Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors

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Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling

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TGF-β-driven downregulation of the transcription factor TCF7L2 affects Wnt/β-catenin signaling in PDGFRα+ fibroblasts

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Cholesterol absorption blocker ezetimibe prevents muscle wasting in severe dysferlin‐deficient and mdx mice

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Human Cell Modeling for Cardiovascular Diseases

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Cardiac fibroblast diversity in health and disease

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Tissue cross talks governing limb muscle development and regeneration

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Gli1 Defines a Subset of Fibro-adipogenic Progenitors that Promote Skeletal Muscle Regeneration With Less Fat Accumulation

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Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke

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Cellular taxonomy of Hic1+ mesenchymal progenitor derivatives in the limb: from embryo to adult

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Pro-Fibrotic Macrophage Subtypes: SPP1+ Macrophages as a Key Player and Therapeutic Target in Cardiac Fibrosis?

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Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy

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Pleiotropic activation of endothelial function by angiotensin II receptor blockers is crucial to their protective anti-vascular remodeling effects

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Fibroblast and Myofibroblast Subtypes: Single Cell Sequencing

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Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci

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Life of Pi: Exploring functions of Pi16+ fibroblasts

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A New Hypothetical Concept in Metabolic Understanding of Cardiac Fibrosis: Glycolysis Combined with TGF-β and KLF5 Signaling

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New insights into spatio-temporal dynamics of mesenchymal progenitor cell ingress during peri-implant wound healing: Provided by intravital imaging

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Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts

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In vitro assessment of anti-fibrotic drug activity does not predict in vivo efficacy in murine models of Duchenne muscular dystrophy

Théret, M., Low, M., Rempel, L., Li, F. F., Tung, L. W., Contreras, O., Chang, C.-K., Wu, A., Soliman, H. S., & Rossi, F. M. V. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119482 · Cited by 15 · see citing works

Single-cell transcriptome dynamics of the autotaxin-lysophosphatidic acid axis during muscle regeneration reveal proliferative effects in mesenchymal fibro-adipogenic progenitors

Contreras, O., & Harvey, R. P. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1017660 · Cited by 14 · see citing works

The Myofibroblast Fate of Therapeutic Mesenchymal Stromal Cells: Regeneration, Repair, or Despair?

Younesi, F. S., & Hinz, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168712 · Cited by 14 · see citing works

Emerging skeletal muscle stromal cell diversity: Functional divergence in fibro/adipogenic progenitor and mural cell populations

Ritso, M., Tung, L. W., & Rossi, F. M. V. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112947 · Cited by 14 · see citing works

Cell diversity and plasticity during atrioventricular heart valve EMTs

Lotto, J., Cullum, R., Drissler, S., Arostegui, M., Garside, V. C., Fuglerud, B. M., Clement-Ranney, M., Thakur, A., Underhill, T. M., & Hoodless, P. A. (2023) · Nature Communications · doi:10.1038/s41467-023-41279-6 · Cited by 13 · see citing works

Spatiotemporal signaling underlies progressive vascular rarefaction in myocardial infarction

Tung, L. W., Groppa, E., Soliman, H., Lin, B., Chang, C.-K., Cheung, C. W., Ritso, M., Guo, D., Rempel, L., Sinha, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-44227-6 · Cited by 12 · see citing works

A Guide to Examining Intramuscular Fat Formation and its Cellular Origin in Skeletal Muscle

Johnson, C. D., Zhou, L. Y., & Kopinke, D. (2022) · Journal of Visualized Experiments · doi:10.3791/63996 · Cited by 12 · see citing works

Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction

Murtha, L. A., Hardy, S. A., Mabotuwana, N. S., Bigland, M. J., Bailey, T., Raguram, K., Liu, S., Ngo, D. T. M., Sverdlov, A. L., Tomin, T., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-41894-9 · Cited by 12 · see citing works

Hippo-deficient cardiac fibroblasts differentiate into osteochondroprogenitorsPreprint

Tsai, C.-R., Kim, J. K., Li, X., Czarnewski, P., Li, G., Meng, F., Zheng, M., Zhao, X., Steimle, J. D., Grisanti, F., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.06.556593 · Cited by 12 · see citing works

Hic1 identifies a specialized mesenchymal progenitor population in the embryonic limb responsible for bone superstructure formation

Arostegui, M., Scott, R. W., & Underhill, T. M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112325 · Cited by 11 · see citing works

Prx1 + and Hic1+ Mesenchymal Progenitors Are Present Within the Epidural Fat and Dura Mater and Participate in Dural Injury Repair

Shah, S., Mudigonda, S., Underhill, T. M., SALO, P. T., Mitha, A. P., & Krawetz, R. J. (2022) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szab014 · Cited by 11 · see citing works

Proteoglycan 4 is present within the dura mater and produced by mesenchymal progenitor cells

Mudigonda, S., Shah, S., Das, N., Corpuz, J. M., Ninkovic, N., Al-Jezani, N., Underhill, T. M., SALO, P. T., Mitha, A. P., Lyons, F., et al. (2022) · Cell and Tissue Research · doi:10.1007/s00441-022-03647-4 · Cited by 11 · see citing works

