Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982

The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

Arber, D. A., Orazi, A., Hasserjian, R., Thiele, J., Borowitz, M. J., Le Beau, M. M., Bloomfield, C. D., Cazzola, M., & Vardiman, J. W. (2016) · Blood · doi:10.1182/blood-2016-03-643544 · Cited by 10,119

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738

Signatures of mutational processes in human cancer

Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

Tahiliani, M., Koh, K. P., Shen, Y., Pastor, W. A., Bandukwala, H., Brudno, Y., Agarwal, S., Iyer, L. M., Liu, D. R., Aravind, L., et al. (2009) · Science · doi:10.1126/science.1170116 · Cited by 5,836

Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia

The Cancer Genome Atlas Research Network (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301689 · Cited by 5,078

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Genomic classification and prognosis in acute myeloid leukemia

Papaemmanuil, E., Gerstung, M., Bullinger, L., Gaidzik, V. I., Paschka, P., Roberts, N. D., Potter, N. E., Heuser, M., Thol, F., Bolli, N., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1516192 · Cited by 4,350

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

Ito, S., Shen, L., Dai, Q., Wu, S. C., Collins, L. B., Swenberg, J. A., He, C., & Zhang, Y. (2011) · Science · doi:10.1126/science.1210597 · Cited by 3,451

DNA methylation: roles in mammalian development

Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Xu, W., Yang, H., Liu, Y., Yang, Y., Wang, P., Kim, S.-H., Ito, S., Yang, C., Wang, P., Xiao, M.-T., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.12.014 · Cited by 2,875

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836

The molecular hallmarks of epigenetic control

Allis, C. D., & Jenuwein, T. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.59 · Cited by 2,809

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766

Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

Ito, S., D’Alessio, A. C., Taranova, O., Hong, K., Sowers, L. C., & Zhang, Y. (2010) · Nature · doi:10.1038/nature09303 · Cited by 2,628

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

Orkin, S. H., & Zon, L. I. (2008) · Cell · doi:10.1016/j.cell.2008.01.025 · Cited by 2,570

DNMT3A Mutations in Acute Myeloid Leukemia

Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

Steensma, D. P., Bejar, R., Jaiswal, S., Lindsley, R. C., Sekeres, M. A., Hasserjian, R. P., & Ebert, B. L. (2015) · Blood · doi:10.1182/blood-2015-03-631747 · Cited by 1,971

Putting p53 in context

Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906

Age-related mutations associated with clonal hematopoietic expansion and malignancies

Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874

The origin and evolution of mutations in acute myeloid leukemia

Welch, J. S., Ley, T. J., Link, D. C., Miller, C. A., Larson, D. E., Koboldt, D. C., Wartman, L. D., Lamprecht, T. L., Liu, F., Xia, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.023 · Cited by 1,575

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482

Endogenous DNA damage as a source of genomic instability in cancer

Tubbs, A., & Nussenzweig, A. (2017) · Cell · doi:10.1016/j.cell.2017.01.002 · Cited by 1,452

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Ko, M., Huang, Y., Jankowska, A. M., Pape, U. J., Tahiliani, M., Bandukwala, H. S., An, J., Lamperti, E. D., Koh, K. P., Ganetzky, R. D., et al. (2010) · Nature · doi:10.1038/nature09586 · Cited by 1,340

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.001 · Cited by 1,339

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

Pang, W. W., Price, E. A., Sahoo, D., Beerman, I., Maloney, W. J., Rossi, D. J., Schrier, S. L., & Weissman, I. L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116110108 · Cited by 991

Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition

Muotri, A. R., Chu, V. T., Marchetto, M. C. N., Deng, W., Moran, J. V., & Gage, F. H. (2005) · Nature · doi:10.1038/nature03663 · Cited by 942

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

Quivoron, C., Couronné, L., Della Valle, V., Lopez, C. K., Plo, I., Wagner-Ballon, O., Do Cruzeiro, M., Delhommeau, F., Arnulf, B., Stern, M.-H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.06.003 · Cited by 924

