The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
Open accessPublished version of a preprint
Abstract
Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system following injury, such as following infection or inflammation. These challenges impair HSC function, but whether this functional impairment extends beyond the duration of inflammatory exposure is unknown. Unexpectedly, we observed an irreversible depletion of functional HSCs following challenge with inflammation or bacterial infection, with no evidence of any recovery up to 1 year afterward. HSCs from challenged mice demonstrated multiple cellular and molecular features of accelerated aging and developed clinically relevant blood and bone marrow phenotypes not normally observed in aged laboratory mice but commonly seen in elderly humans. In vivo HSC self-renewal divisions were absent or extremely rare during both challenge and recovery periods. The progressive, irreversible attrition of HSC function demonstrates that temporally discrete inflammatory events elicit a cumulative inhibitory effect on HSCs. This work positions early/mid-life inflammation as a mediator of lifelong defects in tissue maintenance and regeneration.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Moreover, Bogeska et al. showed that inflammatory exposure induces long-term impairment of HSC self-renewal and accelerates their functional aging, contributing to persistent immune dysregulation [83].”
From Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation (2025) · cites this paper as [83]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“while repetitive sterile inflammation did not result in major gene expression changes, it resulted in hypomethylation of promoters of inflammatory (particularly interferon) response genes, leading them to conclude that self-renewal is epigenetically regulated in this model.”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [65]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Inflammation drives impaired self-renewal activity and accelerates aging of HSCs. Exposure to inflammatory stimuli during the early to mid-life stages in mice can lead to the eventual development of peripheral blood hemocytopenia, bone marrow (BM) cytopenia, and BM adipocyte accumulation, features that together constitute typical features of hematopoiesis in the elderly.17”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“Chronic pro-inflammatory signaling due to chronic infections or repetitive sterile inflammation, however, has been shown to be detrimental to HSPC self-renewal, promoting loss of quiescence and differentiation [61–65].”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [65]
The cited source says what the claim attributes to it.
In the citing paper
“the authors showed that the demise of the functional stem cell population was not due to systemic inhibitory effects of inflammation on hematopoiesis but was due to increased proliferation of HSPCs, as label-retaining long-term HSPCs did not lose their repopulating capacity with chronic inflammation [65].”
From Clonal hematopoiesis and inflammation – the perpetual cycle (2023) · cites this paper as [65]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Horvath, S., & Raj, K. (2018) · Nature Reviews Genetics · doi:10.1038/s41576-018-0004-3 · Cited by 3,095 · cited 1×
“…analysis of the DNA methylome clockinpurifiedLT-HSCs,amethodologythatcanaccuratelypre-dict biological age by evaluating progressive methylation programming events at specific CpG loci and which has recently been linked with the evolution of ARCH in humans (Horvath and Raj, 2018; Nachun et al., 2021).”
Hu, Y., & Smyth, G. K. (2009) · Journal of Immunological Methods · doi:10.1016/j.jim.2009.06.008 · Cited by 2,084
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
Wilson, A., Laurenti, E., Oser, G., van der Wath, R. C., Blanco-Bose, W., Jaworski, M., Offner, S., Dunant, C. F., Eshkind, L., Bockamp, E., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.048 · Cited by 1,908
SC3: consensus clustering of single-cell RNA-seq data
Kiselev, V. Y., Kirschner, K., Schaub, M. T., Andrews, T., Yiu, A., Chandra, T., Natarajan, K. N., Reik, W., Barahona, M., Green, A. R., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4236 · Cited by 1,500
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 297
Immunosenescence: Molecular Mechanisms, Diseases, and Therapeutic Innovations
Gong, N., Pan, X., Deng, Y., Che, J., Bao, J., Wang, M., Xu, C., Liu, X., & Shi, Y. (2025) · MedComm · doi:10.1002/mco2.70515 · Cited by 14
Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions
Miyawaki, M., Hashimoto, S., Ogawa, S., & Kase, Y. (2026) · Aging Cell · doi:10.1111/acel.70385 · Cited by 10
“Building on this, recent murine work has provided definitive evidence that even discrete and temporally separated inflammatory episodes cause long-lasting and cumulative impairments in HSC self-renewal capacity, with no recovery observed up to 1 year post-challenge (Bogeska et al. 2022).”