YAP-Induced Glycolysis Drives Fibroinflammation and Disrupts Fibroblast Fidelity

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OpenEMMU: A versatile, open-source EdU multiplexing methodology for studying DNA replication and cell cycle dynamics

Contreras, O., Thekkedam, C. G., Zaunders, J. J., Aguirre-MacLennan, I., Murray, N. J., Gonzalez-Cordero, A., & Harvey, R. P. (2025) · iScience · doi:10.1016/j.isci.2025.113380 · Cited by 8 · see citing works

Canadian Contributions in Fibroblast Biology

Al‐Hattab, D. S., Chattopadhyaya, S., & Czubryt, M. P. (2022) · Cells · doi:10.3390/cells11152272 · Cited by 8 · see citing works

Single-cell analysis of mesenchymal cells in permeable neural vasculature reveals novel diverse subpopulations of fibroblasts

Bastedo, W. E., Scott, R. W., Arostegui, M., & Underhill, T. M. (2024) · Fluids and Barriers of the CNS · doi:10.1186/s12987-024-00535-7 · Cited by 6 · see citing works

Animal Models and Molecular Pathogenesis of Arrhythmogenic Cardiomyopathy Associated with Pathogenic Variants in Intercalated Disc Genes

Vencato, S., Romanato, C., Rampazzo, A., & Calore, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116208 · Cited by 7 · see citing works

The fibroblast epigenome underlies SS18::SSX-mediated transformation in synovial sarcoma

Hill, L. A., Scott, R. W., Martin, L., Arostegui, M., Davenport, G., Vemon, M., Hofvander, J., Wang, X. Q., Li, J., Nielsen, T. O., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-65850-5 · Cited by 7 · see citing works

The critical role of PDGFRa + Sca1 + fibroblasts in angiogenesis and vascular repair in the corpus cavernosum

Liu, B., Li, Z., Han, Z., Chen, Y., Xu, Y., Xu, J., Hu, H., Ou, N., Zheng, X., Yin, Y., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04434-y · Cited by 6 · see citing works

Single-cell RNA sequencing reveals the contribution of smooth muscle cells and endothelial cells to fibrosis in human atrial tissue with atrial fibrillation

An, N., Yang, F., Zhang, G., Jiang, Y., Liu, H., Gao, Y., Li, Y., Ji, P., Shang, H., & Xing, Y. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00999-1 · Cited by 5 · see citing works

Ex uno, plures–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology

Forte, E., McLellan, M. A., Skelly, D. A., & Rosenthal, N. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042071 · Cited by 5 · see citing works

Genetic lineage tracing identifies cardiac mesenchymal-to-adipose transition in an arrhythmogenic cardiomyopathy model

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Targeting fibrosis in the Duchenne Muscular Dystrophy mice model: an uphill battlePreprint

Théret, M., Low, M., Rempel, L., Li, F. F., Tung, L. W., Contreras, O., Chang, C.-K., Wu, A., Soliman, H., & Rossi, F. M. V. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.20.427485 · Cited by 5 · see citing works

Fibroblasts—The emerging therapeutic target of the cardiovascular system?

Asselberghs, S., Halder, M., Kramann, R., & Sluimer, J. C. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100072 · Cited by 4 · see citing works

Exogenously delivered iPSCs disrupt the natural repair response of endogenous MPCs after bone injury

Ferrie, L., Premnath, P., Olsen, A., Larijani, L., Besler, B. A., Rancourt, D. E., Duncan, N. A., Underhill, T. M., & Krawetz, R. J. (2023) · Scientific Reports · doi:10.1038/s41598-023-36609-z · Cited by 4 · see citing works

Cardiomyocyte and stromal cell cross-talk influences the pathogenesis of arrhythmogenic cardiomyopathy: a multi-level analysis uncovers DLK1-NOTCH pathway role in fibro-adipose remodelling

Maione, A. S., Iengo, L., Sala, L., Massaiu, I., Chiesa, M., Lippi, M., Ghilardi, S., Florindi, C., Lodola, F., Zaza, A., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02232-8 · Cited by 4 · see citing works

Cross-tissue single-cell transcriptomics reveals organizing principles of fibroblasts in health and diseasePreprint

Buechler, M., Pradhan, R., Calviello, A. K., Muller, S., Bourgon, R., & Turley, S. (2021) · bioRxiv · doi:10.1101/2021.01.15.426912 · Cited by 3 · see citing works

Single-cell dissection of obesity-exercise axis in adipose-muscle tissuesPreprint

Yang, J.-Y., Vamvini, M., Nigro, P., Ho, L., Galani, K., Alvarez, M., Tanigawa, Y., Laakso, M., Agudelo, L. Z., Pajukanta, P., et al. (2021) · bioRxiv · doi:10.1101/2021.11.22.469622 · Cited by 4 · see citing works

Cardiac fibroblast heterogeneity and dynamics through the lens of single-cell dual ‘omics

Harvey, R. P., Patrick, R., Janbandhu, V. C., & Contreras, O. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac037 · Cited by 4 · see citing works

