Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration

Fiji: an open-source platform for biological-image analysis

Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890

Fast gapped-read alignment with Bowtie 2

Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

Trapnell, C., Cacchiarelli, D., Grimsby, J., Pokharel, P., Li, S., Morse, M., Lennon, N. J., Livak, K. J., Mikkelsen, T. S., & Rinn, J. L. (2014) · Nature Biotechnology · doi:10.1038/nbt.2859 · Cited by 7,314

Spatial reconstruction of single-cell gene expression data

Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055

Reversed graph embedding resolves complex single-cell trajectories

Qiu, X., Mao, Q., Tang, Y., Wang, L., Chawla, R., Pliner, H. A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4402 · Cited by 5,070

The single-cell transcriptional landscape of mammalian organogenesis

Cao, J., Spielmann, M., Qiu, X., Huang, X., Ibrahim, D. M., Hill, A. J., Zhang, F., Mundlos, S., Christiansen, L., Steemers, F. J., et al. (2019) · Nature · doi:10.1038/s41586-019-0969-x · Cited by 4,490

Differential analysis of gene regulation at transcript resolution with RNA-seq

Trapnell, C., Hendrickson, D. G., Sauvageau, M., Goff, L., Rinn, J. L., & Pachter, L. (2013) · Nature Biotechnology · doi:10.1038/nbt.2450 · Cited by 3,492

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381

Fibrosis: from mechanisms to medicines

Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868

Fibroblasts: Origins, definitions, and functions in health and disease

Plikus, M. V., Wang, X., Sinha, S., Forte, E., Thompson, S. M., Herzog, E. L., Driskell, R. R., Rosenthal, N. A., Biernaskie, J. A., & Horsley, V. (2021) · Cell · doi:10.1016/j.cell.2021.06.024 · Cited by 1,247

Cross-tissue organization of the fibroblast lineage

Buechler, M. B., Pradhan, R., Krishnamurty, A. T., Cox, C. B., Calviello, A. K., Wang, A. W., Yang, Y. A., Tam, L., Caothien, R. H., Roose‐Girma, M., et al. (2021) · Nature · doi:10.1038/s41586-021-03549-5 · Cited by 1,100

Fibroblast and myofibroblast activation in normal tissue repair and fibrosis

Younesi, F. S., Miller, A. E., Barker, T. H., Rossi, F. M. V., & Hinz, B. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00716-0 · Cited by 755

Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

Petrany, M. J., Swoboda, C. O., Sun, C., Chetal, K., Chen, X., Weirauch, M. T., Salomonis, N., & Millay, D. P. (2020) · Nature Communications · doi:10.1038/s41467-020-20063-w · Cited by 397

Perspectives on skeletal muscle stem cells

Relaix, F., Bencze, M., Borok, M. J., Vartanian, A. D., Gattazzo, F., Mademtzoglou, D., Perez-Diaz, S., Prola, A., Fernandez, P. C. R., Rotini, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20760-6 · Cited by 407

The myofibroblast at a glance

Pakshir, P., Noskovicova, N., Lodyga, M., Son, D. O., Schuster, R., Goodwin, A., Karvonen, H., & Hinz, B. (2020) · Journal of Cell Science · doi:10.1242/jcs.227900 · Cited by 293

Temporal Dynamics and Heterogeneity of Cell Populations during Skeletal Muscle Regeneration

Oprescu, S. N., Yue, F., Qiu, J., Brito, L. F., & Kuang, S. (2020) · iScience · doi:10.1016/j.isci.2020.100993 · Cited by 298

Identification, discrimination and heterogeneity of fibroblasts

Lendahl, U., Muhl, L., & Betsholtz, C. (2022) · Nature Communications · doi:10.1038/s41467-022-30633-9 · Cited by 256

Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

Abbasi, S., Sinha, S., Labit, E., Rosin, N. L., Yoon, G., Rahmani, W. M., Jaffer, A., Sharma, N. C., Hagner, A., Shah, P. T., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.07.008 · Cited by 203

Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases

Molina, T., Fabre, P., & Dumont, N. A. (2021) · Open Biology · doi:10.1098/rsob.210110 · Cited by 205

The inflammatory speech of fibroblasts

Schuster, R., Rockel, J. S., Kapoor, M., & Hinz, B. (2021) · Immunological Reviews · doi:10.1111/imr.12971 · Cited by 181

Mesenchymal Bmp3b expression maintains skeletal muscle integrity and decreases in age-related sarcopenia

