Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition
Fujii, Masayuki, Matano, Mami, Toshimitsu, Kohta, Takano, Ai, Mikami, Yohei, Nishikori, Shingo, Sugimoto, Shinya, Sato, Toshiro·2018·Cell Stem Cell
Cited by (560)
Items 201–300 of 560
- Cancer organoid applications to investigate chemotherapy resistanceKenji Harada, Naoya Sakamoto · 2022 · Frontiers in Molecular Biosciences
- Stem cells for organoidsShutong Qian, Jiayi Mao, Zhimo Liu, Binfan Zhao, Qiuyu Zhao, Bolun Lu, Liucheng Zhang, Xiyuan Mao, Liying Cheng, Wenguo Cui et al. · 2022 · Smart Medicine
- The Patient-Derived Cancer Organoids: Promises and Challenges as Platforms for Cancer DiscoveryBae, JuneSung, Choi, Yun Sik, Cho, Gunsik, Jang, Se Jin · 2022 · Cancers
- Shifting paradigms in tissue stem cell biology: Insights from the intestineHans C. Clevers · 2026 · Cell
- Robust Three-Dimensional (3D) Expansion of Bovine Intestinal Organoids: An In Vitro Model as a Potential Alternative to an In Vivo SystemBo Ram Lee, Hyeon Yang, Sang-In Lee, Inamul Haq, Sun‐A Ock, Hayeon Wi, Hwi-Cheul Lee, Poongyeon Lee, Jae Gyu Yoo · 2021 · Animals
- Gutsy science: In vitro systems of the human intestine to model oral drug dispositionChristopher M. Arian, Tomoki Imaoka, Jade Yang, Edward J. Kelly, Kenneth E. Thummel · 2021 · Pharmacology & Therapeutics
- Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectorsJonas Becker, Megan Lynn Stanifer, Sarah R. Leist, Bettina Stolp, Olena Maiakovska, Ande West, Ellen Wiedtke, Kathleen Börner, Ali Ghanem, Ina Ambiel et al. · 2022 · Molecular Therapy
- Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive reviewVenkatesh Chunduri, Srinivas Maddi · 2022 · ADMET & DMPK
- Gastrointestinal organoid technology advances studies of enteric virus biologyAbimbola Olayinka Kolawole, Christiane E. Wobus · 2020 · PLoS Pathogens
- Corticosteroids impair epithelial regeneration in immune-mediated intestinal damageViktor Arnhold, Winston Yun-Han Chang, Suze A. Jansen, Govindarajan Thangavelu, Marco Calafiore, Paola Vinci, Ya–Yuan Fu, Takahiro Ito, Shuichiro Takashima, Anastasiya Egorova et al. · 2024 · Journal of Clinical Investigation
- Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinomaTaro Shinozaki, Kazuhiro Togasaki, Junko Hamamoto, Akifumi Mitsuishi, Takahiro Fukushima, Kai Sugihara, Toshiki Ebisudani, Masahiko Okada, Ayaka Saito, Lisa Shigematsu et al. · 2025 · Nature Communications
- Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived intestinal organoidsPan Xu, Heike E. F. Becker, Montserrat Elizalde, Marieke J. Pierik, Ad Masclee, Daisy M.A.E. Jonkers · 2021 · American Journal of Physiology-Gastrointestinal and Liver Physiology
- Interleukin-4 Promotes Tuft Cell Differentiation and Acetylcholine Production in Intestinal Organoids of Non-Human PrimateAkihiko Inaba, Ayane Arinaga, Keisuke Tanaka, Takaho A. Endo, Norihito Hayatsu, Yasushi Okazaki, Takumi Yamane, Yuichi Oishi, Hiroo Imai, Ken Iwatsuki · 2021 · International Journal of Molecular Sciences
- Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery researchTatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi · 2024 · Stem Cell Research & Therapy
- Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPRSkoufou-Papoutsaki, Nefeli, Adler, Sam, D'Santos, Paula, Mannion, Liz, Mehmed, Shenay, Kemp, Richard, Smith, Amy, Perrone, Francesca, Nayak, Komal, Russell, Alasdair et al. · 2023 · Disease Models & Mechanisms
