The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Tumor Neurobiology and the War of Nerves in Cancer
Abstract
Nerves are emerging regulators of cancer progression. Cancer cells induce the outgrowth of nerves in the tumor microenvironment through the release of neurotrophic factors, and in return nerves liberate neurotransmitters that activate cancer growth and dissemination. Although sympathetic nerves drive tumor angiogenesis via the liberation of noradrenaline, sensory and parasympathetic nerves stimulate cancer stem cells. Interestingly, recent evidence indicates that parasympathetic nerves can eventually inhibit tumor progression, suggesting a yin–yang type of regulation of cancer by nerves. From a broader perspective, the question of a higher level of control of cancer development by the central nervous system should be raised. Significance: Nerves are emerging regulators of cancer initiation, progression, and metastasis. Here, we review the evidence to date and explore the basic and clinical ramifications of these findings.
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Cites
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Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion
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Cited by
The updated landscape of tumor microenvironment and drug repurposing
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Loss of p53 drives neuron reprogramming in head and neck cancer
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Metastasis-Initiating Cells and Ecosystems
Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372
Lei, Y., Liao, F., Tian, Y., Wang, Y., Xia, F., & Wang, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1321176 · Cited by 35
Metadata
- Authors
- Faulkner, S., Jobling, P., March, B., Jiang, C. C., & Hondermarck, H.
- Venue
- Cancer Discovery
- Published
- 2019-06-01
- Volume
- 9
- Issue
- 6
- Pages
- 702-710
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- OpenAlex
- W2927114316
- Cited by
- 267
- References
- 78
- FWCI
- 22.32
- Type
- journal article
- Language
- en
- Open access
- closed
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