584105 · Cited by 203 · see citing works
Self-citation20 years studying p53 functions in genetically engineered mice
Donehower, L. A., & Lozano, G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2731 · Cited by 193 · see citing works
Cancer and ageing: convergent and divergent mechanisms
Serrano, M., & Blasco, M. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2242 · Cited by 182 · cited 1× · see citing works
“Finally, inactivation of p53 may not be sufficient to sustain viability in the setting of extremely severe telomere dysfunction and rampant chromosomal stabilit”
Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance.
Vianna, C. R., Huntgeburth, M., Coppari, R., Choi, C. S., Lin, J., Krauss, S., Barbatelli, G., Tzameli, I., Kim, Y.-B., Cinti, S., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.11.003 · Cited by 181 · see citing works
Dyskeratosis congenita, stem cells and telomeres
Kirwan, M., & Dokal, I. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.01.010 · Cited by 180 · see citing works
Genetic Modulation of Senescent Phenotypes in Homo sapiens
Martin, G. M. (2005) · Cell · doi:10.1016/j.cell.2005.01.031 · Cited by 171 · see citing works
Ferrón, S., Mira, H., Franco, S., Cano-Jaimez, M., Bellmunt, E., Ramírez, C., Fariñas, I., & Blasco, M. A. (2004) · Development · doi:10.1242/dev.01215 · Cited by 152 · see citing works
Telomere length regulation during postnatal development and ageing in Mus spretus
Coviello-McLaughlin, G. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.3051 · Cited by 141 · see citing works
Mitochondria, telomeres and cell senescence
Passos, J. F., & von Zglinicki, T. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.04.006 · Cited by 133 · see citing works
The Arf/p53 Pathway in Cancer and Aging
Matheu, A., Maraver, A., & Serrano, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6851 · Cited by 129 · see citing works
Farazi, P. A., Glickman, J. N., Horner, J. W., & DePinho, R. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4608 · Cited by 119 · see citing works
Self-citationChen, M. L., Logan, T. D., Hochberg, M. L., Shelat, S. G., Yu, X., Wilding, G. E., Tan, W., Kujoth, G. C., Prolla, T. A., Selak, M. A., et al. (2009) · Blood · doi:10.1182/blood-2008-08-169474 · Cited by 108 · see citing works
Begus‐Nahrmann, Y., Lechel, A., Obenauf, A. C., Nalapareddy, K., Peit, E., Hoffmann, E. M., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H. A., et al. (2009) · Nature Genetics · doi:10.1038/ng.426 · Cited by 104 · see citing works
Morales, M., Theunissen, J.-W. F., Kim, C. F. B., Kitagawa, R., Kastan, M. B., & Petrini, J. H. J. (2005) · Genes & Development · doi:10.1101/gad.1373705 · Cited by 87 · see citing works
Flores, I., & Blasco, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004934 · Cited by 83 · see citing works
Advanced Telomere Shortening in Respiratory Chain Disorders
Oexle, K., & Zwirner, A. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.6.905 · Cited by 76 · see citing works
Vijg, J. (2007) · doi:10.1093/acprof:oso/9780198569237.001.0001 · Cited by 63 · see citing works
Sarcopenia: Age-Related Skeletal Muscle Changes from Determinants to Physical Disability
Iorio, A. D., Abate, M., Renzo, D. D., Russolillo, A., Battaglini, C. L., Ripari, P., Saggini, R., Paganelli, R., & Abate, G. (2006) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200601900401 · Cited by 57 · see citing works
Khoo, C. M., Carrasco, D. R., Bosenberg, M. W., Paik, J.-H., & DePinho, R. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700093104 · Cited by 52 · see citing works
Self-citationRegulation and Function of Skeletal Muscle Stem CellsPreprint
Cerletti, M., Shadrach, J. L., Jurga, S., Sherwood, R. I., & Wagers, A. J. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.054 · Cited by 40 · see citing works
Prevalence and Impact of Dementia-related Functional Limitations in the United States, 2001 to 2005
Arrighi, H. M., McLaughlin, T. P., & Leibman, C. W. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181a1a87d · Cited by 17 · see citing works