Ben-Crentsil, N. A., Ismail, W. M., Balasis, M. E., Newman, H., Quintana, A., Binder, M., Kruer, T. L., Neupane, S., Ferrall‐Fairbanks, M. C., Fernandez, J. A., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-24-0093 · Cited by 10
The evolving hematopoietic niche during development
Sánchez‐Lanzas, R., Jiménez‐Pompa, A., & Ganuza, M. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1488199 · Cited by 12
Self-citationKoide, S., Oshima, M., Kamiya, T., Zheng, Z., Liu, Z., Rizq, O., Nishiyama, A., Murakami, K., Yamada, Y., Nakajima-Takagi, Y., et al. (2025) · Blood · doi:10.1182/blood.2024025776 · Cited by 10
From Immune Dysregulations to Therapeutic Perspectives in Myelodysplastic Syndromes: A Review
Comont, T., Treiner, E., & Vergez, F. (2021) · Diagnostics · doi:10.3390/diagnostics11111982 · Cited by 10
HSC-derived fatty acid oxidation in steady-state and stressed hematopoiesis
Mistry, J. J., Bowles, K. M., & Rushworth, S. A. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.10.003 · Cited by 13
“This depletion had no initial consequences on the mice, however, they developed clinically relevant features of ageing, comparable to elderly humans [77].”
BackgroundClonal hematopoiesis and bone marrow inflammation
Xie, X., Su, M., Ren, K., Ma, X., Lv, Z., Li, Z., Mei, Y., & Ji, P. (2022) · Translational research · doi:10.1016/j.trsl.2022.11.004 · Cited by 10
Reappraisal of the Concept of Accelerated Aging in Neurodegeneration and Beyond
Statsenko, Y. A., Kuznetsov, N. V., Morozova, D., Liaonchyk, K., Simiyu, G. L., Smetanina, D., Kashapov, A., Meribout, S., Gorkom, K., Hamoudi, R., et al. (2023) · Cells · doi:10.3390/cells12202451 · Cited by 8
Patel, B., Zhou, Y., Babcock, R. L., Ma, F., Zal, M. A., Kumar, D., Medik, Y. B., Kahn, L. M., Pineda, J. E., Park, E. M., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02218-6 · Cited by 11
Liu, W., Zhang, X., Liu, J., Pu, L., Ai, L., Xu, H., Wang, G., Wang, D., Song, X., Zhang, Y., et al. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.03.010 · Cited by 9
Inflammatory signaling in the pathogenesis of acute myeloid leukemia
Baumann, A., & Ellegast, J. M. (2025) · HemaSphere · doi:10.1002/hem3.70188 · Cited by 9
Chia, D. J., Singh, A., Lin, Y., Popko, N., Mastro, D., Liu, Y., Tran, T. M., King, J. K., Rao, D. S., & Hoffmann, A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116193 · Cited by 9
“1,81 While paracrine mediators of HSC quiescence and maintenance are produced by local niches, 82 our findings raise the possibility of an additional HSC-intrinsic mechanism of quiescence regulation.”
Rettkowski, J., & Cabezas‐Wallscheid, N. (2025) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101323-023806 · Cited by 12
Morabito, G., Dönertaş, H. M., Sperti, L., Seidel, J., Zonouzi, A. P., Poeschla, M., & Valenzano, D. R. (2026) · Nature Aging · doi:10.1038/s43587-026-01086-2 · Cited by 19
“Chronic inflammation, in turn, exacerbates aging of the immune niche 8 .”
Hematopoietic Stem Cells and Their Bone Marrow Niches
Pinho, S., & Zhao, M. L. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-99-7471-9_2 · Cited by 9
Decoding Clonal Hematopoiesis: Emerging Themes and Novel Mechanistic Insights
Pendse, S., & Loeffler, D. (2024) · Cancers · doi:10.3390/cancers16152634 · Cited by 8
“Inflammation depletes and/or impairs the self-renewal capacity of normal HSCs [62,89], while mutant HSCs evade and/or suppress inflammation to improve their fitness in conditions detrimental to normal HSCs (Figure 4).”
BackgroundZeng, H., Chen, N., Chen, F., Zhong, X., Yang, L., Lu, Y., Chen, M., Shen, M., Wang, S., Chen, S., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01959-2 · Cited by 8
Liao, P., Tong, S., Du, L., Mei, J., Wang, B., Lu, Y., Yao, M., Zhang, C., Liu, D., Zhong, Z., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.09.013 · Cited by 8
“Specifically, inflammaging in the bone marrow microenvironment induces impaired HSC self-renewal [3] and the expansion of myeloid-biased progenitor cells at the expense of lymphoid progenitors [4].”
