Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673 · see citing works

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors

Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works

A global double-fluorescent Cre reporter mouse

Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L., & Luo, L. (2007) · genesis · doi:10.1002/dvg.20335 · Cited by 3,491 · see citing works

Direct conversion of fibroblasts to functional neurons by defined factors

Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature · doi:10.1038/nature08797 · Cited by 3,017 · see citing works

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454 · see citing works

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

Mederacke, I., Hsu, C. C., Troeger, J. S., Huebener, P., Mu, X., Dapito, D. H., Pradere, J.-P., & Schwabe, R. F. (2013) · Nature Communications · doi:10.1038/ncomms3823 · Cited by 1,443 · see citing works

In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

Li, Q., Huang, Y., Spencer, C. I., Foley, A., Vedantham, V., Liu, L., Conway, S. J., Fu, J., & Srivastava, D. (2012) · Nature · doi:10.1038/nature11044 · Cited by 1,353 · see citing works

Heart repair by reprogramming non-myocytes with cardiac transcription factors

Song, K., Nam, Y., Luo, X., Qi, X., Tan, W. H., Huang, G. N., Acharya, A., Smith, C. L., Tallquist, M. D., Neilson, E. G., et al. (2012) · Nature · doi:10.1038/nature11139 · Cited by 1,141 · see citing works

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., & Hui, L. (2011) · Nature · doi:10.1038/nature10116 · Cited by 864 · see citing works

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Sekiya, S., & Suzuki, A. (2011) · Nature · doi:10.1038/nature10263 · Cited by 846 · see citing works

In Vivo Direct Reprogramming of Reactive Glial Cells into Functional Neurons after Brain Injury and in an Alzheimer’s Disease Model

Guo, Z., Zhang, L., Wu, Z., Chen, Y., Wang, F., & Chen, G. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.12.001 · Cited by 829 · see citing works

Therapy for Fibrotic Diseases: Nearing the Starting Line

Friedman, S. L., Sheppard, D., Duffield, J. S., & Violette, S. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004700 · Cited by 655 · see citing works

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

Son, E., Ichida, J. K., Wainger, B. J., Toma, J. S., Rafuse, V. F., Woolf, C. J., & Eggan, K. C. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.07.014 · Cited by 629 · see citing works

Direct reprogramming of mouse fibroblasts to neural progenitors

Kim, J., Efe, J. A., Zhu, S., Talantova, M. V., Xu, Y., Wang, S., Lipton, S. A., Zhang, K., & Ding, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103113108 · Cited by 568 · see citing works

Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes

Huang, P., Zhang, L., Gao, Y., He, Z., Yao, D., Wu, Z., Cen, J., Chen, X., Liu, C., Hu, Y., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.003 · Cited by 560 · see citing works

Direct Reprogramming of Mouse and Human Fibroblasts into Multipotent Neural Stem Cells with a Single Factor

Ring, K. L., Tong, L. M., Balestra, M. E., Javier, R., Andrews-Zwilling, Y. S., Li, G., Walker, D., Zhang, W. R., Kreitzer, A. C., & Huang, Y. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.018 · Cited by 540 · see citing works

CellNet: Network Biology Applied to Stem Cell Engineering

Cahan, P., Li, H., Morris, S. A., da Rocha, E. L., Daley, G. Q., & Collins, J. J. (2014) · Cell · doi:10.1016/j.cell.2014.07.020 · Cited by 522 · see citing works

Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors

Han, D., Tàpia, N., Hermann, A., Hemmer, K., Höing, S., Araúzo-Bravo, M. J., Zaehres, H., Wu, G., Frank, S., Moritz, S., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.021 · Cited by 514 · see citing works

Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

Thier, M. C., Wörsdörfer, P., Lakes, Y. B., Gorris, R., Herms, S., Opitz, T., Seiferling, D., Quandel, T., Hoffmann, P., Nöthen, M. M., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.03.003 · Cited by 485 · see citing works

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

Malato, Y., Naqvi, S., Schürmann, N., Ng, R., Wang, B., Zape, J., Kay, M. A., Grimm, D., & Willenbring, H. (2011) · Journal of Clinical Investigation · doi:10.1172/jci59261 · Cited by 434 · see citing works

