The DOI matches its Crossref record; 172 of the 172 references it cites were found in a registry or an index.
Cancer Stem Cells: The Architects of the Tumor Ecosystem
Open accessAbstract
SUMMARY Cancer stem cells (CSCs) proactively remodel their microenvironment to maintain a supportive niche. Viewed through the lens of an ecosystem, numerous tumor components have multi-directional interactions involving CSCs, supporting the complexity of tumors to maintain growth in a dynamic host. In this Perspective, we discuss how CSCs are active architects of their microenvironment and drive interactions with other tumor components, such as immune cells, cancer-associated fibroblasts and differentiated cells, blood vessels, and other extracellular cues to engineer a sustainable niche. We also highlight considerations for modeling this dynamic tumor ecology and discuss potential therapeutic strategies for targeting these multifaceted interactions.
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Cites
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Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
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Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
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Metadata
- Authors
- Prager, B. C., Xie, Q., Bao, S., & Rich, J. N.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 24
- Issue
- 1
- Pages
- 41-53
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2907897113
- Cited by
- 587
- References
- 172
- FWCI
- 28.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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