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Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1
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“By contrast, in vitro studies of engineered heterozygous NRXN1+/− human neurons reveal robust changes in excitatory neurotransmission that are not recapitulated in matched NRXN1+/− mouse neurons12,13”
From Phenotypic complexities of rare heterozygous neurexin-1 deletions (2025) · cites this paper as [12]
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Metadata
- Authors
- Pak, C., Danko, T., Zhang, Y., Aoto, J., Anderson, G., Maxeiner, S., Yi, F., Wernig, M., & Südhof, T. C.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 17
- Issue
- 3
- Pages
- 316-328
- ISSN
- 1934-5909
- PMC
- PMC4560990
- Cited by
- 217
- References
- 16
- Language
- en
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