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells

Lujan, E., Chanda, S., Ahlenius, H., Südhof, T. C., & Wernig, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121003109 · Cited by 421 · see citing works

In vivo conversion of astrocytes to neurons in the injured adult spinal cord

Su, Z., Niu, W., Liu, M.-L., Zou, Y., & Zhang, C. (2014) · Nature Communications · doi:10.1038/ncomms4338 · Cited by 413 · see citing works

Generation of induced neurons via direct conversion in vivo

Torper, O., Pfisterer, U., Wolf, D. A., Pereira, M., Lau, S., Jakobsson, J., Björklund, A., Grealish, S., & Parmar, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303829110 · Cited by 412 · see citing works

Human Hepatocytes with Drug Metabolic Function Induced from Fibroblasts by Lineage Reprogramming

Du, Y., Wang, J., Jia, J., Song, N., Xiang, C., Xu, J., Hou, Z., Su, X., Liu, B., Jiang, T., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.01.008 · Cited by 320 · see citing works

Dissecting Engineered Cell Types and Enhancing Cell Fate Conversion via CellNet

Morris, S. A., Cahan, P., Li, H., Zhao, A., Roman, A. K. S., Shivdasani, R. A., Collins, J. J., & Daley, G. Q. (2014) · Cell · doi:10.1016/j.cell.2014.07.021 · Cited by 267 · see citing works

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

Grande, A. W., Sumiyoshi, K., López‐Juárez, A., Howard, J., Sakthivel, B., Aronow, B. J., Campbell, K., & Nakafuku, M. (2013) · Nature Communications · doi:10.1038/ncomms3373 · Cited by 225 · see citing works

Overcoming promoter competition in packaging cells improves production of self-inactivating retroviral vectors

Schambach, A., Mueller, D., Galla, M., Verstegen, M. M. A., Wagemaker, G., Loew, R., Baum, C., & Bohne, J. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302807 · Cited by 143 · see citing works

A Novel Murine Model to Deplete Hepatic Stellate Cells Uncovers Their Role in Amplifying Liver Damage in Mice

Puche, J. E., Lee, Y. A., Jiao, J., Aloman, C., Fiel, M. I., Muñoz, U., Kraus, T., Lee, T., Yee, H. F., & Friedman, S. L. (2013) · Hepatology · doi:10.1002/hep.26053 · Cited by 136 · see citing works

Resetting the transcription factor network reverses terminal chronic hepatic failure

Nishikawa, T., Bell, A., Brooks, J. M., Setoyama, K., Melis, M., Han, B., Fukumitsu, K., Handa, K., Tian, J., Kaestner, K. H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73137 · Cited by 124 · see citing works

p75 neurotrophin receptor signaling regulates hepatic myofibroblast proliferation and apoptosis in recovery from rodent liver fibrosis†

Kendall, T. J., Hennedige, S., Aucott, R. L., Hartland, S. N., Vernon, M. A., Benyon, R. C., & Iredale, J. P. (2008) · Hepatology · doi:10.1002/hep.22701 · Cited by 119 · see citing works

MicroRNA-221 regulates FAS-induced fulminant liver failure

Sharma, A. D., Narain, N., Händel, E.-M., Iken, M., Singhal, N., Cathomen, T., Manns, M. P., Schöler, H. R., Ott, M., & Cantz, T. (2011) · Hepatology · doi:10.1002/hep.24243 · Cited by 76 · see citing works

Polyclonal fluctuation of lentiviral vector–transduced and expanded murine hematopoietic stem cells

Maetzig, T., Brugman, M. H., Bartels, S., Heinz, N., Kustikova, O. S., Modlich, U., Li, Z., Galla, M., Schiedlmeier, B., Schambach, A., et al. (2011) · Blood · doi:10.1182/blood-2010-08-303222 · Cited by 55 · see citing works

Development of Adenoviral Delivery Systems to Target Hepatic Stellate Cells In Vivo