Givinostat inhibits in vitro differentiation of cardiac fibroadipogenic precursors from a mouse model of arrhythmogenic cardiomyopathy

Vencato, S., Romanato, C., Forino, M., Fossati, G., Velle, A., Facchinello, N., Braghetta, P., Licandro, S. A., Romualdi, C., Calore, M., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118549 · Cited by 3 · see citing works

Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens

Kim, J., & Braun, T. W. (2020) · Cell stem cell · doi:10.1016/j.stem.2019.12.010 · Cited by 3 · see citing works

TGF-β-driven downregulation of the Wnt/β-Catenin transcription factor TCF7L2/TCF4 in PDGFRα + fibroblastsPreprint

Contreras, O., Soliman, H., Théret, M., Rossi, F. M. V., & Brandan, E. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.05.895334 · Cited by 2 · see citing works

Antxr2-mediated fine-tuning of Collagen VI ensures skeletal muscle functionPreprint

Metti, S., Bracq, L. J., Signor, M., Facchinello, N., Gambarotto, L., Nogara, L., Pigato, G., Abrami, L., Kunz, B., Duc, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.11.675515 · Cited by 2 · see citing works

Mesenchymal progenitor–derived proteoglycan 4 regulates the transdifferentiation of chondrocytes into osteoblasts during fracture healing

Ninkovic, N., Corpuz, J. M., Stahl, A. R., Olsen, A., Unger, C. M., Ardebili, A. A., Sun, H., Cha, J., Kaketsis, D. A., Manske, S. L., et al. (2025) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szaf043 · Cited by 1 · see citing works

Mapping the Tissue‐of‐Origins of Mesenchymal Stromal Cells in Injury Repair

Tang, X. T., Liu, Y. L., Du, Y. A., Wang, S., & Zhou, B. O. (2025) · Advanced Science · doi:10.1002/advs.202509533 · Cited by 1 · see citing works

Characterization of genomic regulation profiles in human mitral valve whole tissue to annotate genetic risk loci for mitral valve prolapsePreprint

Kyryachenko, S., Georges, A. B., Yu, M., Berrandou, T.-E., Bruneval, P., Rubio, T., Gronwald, J., Baraki, H., Kutschka, I., Norris, R. A., et al. (2020) · medRxiv · doi:10.1101/2020.06.04.20122010 · Cited by 1 · see citing works

Mesenchymal Progenitors set the homeostatic inflammatory milieu via the TAK1-NFkB axisPreprint

Théret, M., Messing, M., White, Z. R., Wei, T. L., Rempel, L., Mark, H., Hashimoto, J., Li, F., Julyanne, B., Li, Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.11.519940

The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis

Zhang, Y., Guan, Z., Gong, H., Ni, Z., Xiao, Q., Guo, X., & Xu, Q. (2024) · Cardiology Discovery · doi:10.1097/cd9.0000000000000130

Fibro-Adipogenic Progenitor Isolation, Expansion, and Differentiation from the Spiny Mouse Model

Lin, B., Soliman, H., Rossi, F. M. V., & Théret, M. (2024) · Journal of Visualized Experiments · doi:10.3791/66717

Metformin inhibits proliferation of residing fibroadipogenic progenitor cells from failing human hearts

Larsen, A. H., Lin, L., Møller, A. B., Farup, J., Tolbod, L. P., Billeskov, T. B., Brorson, J., Sundelin, E. I. O., Jakobsen, S., Nørrelund, H., et al. (2026) · ESC Heart Failure · doi:10.1093/eschf/xvag001

Shared mechanisms of organ fibrosis

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FAPs orchestrate ANTXR2-mediated fine-tuning of collagen VI to ensure skeletal muscle function

Metti, S., Bracq, L. J., Signor, M., Facchinello, N., Gambarotto, L., Nogara, L., Pigato, G., Abrami, L., Kunz, B., Duc, J., et al. (2026) · The Journal of Cell Biology · doi:10.1083/jcb.202606056

The role of cardiac-resident mesenchymal progenitors in the development of fibrosis in the heart

Paylor, B. (2016) · cIRcle (University of British Columbia) · doi:10.14288/1.0135682

Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure

Hamid, T., Xu, Y., Ismahil, M. A., Rokosh, G. D., Jinno, M., Zhou, G., Wang, Q., & Prabhu, S. D. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.01.004 · Cited by 33 · see citing works

Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of Pdgf SignalingPreprint

Hamid, T., Xu, Y., Ismahil, M. A., Rokosh, G. D., Jinno, M., Zhou, G., & Prabhu, S. D. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3833675 · Cited by 4 · see citing works

Abstract Thu148: PDGFRβ Expression Marks a Multipotent Cardiac Fibroblast Population that Drives Fibrosis and Inflammation in Heart Failure

Hamid, T., Ismahil, M. A., Rajasekar, S., Liu, W., Zhu, Y., Sonkar, R., Katsnelson, M., Rokosh, G. D., & Prabhu, S. D. (2025) · Circulation Research · doi:10.1161/res.137.suppl_1.thu148

Tissue-resident Sca1+ PDGFRα+ mesenchymal progenitors are the cellular source of fibrofatty infiltration in arrhythmogenic cardiomyopathy

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