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Clegg, A., Young, J., Iliffe, S., Rikkert, M. O., & Rockwood, K. (2013) · The Lancet · doi:10.1016/s0140-6736(12)62167-9 · Cited by 9,503 · see citing works
The DNA Damage Response: Making It Safe to Play with Knives
Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368 · see citing works
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
Stephens, P. J., Greenman, C. D., Fu, B., Yang, F., Bignell, G. R., Mudie, L. J., Pleasance, E. D., Lau, K. W., Beare, D., Stebbings, L. A., et al. (2011) · Cell · doi:10.1016/j.cell.2010.11.055 · Cited by 2,414 · see citing works
Wallace, D. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3365 · Cited by 2,404 · see citing works
Stem cells: past, present, and future
Zakrzewski, W., Dobrzyński, M., Szymonowicz, M. K., & Rybak, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1165-5 · Cited by 1,886 · see citing works
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585 · see citing works
HIV Infection, Inflammation, Immunosenescence, and Aging
Deeks, S. G. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-042909-093756 · Cited by 1,349 · see citing works
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319 · see citing works
Self-citationThe patterns and dynamics of genomic instability in metastatic pancreatic cancer
Campbell, P. J., Yachida, S., Mudie, L. J., Stephens, P. J., Pleasance, E. D., Stebbings, L. A., Morsberger, L. A., Latimer, C., McLaren, S., Lin, M.-L., et al. (2010) · Nature · doi:10.1038/nature09460 · Cited by 1,317 · see citing works
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
Jaskelioff, M., Muller, F. L., Paik, J.-H., Thomas, E., Jiang, S., Adams, A. C., Sahin, E., Kost-Alimova, M., Protopopov, A., Cadiñanos, J., et al. (2011) · Nature · doi:10.1038/nature09603 · Cited by 857 · see citing works
Self-citationStem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
Causes, consequences, and reversal of immune system aging
Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64096 · Cited by 793 · see citing works
Telomere length in early life predicts lifespan
Heidinger, B. J., Blount, J. D., Boner, W., Griffiths, K., Metcalfe, N. B., & Monaghan, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113306109 · Cited by 713 · see citing works
Role of Telomeres and Telomerase in Aging and Cancer
Shay, J. W. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0062 · Cited by 668 · see citing works
Metabolic Plasticity in Stem Cell Homeostasis and Differentiation
Folmes, C. D. L., Dzeja, P. P., Nelson, T. J., & Terzic, A. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.10.002 · Cited by 664 · see citing works
Detectable clonal mosaicism from birth to old age and its relationship to cancer
Laurie, C. C., Laurie, C. A., Rice, K., Doheny, K. F., Zelnick, L. R., McHugh, C. P., Ling, H., Hetrick, K. N., Pugh, E. W., Amos, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2271 · Cited by 594 · see citing works
Detectable clonal mosaicism and its relationship to aging and cancer
Jacobs, K. B., Yeager, M., Zhou, W., Wacholder, S., Wang, Z., Rodriguez-Santiago, B., Hutchinson, A., Deng, X., Liu, C., Horner, M.-J., et al. (2012) · Nature Genetics · doi:10.1038/ng.2270 · Cited by 589 · see citing works
Mitochondria as signaling organelles
Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576 · see citing works
Stem cell metabolism in tissue development and aging
Shyh‐Chang, N., Daley, G. Q., & Cantley, L. C. (2013) · Development · doi:10.1242/dev.091777 · Cited by 573 · see citing works
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
Lapasset, L., Milhavet, O., Prieur, A., Besnard, E., Babled, A., Aït-Hamou, N., Leschik, J., Pellestor, F., Ramirez, J.-M., De Vos, J., et al. (2011) · Genes & Development · doi:10.1101/gad.173922.111 · Cited by 570 · see citing works
Boskey, A. L., & Coleman, R. M. (2010) · Journal of Dental Research · doi:10.1177/0022034510377791 · Cited by 555 · see citing works
Asghar, M., Hasselquist, D., Hansson, B., Zehtindjiev, P., Westerdahl, H., & Bensch, S. (2015) · Science · doi:10.1126/science.1261121 · Cited by 508 · see citing works