Reetz, J., Genz, B., Meier, C., Kowtharapu, B. S., Timm, F., Vollmar, B., Herchenröder, O., Abshagen, K., & Pützer, B. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067091 · Cited by 37 · see citing works

Induction of a mature hepatocyte phenotype in adult liver derived progenitor cells by ectopic expression of transcription factors

Iacob, R. A., Rüdrich, U., Rothe, M., Kirsch, S., Maasoumy, B., Narain, N., Verfaillie, C. M., Sancho‐Bru, P., Iken, M., Popescu, I., et al. (2011) · Stem Cell Research · doi:10.1016/j.scr.2011.02.002 · Cited by 32 · see citing works

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works

Hepatic stellate cells as key target in liver fibrosis

Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485 · see citing works

Mechanisms of Renal Fibrosis

Humphreys, B. D. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034227 · Cited by 1,239 · see citing works

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

Parola, M., & Pinzani, M. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.002 · Cited by 1,183 · see citing works

Fibroblasts: Origins, definitions, and functions in health and disease

Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,162 · see citing works

Wound healing, fibroblast heterogeneity, and fibrosis

Talbott, H. E., Mascharak, S., Griffin, M., Wan, D. C., & Longaker, M. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.07.006 · Cited by 745 · see citing works

Advances in Pluripotent Stem Cells: History, Mechanisms, Technologies, and Applications

Liu, G., David, B. T., Trawczynski, M., & Fessler, R. G. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09935-x · Cited by 527 · see citing works

Direct cell reprogramming: approaches, mechanisms and progress

Wang, H., Yang, Y., Liu, J., & Li, Q. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00335-z · Cited by 438 · see citing works

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 348 · see citing works

A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion

Chen, Y., Ma, N., Pei, Z.-F., Wu, Z., Monte, F. H. D., Keefe, S. H., Yellin, E., Chen, M. S., Yin, J.-C., Lee, G., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.003 · Cited by 316 · see citing works

In Vivo Cellular Reprogramming: The Next Generation

Srivastava, D., & DeWitt, N. (2016) · Cell · doi:10.1016/j.cell.2016.08.055 · Cited by 292 · see citing works

Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression

Caligiuri, A., Gentilini, A., Pastore, M., Gitto, S., & Marra, F. (2021) · Cells · doi:10.3390/cells10102759 · Cited by 273 · see citing works

A Roadmap for Human Liver Differentiation from Pluripotent Stem Cells

Ang, L. T., Tan, A. K. Y., Autio, M. I., Goh, S. H., Choo, S. H., Lee, K. L., Tan, J., Pan, B., Lee, J. J. H., Lum, J. J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.087 · Cited by 220 · see citing works

In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells

Li, H., & Chen, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.004 · Cited by 174 · see citing works

GATA4-dependent organ-specific endothelial differentiation controls liver development and embryonic hematopoiesis

Géraud, C., Reiners-Koch, P.-S., Zierow, J., Klapproth, K., Busch, K., Olsavszky, V., Leibing, T., Demory, A., Ulbrich, F., Diett, M., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90086 · Cited by 163 · see citing works

In Vivo Interplay between p27Kip1, GATA3, ATOH1, and POU4F3 Converts Non-sensory Cells to Hair Cells in Adult Mice

Walters, B. J., Coak, E., Dearman, J., Bailey, G. F., Yamashita, T., Kuo, B., & Zuo, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.044 · Cited by 145 · see citing works

Fibroblast Activation Protein Activates Macrophages and Promotes Parenchymal Liver Inflammation and Fibrosis

Yang, A.-T., Kim, Y.-O., Yan, X.-Z., Abe, H., Aslam, M., Park, K.-S., Zhao, X.-Y., Jia, J.-D., Klein, T., You, H., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.005 · Cited by 144 · see citing works

Shp2 promotes liver cancer stem cell expansion by augmenting β‐catenin signaling and predicts chemotherapeutic response of patients

Xiang, D., Cheng, Z., Liu, H., Wang, X. B., Han, T., Sun, W. C., Li, X., Yang, W., Chen, C. Y., Xia, M., et al. (2016) · Hepatology · doi:10.1002/hep.28919 · Cited by 142 · see citing works