- Efficient transgenesis and homology-directed gene targeting in monolayers of primary human small intestinal and colonic epithelial stem cellsKeith A. Breau, Meryem T. Ok, Ismael Gomez-Martinez, Joseph Burclaff, Nathan P. Kohn, Scott T. Magness · 2022 · Stem Cell Reports
- Tumor Organoid Model and Its Pharmacological Applications in Tumorigenesis PreventionXiaolei Cao, Wenjie Zheng, Yuwei Qiang, Ninghua Yao, Fan Zuo, Shi Qiu · 2022 · Current Molecular Pharmacology
- Cartilaginous Organoids: Advances, Applications, and PerspectivesYuhao Yu, Juan Wang, Yamin Li, Yunsu Chen, Wenguo Cui · 2022 · Advanced NanoBiomed Research
- Adapting systems biology to address the complexity of human disease in the single-cell eraDavid S. Fischer, Martin Arreola Villanueva, Peter S. Winter, Alex K. Shalek · 2025 · Nature Reviews Genetics
- 4D Materials with Photoadaptable Properties Instruct and Enhance Intestinal Organoid DevelopmentF. Max Yavitt, Bruce E. Kirkpatrick, Michael R. Blatchley, Kristi S. Anseth · 2022 · ACS Biomaterials Science & Engineering
- Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic FibrosisMarlou C. Bierlaagh, Anabela Santo Ramalho, Iris A. L. Silva, Annelotte M. Vonk, Rutger M. van den Bor, Peter van Mourik, Johanna Pott, Sylvia W.F. Suen, Sylvia F. Boj, Robert G.J. Vries et al. · 2024 · Journal of Cystic Fibrosis
- A patient-derived organoid model captures fetal-like plasticity in colorectal cancerLiang Xiong, Ying Xu, Zhao-Ya Gao, Jingyi Shi, Yun-Fan Wang, Xiao-Dong Wang, Wen-Sheng Huang, Ming Li, Long-Teng Wang, Jun Xu et al. · 2025 · Cell Research
- Single-cell transcriptomics identifies chondrocyte differentiation dynamics in vivo and in vitroJohn E. G. Lawrence, Woods Jon S, Kenny Roberts, Dinithi Sumanaweera, Petra Balogh, Tong Li, Alexander V. Predeus, Peng He, Krzysztof Polański, Elena Prigmore et al. · 2025 · Developmental Cell
- New developments and applications of human organoidsAmanda Andersson-Rolf, Hans C. Clevers · 2026 · Nature Reviews Molecular Cell Biology
- Organoid Culture Development for Skeletal SystemsJia Qing, Qian Guo, Longwei Lv, Xiao Zhang, Yunsong Liu, Boon Chin Heng, Zheng Li, Ping Zhang, Yongsheng Zhou · 2023 · Tissue Engineering Part B Reviews
- Intravitreal Administration of Retinal Organoids-Derived Exosomes Alleviates Photoreceptor Degeneration in Royal College of Surgeons Rats by Targeting the Mitogen-Activated Protein Kinase PathwayHan, Jung, Chang, Hun, Yang, Jin, Choi, Han, Park, Hyo, Jun, Hyoung, Choi, Ji, Paik, Sun-Sook, Chung, Kyung, Shin, Hee et al. · 2023 · International Journal of Molecular Sciences
- Development and characterization of rat duodenal organoids for ADME and toxicology applicationsWilliam D. Hedrich, Julie Panzica-Kelly, Shen-Jue Chen, Brian W. Strassle, Chris Hasson, Lloyd W. Lecureux, Lifei Wang, Weiqi Chen, Tara Sherry, Jinping Gan et al. · 2020 · Toxicology
- The potential application of organoids in breast cancer research and treatmentNasim Ebrahimi, Alireza Nasr Esfahani, Setare Samizade, Atena Mansouri, Masoud Ghanaatian, Samaneh Adelian, Vida Shadman-Manesh, Michael Richard Hamblin · 2021 · Human Genetics
- Introducing the Stem Cell ASCL2 Reporter STAR into Intestinal OrganoidsMaria C. Heinz, Koen C. Oost, Hugo J.G. Snippert · 2020 · STAR Protocols