Toghani, D., Gupte, S., Zeng, S., Mahammadov, E., Crosse, E. I., Seyedhassantehrani, N., Burns, C. S., Gravano, D. M., Radtke, S., Kiem, H., et al. (2025) · Nature Aging · doi:10.1038/s43587-024-00798-7 · Cited by 9
“Because inflammation causes irreversible loss of HSC function 17 , myHSCs must possess specific mechanisms that make them resilient to inflammatory stress.”
Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation
Qoura, L. A., Churov, A. V., Maltseva, O. N., Ерусланова, К. А., & Zeng, G. (2026) · Biogerontology · doi:10.1007/s10522-026-10449-6 · Cited by 9
“Complementing these vascular observations, Bogeska et al. (Bogeska et al. 2022) demonstrated that inflammatory exposure during early to mid-life stages in mice is sufficient to induce premature aging of the hematopoietic system, cul-minating in peripheral blood hemocytopenia, bone marrow cytopenia, and an accumulation…”
The impact of prenatal inflammation on hematopoietic development
Tseng, N. A., & Beaudin, A. E. (2023) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000770 · Cited by 8
“This approach is also similar and potentially comparable to studies in which poly(I:C) is used to induce and study the response of adult HSPCs to type I interferons [8,36,37].”
ResultAging and immunity: the age-old tangoPreprint
Fernández-Maestre, I., Harris, A. S., & Amor, C. (2025) · Genes & Development · doi:10.1101/gad.352644.125 · Cited by 8
The impact of opioids on the hallmarks of ageing
Henriques, A., Silva, J. P., & Carvalho, F. D. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111994 · Cited by 7
“Additionally, stem cell exhaustion is directly linked to other biomarkers, mainly accumulated DNA damage and telomere shortening, as well as chronic inflammation (L ´ opez-Otín et al., 2013; Rossi et al., 2007; Bogeska et al., 2022).”
Lettera, E., Ricci, L. B., Carsana, E., Giannetti, K., Tavella, T., Seffin, L., Farina, G., Gualandi, N., Quaranta, P., Furno, E. L., et al. (2025) · The Journal of Experimental Medicine · doi:10.1084/jem.20251805 · Cited by 11
“…to the proliferative stress induced by ex vivo activation and transplantation, as previously reported for skin epithelial cells and akin to trained immunity in HSCs (Bogeska et al., 2022; Cirovic et al., 2020; de Laval et al., Kaufmann et al., 2018; Naik et al., 2017; Naik and Fuchs, 2022).”
Why hematopoietic stem cells fail in Fanconi anemia: Mechanisms and models
Liu, S., Vivona, E., & Kurre, P. (2024) · BioEssays · doi:10.1002/bies.202400191 · Cited by 8
“[83] Two, the mouse life span is relatively short, and the development of BMF may require a longer time.”
Turning the clock forward: Inflammation accelerates the aging of hematopoietic stem cells
Burns, S. S., & Kapur, R. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.002 · Cited by 7
Gagnon, M.-F., Provost, S., Sun, M., Ayachi, S., Buscarlet, M., Mollica, L. R., Szuber, N., Dubé, M., & Busque, L. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008793 · Cited by 8
“…has been associated with the functional attrition of murine HSCs and accelerated hematopoietic aging phenotypes with myeloid-skewed hematopoiesis 80 In fl am-maging is a major risk factor for the development of cardiometabolic diseases as endothelial damage, alteration of vascular remodeling,…”
Apetroaei, M.-M., Baliou, S., Ιωάννου, Π., Fragkiadaki, P., Ștefan, G., Nedea, M. I., Burcea-Dragomiroiu, G.-T.-A., Velescu, B. Ș., Docea, A. O., Udeanu, D. I., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47040273 · Cited by 6
“Experimental studies in mice indicated that chronic inflammation or repeated acute inflammatory episodes may prematurely deplete the regenerative capacity of the haematopoietic system and impair its functionality [140].”
Role of stem cells in ageing and age-related diseases
Chaudhary, J. K., Danga, A. K., Kumari, A., Bhardwaj, A., & Rath, P. C. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112069 · Cited by 6
Lidonnici, M. R., Chianella, G., Mende, N., Bastos, H. P., Barcella, M., Merelli, I., Storto, M., Romeo, V., Tiboni, F., Scaramuzza, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60676-7 · Cited by 9
“On the contrary, several stress conditions, such asin fl ammation, anemia, and infections 16 , induce dormant HSCs into the cell cycle affecting their lineage commitment 13,17,18 .”