Epithelial Plasticity during Liver Injury and Regeneration

Gadd, V. L., Aleksieva, N., & Forbes, S. J. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.08.016 · Cited by 142 · see citing works

Generation of mature and functional hair cells by co-expression of Gfi1, Pou4f3, and Atoh1 in the postnatal mouse cochlea

Chen, Y., Gu, Y., Li, Y., Li, G., Chai, R., Li, W., & Li, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109016 · Cited by 104 · see citing works

Reprogramming cell fates by small molecules

Ma, X., Kong, L., & Zhu, S. (2017) · Protein & Cell · doi:10.1007/s13238-016-0362-6 · Cited by 98 · see citing works

The clinical manifestations and molecular pathogenesis of radiation fibrosis

Fijardo, M., Kwan, J. Y. Y., Bissey, P.-A., Citrin, D. E., Yip, K. W., & Liu, F. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105089 · Cited by 93 · see citing works

Fibroblast activation and heterogeneity in fibrotic disease

Zhang, X., Zhang, Y., & Liu, Y. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-025-00969-8 · Cited by 77 · see citing works

Advances in cancer stem cell targeting: How to strike the evil at its root

Pützer, B. M., Solanki, M., & Herchenröder, O. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.013 · Cited by 73 · see citing works

Molecular Mechanisms and Potential New Therapeutic Drugs for Liver Fibrosis

Wang, F.-D., Zhou, J., & Chen, E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.787748 · Cited by 74 · see citing works

Liver cell therapy: is this the end of the beginning?

Alwahsh, S. M., Rashidi, H., & Hay, D. C. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2713-8 · Cited by 70 · see citing works

Down-regulation of Beclin1 promotes direct cardiac reprogramming

Wang, L., Ma, H., Huang, P., Xie, Y., Near, D., Wang, H., Xu, J., Yang, Y., Xu, Y., Garbutt, T. A., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay7856 · Cited by 70 · see citing works

The Dynamics of Transcriptional Activation by Hepatic Reprogramming Factors

Horisawa, K., Udono, M., Ueno, K., Ohkawa, Y., Nagasaki, M., Sekiya, S., & Suzuki, A. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.012 · Cited by 68 · see citing works

Phenotypical and Functional Polymorphism of Liver Resident Macrophages

Elchaninov, A. V., Fatkhudinov, T., Vishnyakova, P., Lokhonina, А. V., & Sukhikh, G. T. (2019) · Cells · doi:10.3390/cells8091032 · Cited by 66 · see citing works

Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine

Huang, D. (., Gibeley, S. B., Xu, C., Xiao, Y., Celik, O., Ginsberg, H. N., & Leong, K. W. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909553 · Cited by 65 · see citing works

Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

Nakamori, D., Akamine, H., Takayama, K., Sakurai, F., & Mizuguchi, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-16856-7 · Cited by 64 · see citing works

Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?

Chan, Y.-T., Wang, N., Tan, H. Y., Li, S., & Feng, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00548 · Cited by 62 · see citing works

Engineering Biomaterials with Micro/Nanotechnologies for Cell Reprogramming

Fang, J., Hsueh, Y., Soto, J., Sun, W., Wang, J., Gu, Z., Khademhosseini, A., & Li, S. (2020) · ACS Nano · doi:10.1021/acsnano.9b04837 · Cited by 60 · see citing works

Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis

Guo, S. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12221 · Cited by 58 · see citing works

Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines

Gong, L., Wei, F., Gonzalez, F. J., & Li, G. (2023) · Hepatology · doi:10.1097/hep.0000000000000182 · Cited by 58 · see citing works

Cell Fate Reprogramming in the Era of Cancer Immunotherapy

Zimmermannova, O., Caiado, I., Ferreira, A. G., & Pereira, C.-F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.714822 · Cited by 56 · see citing works

Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming

Merkt, W., Zhou, Y., Han, H., & Lagares, D. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12952 · Cited by 56 · see citing works

A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features

Sgodda, M., Dai, Z., Zweigerdt, R., Sharma, A. D., Ott, M., & Cantz, T. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0023 · Cited by 53 · see citing works