Lin28: Primal Regulator of Growth and Metabolism in Stem Cells
Shyh-Chang, N., & Daley, G. Q. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.03.005 · Cited by 458 · see citing works
Genomic Comparison of the Ants Camponotus floridanus and Harpegnathos saltator
Bonasio, R., Zhang, G., Ye, C., Mutti, N. S., Fang, X., Qin, N., Donahue, G., Yang, P., Li, Q., Li, C., et al. (2010) · Science · doi:10.1126/science.1192428 · Cited by 453 · see citing works
SIRT3 Reverses Aging-Associated Degeneration
Brown, K., Xie, S., Qiu, X., Mohrin, M., Shin, J., Liu, Y., Zhang, D., Scadden, D. T., & Chen, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.005 · Cited by 436 · see citing works
Focus on the Contribution of Oxidative Stress in Skin Aging
Papaccio, F., D’Arino, A., Caputo, S., & Bellei, B. (2022) · Antioxidants · doi:10.3390/antiox11061121 · Cited by 431 · see citing works
The melanocyte lineage in development and disease
Mort, R. L., Jackson, I. J., & Patton, E. E. (2015) · Development · doi:10.1242/dev.106567 · Cited by 416 · see citing works
Ageing and the telomere connection: An intimate relationship with inflammation
Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 386 · see citing works
Axis of ageing: telomeres, p53 and mitochondria
Sahin, E., & DePinho, R. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3352 · Cited by 380 · see citing works
Self-citationPanich, U., Sittithumcharee, G., Rathviboon, N., & Jirawatnotai, S. (2016) · Stem Cells International · doi:10.1155/2016/7370642 · Cited by 374 · see citing works
Sex differences in telomeres and lifespan
Barrett, E. L. B., & Richardson, D. S. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00741.x · Cited by 366 · see citing works
Metabolism of the preimplantation embryo: 40 years on
Leese, H. J. (2012) · Reproduction · doi:10.1530/rep-11-0484 · Cited by 362 · see citing works
Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging
Ziegler, D. V., Wiley, C. D., & Velarde, M. C. (2014) · Aging Cell · doi:10.1111/acel.12287 · Cited by 353 · see citing works
Naive T Cell Maintenance and Function in Human Aging
Goronzy, J. J., Fang, F., Cavanagh, M., Qi, Q., & Weyand, C. M. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500046 · Cited by 348 · see citing works
A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage
Wang, J., Sun, Q., Morita, Y., Jiang, H., Groß, A., Lechel, A., Hildner, K., Guachalla, L. M., Gompf, A., Hartmann, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.040 · Cited by 343 · see citing works
Zambetti, N. A., Ping, Z., Chen, S., Kenswil, K. J. G., Mylona, M. A., Sanders, M. A., Hoogenboezem, R. M., Bindels, E. M. J., Adisty, M. N., Van Strien, P. M. H., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.08.021 · Cited by 342 · see citing works
Gutterman, D. D., Chabowski, D. S., Kadlec, A. O., Durand, M. J., Freed, J. K., Ait‐Aissa, K., & Beyer, A. (2016) · Circulation Research · doi:10.1161/circresaha.115.305364 · Cited by 327 · see citing works
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 322 · see citing works
Mechanisms that Regulate Stem Cell Aging and Life Span
Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320 · see citing works
Mao, P., & Reddy, P. H. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.005 · Cited by 311 · see citing works
Manifestations and mechanisms of stem cell aging
Liu, L. A., & Rando, T. A. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201010131 · Cited by 306 · see citing works
Bullón, P., Newman, H. N., & Battino, M. A. (2013) · Periodontology 2000 · doi:10.1111/j.1600-0757.2012.00455.x · Cited by 304 · see citing works
Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer
HU, J. L., Hwang, S. S., Liesa, M., Gan, B., Sahin, E., Jaskelioff, M., Ding, Z., Ying, H., Boutin, A. T., Zhang, H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.028 · Cited by 292 · see citing works
Self-citationRole of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity
Mori, M. A., Raghavan, P., Thomou, T., Boucher, J., Robida-Stubbs, S., Macotela, Y., Russell, S. J., Kirkland, J. L., Blackwell, T. K., & Kahn, C. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.017 · Cited by 279 · see citing works