He, W., Qiu, H., Feng, Y., Qiu, Q., Zheng, L., Pan, C., Cui, X. J., Sun, Y., Wang, B., & Hu, Y. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08050-9 · Cited by 7
“During in fl ammatory or infectious insults, HSC are dynamically activated to amplify the production of lineage-committed cells, thereby ful fi lling the body ’ s escalated demand for immune effectors and tissue repair mediators [5].”
Hematopoietic Stem Cell Aging: Mechanisms, Microenvironment Influences, and Rejuvenation Strategies
Cui, J., Li, X., Liu, B., Dong, C., & Chang, Y. (2025) · Bioengineering · doi:10.3390/bioengineering12111166 · Cited by 6
“Bogeska et al. [19] found by tracking a mouse model that transient inflammatory exposures can lead to a permanent reduction in functional HSCs, and that even one year after inflammation has subsided, the regeneration capacity of the resting-state HSCs is still not restored.”
Yu, H., Chen, Y., Wang, Y., Li, M., Tang, G., Zhang, R., Qu, G., Jin, X., Zheng, Y., & Jiang, G. (2025) · Particle and Fibre Toxicology · doi:10.1186/s12989-025-00654-5 · Cited by 6
“Chronic inflammatory signaling mediated by HIF-1 α induces lasting epigenetic and functional changes in hematopoietic cells [43].”
Bartram, J., Treichel, S., Song, B. A., Xu, J., Sharma, D., Nasr, W., Frangiosa, M., Harley, A., Nemkov, T. G., D'Alessandro, A., et al. (2026) · Cell stem cell · doi:10.1016/j.stem.2025.12.018 · Cited by 7
Hematopoietic Stem Cells as an Integrative Hub Linking Lifestyle to Cardiovascular Health
Chen, X., Liu, C., Wang, J., & Du, C. (2024) · Cells · doi:10.3390/cells13080712 · Cited by 6
Watt, S. M., & Roubelakis, M. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020671 · Cited by 7
Yu, C., Sheng, Y., Yu, F., Ni, H., Qiu, A., Huang, Y., & Qian, Z. (2023) · Journal of Clinical Investigation · doi:10.1172/jci163911 · Cited by 7
“Moreover, we found that the genes involved in the maintenance of fidelity in the process of DNA repto have a long-lived impairment on HSC function and accelerate hematopoiesis aging (35).”
BackgroundZeb1 maintains long-term adult hematopoietic stem cell function and extramedullary hematopoiesis
Almotiri, A., Abdelfattah, A., Storch, E. K., Stemmler, M. P., Brabletz, S., Brabletz, T., & Rodrigues, N. P. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104177 · Cited by 6
“…that proinflammatory, interferon-like damage to HSC integrity induced by poly I:C administration in this model is irreversible and may endure after long-term Zeb1 deletion or that simultaneous poly I:C administration and Zeb1 deletion may generate a heightened hematologic phenotype [40,41].”
Dissecting dormancy and quiescence in hematopoietic stem cells
Ibneeva, L., & Grinenko, T. (2024) · Frontiers in Hematology · doi:10.3389/frhem.2024.1401713 · Cited by 7
Morabito, G., Dönertaş, H. M., Sperti, L., Seidel, J., Zonouzi, A. P., Poeschla, M., & Valenzano, D. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.02.06.527346 · Cited by 6
Kashatnikova, D. A., Gracheva, A. S., Redkin, I. V., Zakharchenko, V. E., Krylova, T. N., Kuzovlev, A. N., & Salnikova, L. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031239 · Cited by 5
Mechanistic insights into stem cell aging: Pathways and processes
Fauzi, A., Wong, C. Z. E., Tee, P. Y. E., Yau, A. W. N., Rashid, E. A., Tang, Y. Q., & Chia, A. Y. Y. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112160 · Cited by 6
Ottesen, J. T., & Andersen, M. (2023) · Cancers · doi:10.3390/cancers15194806 · Cited by 5
Neoman, N., Kim, H. N., Viduya, J., Goyal, A., Liu, Y. L., & Sakamoto, K. M. (2025) · Stem Cells · doi:10.1093/stmcls/sxaf021 · Cited by 5
Gorur, V., Kranc, K. R., Ganuza, M., & Telfer, P. T. (2023) · Blood Reviews · doi:10.1016/j.blre.2023.101137 · Cited by 6
Self-citationSATB1, senescence and senescence‐related diseases
Qi, W., Bai, J., Wang, R., Zeng, X., & Zhang, L. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31327 · Cited by 6
“Studies in mice show that early to mid ‐ life exposure to inflammatory stimuli leads to peripheral blood hemocytopenia, bone marrow cytopenia, and increased BM adipocytes, mirroring typical aging ‐ related hematopoiesis changes (Bogeska et al., 2022).”