- Transformational Applications of Human Cardiac Organoids in Cardiovascular DiseasesWanling Xuan, Srinivas M. Tipparaju, Muhammad Ashraf · 2022 · Frontiers in Cell and Developmental Biology
- Myocardial infarction from a tissue engineering and regenerative medicine point of view: A comprehensive review on models and treatmentsGozde Basara, Gökhan Bahçecioğlu, S. Gulberk Ozcebe, Bradley W. Ellis, George Ronan, Pınar Zorlutuna · 2022 · Biophysics Reviews
- Human intestinal organoids as models to study enteric bacteria and virusesGrace O. Adeniyi-Ipadeola, Hephzibah Nwanosike, Sasirekha Ramani · 2023 · Current Opinion in Microbiology
- Organoid models: the future companions of personalized drug developmentFrancesco Piraino, Mariana Costa, Marine Meyer, Georgina H. Cornish, Camilla Ceroni, Virginie Garnier, Sylke Hoehnel, Nathalie Brandenberg · 2024 · Biofabrication
- Human gut M cells resemble dendritic cells and present gluten antigenDaisong Wang, Sangho Lim, Willine J. van de Wetering, Carmen López‐Iglesias, Yuu Okura, Yuri Teranishi-Ikawa, Akihiko Mizoroki, Willem Kasper Spoelstra, Talya L. Dayton, Gijs J. F. van Son et al. · 2025 · Nature
- Preclinical tumor organoid models in personalized cancer therapy: Not everyone fits the moldLifeng Hu, Xue Yang, Huanrong Lan, Xingliang Fang, Xiaoyi Chen, Ketao Jin · 2021 · Experimental Cell Research
- Addressing Key Questions in Organoid Models: Who, Where, How, and Why?María Gómez‐Álvarez, Marcos Agustina‐Hernández, Emilio Francés‐Herrero, Adolfo Rodríguez‐Eguren, Clara Bueno-Fernández, Irene Cervelló · 2023 · International Journal of Molecular Sciences
- Tubuloid differentiation to model the human distal nephron and collecting duct in health and diseaseFjodor A. Yousef Yengej, Carla Pou Casellas, Carola M. E. Ammerlaan, Charlotte J.A. Olde Hanhof, Emre Dilmen, Joep Beumer, Harry Begthel, Elise M. G. Meeder, Joost G.J. Hoenderop, Maarten B. Rookmaaker et al. · 2023 · Cell Reports
- Fluorescence-based tracing of transplanted intestinal epithelial cells using confocal laser endomicroscopyFredrik Holmberg Bergenheim, Jakob Benedict Seidelin, Marianne Terndrup Pedersen, Benjamin E. Mead, Kim Bak Jensen, Jeffrey M. Karp, Ole Haagen Nielsen · 2019 · Stem Cell Research & Therapy
- Drug Discovery Oncology in a Mouse: concepts, Models and LimitationsJason E. Long, Maja Jankovic, Danilo Maddalo · 2021 · Future Science OA
- Rapid establishment of human colonic organoid knockout linesWei Gu, Jonathan L. Colarusso, Michael K. Dame, Jason R. Spence, Qiao Zhou · 2022 · STAR Protocols
- Organoids as a Model System for Studying Notch Signaling in Intestinal Epithelial Homeostasis and Intestinal CancerYingtong Dou, Theresa T. Pizarro, Lan Zhou · 2022 · American Journal Of Pathology
- From organoids to bedside: Advances in modeling, decoding and targeting of colorectal cancerJohannes Betge, René Jackstadt · 2022 · International Journal of Cancer
- Tofacitinib Uptake by Patient-Derived Intestinal Organoids Predicts Individual Clinical ResponsivenessKyung Ku Jang, David P. Hudesman, Drew R. Jones, P’ng Loke, Jordan E. Axelrad, Ken Cadwell, Defne Ercelen, Jing Yu Carolina Cen Feng, Sakteesh V. Gurunathan, Luke P. Newell et al. · 2024 · Gastroenterology
- Establishment of porcine and monkey colonic organoids for drug toxicity studyHaonan Li, Yalong Wang, Mengxian Zhang, Hong Wang, Along Cui, Jianguo Zhao, Weizhi Ji, Ye‐Guang Chen · 2021 · Cell Regeneration
- Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2Bartolomeus Joannes Meijer, Wouter L. Smit, Pim J. Koelink, B. Florien Westendorp, Ruben J. de Boer, Jonathan H. M. van der Meer, Jacqueline L.M. Vermeulen, James C. Paton, Adrienne W. Paton, Jun Qin et al. · 2021 · Scientific Reports
- Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorptionKai Tanaka, Tatsuki Mochizuki, Shogo Baba, Shigeto Kawai, Kiyotaka Nakano, Tatsuhiko Tachibana, Kohsuke Uchimura, Atsuhiko Kato, Takashi Miyayama, Tomohito YAMAGUCHI et al. · 2025 · Scientific Reports
- Intestinal secretory differentiation reflects niche-driven phenotypic and epigenetic plasticity of a common signal-responsive terminal cellSwarnabh Bhattacharya, Guodong Tie, Pratik Narendra Pratap Singh, Ermanno Malagola, Onur Eskiocak, Ruiyang He, Judith Kraiczy, Wei Gu, Yakov Perlov, Aybuke Alici-Garipcan et al. · 2025 · Cell stem cell
- An organoid library unveils subtype-specific IGF-1 dependency via a YAP–AP1 axis in human small cell lung cancerTakahiro Fukushima, Kazuhiro Togasaki, Junko Hamamoto, Katsura Emoto, Toshiki Ebisudani, Akifumi Mitsuishi, Kai Sugihara, Taro Shinozaki, Masahiko Okada, Ayaka Saito et al. · 2025 · Nature Cancer
- A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogelsWim B. M. de Lau, Joost J.A.P.M. Wijnakker, Gijs J. F. van Son, Daniel Krueger, Daisong Wang, Matthijs S. Abendroth, Robin Schreurs, Claudia Y. Janda, Fenna L. H. van Rijt, Benjamin Chalopin et al. · 2025 · Nature Biotechnology
- Emergence of oncofetal plasticity is ubiquitous in early colorectal cancersJulian R. Buissant des Amorie, Joris H. Hageman, Sascha R. Brunner, Suzanne E. M. van der Horst, Maria C. Puschhof, Arne van Hoeck, Inge van Lierop, Sjors Middelkamp, Lisa van der Schee, Sven van Kempen et al. · 2026 · Nature
- Effects of human induced pluripotent stem cell-derived intestinal organoids on colitis-model miceAnna Nakanishi, Satoshi Toyama, Daichi Onozato, Chihiro Watanabe, Tadahiro Hashita, Takahiro Iwao, Tamihide Matsunaga · 2022 · Regenerative Therapy
- In Vivo Intestinal Research Using Organoid TransplantationShinya Sugimoto, Eiji Kobayashi, Takanori Kanai∥, Toshiro Sato · 2022 · The Keio Journal of Medicine
- LGR5+ Intestinal Stem Cells Display Sex-Dependent RadiosensitivityRyan Zitter, Rishi Man Chugh, Payel Bhanja, Bruce F. Kimler, Subhrajit Saha · 2023 · Cells
- Molecular mechanisms underlying glucose-dependent insulinotropic polypeptide secretion in human duodenal organoidsNunzio Guccio, Constanza Alcaino, Emily L. Miedzybrodzka, Marta Santos-Hernández, Christopher A. Smith, Adam Davison, Rula Bany Bakar, Richard G. Kay, Frank M. Reimann, Fiona Mary Gribble · 2024 · Diabetologia
- Multiomic analysis reveals cellular, transcriptomic and epigenetic changes in intestinal pouches of ulcerative colitis patientsYu Ning Zhao, Ran RZ Zhou, Bingqing Xie, Cambrian Y. Liu, Martin Kalski, Candace M. Cham, Zhiwei Jiang, Jason Koval, Christopher R. Weber, David T. Rubin et al. · 2025 · Nature Communications
- Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF VariantsJasmin B. Post, Jeanine M.L. Roodhart, Hugo J.G. Snippert · 2020 · Trends in cancer
- Apical-out intestinal organoids as an alternative model for evaluating deoxynivalenol toxicity and Lactobacillus detoxification in bovineMin Gook Lee, Bo Ram Lee, Poongyeon Lee, Soyoung Choi, Jong‐Hui Kim, Mi-Hwa Oh, Jae Gyu Yoo · 2024 · Scientific Reports
