Chromatin repressive complexes in stem cells, development, and cancer

Laugesen, Anne, Helin, Kristian·2014·Cell stem cell

Cited by (354)

Items 101–200 of 354

  1. TET1 is controlled by pluripotency-associated factors in ESCs and downmodulated by PRC2 in differentiated cells and tissues
    Francesco Neri, Danny Incarnato, Anna Křepelová, Daniela Dettori, Stefania Rapelli, Mara Maldotti, Caterina Parlato, Francesca Anselmi, Federico Galvagni, Salvatore Oliviero · 2015 · Nucleic Acids Research
  2. Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum
    Xuesong Feng, Aster H. Juan, Hongjun A. Wang, Kyung Dae Ko, Hossein Zare, Vittorio Sartorelli · 2016 · Development
  3. A critical perspective of the diverse roles of O-GlcNAc transferase in chromatin
    Maria Cristina Gambetta, Jürg Müller · 2015 · Chromosoma
  4. Role of the BAHD1 Chromatin-Repressive Complex in Placental Development and Regulation of Steroid Metabolism
    Goran Lakisic, Alice Lebreton, Renaud Pourpre, Olivia Wendling, Emanuele Libertini, Elizabeth J. Radford, Morwenna Le Guillou, Marie‐France Champy, Marie Wattenhofer‐Donzé, Guillaume Soubigou et al. · 2016 · PLoS Genetics
  5. CHD4/NuRD complex regulates complement gene expression and correlates with CD8 T cell infiltration in human hepatocellular carcinoma
    Simin Shao, Haowei Cao, Zhongkun Wang, Dongmei Zhou, Chaoshen Wu, Shu Wang, Dian Xia, Daoyong Zhang · 2020 · Clinical Epigenetics
  6. EZH1/2 inhibition augments the anti-tumor effects of sorafenib in hepatocellular carcinoma
    Yuko Kusakabe, Tetsuhiro Chiba, Motohiko Oshima, Shuhei Koide, Ola Rizq, Kazumasa Aoyama, Junjie Ao, Tatsuya Kaneko, Hiroaki Kanzaki, Kengo Kanayama et al. · 2021 · Scientific Reports
  7. Compositional and functional diversity of canonical PRC1 complexes in mammals
    Katelyn E. Connelly, Emily C. Dykhuizen · 2016 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  8. USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein
    Yue Ma, Hualin Fu, Zhen Wang, Hai Huang, Jian Ni, Jie Song, Ying Xia, Weilin Jin, Daxiang Cui · 2017 · Oncotarget
  9. PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function
    Xiuli Liu, Xin Liu · 2022 · Frontiers in Oncology
  10. Stem Cells in Cancer: From Mechanisms to Therapeutic Strategies
    Laurence Haddadin, Xueqin Sherine Sun · 2025 · Cells
  11. A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2
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  12. Nascent transcript and single-cell RNA-seq analysis defines the mechanism of action of the LSD1 inhibitor INCB059872 in myeloid leukemia
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  13. EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways
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  14. The Tumorigenic Potential of Human Pluripotent Stem Cells
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  15. Computational methods-guided design of modulators targeting protein-protein interactions (PPIs)
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  16. The function of chromatin modifiers in lineage commitment and cell fate specification
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  17. Altered primary chromatin structures and their implications in cancer development
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  18. Silencing of transgene expression in mammalian cells by DNA methylation and histone modifications in gene therapy perspective
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  19. Histone demethylase KDM6B has an anti-tumorigenic function in neuroblastoma by promoting differentiation
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  20. BTF3 sustains cancer stem-like phenotype of prostate cancer via stabilization of BMI1
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  21. Epigenetics of hematopoietic stem cell aging and disease
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  22. An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injury
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  23. A high-resolution map of transcriptional repression
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  24. Loss of G9a preserves mutation patterns but increases chromatin accessibility, genomic instability and aggressiveness in skin tumours
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  25. Discovery of genes required for body axis and limb formation by global identification of retinoic acid–regulated epigenetic marks
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  26. DNA Methylation in Urothelial Carcinoma
