Cited by 51Cancer Cells and MetastasisColorectal Cancer Treatments and Studies3D Printing in Biomedical Research

Patient-derived tumor models: a more suitable tool for pre-clinical studies in colorectal cancer

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Rizzo, Giulia, Bertotti, Andrea, Leto, Simonetta Maria, Vetrano, Stefania·2021·Journal of Experimental & Clinical Cancer Research

Abstract

Colorectal cancer (CRC), despite the advances in screening and surveillance, remains the second most common cause of cancer death worldwide. The biological inadequacy of pre-clinical models to fully recapitulate the multifactorial etiology and the complexity of tumor microenvironment and human CRC’s genetic heterogeneity has limited cancer treatment development. This has led to the development of Patient-derived models able to phenocopy as much as possible the original inter- and intra-tumor heterogeneity of CRC, reflecting the tumor microenvironment’s cellular interactions. Implantation of patient tissue into immunodeficient mice hosts and the culture of tumor organoids have allowed advances in cancer biology and metastasis. This review highlights the advantages and limits of Patient-derived models as innovative and valuable pre-clinical tools to study progression and metastasis of CRC, develop novel therapeutic strategies by creating a drug screening platform, and predict the efficacy of clinical response to therapy.

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Authors
Rizzo, G., Bertotti, A., Leto, S. M., & Vetrano, S.
Affiliations
  • Humanitas University (IT)
  • Candiolo Cancer Institute (IT)
Corresponding author
Vetrano, Stefania
Venue
Journal of Experimental & Clinical Cancer Research
Published
2021-06-01
Volume
40
Issue
1
Pages
178-178
ISSN
  • 0392-9078 (ISSN-L)
  • 1756-9966
OpenAlex
W3165446525
Cited by
51
References
195
Citations by year
2026: 8 · 2025: 11 · 2024: 6 · 2023: 8 · 2022: 11 · 2021: 7
FWCI
0.97
Type
journal article
Language
en
Open access
Locations
  • Journal of Experimental & Clinical Cancer Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Associazione Italiana Contro le Leucemie - Linfomi e Mieloma (17795)
  • Esprinet Spa Italy
Topics
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
patient-derived tumor models, colorectal cancer, tumor microenvironment, tumor heterogeneity, tumor organoids, xenografts, metastasis, drug screening, predictive biomarkers, preclinical models
MeSH terms
Animals, Antineoplastic Agents, Humans, Neoplasm Metastasis, Organoids, Colorectal Neoplasms, Xenograft Model Antitumor Assays, Mice, Tumor Microenvironment

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