Cervical organoids go viral
Open accessAbstract
In this issue of Cell Stem Cell, Lõhmussaar et al. (2021) describe a versatile platform for generating long-term patient-derived organoids from hysterectomies and Pap brush cells. They establish malignant and benign cervix tissue organoids from both endo- and ectocervix that have applications ranging from precision medicine to infection modeling.
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Patient-derived tumor organoids can be generated from minimally invasive Pap brush material.
“Patient-derived tumor organoids can be generated from samples obtained from minimally invasive Pap brush material55,56 .”
From Organoids (2022) · cites this paper as [55]
Patient-derived organoids can generate xenografts, confirm their tumorigenic capacity, and recapitulate the histology of parental tumors.
“Patient-derived organoids can also generate xenografts, confirm their tumorigenic capacity and recapitulate the histology of parental tumors15,55.”
From Organoids (2022) · cites this paper as [55]
Cites
An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity
Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0422-6 · Cited by 834 · see citing works
Functional precision cancer medicine—moving beyond pure genomics
Letai, A. (2017) · Nature Medicine · doi:10.1038/nm.4389 · Cited by 366 · see citing works
Phan, N., Hong, J. J., Tofig, B., Mapua, M., Elashoff, D., Moatamed, N. A., Huang, J., Memarzadeh, S., Damoiseaux, R., & Soragni, A. (2019) · Communications Biology · doi:10.1038/s42003-019-0305-x · Cited by 269 · see citing works
Self-citationPatient-derived organoids model cervical tissue dynamics and viral oncogenesis in cervical cancer
Lõhmussaar, K., Oka, R., Espejo Valle-Inclan, J., Smits, M. H. H., Wardak, H., Korving, J., Begthel, H., Proost, N., van de Ven, M., Kranenburg, O. W., et al. (2021) · Cell Stem Cell · doi:10.1016/j.stem.2021.03.012 · Cited by 211 · see citing works
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia
Chumduri, C., Gurumurthy, R. K., Berger, H., Dietrich, O., Kumar, N., Koster, S., Brinkmann, V., Hoffmann, K., Drabkina, M., Arampatzi, P., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-020-00619-0 · Cited by 134 · see citing works
Organoid systems to study the human female reproductive tract and pregnancy
Alzamil, L., Νικολακοπούλου, Κ., & Turco, M. Y. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0565-5 · Cited by 121 · see citing works
Menstrual flow as a non-invasive source of endometrial organoids
Cindrová‐Davies, T., Zhao, X., Elder, K. T., Jones, C. J. P., Moffett, A., Burton, G. J., & Turco, M. Y. (2021) · Communications Biology · doi:10.1038/s42003-021-02194-y · Cited by 101 · see citing works
Villa, P. L., Jackson, R., Eade, S., Escott, N. G., & Zehbe, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-36150-4 · Cited by 21 · see citing works
Preclinical rare cancer research to inform clinical trial design
Barker, H. E., & Scott, C. L. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0172-2 · Cited by 14 · see citing works
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Zhao, Z., Chen, X., Dowbaj, A. M., Sljukic, A., Bratlie, K., Lin, L., Fong, E. L. S., Balachander, G. M., Chen, Z., Soragni, A., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00174-y · Cited by 1,001 · see citing works
Self-citationFemale Reproductive Tract Organoids: Applications from Physiology to Pathology
Wang, X., Yang, D., & Peng, H. (2025) · Biomolecules · doi:10.3390/biom15070925 · Cited by 10 · see citing works
Organoid technology in cervical cancer research
Ye, H. (2025) · American Journal of Cancer Research · doi:10.62347/fntd1712 · Cited by 5 · see citing works
Cellular plasticity and heterogeneity underlying therapy resistance in 3D cervical cancer models
Olvera-Valencia, M., Grijalva-Pérez, A., Millán-Catalán, O., Albino-Sanchez, M. E., Cháirez‐Ramírez, M. H., Méndez‐Martínez, R., López–Urrutia, E., Pérez‐Plasencia, C., & García-Carrancá, A. M. (2026) · Hereditas · doi:10.1186/s41065-026-00668-9 · Cited by 1 · see citing works
- Authors
- Sartini, S., & Soragni, A.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Soragni, Alice
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 28
- Issue
- 8
- Pages
- 1337-1338
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W3192951291
- Cited by
- 4
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2022: 1
- FWCI
- 0.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 369 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (R01CA240718)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- patient-derived organoids, endocervix, ectocervix, cervical cancer, precision medicine
- MeSH terms
- Cervix Uteri, Female, Humans, Organoids, Precision Medicine
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