    Wolfgang A. Schulz, Wolfgang Goering · 2016 · Epigenomics
  27. The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
    Alexandra Santanach, Enrique Blanco, Hua Liang Jiang, Kelly R. Molloy, Miriam Sansó, John LaCava, Lluís Morey, Luciano Di Croce · 2017 · Nature Communications
  28. SCML2 promotes heterochromatin organization in late spermatogenesis
    So Maezawa, Kazuteru Hasegawa, Kris G. Alavattam, Mayuka Funakoshi, Taiga Sato, Artem Barski, Satoshi H. Namekawa · 2018 · Journal of Cell Science
  29. Chromatin Regulators in Pancreas Development and Diabetes
    Stephanie A. Campbell, Brad G. Hoffman · 2016 · Trends in Endocrinology and Metabolism
  30. Sperm-borne microRNA-34c regulates maternal mRNA degradation and preimplantation embryonic development in mice
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  31. Protein sequestration at the nuclear periphery as a potential regulatory mechanism in premature aging
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  32. Epigenetic control in Kaposi sarcoma-associated herpesvirus infection and associated disease
    Jacqueline Fröhlich, Adam T. Grundhoff · 2020 · Seminars in Immunopathology
  33. Towards a Better Vision of Retinoic Acid Signaling during Eye Development
    Gregg Duester · 2022 · Cells
  34. Polycomb Group Protein-Mediated Histone Modifications during Cell Differentiation
    Abdul Aziz Khan, Andrew Lee, Tae‐Young Roh · 2015 · Epigenomics
  35. Rational discovery of antimetastatic agents targeting the intrinsically disordered region of MBD2
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  36. BRMS1: a multifunctional signaling molecule in metastasis
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  37. Histone modification alteration coordinated with acquisition of promoter DNA methylation during Epstein-Barr virus infection
    Sayaka Funata, Keisuke Matsusaka, Ryota Yamanaka, Shogo Yamamoto, Atsushi Okabe, Masaki Fukuyo, Hiroyuki Aburatani, Masashi Fukayama, Atsushi Kaneda · 2017 · Oncotarget
  38. LncRNA embryonic stem cells expressed 1 (Lncenc1) is identified as a novel regulator in neuropathic pain by interacting with EZH2 and downregulating the expression of Bai1 in mouse microglia
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  39. LncAY controls BMI1 expression and activates BMI1/Wnt/β-catenin signaling axis in hepatocellular carcinoma
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  40. Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver
    Chi Zhang, Filippo Macchi, Elena Magnani, Kirsten C. Sadler · 2021 · Nature Communications
  41. RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity
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  42. MTA1 expression in human cancers – Clinical and pharmacological significance
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  43. Overlapping functions of RBBP4 and RBBP7 in regulating cell proliferation and histone H3.3 deposition during mouse preimplantation development
    Lieying Xiao, Yanna Dang, Bingjie Hu, Lei Luo, Panpan Zhao, Shaohua Wang, Kun Zhang · 2021 · Epigenetics
  44. PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice
    Emily T. Maclary, Michael Hinten, Clair E. Harris, Shriya Sethuraman, Srimonta Gayen, Sundeep Kalantry · 2017 · Genome biology
  45. An Essential Role of Maspin in Embryogenesis and Tumor Suppression
    Sijana H. Dzinic, M. Margarida Bernardo, Xiaohua Li, Rodrigo Fernandez‐Valdivia, Ye-Shih Ho, Qing‐Sheng Mi, Subhayu Bandyopadhyay, Fulvio Lonardo, Semir Vranić, Daniel S.M. Oliveira et al. · 2016 · Cancer Research
  46. HDAC1 and HDAC2 independently regulate common and specific intrinsic responses in murine enteroids
    Alexis Gonneaud, Naomie Turgeon, Christine M. Jones, Cassandra Couture, Dominique Lévesque, François‐Michel Boisvert, François Boudreau, Claude Asselin · 2019 · Scientific Reports
  47. Polycomb-dependent repression of the potassium channel-encoding gene KCNA5 promotes cancer cell survival under conditions of stress
    Katherine Elizabeth Ryland, Laurie Kathleen Svoboda, Eileen D. Vesely, Jeremy C. McIntyre, L Zhang, Jeffrey R. Martens, Elizabeth R. Lawlor · 2014 · Oncogene
  48. A positive role for polycomb in transcriptional regulation via H4K20me1
    Xiangdong Lv, Zhijun Han, Hao Chen, Bo Yang, Xiaofeng Yang, Yuanxin Xia, Chenyu Pan, Lin Fu, Shuo Zhang, Hui Ling Han et al. · 2016 · Cell Research
  49. Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