- The application of organoids in treatment decision-making for digestive system cancers: progress and challengesYufei Wang, Limin Zhang, Louis Zizhao Wang, Yang Cao, Lulu Huang, Gautam Sethi, Xiaoguang Chen, Lingzhi Wang, Boon Cher Goh · 2025 · Molecular Cancer
- Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem CellsLauren A. Shechtman, Christina M. Piarowski, Jennifer K. Scott, Erin Jennifer Golden, Dany Gaillard, Linda A. Barlow · 2021 · Journal of Visualized Experiments
- Photo-Crosslinking Hydrogel Based on Porcine Small Intestinal Submucosa Decellularized Matrix/Fish Collagen/GelMA for Culturing Small Intestinal Organoids and Repairing Intestinal DefectsZihao Jia, Ziwei Wang · 2025 · International Journal of Molecular Sciences
- The World of Organoids: Gastrointestinal Disease Modelling in the Age of 3R and One Health with Specific Relevance to Dogs and CatsGeorg Csukovich, Barbara Pratscher, Iwan Anton Burgener · 2022 · Animals
- Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal OrganoidsJulia Y. Co, Jessica A. Klein, Serah Kang, Kimberly A. Homan · 2023 · Advanced Biology
- Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic SignaturesTatiana A. Karakasheva, Yusen Zhou, Hongbo Michael Xie, Gloria E. Soto, Tiana D. Johnson, Madison A. Stoltz, Daana M. Roach, Noor Nema, Chizoba N. Umeweni, Kaitlyn E. Naughton et al. · 2023 · Gastro Hep Advances
- Establishment of an ulcerative colitis model using colon organoids derived from human induced pluripotent stem cellsFuki Yokoi, Sayaka Deguchi, Yukio Watanabe, Kazuo Takayama · 2024 · iScience
- Engineering the Future of Regenerative Medicines in Gut Health with Stem Cell-Derived Intestinal OrganoidsDinesh Kumar, Sonia Gupta, Vrinda Gupta, Rajni Tanwar, Anchal Chandel · 2025 · Stem Cell Reviews and Reports
- BMP Antagonists Secreted by Mesenchymal Stromal Cells Improve Colonic Organoid Formation: Application for the Treatment of Radiation-induced InjuryLara Moussa, Alexia Lapière, Claire Squiban, Christelle Demarquay, Fabien Milliat, Noëlle Mathieu · 2020 · Cell Transplantation
- Harnessing pluripotent stem cells as models to decipher human evolutionMichael Dannemann, Irene Gallego Romero · 2021 · FEBS Journal
- Application of tumoroids derived from advanced colorectal cancer patients to predict individual response to chemotherapyLei Yao, Xiao-Long Zao, Xiao-Fei Pan, Hao-Gang Zhang, Fu-Jing Wang, Peng-Fei Qiao · 2022 · Journal of Chemotherapy
- Modelling adult stem cells and their niche in health and disease with epithelial organoidsLili Szabó, Anna C. Seubert, Kai Kretzschmar · 2022 · Seminars in Cell and Developmental Biology
- Dynamics and plasticity of stem cells in the regenerating human colonic epitheliumKoen C. Oost, Maurice Kahnwald, Silvia Barbiero, Gustavo de Medeiros, Simon Suppinger, Véronique Kalck, Ludivine Challet Meylan, Sébastien A. Smallwood, Michael B. Stadler, Prisca Liberali · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Organoids for disease modeling and treatment: state-of-the-artMingyi Xu, Dexiao Kong, Shan Sun, Yuanxin Wang, Gang Su, Shanshan Zhang, Jianhui Yan, Zhihai Han, Jing Li, Leisheng Zhang · 2026 · Experimental Hematology and Oncology
- Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu-Hsien Sam Wu, Andrea Català-Bordes, Tomasz Witold Radaszkiewicz, Ingrid Jordens, Ji‐Hyun Lee, Aileen-Diane Bamford, Fiona Farnhammer et al. · 2023 · Science Advances
- Deciphering the Tumor Microenvironment of Colorectal Cancer and Guiding Clinical Treatment With Patient-Derived Organoid Technology: Progress and ChallengesJingwei Li, Jianhua Liu, Wuzheng Xia, Hongwei Yang, Weihong Sha, Hao Hui Chen · 2024 · Technology in Cancer Research & Treatment
- Toxigenic Clostridium perfringens Isolated from At-Risk Paediatric Inflammatory Bowel Disease PatientsJames Kuo, Jasmina Uzunović, Amanda R. Jacobson, Michelle Dourado, Sarah Gierke, Manohary Rajendram, Daniela Keilberg, Jordan S. Mar, Emily Stekol, Joanna Curry et al. · 2024 · Journal of Crohn s and Colitis
- Progress, application and challenges of liver organoidsChen Sang, Jian Lin, Shuyi Ji, Qiang Gao · 2024 · Clinical Cancer Bulletin
- Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modificationSimone M. Haag, Shiqi Xie, Céline Eidenschenk, Jean‐Philippe Fortin, Marinella G. Callow, Mike Costa, Aaron T. L. Lun, Chris Cox, Sunny Z. Wu, Rachana Pradhan et al. · 2024 · Nature Genetics
- Recent evolution of the developing human intestine affects metabolic and barrier functionsQianhui Yu, Umut Kilik, Stefano Secchia, Lukas Adam, Yu-Hwai Tsai, Christiana Fauci, Jasper Janssens, Charlie J. Childs, Katherine D. Walton, Rubén López-Sandoval et al. · 2025 · Science
- Experimental Modeling of Necrotizing Enterocolitis in Human Infant Intestinal EnteroidsChristie L. Buonpane, Guillermo J. Ares, Carrie Yewen. Yuan, Camille Schlegel, Heather L. Liebe, Catherine J. Hunter · 2020 · Journal of Investigative Surgery
- Regulation of the Intestinal Extra-Adrenal Steroidogenic Pathway Component LRH-1 by Glucocorticoids in Ulcerative ColitisGlauben Landskron, Karen Dubois‐Camacho, Octavio Orellana‐Serradell, Marjorie De la Fuente, Daniela Parada‐Venegas, Mirit Bitrán, David Díaz-Jiménez, Shuang Tang, John Anthony Cidlowski, Xiaoling Li et al. · 2022 · Cells
- Lipoic acid functions in Paneth cells to prevent human intestinal stem cell agingZehong Zhang, Qianyi Wan, Yuedan Zhu, Jinbao Ye, Fang Fu, Xinxin Fan, Haiou Chen, Gang Ren, Wei Jiang, Xiaoxin Guo et al. · 2025 · Nature Communications
- Deep visual proteomics reveals an in vivo-like phenotype of orthotopically transplanted human colon organoidsFrederik Post, Annika Hausmann, Sonja Kabatnik, Sophia Steigerwald, Alexandra Brand, Ditte L. Clement, Jonathan Skov, Kadi Lõhmussaar, Hjalte List Larsen, Martti Maimets et al. · 2025 · Cell Systems
- Towards human organ generation using interspecies blastocyst complementation: Challenges and perspectives for therapyHemanta Sarmah, Anri Sawada, Youngmin Hwang, Akihiro Miura, Yuko Shimamura, Junichi Tanaka, Kazuhiko Yamada, Munemasa Mori · 2023 · Frontiers in Cell and Developmental Biology
- Clinical challenges of short bowel syndrome and the path forward for organoid-based regenerative medicineRyoma Endo, Shinya Sugimoto, Koji Shirosaki, Hirochika Kato, Motoshi Wada, Takanori Kanai∥, Toshiro Sato · 2023 · Regenerative Therapy
- Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic studyKentaro Okada, Jumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi · 2023 · Drug Metabolism and Pharmacokinetics