Hematopoiesis: a human perspective

Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895

Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

Wong, T. N., Ramsingh, G., Young, A. L., Miller, C. A., Touma, W., Welch, J. S., Lamprecht, T. L., Shen, D., Hundal, J., Fulton, R. S., et al. (2015) · Nature · doi:10.1038/nature13968 · Cited by 892

Current concepts in the pathophysiology and treatment of aplastic anemia

Young, N. S., Calado, R. T., & Scheinberg, P. (2006) · Blood · doi:10.1182/blood-2006-03-010777 · Cited by 888

The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions

Bolouri, H., Farrar, J. E., Triche, T. J., Ries, R. E., Lim, E. L., Alonzo, T. A., Ma, Y. P., Moore, R. A., Mungall, A. J. J., Marra, M. A., et al. (2017) · Nature Medicine · doi:10.1038/nm.4439 · Cited by 869

Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes

Coombs, C. C., Zehir, A., Devlin, S. M., Kishtagari, A., Syed, A., Jonsson, P., Hyman, D. M., Solit, D. B., Robson, M. E., Baselga, J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.07.010 · Cited by 866

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

Blaschke, K., Ebata, K. T., Karimi, M. M., Zepeda-Martínez, J. A., Goyal, P., Mahapatra, S., Tam, A., Laird, D. J., Hirst, M., Rao, A., et al. (2013) · Nature · doi:10.1038/nature12362 · Cited by 865

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830

Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

Zhang, Q., Zhao, K., Shen, Q., Han, Y., Gu, Y., Li, X., Zhao, D., Liu, Y., Wang, C., Zhang, X., et al. (2015) · Nature · doi:10.1038/nature15252 · Cited by 807

Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly

Zink, F., Stacey, S. N., Norddahl, G. L., Frigge, M. L., Magnusson, O. T., Jonsdottir, I., Thorgeirsson, T. E., Sigurdsson, A., Gudjonsson, S. A., Gudmundsson, J., et al. (2017) · Blood · doi:10.1182/blood-2017-02-769869 · Cited by 777

Prognostic Mutations in Myelodysplastic Syndrome after Stem-Cell Transplantation

Lindsley, R. C., Saber, W., Mar, B. G., Redd, R., Wang, T., Haagenson, M. D., Grauman, P. V., Hu, Z.-H., Spellman, S. R., Lee, S. J., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1611604 · Cited by 776

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.032 · Cited by 707

Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission

Corces-Zimmerman, M. R., Hong, W.-J., Weissman, I. L., Medeiros, B. C., & Majeti, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324297111 · Cited by 705

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

Young, A. L., Challen, G. A., Birmann, B. M., & Druley, T. E. (2016) · Nature Communications · doi:10.1038/ncomms12484 · Cited by 692

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Flach, J., Bakker, S. T., Mohrin, M., Conroy, P. C., Pietras, E. M., Reynaud, D., Alvarez, S., Diolaiti, M. E., Ugarte, F., Forsberg, E. C., et al. (2014) · Nature · doi:10.1038/nature13619 · Cited by 650

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

Yoshizato, T., Dumitriu, B., Hosokawa, K., Makishima, H., Yoshida, K., Townsley, D., Sato-Otsubo, A., Sato, Y., Liu, D., Suzuki, H., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1414799 · Cited by 646

Effect of Mutation Order on Myeloproliferative Neoplasms

Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412098 · Cited by 607

The ageing haematopoietic stem cell compartment

Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature · doi:10.1038/nature23876 · Cited by 545 · cited 2×

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age

Busque, L., Mio, R., Mattioli, J., Brais, E., Blais, N., Lalonde, Y., Maragh, M., & Gilliland, D. (1996) · Blood · doi:10.1182/blood.v88.1.59.59 · Cited by 543

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534

DNMT3A in haematological malignancies

Yang, L., Rau, R. E., & Goodell, M. A. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3895 · Cited by 525

