The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches
Open accessAbstract
SUMMARY Basal cell carcinoma (BCC) is characterized by frequent loss of PTCH1, leading to constitutive activation of the Hedgehog pathway. Although the requirement for Hedgehog in BCC is well-established, the identity of disease-initiating cells and the compartments in which they reside remain controversial. By using several inducible Cre drivers to delete Ptch1 in different cell compartments in mice, we show here that multiple hair follicle stem cell populations readily develop BCC-like tumors. In contrast, stem cells within the interfollicular epidermis do not efficiently form tumors. Notably, we observed that innervated Gli1-expressing progenitors within mechanosensory touch dome epithelia are highly tumorigenic. Sensory nerves activate Hedgehog signaling in normal touch domes, while denervation attenuates touch dome-derived tumors. Together, our studies identify varying tumor susceptibilities among different stem cell populations in the skin, highlight touch dome epithelia as “hot spots” for tumor formation, and implicate cutaneous nerves as mediators of tumorigenesis.
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Cites
Autonomic nerve development contributes to prostate cancer progression
Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S. (2013) · Science · doi:10.1126/science.1236361 · Cited by 1,287
Variations of basal cell carcinomas according to gender, age, location and histopathological subtype
Scrivener, Y., Grosshans, E., & Cribier, B. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04804.x · Cited by 459
Human Merkel cells – aspects of cell biology, distribution and functions
Moll, I., Roessler, M., Brandner, J. M., Eispert, A.-C., Houdek, P., & Moll, R. (2005) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2004.12.023 · Cited by 166
Anatomical mapping of Merkel cells in normal human adult epidermis
LACOUR, J. P., DUBOIS, D., PISANI, A., & ORTONNE, J. P. (1991) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1991.tb14790.x · Cited by 112
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Hayakawa, Y., Sakitani, K., Konishi, M., Asfaha, S., Niikura, R., Tomita, H., Renz, B. W., Tailor, Y., Macchini, M., Middelhoff, M., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2016.11.005 · Cited by 573
β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer
Renz, B. W., Takahashi, R., Tanaka, T., Macchini, M., Hayakawa, Y., Dantes, Z., Maurer, H. C., Chen, X., Jiang, Z., Westphalen, C. B., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.11.007 · Cited by 543
Zahalka, A. H., & Frenette, P. S. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-019-0237-2 · Cited by 470
Peris, K., Fargnoli, M. C., Kaufmann, R., Arenberger, P., Bastholt, L., Seguin, N. B., Bataille, V., Brochez, L., del Marmol, V., Dummer, R., et al. (2023) · European Journal of Cancer · doi:10.1016/j.ejca.2023.113254 · Cited by 308
Tumor Neurobiology and the War of Nerves in Cancer
Faulkner, S., Jobling, P., March, B., Jiang, C. C., & Hondermarck, H. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1398 · Cited by 267
Metadata
- Authors
- Peterson, S. C., Eberl, M., Vagnozzi, A. N., Belkadi, A., Veniaminova, N. A., Verhaegen, M. E., Bichakjian, C. K., Ward, N. L., Dlugosz, A. A., & Wong, S. Y.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 16
- Issue
- 4
- Pages
- 400-412
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2019667717
- Cited by
- 368
- References
- 4
- FWCI
- 12.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Peterson, S. C., Eberl, M., Vagnozzi, A. N., Belkadi, A., Veniaminova, N. A., Verhaegen, M. E., Bichakjian, C. K., Ward, N. L., Dlugosz, A. A., & Wong, S. Y. (2015). Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches. Cell Stem Cell. https://doi.org/10.1016/j.stem.2015.02.006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