Antifibrotics in chronic liver disease: tractable targets and translational challenges

Ramachandran, P., & Henderson, N. C. (2016) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(16)30110-8 · Cited by 51 · see citing works

Core Transcription Factors, MicroRNAs, and Small Molecules Drive Transdifferentiation of Human Fibroblasts Towards The Cardiac Cell Lineage

Christoforou, N., Chakraborty, S., Kirkton, R. D., Adler, A. F., Addis, R. C., & Leong, K. W. (2017) · Scientific Reports · doi:10.1038/srep40285 · Cited by 47 · see citing works

Assessment of engineered cells using CellNet and RNA-seq

Radley, A., Schwab, R. M., Tan, Y., Kim, J., Lo, E. K. W., & Cahan, P. (2017) · Nature Protocols · doi:10.1038/nprot.2017.022 · Cited by 44 · see citing works

Senolytic treatment reduces oxidative protein stress in an aging male murine model of post‐traumatic osteoarthritis

Chin, A. F., Han, J., Clement, C. C., Choi, Y., Zhang, H., Browne, M., Jeon, O. H., & Elisseeff, J. H. (2023) · Aging Cell · doi:10.1111/acel.13979 · Cited by 49 · see citing works

Gene regulatory networks in differentiation and direct reprogramming of hepatic cells

Gérard, C., Tys, J., & Lemaigre, F. P. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.003 · Cited by 46 · see citing works

The control of conjunctival fibrosis as a paradigm for the prevention of ocular fibrosis-related blindness. “Fibrosis has many friends”

Khaw, P. T., Bouremel, Y., Brocchini, S., & Henein, C. (2020) · Eye · doi:10.1038/s41433-020-1031-9 · Cited by 46 · see citing works

Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis

Li, P., Li, Y., Zhu, L., Yang, Z. H., He, J., Wang, L., Shang, Q., Pan, H., Wang, H., Ma, X., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.12.008 · Cited by 46 · see citing works

Progress in stem cell‐based therapy for liver disease

Shiota, G., & Itaba, N. (2016) · Hepatology Research · doi:10.1111/hepr.12747 · Cited by 45 · see citing works

Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor

Guo, R., Tang, W., Yuan, Q., Hui, L., Wang, X., & Xie, X. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.06.013 · Cited by 45 · see citing works

Hepatic stellate cells: fibrogenic, regenerative or both? Heterogeneity and context are key

Bansal, M. B. (2016) · Hepatology International · doi:10.1007/s12072-016-9758-x · Cited by 42 · see citing works

Wnt4 negatively regulates the TGF-β1-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK

Liu, J., Zhao, B., Zhu, H., Pan, Q., Cai, M., Bai, X., Li, X., Hu, X., Zhang, M., Shi, J., et al. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03110-x · Cited by 41 · see citing works

Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Krooss, S. A., Dai, Z., Schmidt, F., Rovai, A., Fakhiri, J., Dhingra, A., Yuan, Q., Yang, T., Balakrishnan, A., Steinbrück, L., et al. (2019) · iScience · doi:10.1016/j.isci.2019.100764 · Cited by 42 · see citing works

Targeting HSP47 and HSP70: promising therapeutic approaches in liver fibrosis management

El-Fattah, E. E. A., & Zakaria, A. Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03759-z · Cited by 41 · see citing works

Antifibrotics in liver disease: are we getting closer to clinical use?

Bansal, M. B., & Chamroonkul, N. (2018) · Hepatology International · doi:10.1007/s12072-018-9897-3 · Cited by 40 · see citing works

Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail

Mathison, M. N., Singh, V., Sanagasetti, D., Yang, L., Pinnamaneni, J. P., Yang, J., & Rosengart, T. K. (2017) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2017.06.035 · Cited by 36 · see citing works

Wound healing and fibrosis: current stem cell therapies

Jones, R. E., Foster, D. S., Hu, M. S.-M., & Longaker, M. T. (2019) · Transfusion · doi:10.1111/trf.14836 · Cited by 36 · see citing works

Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells

Jain, N., Goyal, Y., Dunagin, M. C., Cote, C. J., Mellis, I. A., Emert, B. L., Jiang, C., Dardani, I. P., Reffsin, S., Arnett, M. J., et al. (2024) · Cell Systems · doi:10.1016/j.cels.2024.01.001 · Cited by 30 · see citing works

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

Takashima, Y., Horisawa, K., Udono, M., Ohkawa, Y., & Suzuki, A. (2018) · Cancer Science · doi:10.1111/cas.13798 · Cited by 35 · see citing works

Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources

Seo, Y., Shin, K., Kim, H. H., & Kim, H. (2019) · Stem Cells International · doi:10.1155/2019/9281329 · Cited by 35 · see citing works

Perivascular stromal cells: Directors of tissue immune niches

Sbierski‐Kind, J., Mroz, N. M., & Molofsky, A. B. (2021) · Immunological Reviews · doi:10.1111/imr.12984 · Cited by 33 · see citing works

In vivo reprogramming for tissue regeneration and organismal rejuvenation

Taguchi, J., & Yamada, Y. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.07.008 · Cited by 34 · see citing works

Highly Efficient Intracellular Protein Delivery by Cationic Polyethyleneimine-Modified Gelatin Nanoparticles

Chou, M.-J., Yu, H.-Y., Hsia, J.-C., Chen, Y., Hung, T.-T., Chao, H., Chern, E., & Huang, Y. (2018) · Materials · doi:10.3390/ma11020301 · Cited by 34 · see citing works

The therapeutic potential of induced hepatocyte-like cells generated by direct reprogramming on hepatic fibrosis

Park, S., Hwang, S. I., Kim, J., Hwang, S., Kang, S., Yang, S., Kim, J., Kang, W., Kim, K., Han, D., et al. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1127-3 · Cited by 34 · see citing works

Direct cell-fate conversion of somatic cells: Toward regenerative medicine and industries

Horisawa, K., & Suzuki, A. (2020) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.96.012 · Cited by 34 · see citing works

Loss-of-function mutations in Zn-finger DNA-binding domain of HNF4A cause aberrant transcriptional regulation in liver cancer

Taniguchi, H., Fujimoto, A., Kono, H., Furuta, M., Fujita, M., & Nakagawa, H. (2018) · Oncotarget · doi:10.18632/oncotarget.25456 · Cited by 32 · see citing works

Design Approaches for Generating Organ Constructs

Xia, Y. F., & Belmonte, J. C. I. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.05.016 · Cited by 32 · see citing works

Space of Disse: a stem cell niche in the liver

Häussinger, D., & Kordes, C. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0283 · Cited by 32 · see citing works

New Technologies To Enhance In Vivo Reprogramming for Regenerative Medicine

Larouche, J. A., & Aguilar, C. A. (2018) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.11.003 · Cited by 28 · see citing works

GPC-3 in hepatocellular carcinoma; A novel biomarker and molecular target

Tehrani, H. A., Zangi, M., Fathi, M., Vakili, K. G., Hassan, M., Rismani, E., Hossein‐Khannazer, N., & Vosough, M. (2024) · Experimental Cell Research · doi:10.1016/j.yexcr.2024.114391 · Cited by 27 · see citing works

Direct reprogramming of somatic cells into induced hepatocytes: Cracking the Enigma code

Rombaut, M., Boeckmans, J., Rodrigues, R. M., van Grunsven, L. A., Vanhaecke, T., & Kock, J. D. (2021) · Journal of Hepatology · doi:10.1016/j.jhep.2021.04.048 · Cited by 26 · see citing works

Therapeutic and diagnostic targeting of fibrosis in metabolic, proliferative and viral disorders

Sofias, A. M., Lorenzi, F. D., Peña, Q., Shalmani, A. A., Vucur, M., Wang, J., Kiessling, F. M., Shi, Y., Consolino, L., Storm, G., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113831 · Cited by 27 · see citing works

Hepatoprotective effect of Qushihuayu formula on non-alcoholic steatohepatitis induced by MCD diet in rat

Lan, Q., Ren, Z., Chen, Y., Cui, G., Choi, I. C., Ung, C. O. L., Yu, H. H., & Lee, S. M. (2021) · Chinese Medicine · doi:10.1186/s13020-021-00434-1 · Cited by 25 · see citing works