Uezumi, A., Ikemoto‐Uezumi, M., Zhou, H., Kurosawa, T., Yoshimoto, Y., Nakatani, M., Hitachi, K., Yamaguchi, H., Wakatsuki, S., Araki, T., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci139617 · Cited by 166

Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle

Waisman, A., Norris, A. M., Costa, M. E., & Kopinke, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-91191-6 · Cited by 158

Origins, potency, and heterogeneity of skeletal muscle fibro-adipogenic progenitors—time for new definitions

Contreras, O., Rossi, F. M. V., & Théret, M. (2021) · Skeletal Muscle · doi:10.1186/s13395-021-00265-6 · Cited by 163

Multipotent stromal cells: One name, multiple identities

Soliman, H., Theret, M., Scott, W., Hill, L., Underhill, T. M., Hinz, B., & Rossi, F. M. V. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.09.001 · Cited by 147

Human skeletal muscle CD90+ fibro-adipogenic progenitors are associated with muscle degeneration in type 2 diabetic patients

Farup, J., Just, J., de Paoli, F. V., Lin, L., Jensen, J., Billeskov, T. B., Sánchez-Román, I., Cömert, C., Møller, A. B., Madaro, L., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.001 · Cited by 162

Evolving Roles of Muscle-Resident Fibro-Adipogenic Progenitors in Health, Regeneration, Neuromuscular Disorders, and Aging

Théret, M., Rossi, F. M. V., & Contreras, O. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.673404 · Cited by 154

Signaling pathways regulating the fate of fibro/adipogenic progenitors (FAPs) in skeletal muscle regeneration and disease

Giuliani, G., Rosina, M., & Reggio, A. (2021) · FEBS Journal · doi:10.1111/febs.16080 · Cited by 144

Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

Julien, A., Kanagalingam, A., Martínez‐Sarrà, E., Megret, J., Luka, M., Ménager, M. M., Relaix, F., & Colnot, C. (2021) · Nature Communications · doi:10.1038/s41467-021-22842-5 · Cited by 128

Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease

Chen, W., You, W., Valencak, T. G., & Shan, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101682 · Cited by 120

Mesenchymal Stem Cells Adaptively Respond to Environmental Cues Thereby Improving Granulation Tissue Formation and Wound Healing

Jiang, D., & Scharffetter‐­Kochanek, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00697 · Cited by 110

Fibrosis: cross-organ biology and pathways to development of innovative drugs

Rieder, F., Nagy, L. E., Maher, T. M., Distler, J. H. W., Kramann, R., Hinz, B., & Prunotto, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01158-9 · Cited by 134

Early-life inflammation primes a T helper 2 cell–fibroblast niche in skin

Boothby, I. C., Kinet, M., Boda, D. P., Kwan, E. Y., Clancy, S., Cohen, J. N., Habrylo, I. B., Lowe, M. M., Pauli, M. L., Yates, A. E., et al. (2021) · Nature · doi:10.1038/s41586-021-04044-7 · Cited by 106

Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury

Sastourné-Arrey, Q., Mathieu, M., Contreras, X., Monferran, S., Bourlier, V., Gil‐Ortega, M., Murphy, E. E., Laurens, C., Varin, A., Guissard, C., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35524-7 · Cited by 96

Skeletal muscle aging, cellular senescence, and senotherapeutics: current knowledge and future directions

Englund, D. A., Zhang, X., Aversa, Z., & LeBrasseur, N. K. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111595 · Cited by 94

Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors

Soliman, H., Paylor, B., Scott, R. W., Lemos, D. R., Chang, C., Arostegui, M., Low, M., Lee, C., Fiore, D., Braghetta, P., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.12.008 · Cited by 86

Myogenic Differentiation of Stem Cells for Skeletal Muscle Regeneration

Yu, D., Cai, Z., Li, D., Zhang, Y., He, M., Yang, Y., Liu, D., Xie, W., Li, Y., & Xiao, W. (2021) · Stem Cells International · doi:10.1155/2021/8884283 · Cited by 86

Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations

Leinroth, A. P., Mirando, A. J., Rouse, D. C., Kobayahsi, Y., Tata, P. R., Rueckert, H. E., Liao, Y., Long, J. T., Chakkalakal, J. V., & Hilton, M. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110785 · Cited by 69

Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling

Flores‐Opazo, M., Kopinke, D., Helmbacher, F., Fernández‐Verdejo, R., Tuñón‐Suárez, M., Lynch, G. S., & Contreras, O. (2024) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2024.101277 · Cited by 66