    Ryan Wellington Logan, Angela Renee Ozburn, Rachel N. Arey, Kyle D. Ketchesin, Alicia Winquist, Andrew Crain, Brian T. D. Tobe, Darius D. Becker‐Krail, Matthew B. Jarpe, Xiangning Xue et al. · 2020 · Molecular Psychiatry
  50. Druggable Biochemical Pathways and Potential Therapeutic Alternatives to Target Leukemic Stem Cells and Eliminate the Residual Disease in Chronic Myeloid Leukemia
    Fabien Muselli, Jean‐François Peyron, Didier Mary · 2019 · International Journal of Molecular Sciences
  51. Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects
    Jinxiao Ru, Yuxi Wang, Zijia Li, Jiaxing Wang, Changyu Ren, Jifa Zhang · 2023 · European Journal of Medicinal Chemistry
  52. Propagation of trimethylated H3K27 regulated by polycomb protein EED is required for embryogenesis, hematopoietic maintenance, and tumor suppression
    Takeshi Ueda, Yuichiro Nakata, Akiko Nagamachi, Norimasa Yamasaki, Akinori Kanai, Yasuyuki Sera, Masato Sasaki, Hirotaka Matsui, Zen‐ichiro Honda, Hideaki Oda et al. · 2016 · Proceedings of the National Academy of Sciences
  53. Sin3a regulates the developmental progression through morula‐to‐blastocyst transition via Hdacl
    Panpan Zhao, Shuang Li, Huanan Wang, Yanna Dang, Lefeng Wang, Tong Liu, Shaohua Wang, Xinhong Li, Kun Zhang · 2019 · The FASEB Journal
  54. Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration
    Shashank Gandhi, Erica J. Hutchins, Krystyna Maruszko, Jong H Park, Matthew Thomson, Marianne E. Bronner-Fraser · 2020 · eLife
  55. Reprogramming CBX8-PRC1 function with a positive allosteric modulator
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  56. Epigenetic controls of Sonic hedgehog guarantee fidelity of epithelial adult stem cells trajectory in regeneration
    Fanyuan Yu, Feifei Li, Liwei Zheng, Ling Ye · 2022 · Science Advances
  57. Distinct Roles for Intestinal Epithelial Cell‐Specific Hdac1 and Hdac2 in the Regulation of Murine Intestinal Homeostasis
    Alexis Gonneaud, Naomie Turgeon, François Boudreau, Nathalie Perreault, Nathalie Rivard, Claude Asselin · 2015 · Journal of Cellular Physiology
  58. Mutations and deletions of PRC2 in prostate cancer
    Payal Jain, Luciano Di Croce · 2016 · BioEssays
  59. Construction of a prognostic model with histone modification-related genes and identification of potential drugs in pancreatic cancer
    Yuan Chen, Ruiyuan Xu, Rexiati Ruze, Jinshou Yang, Huanyu Wang, Jianlu Song, Lei You, Chengcheng Wang, Yupei Zhao · 2021 · Cancer Cell International
  60. CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency
    Dawei Huo, Zhaowei Yu, Rui Li, Meihan Gong, Simone Sidoli, Xukun Lu, Yuying Hou, Zhongye Dai, Yu Kong, Guifen Liu et al. · 2022 · Molecular Cell
  61. The mTOR chromatin-bound interactome in prostate cancer
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  62. JARID2 coordinates with the NuRD complex to facilitate breast tumorigenesis through response to adipocyte‐derived leptin
    Wei Liu, Yi Zeng, Xinhui Hao, Xin Wang, Jiaxiang Liu, Tianyang Gao, Mengdi Wang, Jingyao Zhang, Miaomiao Huo, Ting Hu et al. · 2023 · 癌症:英文版
  63. Promoter Methylation Analysis Reveals That KCNA5 Ion Channel Silencing Supports Ewing Sarcoma Cell Proliferation
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  64. Drosophila DNA-Binding Proteins in Polycomb Repression
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  65. Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury
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  66. Role of Retinoic Acid Signaling, FGF Signaling and Meis Genes in Control of Limb Development
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  67. REST represses a subset of the pancreatic endocrine differentiation program
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  68. Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice1
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  72. Structural heterogeneity of the mammalian polycomb repressor complex in immune regulation
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  75. The Polycomb proteins RING1B and EZH2 repress the tumoral pro-inflammatory function in metastasizing primary cutaneous squamous cell carcinoma
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  79. Perspective on unraveling the versatility of ‘co-repressor’ complexes
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  94. A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis
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  99. Dissecting chromatin-mediated gene regulation and epigenetic memory through mathematical modelling
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