Gene therapy approaches in the non-human primate model of Parkinson’s disease

Pignataro, D., Sucunza, D., Rico, A. J., Dopeso‐Reyes, I. G., Roda, E., Rodriguez-Perez, A. I., Labandeira-García, J. L., Broccoli, V., Kato, S., Kobayashi, K., et al. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1681-3 · Cited by 26 · see citing works

Strategies for in vivo reprogramming

Ofenbauer, A., & Tursun, B. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.06.002 · Cited by 25 · see citing works

The novel tool of cell reprogramming for applications in molecular medicine

Mall, M., & Wernig, M. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1550-4 · Cited by 24 · see citing works

Hepatic microenvironment underlies fibrosis in chronic hepatitis B patients

Yao, Q., Feng, Y., Han, P., Yang, F., & Song, G. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i27.3917 · Cited by 24 · see citing works

Cell and Tissue Therapy for the Treatment of Chronic Liver Disease

Bram, Y., Nguyen, D.-H. T., Gupta, V., Park, J., Richardson, C., Chandar, V., & Schwartz, R. E. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-112619-044026 · Cited by 24 · see citing works

Reprogramming the spleen into a functioning ‘liver’ in vivo

Liu, C., Wang, L., Xu, M., Sun, Y., Xing, Z., Zhang, J., Wang, C., & Dong, L. (2022) · Gut · doi:10.1136/gutjnl-2021-325018 · Cited by 25 · see citing works

Reprogramming cellular identity in vivo

Leaman, S., Marichal, N., & Berninger, B. (2022) · Development · doi:10.1242/dev.200433 · Cited by 22 · see citing works

HNF4A Regulates the Proliferation and Tumor Formation of Cervical Cancer Cells through the Wnt/ β ‐Catenin Pathway

Ma, H.-M., Zhang, Q., Yang, X., Hu, Y., Zhang, J., Chen, L., Zhao, B., Yang, W., & Xu, R. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8168988 · Cited by 22 · see citing works

Direct cellular reprogramming and inner ear regeneration

Atkinson, P. J., Kim, G. S., & Cheng, A. G.-L. (2018) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2019.1564035 · Cited by 23 · see citing works

Liver stem cells: Plasticity of the liver epithelium

Tsuchiya, A., & Lu, W. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i9.1037 · Cited by 23 · see citing works

Chemically induced cell fate reprogramming and the acquisition of plasticity in somatic cells

Zhao, Y. (2019) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2019.04.025 · Cited by 20 · see citing works

Engineering kidney cells: reprogramming and directed differentiation to renal tissues

Kaminski, M. M., Tošić, J., Pichler, R., Arnold, S. J., & Lienkamp, S. S. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2629-5 · Cited by 20 · see citing works

Mitigation of liver fibrosis via hepatic stellate cells mitochondrial apoptosis induced by metformin

Su, Y., Lu, S., Hou, C., Ren, K., Wang, M., Liu, X., Zhao, S., & Liu, X. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108683 · Cited by 20 · see citing works

Alternative Cell Sources for Liver Parenchyma Repopulation: Where Do We Stand?

Tricot, T., De Boeck, J., & Verfaillie, C. (2020) · Cells · doi:10.3390/cells9030566 · Cited by 20 · see citing works

Innovation for hepatotoxicity in vitro research models: A review

Han, W., Wu, Q., Zhang, X., & Duan, Z. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3711 · Cited by 20 · see citing works

Stationed or Relocating: The Seesawing EMT/MET Determinants from Embryonic Development to Cancer Metastasis

Li, C., Hsu, T., Chang, Y., Chan, M., Lu, P., & Hsiao, M. (2021) · Biomedicines · doi:10.3390/biomedicines9091265 · Cited by 19 · see citing works

Fibroblasts: New players in the central nervous system?

Duan, L., & Yu, X. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.01.014 · Cited by 19 · see citing works

Can Nutraceuticals Support the Treatment of MASLD/MASH, and thus Affect the Process of Liver Fibrosis?