Clinical significance of somatic mutation in unexplained blood cytopenia

Malcovati, L., Gallì, A., Travaglino, E., Ambaglio, I., Rizzo, E., Molteni, E., Elena, C., Ferretti, V. V., Catricalà, S., Bono, E. B., et al. (2017) · Blood · doi:10.1182/blood-2017-01-763425 · Cited by 482

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

Gibson, C. J., Lindsley, R. C., Tchekmedyian, V., Mar, B. G., Shi, J., Jaiswal, S., Bosworth, A., Francisco, L., He, J., Bansal, A., et al. (2017) · Journal of Clinical Oncology · doi:10.1200/jco.2016.71.6712 · Cited by 480

Making sense of hematopoietic stem cell niches

Boulais, P. E., & Frenette, P. S. (2015) · Blood · doi:10.1182/blood-2014-09-570192 · Cited by 469

Nonrandom X-inactivation patterns in normal females: lyonization ratios vary with age

Busque, L., Mio, R., Mattioli, J., et al. (1996) · Blood · doi:10.1182/blood.v88.1.59.bloodjournal88159 · Cited by 462

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

黒瀬, 圭., Gilley, K., Matsumoto, S., Watson, P. H., Zhou, X.-P., & Eng, C. (2002) · Nature Genetics · doi:10.1038/ng1013 · Cited by 418

Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study

Takahashi, K., Wang, F., Kantarjian, H., Doss, D., Khanna, K., Thompson, E., Zhao, L., Patel, K., Neelapu, S., Gumbs, C., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30626-x · Cited by 399

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

Abyzov, A. S., Mariani, J., Palejev, D., Zhang, Y., Haney, M. S., Tomasini, L., Ferrandino, A. F., Belmaker, L. R., Szekely, A. M., Wilson, M., et al. (2012) · Nature · doi:10.1038/nature11629 · Cited by 385

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

Buscarlet, M., Provost, S., Zada, Y. F., Barhdadi, A., Bourgoin, V., Lépine, G., Mollica, L., Szuber, N., Dubé, M.-P., & Busque, L. (2017) · Blood · doi:10.1182/blood-2017-04-777029 · Cited by 383

Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells

Challen, G. A., Sun, D., Mayle, A., Jeong, M., Luo, M., Rodriguez, B., Mallaney, C., Celik, H., Yang, L., Xia, Z., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.06.018 · Cited by 354

Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche

Chen, J. Y., Miyanishi, M., Wang, S. K., Yamazaki, S., Sinha, R., Kao, K. S., Seita, J., Sahoo, D., Nakauchi, H., & Weissman, I. L. (2016) · Nature · doi:10.1038/nature16943 · Cited by 345

MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance

Kwok, B., Hall, J., Witte, J. S., Xu, Y., Reddy, P., Lin, K., Flamholz, R., Dabbas, B., Yung, A., Al-Hafidh, J., et al. (2015) · Blood · doi:10.1182/blood-2015-08-667063 · Cited by 322

Mechanisms that Regulate Stem Cell Aging and Life Span

Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320

Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: A proof-of-concept, case-control study

Gillis, N. K., Ball, M., Zhang, Q., Ma, Z., Zhao, Y., Yoder, S. J., Balasis, M. E., Mesa, T. E., Sallman, D. A., Lancet, J. E., et al. (2017) · The Lancet Oncology · doi:10.1016/s1470-2045(16)30627-1 · Cited by 317

Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells

Yahata, T., Takanashi, T., Muguruma, Y., Ibrahim, A. A., Matsuzawa, H., Uno, T., Sheng, Y., Onizuka, M., Ito, M., Kato, S., et al. (2011) · Blood · doi:10.1182/blood-2011-01-330050 · Cited by 313

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

Rampal, R., Ahn, J., Abdel-Wahab, O., Nahas, M., Wang, K., Lipson, D., Otto, G. A., Yelensky, R., Hricik, T., McKenney, A. S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407792111 · Cited by 301

A new world of Polycombs: unexpected partnerships and emerging functions

Schwartz, Y. B., & Pirrotta, V. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3603 · Cited by 299