Hu, X., He, Y., Li, S., Jiang, Y., Yu, R., Wu, Y., Fu, X., Song, Y., Lin, C., Shi, J., et al. (2025) · Development · doi:10.1242/dev.204226 · Cited by 5
Ma, J., Xia, T.-J., Li, S., Yin, S., Luo, S., & Li, G. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.11.003 · Cited by 5
Acute effects of TLR3 agonist Poly(I:C) on bone marrow hematopoietic progenitor cells in mice
Shu, X., Xie, Y., Shu, M., Ou, X., Yang, J., Wu, Z., Zhang, X., Zhang, J., Zeng, H., & Shao, L. (2024) · Immunology Letters · doi:10.1016/j.imlet.2024.106927 · Cited by 4
TLR2 agonism suppresses myeloid leukemogenesis by reprogramming leukemia stem cells
Lawler, M. E., Romer-Seibert, J. S., Bowman, M. S., Mitra, R., Eischen, C. M., Bowman, R. L., & Meyer, S. E. (2025) · Blood Advances · doi:10.1182/bloodadvances.2025017018 · Cited by 4
Premature aging in serious mental illness
Diniz, B. S., Fries, G. R., Kuo, C.-L., Xu, M., & Lenze, E. J. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02322-4 · Cited by 4
Park, C. S., Bridges, C. S., Lewis, A. H., Chen, T. J., Shai, S., Du, W., Puppi, M., Zorman, B., Pavel, S., & Lacorazza, H. D. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104730 · Cited by 5
Bruno, F., Georgiou, C., Cunningham, D., Atkinson, S., Bett, L., Secchi, M., Antón, S. G., Birch, F., Langhorne, J., & Celso, C. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26062816 · Cited by 4
“Many studies reported that forced entry into the cell cycle resulted in replication stress within HSCs, leading to their loss of functionality, demonstrated by a decrease in repopulation potential in transplantation assays [10,11].”
Fan, W., Zheng, T., Mao, M., Gao, P., Yang, Y., Wang, R., Yang, Y., Zuo, Y., Yuan, T., Bai, R., et al. (2025) · Advanced Science · doi:10.1002/advs.202506982 · Cited by 4
Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory
Pasco, S. T., Martín‐Ruiz, I., Araujo‐Aris, S., Barriales, D., Castelo, J., Egia‐Mendikute, L., González-Lopez, M., Martín, J., Molina, E., Mugica, M., et al. (2025) · Immunology · doi:10.1111/imm.70047 · Cited by 4
“Furthermore, even single inflammatory episodes have significant, long-term impacts on a host's HSC capacities [10].”
Epigenetics of hematopoietic stem cell aging
Yokomizo‐Nakano, T., Oshima, M., & Iwama, A. (2024) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000818 · Cited by 4
“© Bogeska et al. successfully applied the DNA methyl-ome clock to inflammation-driven accelerated aging innate immunity, demonstrate a biological age corresponding to that of elderly mice [35 & ].”