- Single-cell transcriptomics of rectal organoids from individuals with perianal fistulizing Crohn’s disease reveals patient-specific signaturesShanta Murthy, Murugadas Anbazhagan, Sushma Chowdary Maddipatla, Vasantha L. Kolachala, Anne Dodd, Ranjit Singh Pelia, David J. Cutler, Jason D. Matthews, Subra Kugathasan · 2024 · Scientific Reports
- In Vitro Evaluation of the Safety and Efficacy of Cibisatamab Using Adult Stem Cell-Derived Organoids and Colorectal Cancer SpheroidsVictor Anstett, Elisa Heinzelmann, Francesco Piraino, Aline Roch, Antonius Chrisnandy, Maxim N. Norkin, Virginie Garnier, Krisztián Homicskó, Sylke Hoehnel, Nathalie Brandenberg · 2025 · Cancers
- Understanding the Differentiation Pathway to Bestrophin 4-Positive Cells in Human Colonic EpitheliumYusuke Wakisaka, Shinya Sugimoto, Mayumi Oda, Strahil Iv. Pastuhov, Masayuki Fujii, Toshiro Sato, Sirirat Takahashi, Mami Matano, Yuki Ohta, Megumu Saito et al. · 2025 · Gastroenterology
- Lactoferrin-osteopontin complexes: insights into intestinal organoid bioavailability and gut microbiota modulationCamilla Ceroni, Loı̈c Dayon, Pieter Van den Abbeele, Aline Roch, Juliane Dervaux, Marion Ernest, Pascaline Sirugue, Aurélien Baudot, Marine R.-C. Kraus, Nathalie Brandenberg et al. · 2025 · Communications Biology
- Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studiesJumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Ryuga Nomoto, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi · 2021 · Biochemical and Biophysical Research Communications
- Acute radiation syndrome drug discovery using organ-on-chip platformsVijay Kumar Singh, Thomas M. Seed · 2022 · Expert Opinion on Drug Discovery
- Stem-cell-derived models: tools for studying role of microbiota in intestinal homeostasis and diseaseRishu Dheer, Vincent Bensan Young · 2020 · Current Opinion in Gastroenterology
- Experimental Models for SARS-CoV-2 InfectionTaewoo Kim, Jeong Seok Lee, Young Seok Ju · 2021 · Molecules and Cells
- An extracellular matrix niche secreted by epithelial cells drives intestinal organoid formationAntonius Chrisnandy, Matthias P. Lütolf · 2025 · Developmental Cell
- Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrierKonstanze Brandauer, Alexandra Lorenz, Silvia Schobesberger, Patrick Schuller, Martin Frauenlob, Sarah Spitz, Peter Ertl · 2025 · Lab on a Chip
- Application of Organoids in Carcinogenesis Modeling and Tumor VaccinationZeyu Wang, Shasha Zhao, Xiaolin Lin, Guanglong Chen, Jiawei Kang, Zhongping Ma, Yiming Wang, Zhi Li, Xiuying Xiao, Aina He et al. · 2022 · Frontiers in Oncology
- Single-Cell RNA Sequencing for Analyzing the Intestinal Tract in Healthy and Diseased IndividualsHua Yan, Yumeng Ye, HanZheng Zhao, Hongyan Zuo, Yang Li · 2022 · Frontiers in Cell and Developmental Biology
- Redesigning hydrogel geometry for enhanced organoidsKillian Hillion, Maxime M. Mahé · 2022 · Nature Methods
- Generation and Manipulation of Rat Intestinal OrganoidsEleanor Zagoren, Anderson Kenedy Santos, Nadia A. Ameen, Kaelyn Sumigray · 2023 · Journal of Visualized Experiments
- Modeling Gastrointestinal Diseases Using Organoids to Understand Healing and Regenerative ProcessesAlexane Ollivier, Maxime M. Mahé, Géraldine Guasch · 2021 · Cells
- Assessment of source material for human intestinal organoid culture for research and clinical usePaulo C. M. Urbano, Hamish C. K. Angus, Safina Gadeock, Michael Schultz, Roslyn A. Kemp · 2022 · BMC Research Notes