Metabolic reprogramming of skeletal muscle by resident macrophages points to CSF1R inhibitors as muscular dystrophy therapeutics

Babaeijandaghi, F., Cheng, R., Kajabadi, N., Soliman, H. S., Chang, C.-K., Smandych, J., Tung, L. W., Long, R., Ghassemi, A., & Rossi, F. M. V. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abg7504 · Cited by 70

Advances in Chromatin and Chromosome Research: Perspectives from Multiple Fields

Agbleke, A. A., Amitai, A., Buenrostro, J. D., Chakrabarti, A., Chu, L., Hansen, A. S., Koenig, K. M., Labade, A. S., Liu, S., Nozaki, T., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.003 · Cited by 61

Hedgehog signaling via its ligand DHH acts as cell fate determinant during skeletal muscle regeneration

Norris, A. M., Appu, A. B., Johnson, C. D., Zhou, L. Y., McKellar, D. W., Renault, M., Hammers, D. W., Cosgrove, B. D., & Kopinke, D. (2023) · Nature Communications · doi:10.1038/s41467-023-39506-1 · Cited by 54

PDGF-PDGFR network differentially regulates the fate, migration, proliferation, and cell cycle progression of myogenic cells

Contreras, O., Córdova-Casanova, A., & Brandan, E. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.110036 · Cited by 60

Tendon Stem/Progenitor Cell Subpopulations and Their Implications in Tendon Biology

Huang, Z., Yin, Z., Xu, J., Yang, F., Heng, B. C., Jiang, X., Chen, W., & Shen, W. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.631272 · Cited by 54

Single‐Cell RNA‐Sequencing Provides Insight into Skeletal Muscle Evolution during the Selection of Muscle Characteristics

Xu, D., Wan, B., Qiu, K., Wang, Y., Zhang, X., Jiao, N., Yan, E., Wu, J. W., Yu, R., Gao, S., et al. (2023) · Advanced Science · doi:10.1002/advs.202305080 · Cited by 55

TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts

Contreras, O., Soliman, H. S., Théret, M., Rossi, F. M. V., & Brandan, E. (2020) · Journal of Cell Science · doi:10.1242/jcs.242297 · Cited by 52

A bird’s eye view of fibroblast heterogeneity: A pan‐disease, pan‐cancer perspective

Pradhan, R., Krishnamurty, A. T., Fletcher, A. L., Turley, S. J., & Müller, S. (2021) · Immunological Reviews · doi:10.1111/imr.12990 · Cited by 51

Diverse Roles of Cellular Senescence in Skeletal Muscle Inflammation, Regeneration, and Therapeutics

Saito, Y., & Chikenji, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.739510 · Cited by 53

Spatiotemporal mapping of immune and stem cell dysregulation after volumetric muscle loss

Larouche, J. A., Wallace, E. C., Spence, B. D., Johnson, S. A., Mangesh, K., Buras, E. D., Brown, B. N., Badylak, S. F., & Aguilar, C. A. (2023) · JCI Insight · doi:10.1172/jci.insight.162835 · Cited by 47

MuSCs and IPCs: roles in skeletal muscle homeostasis, aging and injury

Jiang, H., Liu, B., Lin, J., Xue, T., Han, Y., Lu, C., Zhou, S., Gu, Y., Xu, F., Shen, Y., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-05096-w · Cited by 53

Distinct myofibre domains of the human myotendinous junction revealed by single-nucleus RNA sequencing

Karlsen, A., Yeung, C. C., Schjerling, P., Denz, L., Hoegsbjerg, C., Jakobsen, J. R., Krogsgaard, M. R., Koch, M., Schiaffino, S., Kjær, M., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.260913 · Cited by 44

Neural G0: a quiescent‐like state found in neuroepithelial‐derived cells and glioma

O’Connor, S. A., Feldman, H. M., Arora, S., Hoellerbauer, P., Toledo, C. M., Corrin, P. D., Carter, L. M., Kufeld, M., Bolouri, H., Basom, R., et al. (2021) · Molecular Systems Biology · doi:10.15252/msb.20209522 · Cited by 48

Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration

Krawetz, R. J., Abubacker, S., Leonard, C. A., Masson, A. O., Shah, S., Narendran, N., Tailor, P., Regmi, S. C., Labit, E., Ninkovic, N., et al. (2022) · npj Regenerative Medicine · doi:10.1038/s41536-022-00228-5 · Cited by 42

Runx2-Twist1 interaction coordinates cranial neural crest guidance of soft palate myogenesis