BackgroundClonal hematopoiesis of indeterminate potential and atrial fibrillation
Liu, J., Zhang, N., Teng, G., Tse, G., Bai, J., Lip, G. Y. H., & Liu, T. (2025) · Heart Rhythm · doi:10.1016/j.hrthm.2025.05.011 · Cited by 4
Milsom, M. D., & Essers, M. A. G. (2023) · Cells and Development · doi:10.1016/j.cdev.2023.203844 · Cited by 4
Self-citationMazzarini, M., Arciprete, F., Picconi, O., Valeri, M., Verachi, P., Martelli, F., Migliaccio, A. R., Falchi, M., & Zingariello, M. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1166758 · Cited by 4
Sun, T., Li, D., Huang, L., & Zhu, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1141779 · Cited by 4
Clones of aging: When better fitness can be dangerous
Marongiu, F., Cheri, S., & Laconi, E. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151340 · Cited by 4
Lettera, E., Scala, S., Ricci, L. B., Tavella, T., della Volpe, L., Furno, E. L., Kaufmann, K. B., García‐Prat, L., Quaranta, P., Hernández, R. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.15.557553 · Cited by 4
IFN alpha signaling drives hematopoietic stem cells malfunction under acute inflammation
Han, X., Zhao, M., Wang, K., Ma, W., Wu, B., Yu, Y., Liang, X., Mo, W., Chen, X., Zhou, M. D., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114012 · Cited by 3
Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan
Xu, Y., Lee, M. K. S., de Weerd, N. A., Fu, Z., Veiga, C. B., Dragoljevic, D., Sviridov, D., Hertzog, P. J., Fleetwood, A. J., & Murphy, A. J. (2025) · iScience · doi:10.1016/j.isci.2025.112347 · Cited by 4
Phthalide compounds from the roots of Angelica sinensis and their blood-replenishing bioactivities
Li, J., Wu, X., Wang, Z., Yang, Y., Wang, Y., Chen, P., Zhang, M., Bai, Y., Shi, Y., & Yang, Z. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.107026 · Cited by 3
An inflammatory and quiescent HSC subpopulation expands with age in humans
Safina, K. R., Salik, B., Kotliar, D., Curtis, M. L., Good, J., Weng, C., David, S., Raychaudhuri, S., Kreso, A., Trowbridge, J. J., et al. (2026) · Genome biology · doi:10.1186/s13059-026-03936-z · Cited by 4
“Inflammation has been linked to HSC activation and exhaustion [27–29].”
Liu, C., Sun, Z., Li, C., Zhou, Y., Gao, X., Zhong, Y., Luo, X., Wang, C., Zhang, Y., Ni, C., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02574-y · Cited by 3
Rodriguez-Correa, E., Grünschläger, F., Nizharadze, T., Anstee, N., Al-Sabah, J., Kumpošt, V., Sedlmeier, A., Li, C., Ball, M., Fotopoulou, F., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-01958-0 · Cited by 6
“Perhaps such a phenotype might even be selected for during ageing, because clones that actively contribute to blood formation will be preferentially lost from the HSC pool 44,45 .”
Self-citationLi, Y., Sun, T., Chen, J., & Zhang, L. (2024) · Global Medical Genetics · doi:10.1055/s-0044-1779665 · Cited by 3
An Update on Neuroaging on Earth and in Spaceflight
Kuznetsov, N. V., Statsenko, Y. A., & Ljubisavljević, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041738 · Cited by 6
Zimolova, V., Burócziová, M., Berková, L., Grusanovic, S., Gurský, J., Janotka, Ľ., Kašpárek, P., Pecinová, A., Kundrát, D., Hrčkulák, D., et al. (2025) · Leukemia · doi:10.1038/s41375-025-02737-w · Cited by 3
PURE-seq integrates FACS and PIP-seq for single-cell genomics of ultra-rare cells
Pan, S., Fernández-Maestre, I., Chang, K., Haver, S. V., Wereski, M. G., Haugh, A. M., Tsai, K. K., DAUD, A. I., Bowman, R. L., Vasudevan, H. N., et al. (2026) · Nature Communications · doi:10.1038/s41467-025-68146-w · Cited by 5
“Recent studies have identi fi ed genes that may regulate hematopoietic aging, revealing differences in gene expression and aging biomarkers, as well as an inclination towards myeloid-biasedhematopoiesisasearlyasmiddleageinmice 38,39 .”
Reece, A. S., & Hulse, G. K. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1182536 · Cited by 3
Karatepe, K., de Faria, B. M., Zhang, J., Chen, X., Pinto, H. B., Fyodorov, D. V., Sefik, E., Willcockson, M. A., Flavell, R. A., Skoultchi, A. I., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2509412122 · Cited by 2
Alzheimer’s disease causes bone marrow myelopoiesis dysfunctionPreprint
Abellanas, M. A., Basurco, L., Purnapatre, M., Burgaletto, C., Castellani, G., Colaiuta, S. P., Ramos, J. M. P., Ibraheem, A., Murad, S., Antonello, P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.06.680030 · Cited by 3
Causal relationship between obesity and anorectal abscess: a Mendelian randomization study
Zeng, X., Wang, H., Deng, Y., Deng, Z., Bi, W., & Fu, H. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1437849 · Cited by 2
Xiu, Y., Xiong, M., Yang, H., Wang, Q., Zhao, X. Q., Long, J., Liang, F., Liu, N., Chen, F., Gao, M., et al. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150661 · Cited by 2
Chen, Z., Ang, H., Li, J., Yu, M., Chen, X., & Wang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1576118 · Cited by 4
Aprile, A., Lidonnici, M. R., & Ferrari, G. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102419 · Cited by 2
“112,113 Additionally, inflammatory stimuli can directly damage BM niche components.”