Breast-Cancer Stromal Cells with TP53 Mutations and Nodal Metastases

Patócs, A., Zhang, L., Xu, Y., Weber, F., Caldés, T., Mutter, G. L., Platzer, P., & Eng, C. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa071825 · Cited by 297

Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis

Rasmussen, K. D., Jia, G., Johansen, J. V., Pedersen, M. T., Rapin, N., Bagger, F. O., Porse, B. T., Bernard, O. A., Christensen, J., & Helin, K. (2015) · Genes & Development · doi:10.1101/gad.260174.115 · Cited by 270

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

McConnell, M. J., Moran, J. V., Abyzov, A., Akbarian, S., Bae, T., Cortes-Ciriano, I., Erwin, J. A., Fasching, L., Flasch, D. A., Freed, D., et al. (2017) · Science · doi:10.1126/science.aal1641 · Cited by 262

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Zhang, X., Su, J., Jeong, M., Ko, M., Huang, Y., Park, H. J., Guzman, A., Lei, Y., Huang, Y.-H., Rao, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3610 · Cited by 258

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., et al. (2016) · Nature Medicine · doi:10.1038/nm.4210 · Cited by 256

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer

Ruark, E., Snape, K. M. G., Humburg, P., Loveday, C., Bajrami, I., Brough, R., Rodrigues, D. N., Renwick, A., Seal, S., Ramsay, E., et al. (2012) · Nature · doi:10.1038/nature11725 · Cited by 250

Evidence that hematopoiesis may be a stochastic process in vivo

Abkowitz, J. L., Catlin, S. N., & Guttorp, P. M. (1996) · Nature Medicine · doi:10.1038/nm0296-190 · Cited by 246

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

Shih, A. H., Jiang, Y., Meydan, C., Shank, K., Pandey, S., Barreyro, L., Antony-Debre, I., Viale, A., Socci, N., Sun, Y., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.03.009 · Cited by 236

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

Mayle, A., Yang, L., Rodriguez, B., Zhou, T., Chang, E., Curry, C. V., Challen, G. A., Li, W., Wheeler, D., Rebel, V. I., et al. (2015) · Blood · doi:10.1182/blood-2014-08-594648 · Cited by 235

Epigenetic control of adult stem cell function

Avgustinova, A., & Benitah, S. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.76 · Cited by 222

CpG island hypermethylation mediated by DNMT3A is a consequence of AML progression

Spencer, D. H., Russler-Germain, D. A., Ketkar, S., Helton, N. M., Lamprecht, T. L., Fulton, R. S., Fronick, C. C., O’Laughlin, M., Heath, S. E., Shinawi, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.01.021 · Cited by 219

Clonal hematopoiesis in acquired aplastic anemia

Ogawa, S. (2016) · Blood · doi:10.1182/blood-2016-01-636381 · Cited by 205

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2

Inoue, S., Li, W. Y., Tseng, A., Beerman, I., Elia, A., Bendall, S. C., Lemonnier, F., Kron, K. J., Cescon, D. W., Hao, Z., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.018 · Cited by 204

De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells

Tadokoro, Y., Ema, H., Okano, M., Li, E., & Nakauchi, H. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20060750 · Cited by 203

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

Pan, W. Q., Zhu, S., Qu, K., Meeth, K. M., Cheng, J., He, K., Ma, H., Liao, Y., Wen, X., Roden, C., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.020 · Cited by 202

Aging-Induced Stem Cell Mutations as Drivers for Disease and Cancer

Adams, P. D., Jasper, H., & Rudolph, K. L. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.002 · Cited by 182

Targeted sequencing identifies patients with preclinical MDS at high risk of disease progression

Cargo, C. A., Rowbotham, N. J., Evans, P., Barrans, S., Bowen, D., Crouch, S., & Jack, A. (2015) · Blood · doi:10.1182/blood-2015-08-663237 · Cited by 179