Han, X., Feng, J., Guo, T., Loh, Y. E., Yuan, Y., Ho, T., Cho, C. K., Li, J., Jing, J., Janečková, E., et al. (2021) · eLife · doi:10.7554/elife.62387 · Cited by 41

Cardiac fibroblast diversity in health and disease

Soliman, H. S., & Rossi, F. M. V. (2020) · Matrix Biology · doi:10.1016/j.matbio.2020.05.003 · Cited by 40

Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy

Wang, X., Chen, J., Homma, S. T., Wang, Y., Smith, G. R., Ruf-Zamojski, F. M., Sealfon, S. C., & Zhou, L. (2022) · iScience · doi:10.1016/j.isci.2022.105775 · Cited by 45

Thrown for a loop: fibro-adipogenic progenitors in skeletal muscle fibrosis

Loomis, T., & Smith, L. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00245.2023 · Cited by 39

DPPIV+ fibro-adipogenic progenitors form the niche of adult skeletal muscle self-renewing resident macrophages

Babaeijandaghi, F., Kajabadi, N., Long, R., Tung, L. W., Cheung, C. W., Ritso, M., Chang, C.-K., Cheng, R., Huang, T., Groppa, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43579-3 · Cited by 40

Tissue cross talks governing limb muscle development and regeneration

Helmbacher, F., & Stricker, S. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.05.005 · Cited by 42

Gli1 Defines a Subset of Fibro-adipogenic Progenitors that Promote Skeletal Muscle Regeneration With Less Fat Accumulation

Yao, L., Tichy, E. D., Zhong, L., Mohanty, S., Wang, L., Ai, E., Yang, S., Mourkioti, F., & Qin, L. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4265 · Cited by 39

Off‐target effects of statins: molecular mechanisms, side effects and the emerging role of kinases

Lagunas‐Rangel, F. A., Liepinsh, E., Fredriksson, R., Alsehli, A. M., Williams, M. J., Dambrova, M., Jönsson, J., & Schiöth, H. B. (2024) · British Journal of Pharmacology · doi:10.1111/bph.17309 · Cited by 42

Macrophages in Skeletal Muscle Dystrophies, An Entangled Partner

Théret, M., Saclier, M., Messina, G., & Rossi, F. M. V. (2021) · Journal of Neuromuscular Diseases · doi:10.3233/jnd-210737 · Cited by 41

Activation of skeletal muscle–resident glial cells upon nerve injury

Proietti, D., Giordani, L., Bardi, M. D., D’Ercole, C., Lozanoska‐Ochser, B., Amadio, S., Volonté, C., Marinelli, S., Muchir, A., Bouché, M., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.143469 · Cited by 33

It takes all kinds: heterogeneity among satellite cells and fibro-adipogenic progenitors during skeletal muscle regeneration

Collins, B. C., & Kardon, G. (2021) · Development · doi:10.1242/dev.199861 · Cited by 40

Muscle fibro-adipogenic progenitors from a single-cell perspective: Focus on their “virtual” secretome

Négroni, E., Kondili, M., Muraine, L., Bensalah, M., Butler-Browne, G. S., Mouly, V., Bigot, A., & Trollet, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.952041 · Cited by 42

Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice

Wang, C., Zhao, B., Zhai, J., Wang, A., Cao, N., Liao, T., Su, R., He, L., Li, Y., Pei, X., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05843-8 · Cited by 35

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke

Bernier, L., Hefendehl, J. K., Scott, R. W., Tung, L. W., Lewis, C. B., Soliman, H., Simm, S., Dissing‐Olesen, L., Hofmann, J. C., Guo, D., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01872-y · Cited by 38

A story of fibers and stress: Matrix‐embedded signals for fibroblast activation in the skin

Sawant, M., Hinz, B., Schönborn, K., Zeinert, I., Eckes, B., Krieg, T., & Schuster, R. (2021) · Wound Repair and Regeneration · doi:10.1111/wrr.12950 · Cited by 36

Progressive and Coordinated Mobilization of the Skeletal Muscle Niche throughout Tissue Repair Revealed by Single-Cell Proteomic Analysis

Borok, M. J., Didier, N., Gattazzo, F., Ozturk, T., Corneau, A., Rouard, H., & Relaix, F. (2021) · Cells · doi:10.3390/cells10040744 · Cited by 33

Bap1/SMN axis in Dpp4+ skeletal muscle mesenchymal cells regulates the neuromuscular system

