The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty
Open accessAbstract
The human testis undergoes dramatic developmental and structural changes during puberty, including proliferation and maturation of somatic niche cells, and the onset of spermatogenesis. To characterize this understudied process, we profiled and analyzed single-cell transcriptomes of ∼10,000 testicular cells from four boys spanning puberty and compared them to those of infants and adults. During puberty, undifferentiated spermatogonia sequentially expand and differentiate prior to the initiation of gametogenesis. Notably, we identify a common pre-pubertal progenitor for Leydig and myoid cells and delineate candidate factors controlling pubertal differentiation. Furthermore, pre-pubertal Sertoli cells exhibit two distinct transcriptional states differing in metabolic profiles before converging to an alternative single mature population during puberty. Roles for testosterone in Sertoli cell maturation, antimicrobial peptide secretion, and spermatogonial differentiation are further highlighted through single-cell analysis of testosterone-suppressed transfemale testes. Taken together, our transcriptional atlas of the developing human testis provides multiple insights into developmental changes and key factors accompanying male puberty.
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Cites
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174
Control of puberty onset and fertility by gonadotropin-releasing hormone neurons
Herbison, A. E. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.70 · Cited by 515
Cited by
Transfer learning enables predictions in network biology
Theodoris, C. V., Xiao, L., Chopra, A., Chaffin, M. D., Al Sayed, Z. R., Hill, M. C., Mantineo, H., Brydon, E. M., Zeng, Z., Liu, X. S., et al. (2023) · Nature · doi:10.1038/s41586-023-06139-9 · Cited by 1,193
Pan, F., Xiao, X., Guo, J., Song, Y., Li, H., Patel, D. P., Spivak, A. M., Alukal, J. P., Zhang, X., Xiong, C., et al. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.04.024 · Cited by 485
Self-citationZhao, L., Yao, C., Xing, X., Jing, T., Li, P., Zhu, Z., Yang, C., Zhai, J., Tian, R., Chen, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19414-4 · Cited by 298
hECA: The cell-centric assembly of a cell atlas
Chen, S., Luo, Y., Gao, H., Li, F., Chen, Y., Li, J., You, R., Hao, M., Bian, H., Xi, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104318 · Cited by 48
Metadata
- Authors
- Guo, J., Nie, X., Giebler, M., Mlcochova, H., Wang, Y., Grow, E. J., Kim, R., Tharmalingam, M., Matilionyte, G., Lindskog, C., Carrell, D. T., Mitchell, R. T., Goriely, A., Hotaling, J. M., & Cairns, B. R.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 26
- Issue
- 2
- Pages
- 262-276.e4
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2998033724
- Cited by
- 315
- References
- 3
- FWCI
- 32.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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