The DOI matches its Crossref record; 113 of the 113 references it cites were found in a registry or an index.
Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies
Open accessAbstract
Clonal hematopoiesis (CH) broadly describes the expansion of a clonal population of blood cells with one or more somatic mutations. Individuals with CH are at greater risk for hematological malignancies, cardiovascular disease, and increased mortality from non-hematological cancers. Understanding the causes of CH and how these mutant cells interact with cells of other tissues will provide critical insights into preleukemic development, stem cell biology, host-immune interactions, and cancer evolution. Here we discuss the clinical manifestations of CH, mechanisms contributing to its development, the role of CH in clonal evolution toward leukemia, and the contribution of CH to non-hematological disease states.
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“clonal hematopoiesis-associated mutations alter the behavior of hematopoietic stem cells (HSCs); some also confer a fitness advantage, leading to clonal expansion [27,28].”
From Clonal Hematopoiesis of Indeterminate Potential as an Emerging Interdisciplinary Risk Factor in Alzheimer’s Disease: Current Evidence and Future Directions (2026) · cites this paper as [28]
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Jaiswal, S., & Ebert, B. L. (2019) · Science · doi:10.1126/science.aan4673 · Cited by 1,156
“The role of CHIP-associated genes in hematopoiesis has been extensively reviewed elsewhere (41, 42).”
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Razavi, P., Li, B. T., Brown, D. N., Jung, B., Hubbell, E. A., Shen, R., Abida, W. M., Juluru, K., de Bruijn, I., Hou, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0652-7 · Cited by 808
Heuser, M., Freeman, S. D., Ossenkoppele, G. J., Buccisano, F., Hourigan, C. S., Ngai, L. L., Tettero, J. M., Bachas, C., Baer, C. R., Béné, M. C., et al. (2021) · Blood · doi:10.1182/blood.2021013626 · Cited by 767
Metadata
- Authors
- Bowman, R. L., Busque, L., & Levine, R. L.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Hôpital Maisonneuve-Rosemont (CA)
- Corresponding author
- Levine, Ross L.
- Venue
- Cell stem cell
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 22
- Issue
- 2
- Pages
- 157-170
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC5804896
- OpenAlex
- W2786854070
- Cited by
- 448
- References
- 112
- Citations by year
- 2026: 29 · 2025: 38 · 2024: 37 · 2023: 56 · 2022: 54 · 2021: 69 · 2020: 67 · 2019: 71 · 2018: 25
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Cancer Institute (P30 CA008748)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Keywords
- clonal hematopoiesis, somatic mutations, hematologic malignancies, leukemia, clonal evolution, hematopoietic stem cells, cardiovascular disease, tumor evolution
- MeSH terms
- Hematopoiesis, Humans, Mutation, Stochastic Processes, Hematologic Neoplasms, Epigenesis, Genetic, Clonal Evolution
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