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Cited by 371Hematopoietic Stem Cell TransplantationBlood disorders and treatmentsAcute Myeloid Leukemia Research

Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment

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Kovtonyuk, Larisa V., Fritsch, Kristin, Feng, Xiaomin, Manz, Markus G., Takizawa, Hitoshi·2016·Frontiers in Immunology
DOI 10.3389/fimmu.2016.00502PMC PMC5107568
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Abstract

All hematopoietic and immune cells are continuously generated by hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) through highly organized process of stepwise lineage commitment. In the steady state, HSCs are mostly quiescent, while HPCs are actively proliferating and contributing to daily hematopoiesis. In response to hematopoietic challenges, e.g., life-threatening blood loss, infection, and inflammation, HSCs can be activated to proliferate and engage in blood formation. The HSC activation induced by hematopoietic demand is mediated by direct or indirect sensing mechanisms involving pattern recognition receptors or cytokine/chemokine receptors. In contrast to the hematopoietic challenges with obvious clinical symptoms, how the aging process, which involves low-grade chronic inflammation, impacts hematopoiesis remains undefined. Herein, we summarize recent findings pertaining to functional alternations of hematopoiesis, HSCs, and the bone marrow (BM) microenvironment during the processes of aging and inflammation and highlight some common cellular and molecular changes during the processes that influence hematopoiesis and its cells of origin, HSCs and HPCs, as well as the BM microenvironment. We also discuss how age-dependent alterations of the immune system lead to subclinical inflammatory states and how inflammatory signaling might be involved in hematopoietic aging. Our aim is to present evidence supporting the concept of "Inflamm-Aging," or inflammation-associated aging of hematopoiesis.

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Authors
Kovtonyuk, L. V., Fritsch, K., Feng, X., Manz, M. G., & Takizawa, H.
Affiliations
  • University of Zurich (CH)
  • International Research Center for Medical Sciences, Kumamoto University (JP)
Corresponding author
Takizawa, Hitoshi
ORCID
Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2016-11-14
Volume
7
Pages
502-502
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2016.00502
PMC
PMC5107568
OpenAlex
W2553708507
Cited by
371
References
148
Citations by year
2026: 38 · 2025: 32 · 2024: 40 · 2023: 37 · 2022: 36 · 2021: 56 · 2020: 49 · 2019: 39 · 2018: 30 · 2017: 14
FWCI
3.93
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
  • Zurich Open Repository and Archive (University of Zurich)
Funders
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030_146528/1)
  • Japan Society for the Promotion of Science (15H01519)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords
inflammaging, hematopoiesis, hematopoietic stem cells, hematopoietic progenitor cells, bone marrow microenvironment, aging, low-grade inflammation, HSC quiescence, hepatic stellate cell activation, pattern recognition receptors, age-related immune dysfunction

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