Age-related changes in human hematopoietic stem/progenitor cells

Kuranda, K., Vargaftig, J., Rochère, P. D. L., Dosquet, C., Charron, D. J., Bardin, F., Tonnelle, C., Bonnet, D. A., & Goodhardt, M. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00675.x · Cited by 177

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

Kleiblova, P., Shaltiel, I. A., Benada, J., Ševčík, J., Pecháčková, S., Pohlreich, P., Voest, E. E., Dundr, P., Bartek, J., Kleibl, Z., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210031 · Cited by 170

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

Lobry, C., Ntziachristos, P., Ndiaye‐Lobry, D., Oh, P., Cimmino, L., Zhu, N., Araldi, E., Hu, W., Freund, J. E., Abdel-Wahab, O. I., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121484 · Cited by 169

Self-induced correction of the genetic defect in tyrosinemia type I.

Kvittingen, E. A., Rootwelt, H., Berger, R., & Brandtzaeg, P. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117509 · Cited by 168

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

Yang, L., Rodriguez, B. A. T., Mayle, A., Park, H. J., Lin, X., Luo, M., Jeong, M., Curry, C. V., Kim, S.-B., Ruau, D., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.003 · Cited by 165

Extensive genetic variation in somatic human tissues

O’Huallachain, M., Karczewski, K. J., Weissman, S. M., Urban, A. E., & Snyder, M. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213736109 · Cited by 156

Irradiation selects for p53-deficient hematopoietic progenitors.

Marusyk, A., Porter, C. C., Zaberezhnyy, V., & DeGregori, J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000324 · Cited by 151

The microenvironment in human myeloid malignancies: emerging concepts and therapeutic implications

Medyouf, H. (2017) · Blood · doi:10.1182/blood-2016-11-696070 · Cited by 133

Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells

Pan, F., Wingo, T. S., Zhao, Z., Gao, R., Makishima, H., Qu, G., Lin, L., Yu, M., Ortega, J. R., Wang, J., et al. (2017) · Nature Communications · doi:10.1038/ncomms15102 · Cited by 117

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesisPreprint

Inoue, D., Bradley, R. K., & Abdel-Wahab, O. I. (2016) · Genes & Development · doi:10.1101/gad.278424.116 · Cited by 112

Molecular genetic alterations in the laser‐capture–microdissected stroma adjacent to bladder carcinoma

Paterson, R. F., Ulbright, T. M., MacLennan, G. T., Zhang, S., Pan, C.-X., Sweeney, C. J., Moore, C. R., Foster, R. S., Koch, M. O., Eble, J. N., et al. (2003) · Cancer · doi:10.1002/cncr.11747 · Cited by 106

Somatic Mosaic Mutations in PPM1D and TP53 in the Blood of Women With Ovarian Carcinoma

Swisher, E. M., Harrell, M. I., Norquist, B. M., Walsh, T., Brady, M. F., Lee, M. J., Hershberg, R. M., Kalli, K. R., Lankes, H. A., Konnick, E. Q., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2015.6053 · Cited by 105

A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11

Fisher, C. L. (2003) · Gene · doi:10.1016/s0378-1119(03)00430-x · Cited by 99

CHIP, ICUS, CCUS and other four-letter words

Bejar, R. L. (2017) · Leukemia · doi:10.1038/leu.2017.181 · Cited by 90

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria

Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A. V., Nativi, C., Layton, M., de la Fuente, J., et al. (2013) · Blood · doi:10.1182/blood-2012-11-469353 · Cited by 89

Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement

Dai, Y., Wang, Y., Huang, J.-Y., Li, X., Shi, X., Xu, J., Lu, J., Su, X., Yang, Y., Zhang, W., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703476114 · Cited by 82

TET2 Plays an Essential Role in Erythropoiesis by Regulating Lineage-Specific Genes via DNA Oxidative Demethylation in a Zebrafish Model

Ge, L., Zhang, R., Wan, F., Guo, D., Wang, P., Xiang, L., & Shao, J.-Z. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01061-13 · Cited by 75

DNA-damage response gene GADD45A induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival

Wingert, S., Thalheimer, F. B., Haetscher, N., Rehage, M., Schroeder, T., & Rieger, M. A. (2016) · Stem Cells · doi:10.1002/stem.2282 · Cited by 62

Somatic mutations in leukocytes infiltrating primary breast cancers

Kleppe, M., Comen, E. A., Wen, H. Y., Bastian, L., Blum, B., Rapaport, F. T., Keller, M., Granot, Z., Socci, N., Viale, A. J., et al. (2015) · npj Breast Cancer · doi:10.1038/npjbcancer.2015.5 · Cited by 57

Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patients

Zajkowicz, A., Butkiewicz, D., Drosik, A., Giglok, M., Suwiński, R., & Rusin, M. (2015) · British Journal of Cancer · doi:10.1038/bjc.2015.79 · Cited by 54

Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis

Thol, F. R., Klesse, S., Köhler, L.-M., Gabdoulline, R. R., Kloos, A., Liebich, A., Wichmann, M., Chaturvedi, A., Fabisch, J., Gaidzik, V. I., et al. (2016) · Leukemia · doi:10.1038/leu.2016.345 · Cited by 52

An unprecedented march for science

Appenzeller, T., & Staff, S. N. (2017) · Science · doi:10.1126/science.356.6336.356 · Cited by 46

Loss of Function of TET2 Cooperates with Constitutively Active KIT in Murine and Human Models of Mastocytosis

Vita, S. D., Schneider, R. K., Garcia, M., Wood, J. A., Gavillet, M., Ebert, B. L., Gerbaulet, A., Roers, A., Levine, R. L., Mullally, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096209 · Cited by 38

PPM1D Mutations in Circulating White Blood Cells and the Risk for Ovarian Cancer

Akbari, M. R., Lepage, P., Rosen, B. P., McLaughlin, J. R., Risch, H. A., Minden, M. D., & Narod, S. A. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt323 · Cited by 35

Truncating and missense PPM1D mutations in early‐onset and/or familial/hereditary prostate cancer patients

Cardoso, M., Paulo, P., Maia, S., & Teixeira, M. R. (2016) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22393 · Cited by 17

A view on drug resistance in cancer

Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770

Clonal hematopoiesis in human aging and disease

Jaiswal, S., & Ebert, B. L. (2019) · Science · doi:10.1126/science.aan4673 · Cited by 1,156

p53: 800 million years of evolution and 40 years of discovery

Levine, A. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0262-1 · Cited by 876

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

Razavi, P., Li, B. T., Brown, D. N., Jung, B., Hubbell, E. A., Shen, R., Abida, W. M., Juluru, K., de Bruijn, I., Hou, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0652-7 · Cited by 808

2021 Update on MRD in acute myeloid leukemia: a consensus document from the European LeukemiaNet MRD Working Party

Heuser, M., Freeman, S. D., Ossenkoppele, G. J., Buccisano, F., Hourigan, C. S., Ngai, L. L., Tettero, J. M., Bachas, C., Baer, C. R., Béné, M. C., et al. (2021) · Blood · doi:10.1182/blood.2021013626 · Cited by 767

Clinical Significance of Clonal Hematopoiesis

Cho, H., & Kim, J. (2023) · Korean Journal of Medicine · doi:10.3904/kjm.2023.98.4.185

Clonal Hematopoiesis and Premalignant DiseasesPreprint

Kaner, J. D., Desai, P. M., Mencia-Trinchant, N., Guzmán, M. L., Roboz, G. J., & Hassane, D. C. (2019) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a035675 · Cited by 20

The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases

Zhang, Z., & Sun, J. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_5

Clonal hematopoiesis in the pathogenesis of non-hematologic diseases with therapeutic potential

Lei, L., & Xiong, J. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04285-4

Clonal hematopoiesis: a shared risk factor for cardiovascular diseases and tumors

Zha, L., & Cheng, X. C. (2024) · Oncology and Translational Medicine · doi:10.1097/ot9.0000000000000029