Liu, J., Ding, Y., Liu, Z., & Liang, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00258 · Cited by 272 · see citing works
Brain-Skin Connection: Stress, Inflammation and Skin Aging
Chen, Y., & Lyga, J. W. (2014) · Inflammation & Allergy - Drug Targets · doi:10.2174/1871528113666140522104422 · Cited by 269 · see citing works
Saenen, N. D., Martens, D. S., Neven, K. Y., Alfano, R., Bové, H., Janssen, B. G., Roels, H. A., Plusquin, M., Vrijens, K., & Nawrot, T. S. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0688-z · Cited by 267 · see citing works
Telomerase: Structure, functions, and activity regulation
Zvereva, M. I., Shcherbakova, D. M., & Донцова, О. А. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910130055 · Cited by 266 · see citing works
Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
Zhong, F., Savage, S. A., Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B. P., & Artandi, S. E. (2011) · Genes & Development · doi:10.1101/gad.2006411 · Cited by 262 · see citing works
DNA damage-induced type I interferon promotes senescence and inhibits stem cell function
Yu, Q., Katlinskaya, Y. V., Carbone, C. J., Zhao, B., Katlinski, K. V., Zheng, H., Guha, M., Li, N., Chen, Q., Yang, T., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.069 · Cited by 260 · see citing works
Emerging models and paradigms for stem cell ageing
Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-506 · Cited by 256 · see citing works
A plant-derived natural photosynthetic system for improving cell anabolism
Chen, P., Liu, X., Gu, C., Zhong, P., Song, N., Li, M., Dai, Z., Fang, X., Liu, Z., Zhang, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05499-y · Cited by 251 · see citing works
Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere length
Entringer, S., Epel, E. S., Lin, J., Buß, C., Shahbaba, B., Blackburn, E. H., Simhan, H. N., & Wadhwa, P. D. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2012.11.033 · Cited by 249 · see citing works
Ageing and neurodegenerative diseases
Hung, C.-W., Chen, Y., Hsieh, W.-L., Chiou, S., & Kao, C.-L. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.08.006 · Cited by 248 · see citing works
Tendon injuries: Basic science and new repair proposals
Wu, F., Nerlich, M. N., & Docheva, D. (2017) · EFORT Open Reviews · doi:10.1302/2058-5241.2.160075 · Cited by 244 · see citing works
The role of telomeres and telomerase in cirrhosis and liver cancer
Nault, J., Ningarhari, M., Rebouissou, S., & Zucman‐Rossi, J. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0165-3 · Cited by 241 · see citing works
Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
Conboy, I. M., & Rando, T. A. (2012) · Cell Cycle · doi:10.4161/cc.20437 · Cited by 239 · see citing works
Mitochondrial Rejuvenation After Induced Pluripotency
Suhr, S. T., Chang, E. A., Tjong, J., Alcasid, N. J., Perkins, G. A., Goissis, M. D., Ellisman, M. H., Perez, G. I., & Cibelli, J. B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014095 · Cited by 227 · see citing works
Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Reddy, P. H., & Reddy, T. P. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745401 · Cited by 227 · see citing works
Reactivation of telomerase in cancer
Akıncılar, S. C., Unal, B., & Tergaonkar, V. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2146-9 · Cited by 223 · see citing works
Starkweather, A. R., Alhaeeri, A. A., Montpetit, A. J., Brumelle, J., Filler, K., Montpetit, M., Mohanraj, L., Lyon, D., & Jackson‐Cook, C. K. (2013) · Nursing Research · doi:10.1097/nnr.0000000000000009 · Cited by 217 · see citing works
Changes in Regenerative Capacity through Lifespan
Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216 · see citing works
Kohler, J., Popov, C., Klotz, B. J., Alberton, P., Prall, W. C., Haasters, F., Müller-Deubert, S. M., Ebert, R., Klein‐Hitpaß, L., Jakob, F. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12124 · Cited by 212 · see citing works
Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species
