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Cited by 226Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchBlood disorders and treatments

Haematopoietic stem cell self-renewal in vivo and ex vivo

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Wilkinson, Adam C., Igarashi, Kyomi J., Nakauchi, Hiromitsu·2020·Nature Reviews Genetics
DOI 10.1038/s41576-020-0241-0PMC PMC7894993
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Abstract

The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities.

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Cited by

Sorted by citations

Authors
Wilkinson, A. C., Igarashi, K. J., & Nakauchi, H.
Affiliations
Stanford Medicine (US)
Corresponding author
Nakauchi, Hiromitsu
ORCID
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2020-05-28
Volume
21
Issue
9
Pages
541-554
ISSN
  • 1471-0056 (ISSN-L)
  • 1471-0064
DOI
10.1038/s41576-020-0241-0
PMC
PMC7894993
OpenAlex
W3030978338
Cited by
226
References
16
Citations by year
2026: 27 · 2025: 33 · 2024: 45 · 2023: 46 · 2022: 38 · 2021: 29 · 2020: 8
FWCI
4.75
Type
journal article
Language
en
Open access
Licence
Locations
  • Nature Reviews Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Japan Society for the Promotion of Science (20H05695)
  • National Institute on Aging (R21AG061487)
  • National Heart, Lung, and Blood Institute (K99HL150218, R01HL147124)
  • National Human Genome Research Institute (T32HG000044)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK116944)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
Keywords
hematopoietic stem cells, self-renewal, ex vivo HSC expansion, HSC transplantation, blood homeostasis, bone marrow, fetal liver
MeSH terms
Animals, Hematopoietic Stem Cells, Humans, Cell Lineage

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