Han, J., Lee, D., Jeong, S., Yun, J., Kang, S., Jang, S., Lee, E., Baek, J. H., Jeon, C. O., & Bae, J. (2025) · Advanced Science · doi:10.1002/advs.202415982 · Cited by 3
Pig and human adult hematopoietic stem and progenitor cells are overall transcriptionally similar
Bailey, E., Kalampalika, F., Sánchez‐Lanzas, R., Barclay, J., Jiménez‐Pompa, A., Wang, J., & Ganuza, M. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.105334 · Cited by 4
Self-citationXia, J., Shen, L., Liu, Y., Wang, L., & Liu, F. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2515641122 · Cited by 2
“…cytosolic NLRP3 forms an inflammasome complex that activates Caspase - 1, leading to the cleavage and secretion of proinflammatory cytokines such as IL - 1b and IL - 8 and cleavage of Gasdermin E (GSDME) to induce pyroptosis, a lytic and proinflammatory form of programmed cell death (31–33).”
Ganuza, M., & Yoshimoto, M. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.105352 · Cited by 3
Self-citationLyadova, I. V. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1717370 · Cited by 2
TA-TMA and GVHD are distinct consequences of endothelial injury: a MIDAS consortium study
Hahn, T., Zhao, Q., Miller, E. G., Elder, P., Langenberg, L., Luebbering, N., Abdullah, S., Neidemire-Colley, L. M., Holtan, S. G., Cataland, S. R., et al. (2026) · Blood Advances · doi:10.1182/bloodadvances.2026019747 · Cited by 2
“30-32 We do not propose that creatinine itself is a useful clinical biomarker for the selection of patients for HCT, but that it and our previous similar observation that elevated pro-thrombin time, even within the normal range, increases risk of TA-TMA provide insight into an alternative…”
Loss of STMP1 Perturbs Mitochondrial Cristae and Drives Cellular Inflammation and Heart Failure
Ruberto, F. P., Lee, C. J. M., Ackers-Johnson, M. A., Sridharan, P., Khanchandani, V., Wu, L. H., Xuan, G. L., Luu, T. D. A., Pakkiri, L. S., Bonne, I., et al. (2026) · Circulation · doi:10.1161/circulationaha.124.073677 · Cited by 2
Is the philosopher’s stone to rejuvenate blood stem cells an epigenetic regulator?
Svendsen, A. F., & de Haan, G. (2022) · Nature Aging · doi:10.1038/s43587-022-00305-w · Cited by 2
Role of immunosenescence in impaired wound healing with age
Altintas, I., Andersen, O., & Nehlin, J. O. (2024) · Advances in biogerontology · doi:10.1016/bs.abger.2024.05.005 · Cited by 2
Hematopoietic responses to metal-organic frameworks in adult mice following pulmonary exposure.
Li, M., Yao, L.-L., Wang, Y., Gao, J., Ma, J.-J., Liu, Y., Ding, Y., Zheng, X., Chen, L., Liu, R.-Z., et al. (2024) · Journal of Environmental Science · doi:10.1016/j.jes.2024.08.003 · Cited by 3
Analyzing the causal role of blood cells in aging: a Mendelian randomization study
Zhang, J., Zhang, X., Xiao, B., Ouyang, J., Wang, P., & Peng, X. (2024) · Biogerontology · doi:10.1007/s10522-024-10148-0 · Cited by 2
“…and internal environment accelerate aging, some studies suggest platelets may be involved in cognitive repair during aging(Schroer et al. 2023), while inflammatory stress damages the self-repair ability of hematopoietic stem cells, potentially accelerating aging(Bogeska et al. 2022).”
