The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
Open accessAbstract
Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a mouse model of colorectal cancer (CRC) and human tumor xenografts to investigate the cell of origin of metastases. We found that most disseminated CRC cells in circulation were Lgr5 − and formed distant metastases in which Lgr5 + CSCs appeared. This plasticity occurred independently of stemness-inducing microenvironmental factors and was indispensable for outgrowth, but not establishment, of metastases. Together, these findings show that most colorectal cancer metastases are seeded by Lgr5 − cells, which display intrinsic capacity to become CSCs in a niche-independent manner and can restore epithelial hierarchies in metastatic tumors.
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Metadata
- Authors
- Fumagalli, A., Oost, K. C., Kester, L., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., Heinz, M. C., Postrach, D., Seinstra, D., Sieuwerts, A. M., Martens, J. W. M., van der Elst, S., van Baalen, M., Bhowmick, D., Vrisekoop, N., Ellenbroek, S. I. J., Suijkerbuijk, S. J. E., Snippert, H. J., & van Rheenen, J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 26
- Issue
- 4
- Pages
- 569-578.e7
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W3011631992
- Cited by
- 319
- References
- 55
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Fumagalli, A., Oost, K. C., Kester, L., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., Heinz, M. C., Postrach, D., Seinstra, D., Sieuwerts, A. M., Martens, J. W. M., van der Elst, S., van Baalen, M., Bhowmick, D., Vrisekoop, N., . . . van Rheenen, J. (2020). Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer. Cell Stem Cell. https://doi.org/10.1016/j.stem.2020.02.008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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