Kim, J.-H., Kang, J., Yoo, K., Jeong, J., Park, I., Park, J. H., Rhee, J., Jeon, S. T., Jo, Y., Hann, S., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.158380 · Cited by 30

Cellular interactions and microenvironment dynamics in skeletal muscle regeneration and disease

Rodríguez, C., Timóteo-Ferreira, F., Minchiotti, G., Brunelli, S., & Guardiola, O. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1385399 · Cited by 36

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis

Wischnewski, S., Thäwel, T., Ikenaga, C., Kocharyan, A., Lerma-Martin, C., Zulji, A., Rausch, H.-W., Brenner, D., Thomas, L., Kutza, M., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00645-9 · Cited by 34

Discovery of Muscle-Tendon Progenitor Subpopulation in Human Myotendinous Junction at Single-Cell Resolution

Yan, R., Zhang, H., Ma, Y., Lin, R., Zhou, B., Zhang, T., Fan, C., Zhang, Y., Wang, Z., Fang, T., et al. (2022) · Research · doi:10.34133/2022/9760390 · Cited by 31

All for One and One for All: Regenerating Skeletal MusclePreprint

Hindi, S. M., & Millay, D. P. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040824 · Cited by 29

Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors

Kotsaris, G., Qazi, T. H., Bucher, C. H., Zahid, H., Pöhle‐Kronawitter, S., Ugorets, V., Jarassier, W., Börno, S. T., Timmermann, B., Giesecke‐Thiel, C., et al. (2023) · npj Regenerative Medicine · doi:10.1038/s41536-023-00291-6 · Cited by 31

Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability

Benabdallah, N. S., Dalal, V., Scott, R. W., Marcous, F., Sotiriou, A., Kommoss, F. K. F., Pejkovska, A., Gaspar, L., Wagner, L., Rivera, F. J. S., et al. (2023) · Nature Structural & Molecular Biology · doi:10.1038/s41594-023-01096-3 · Cited by 31

Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult

Arostegui, M., Scott, R. W., Böse, K., & Underhill, T. M. (2022) · Nature Communications · doi:10.1038/s41467-022-32695-1 · Cited by 34

TNFAIP6 defines the MSC subpopulation with enhanced immune suppression activities

Li, L., Yang, L., Chen, X., Chen, X., Diao, L., Zeng, Y., & Xu, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03176-5 · Cited by 34

Role of skeletal muscle satellite cells in the repair of osteoporotic fractures mediated by β‐catenin

Jin, Z., Da, W., Zhao, Y., Wang, T., Xu, H., Shu, B., Gao, X., Shi, Q., Ma, Y., Zhang, Y., et al. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12938 · Cited by 29

Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets

Yoshimoto, Y., & Oishi, Y. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108357 · Cited by 28

Gli1 marks a sentinel muscle stem cell population for muscle regeneration

Peng, J., Han, L., Liu, B., Song, J., Wang, Y., Wang, K., Guo, Q., Liu, X., Li, Y., Zhang, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42837-8 · Cited by 28

A discrete ‘early-responder’ stromal-cell subtype orchestrates immunocyte recruitment to injured tissue

Yaghi, O., Hanna, B. S., Langston, P. K., Michelson, D. A., Jayewickreme, T., Marin-Rodero, M., Benoist, C. O., & Mathis, D. J. (2023) · Nature Immunology · doi:10.1038/s41590-023-01669-w · Cited by 25

DNA methylation alterations in muscle of critically ill patients

Dyck, L. V., Güiza, F., Derese, I., Pauwels, L., Casaer, M. P., Hermans, G., Wouters, P. J., den Berghe, G. V., & Vanhorebeek, I. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12970 · Cited by 25

Advancing skeletal health and disease research with single-cell RNA sequencing

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Jia, L., Wang, W., Liang, J., Niu, S., Wang, Y., Yang, J., Li, L., Wang, G., Xu, X., Mu, L., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-022-2335-6 · Cited by 18

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Zhou, Y., Cao, T., Li, Z., Qiao, H., Dang, E., Shao, S., & Wang, G. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109849 · Cited by 19

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Cameron, A., Wakelin, G., Gaulton, N., Young, L. V., Wotherspoon, S., Hodson, N. W., Lees, M. J., Moore, D. R., & Johnston, A. P. W. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00364.2022 · Cited by 16

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Uhrbom, M., Muhl, L., Genové, G., Liu, J., Palmgren, H., Alexandersson, I., Karlsson, F., Zhou, A., Lunnerdal, S., Gustafsson, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51867-9 · Cited by 17

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