Sokal-Dembowska, A., Jarmakiewicz-Czaja, S., Ferenc, K., & Filip, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105238 · Cited by 19 · see citing works

In Vitro Generated Hepatocyte-Like Cells: A Novel Tool in Regenerative Medicine and Drug Discovery.

Zakikhan, K., Pournasr, B., Massoud, V., & Marjan, N. A. (2017) · PubMed Central · doi:10.22074/cellj.2016.4362 · Cited by 19 · see citing works

In vivo reprogramming as a new approach to cardiac regenerative therapy

Sadahiro, T., & Ieda, M. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.06.019 · Cited by 20 · see citing works

“The Good, the Bad, and the Ugly” – About Diverse Phenotypes of Hepatic Stellate Cells in the Liver

Bogomolova, A., Balakrishnan, A., Ott, M., & Sharma, A. D. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.01.002 · Cited by 18 · see citing works

Homing in on the hepatic scar: recent advances in cell-specific targeting of liver fibrosis

Dobie, R., & Henderson, N. C. (2016) · F1000Research · doi:10.12688/f1000research.8822.1 · Cited by 18 · see citing works

Synergistic control of mechanics and microarchitecture of 3D bioactive hydrogel platform to promote the regenerative potential of engineered hepatic tissue

Kim, S., Park, M. R., Choi, C., Kim, J. B., & Cha, C. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120688 · Cited by 18 · see citing works

Bench to bedside: Current advances in regenerative medicine

Clarke, G., Harley, P., Hubber, E.-L., Manea, T., Manuelli, L., Read, E., & Watt, F. M. (2018) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2018.05.006 · Cited by 18 · see citing works

Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Lim, B., Kamal, A., Gomez Ramos, B., Adrian Segarra, J. M., Ibarra, I. L., Dignas, L., Kindinger, T., Volz, K., Rahbari, M., Rahbari, N., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02081-w · Cited by 17 · see citing works

Emerging advancements in liver regeneration and organogenesis as tools for liver replacement

Huppert, S. S., & Campbell, K. M. (2016) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000365 · Cited by 17 · see citing works

Human Pluripotent Stem Cells: Myths and Future Realities for Liver Cell Therapy

Goldman, O., & Gouon–Evans, V. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.05.019 · Cited by 17 · see citing works

Liver fibrosis: Which mechanisms matter?

Weiskirchen, R., & Tacke, F. (2016) · Clinical Liver Disease · doi:10.1002/cld.581 · Cited by 17 · see citing works

Integrating Vectors for Gene Therapy and Clonal Tracking of Engineered Hematopoiesis

Biasco, L., Rothe, M., Schott, J. W., & Schambach, A. (2017) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2017.06.009 · Cited by 17 · see citing works

TWIST1 expression is associated with high-risk neuroblastoma and promotes primary and metastatic tumor growth

Sepporta, M.-V., Praz, V., Balmas Bourloud, K., Joseph, J.-M., Jauquier, N., Riggi, N., Nardou-Auderset, K., Petit, A., Scoazec, J.-Y., Sartelet, H., et al. (2022) · Communications Biology · doi:10.1038/s42003-021-02958-6 · Cited by 16 · see citing works

Hepatocytes induced from myofibroblasts in vivo

Ridler, C. E. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.62

Conversion of Fibroblasts to Hepatocyte-Like Cells In Vivo

Song, G., Yuan, Q., Dai, Z., Tsay, H.-C., Shen, X., Ott, M., & Sharma, A. D. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-8961-4_10 · Cited by 1 · see citing works

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Sekiya, S., & Suzuki, A. (2011) · Nature · doi:10.1038/nature10263 · Cited by 846 · see citing works

Directly induced hepatogenic cells derived from human fibroblast ameliorate liver fibrosis

Choi, J. S., Han, S.-H., Ryu, H. A., & Kim, S. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3073 · Cited by 3 · see citing works

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors

Huang, P., He, Z., Ji, S., Sun, H., Xiang, D., Liu, C., Hu, Y., Wang, X., & Hui, L. (2011) · Nature · doi:10.1038/nature10116 · Cited by 864 · see citing works