Achuthan, S., Santhoshkumar, T. R., Prabhakar, J., Nair, S. A., & Pillai, M. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200675 · Cited by 207 · see citing works
The GSK-3 Family as Therapeutic Target for Myocardial Diseases
Lal, H., Ahmad, F., Woodgett, J. R., & Force, T. L. (2014) · Circulation Research · doi:10.1161/circresaha.116.303613 · Cited by 205 · see citing works
Yang, J., Huang, T., Petralia, F., Long, Q., Zhang, B., Argmann, C., Zhao, Y. B., Mobbs, C. V., Schadt, E. E., Zhu, J., et al. (2015) · Scientific Reports · doi:10.1038/srep15145 · Cited by 198 · see citing works
Cellular senescence in cancer: from mechanisms to detection
Ou, H., Hoffmann, R. J., González‐López, C., Doherty, G. J., Korkola, J. E., & Muñoz‐Espín, D. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12807 · Cited by 198 · see citing works
Bocker, M., Hellwig, I., Breiling, A., Eckstein, V., Ho, A. D., & Lyko, F. (2011) · Blood · doi:10.1182/blood-2011-01-331926 · Cited by 195 · see citing works
Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation
Deschênes-Simard, X., Gaumont-Leclerc, M.-F., Bourdeau, V., Lessard, F., Moiseeva, O., Forest, V., Igelmann, S., Mallette, F. A., Saba-El-Leil, M. K., Meloche, S., et al. (2013) · Genes & Development · doi:10.1101/gad.203984.112 · Cited by 194 · see citing works
HIF1α is required for survival maintenance of chronic myeloid leukemia stem cells
Zhang, H., Li, H., Xi, H. S., & Li, S. (2012) · Blood · doi:10.1182/blood-2011-10-387381 · Cited by 192 · see citing works
Effects of Age and Heart Failure on Human Cardiac Stem Cell Function
Cesselli, D., Beltrami, A. P., D’Aurizio, F., Marcon, P., Bergamin, N., Toffoletto, B., Pandolfi, M., Puppato, E., Marino, L., Signore, S., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.03.036 · Cited by 190 · see citing works
The fetal programming of telomere biology hypothesis: an update
Entringer, S., de Punder, K., Buß, C., & Wadhwa, P. D. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0151 · Cited by 189 · see citing works
Evolution of the cancer genome
Podlaha, O., Riester, M., De, S., & Michor, F. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.01.003 · Cited by 188 · see citing works
Assessing cell and organ senescence biomarkers
de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187 · see citing works
Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder
Mellon, S. H., Gautam, A., Hammamieh, R., Jett, M., & Wolkowitz, O. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.007 · Cited by 184 · see citing works
The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders
Teng, Y., Fan, Y., Ma, J., Lü, W., Liu, N., Chen, Y.-F., Pan, W., & Tao, X. (2021) · Cells · doi:10.3390/cells10051219 · Cited by 183 · see citing works
Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease
Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.001 · Cited by 182 · see citing works
Self-citationHeart Failure With Preserved Ejection Fraction
Loffredo, F. S., Nikolova, A., Pancoast, J. R., & Lee, R. T. (2014) · Circulation Research · doi:10.1161/circresaha.115.302929 · Cited by 181 · see citing works
Crane, J. D., MacNeil, L. G., Lally, J. S., Ford, R. J., Bujak, A. L., Brar, I. K., Kemp, B. E., Raha, S., Steinberg, G. R., & Tarnopolsky, M. A. (2015) · Aging Cell · doi:10.1111/acel.12341 · Cited by 179 · see citing works
Liu, M., Lei, H., Dong, P., Fu, X., Yang, Z., Yang, Y., Ma, J., Liu, X., Cao, Y., & Xiao, R. (2017) · Cell Transplantation · doi:10.1177/0963689717721221 · Cited by 173 · see citing works
Aging and reprogramming: a two-way street
Mahmoudi, S., & Brunet, A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.10.004 · Cited by 171 · see citing works
Mesenchymal Stem Cell Senescence and Rejuvenation: Current Status and Challenges
Xueke, Z., Hong, Y., Zhang, H., & Li, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00364 · Cited by 166 · see citing works
B cell maintenance and function in aging
Kogut, I., Scholz, J. L., Cancro, M. P., & Cambier, J. C. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.004 · Cited by 166 · see citing works
Normal stem cells and cancer stem cells: similar and different.