Zhong, L., Jiang, W., Liu, Y., & Huang, J. (2025) · Medicine · doi:10.1097/md.0000000000041111 · Cited by 2
Gong, Y., Yang, K. Y., Geng, Z., & Liu, H. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318332 · Cited by 2
Chen, W., Wu, J., She, P., Li, J., Lan, Y., Hu, X., Huangfu, Y. F., Wu, C., Jin, D., Xie, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61680-7 · Cited by 2
Martinez, T. C., Jotte, M. R. M., Khan, S. S., Stoddart, A., Blaylock, H. Z., Malik, A., & McNerney, M. E. (2025) · Blood · doi:10.1182/blood.2024026815 · Cited by 4
O’Connell, A. E., Raveenthiraraj, S., Adegboye, C., Qi, W., Khetani, R. S., Singh, A., Sundaram, N., Emeonye, C., Lin, J., Goldsmith, J. D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.21.537894 · Cited by 2
Qiao, Q., Sun, J., Zheng, Y., Mi, Y., Gong, Y., Liu, J., Rui, W., Ma, Y., Zhou, Y., & Liu, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1507196 · Cited by 1
Clonal hematopoiesis: linking hematopoietic stem cell aging with age-related diseases
Li, Z., Zhou, Z., You, W., Xiao, F., Ju, Z., & Chen, Z. (2025) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2025.9610016 · Cited by 1
Multivalent cannabinoid epigenotoxicities and multigenerational aging
Reece, A. S., & Hulse, G. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13492-0.00001-3 · Cited by 1
Wagner, S., Thielecke, L., & Glauche, I. (2025) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2025.111079 · Cited by 1
Metadata
- Authors
- Bogeska, R., Mikecin, A.-M., Kaschutnig, P., Fawaz, M., Büchler-Schäff, M., Le, D., Ganuza, M., Vollmer, A., Paffenholz, S. V., Asada, N., Rodriguez-Correa, E., Frauhammer, F., Buettner, F., Ball, M., Knoch, J., Stäble, S., Walter, D., Petri, A., Carreño-Gonzalez, M. J., Wagner, V., Brors, B., Haas, S., Lipka, D. B., Essers, M. A. G., Weru, V., Holland-Letz, T., Mallm, J.-P., Rippe, K., Krämer, S., Schlesner, M., McKinney Freeman, S., Florian, M. C., King, K. Y., Frenette, P. S., Rieger, M. A., & Milsom, M. D.
- Affiliations
- German Cancer Research Center (DE)
- University Hospital Frankfurt (DE)
- Baylor College of Medicine (US)
- St. Jude Children's Research Hospital (US)
- Universität Ulm (DE)
- Albert Einstein College of Medicine (US)
- University of Augsburg (DE)
- Institut d'Investigació Biomédica de Bellvitge (ES)
- Goethe University Frankfurt (DE)
- Corresponding author
- Milsom, Michael D.
- ORCID
- Bogeska, Ruzhica
- Mikecin, Ana-Matea
- Le, Duy
- Ganuza, Miguel
- Asada, Noboru
- Rodriguez-Correa, Esther
- Buettner, Florian
- Stäble, Sina
- Carreño-Gonzalez, Martha J.
- Brors, Benedikt
- Haas, Simon
- Lipka, Daniel B.
- Essers, Marieke A.G.
- Weru, Vivienn
- Mallm, Jan-Philipp
- Rippe, Karsten
- Schlesner, Matthias
- Florian, Maria Carolina
- King, Katherine Y.
- Frenette, Paul S.
- Rieger, Michael A.
- Milsom, Michael D.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 29
- Issue
- 8
- Pages
- 1273-1284.e8
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC9357150
- OpenAlex
- W4286254590
- Cited by
- 299
- References
- 66
- Citations by year
- 2026: 67 · 2025: 88 · 2024: 56 · 2023: 60 · 2022: 16
- FWCI
- 40.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion)
- OPUS (Augsburg University) (submittedVersion, cc-by-nc-nd)
- Funders
- Deutsches Krebsforschungszentrum
- Medical Research Council (MR/V009222/1)
- National Heart, Lung, and Blood Institute (F31HL154661, R35HL155672)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK112976, R01DK056638)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- hematopoietic stem cells, HSC self-renewal, inflammation, bacterial infection, accelerated aging, HSC depletion, bone marrow aging, tissue regeneration
- MeSH terms
- Aged, Aging, Animals, Bone Marrow, Hematopoiesis, Hematopoietic Stem Cells, Humans, Inflammation, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
