Neural Subtype Specification from Human Pluripotent Stem Cells

Tao, Yunlong; Zhang, Su-Chun

doi:10.1016/j.stem.2016.10.015

Cited by 287Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Neural Subtype Specification from Human Pluripotent Stem Cells

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Tao, Yunlong, Zhang, Su-Chun·2016·Cell Stem Cell

DOI 10.1016/j.stem.2016.10.015PMC PMC5127287

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Abstract

Human pluripotent stem cells (hPSCs) provide a model to study early neural development, model pathological processes, and develop therapeutics. The generation of functionally specialized neural subtypes from hPSCs relies on fundamental developmental principles learned from animal studies. Manipulation of these principles enables production of highly enriched neural types with functional attributes that resemble those in the brain. Further development to promote faster maturation or aging as well as circuit integration will help realize the potential of hPSC-derived neural cells in disease modeling and cell therapy.

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Differentiation of induced pluripotent stem cells into neural cells recapitulates many neurodevelopmental features observed in prenatal human tissue and occurs in a temporal sequence that roughly corresponds to in vivo corticogenesis.
“Although these models come with their own limitations, including variability and limited functional maturation (Box 1), the differentiation of iPSCs into neural cells recapitulates many of the neurodevelopmental features observed in prenatal human tissue and occurs in a temporal sequence that roughly corresponds to in vivo corticogenesis29–31.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [29]
The Challenges and future directions sections say hPSC neural differentiation mirrors in vivo development and that derived neurons resemble fetal-brain neurons in gene-expression profiles. The subtype-progenitor section describes a cortical sequence matching development, but its stem-cell example uses mouse ESCs; it does not establish that human iPSC-derived cortical cells follow that sequence. (LLM, conf=0.83)
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Authors: Tao, Y., & Zhang, S.-C.
Affiliations: University of Wisconsin–Madison (US)
University of Wisconsin System (US)
Corresponding author: Zhang, Su-Chun
ORCID: Tao, Yunlong
Zhang, Su-Chun
Venue: Cell Stem Cell
Publisher: Elsevier BV
Published: 2016-11
Volume: 19
Issue: 5
Pages: 573-586
ISSN: 1875-9777 (ISSN-L)
1934-5909
DOI: 10.1016/j.stem.2016.10.015
PMC: PMC5127287
OpenAlex: W2548288313
Cited by: 287
References: 107
Citations by year: 2026: 13 · 2025: 35 · 2024: 21 · 2023: 26 · 2022: 38 · 2021: 41 · 2020: 44 · 2019: 34 · 2018: 24 · 2017: 10 · 2016: 1
FWCI: 2.08
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 367 d)
Locations: Cell stem cell (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH-NINDS (NS076352, NS086604)
NIH-NIMH (MH099587, MH100031)
Bleser Family Foundation
Busta Foundation
NICHD (HD076892, U54 HD090256)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: human pluripotent stem cells, neuronal differentiation, disease modeling, cell therapy, circuit integration
MeSH terms: Animals, Cell Differentiation, Humans, Neurons, Body Patterning, Multipotent Stem Cells, Pluripotent Stem Cells, Neural Stem Cells

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Neural Subtype Specification from Human Pluripotent Stem Cells

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