Shackleton, M. (2010) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2010.04.002 · Cited by 175 · see citing works
Chromatin regulation and genome maintenance by mammalian SIRT6
Tennen, R. I., & Chua, K. F. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.07.009 · Cited by 164 · see citing works
SIRT6 is required for maintenance of telomere position effect in human cells
Tennen, R. I., Bua, D. J., Wright, W. E., & Chua, K. F. (2011) · Nature Communications · doi:10.1038/ncomms1443 · Cited by 162 · see citing works
McClay, J. L., Åberg, K. A., Clark, S. L., Nerella, S., Kumar, G., Xie, L. Y., Hudson, A. D., Harada, A., Hultman, C. M., Magnusson, P. K. E., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt511 · Cited by 162 · see citing works
Chromothripsis and Human Disease: Piecing Together the Shattering Process
Maher, C. A., & Wilson, R. K. (2012) · Cell · doi:10.1016/j.cell.2012.01.006 · Cited by 159 · see citing works
Willie, B. M., Birkhold, A., Razi, H., Thiele, T., Aido, M., Kruck, B., Schill, A., Checa, S., Main, R. P., & Duda, G. N. (2013) · Bone · doi:10.1016/j.bone.2013.04.023 · Cited by 159 · see citing works
FOXOs and Sirtuins in Vascular Growth, Maintenance, and Aging
Oellerich, M. F., & Potente, M. (2012) · Circulation Research · doi:10.1161/circresaha.111.246488 · Cited by 157 · see citing works
Rossiello, F., Herbig, U., Longhese, M. P., Fumagalli, M., & di Fagagna, F. D. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.06.009 · Cited by 156 · see citing works
Pont, A. R., Sadri, N., Hsiao, S. J., Smith, S. H., & Schneider, R. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.04.019 · Cited by 156 · see citing works
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
Carrero, D., Soria-Valles, C., & López-Otín, C. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024711 · Cited by 153 · see citing works
Brandenberger, C., & Mühlfeld, C. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2511-x · Cited by 152 · see citing works
Walther, D. M., & Mann, M. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.004523 · Cited by 150 · see citing works
Telomeres and Mitochondria in the Aging Heart
Moslehi, J. J., DePinho, R. A., & Sahin, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.246868 · Cited by 150 · see citing works
Self-citationHuman Cardiac Progenitor Cells Engineered With Pim-I Kinase Enhance Myocardial Repair
Mohsin, S., Khan, M., Toko, H., Bailey, B., Cottage, C. T., Wallach, K., Nag, D., Lee, A. S., Siddiqi, S., Lan, F., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.04.047 · Cited by 149 · see citing works
Obas, V., & Vasan, R. S. (2018) · Clinical Science · doi:10.1042/cs20171156 · Cited by 148 · see citing works
Wang, N., Luo, Z., Jin, M., Sheng, W., Wang, H.-T., Long, X., Wu, Y., Hu, P., Xu, H. A., & Zhang, X. (2019) · Aging · doi:10.18632/aging.101966 · Cited by 148 · see citing works
Transcriptional Signatures of Aging
Stegeman, R., & Weake, V. M. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.06.019 · Cited by 146 · see citing works
- Authors
- Sahin, E., & DePinho, R. A.
- Affiliations
- Harvard University (US)
- Venue
- Nature
- Published
- 2010-03
- Volume
- 464
- Issue
- 7288
- Pages
- 520-528
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3733214
- OpenAlex
- W1988354925
- Cited by
- 759
- References
- 100
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 43 · 2023: 38 · 2022: 34 · 2021: 41 · 2020: 34 · 2019: 38 · 2018: 39 · 2017: 42 · 2016: 48 · 2015: 54 · 2014: 53 · 2013: 55 · 2012: 83
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Cancer Institute (U01CA84313, U01CA084313, R01CA84628, R01CA084628)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- aging, telomeres, telomere dysfunction, telomere capping, p53 activation, DNA damage signaling, genome maintenance, mitochondrial dysfunction, tissue stem cells, stemness, bioenergetics, metabolic regulation, age-related diseases
- MeSH terms
- Aging, Animals, Hematopoietic System, Homeostasis, Humans, Mitochondria, Phenotype, Stem Cells, Tumor Suppressor Protein p53, Telomere, Genome, Telomerase
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