Frenette, Paul S.

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity

Immune cells in cancerPhagocytosis and Immune Regulation

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Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

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Autonomic nerve development contributes to prostate cancer progression

Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S. (2013) · Science

Cancer, Stress, Anesthesia, and Immune ResponseProstate Cancer Treatment and Research

Cited by 1,287

Circadian control of the immune system

Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology

Circadian rhythm and melatoninSleep and Work-Related Fatigue

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The bone marrow microenvironment at single-cell resolution

Tikhonova, A. N., Dolgalev, I., Hu, H., Sivaraj, K. K., Hoxha, E., Cuesta-Domínguez, Á., Pinho, S., Akhmetzyanova, I., Gao, J., Witkowski, M., et al. (2019) · Nature

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

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Neutrophil ageing is regulated by the microbiome

Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature

Hemoglobinopathies and Related DisordersNeutrophil, Myeloperoxidase and Oxidative Mechanisms

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Adrenergic nerves activate an angio-metabolic switch in prostate cancer

Zahalka, A. H., Arnal-Estapé, A., Maryanovich, M., Nakahara, F., Cruz, C. D., Finley, L. W. S., & Frenette, P. S. (2017) · Science

Cancer, Stress, Anesthesia, and Immune ResponseAngiogenesis and VEGF in Cancer

Cited by 548

Nerves in cancer

Zahalka, A. H., & Frenette, P. S. (2020) · Nature Reviews Cancer

Cancer, Stress, Anesthesia, and Immune ResponseVagus Nerve Stimulation Research

Cited by 470

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine

Frenette, P. S., Pinho, S., Lucas, D., & Scheiermann, C. (2013) · Annual Review of Immunology

Mesenchymal stem cell researchHematopoietic Stem Cell Transplantation

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GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells

Greter, M., Helft, J., Chow, A., Hashimoto, D., Mortha, A., Agudo-Cantero, J., Bogunovic, M., Gautier, E. L., Miller, J., Leboeuf, M., et al. (2012) · Immunity

Immunotherapy and Immune ResponsesT-cell and B-cell Immunology

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CD169 + macrophages provide a niche promoting erythropoiesis under homeostasis and stress

Chow, A., Huggins, M., Ahmed, J., Hashimoto, D., Lucas, D., Kunisaki, Y., Pinho, S., Leboeuf, M., Noizat, C., van Rooijen, N., et al. (2013) · Nature Medicine

Hematopoietic Stem Cell TransplantationErythropoietin and Anemia Treatment

Cited by 433

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

Manwani, D., & Frenette, P. S. (2013) · Blood

Hemoglobinopathies and Related DisordersBlood properties and coagulation

Cited by 428

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

Zhang, D., Xu, C., Manwani, D., & Frenette, P. S. (2016) · Blood

Hemoglobinopathies and Related DisordersPlatelet Disorders and Treatments

Cited by 413

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche

Hanoun, M., Zhang, D., Mizoguchi, T., Pinho, S., Pierce, H., Kunisaki, Y., Lacombe, J., Armstrong, S. A., Dührsen, U., & Frenette, P. S. (2014) · Cell stem cell

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 381

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

Chen, G., Zhang, D., Fuchs, T. A., Manwani, D., Wagner, D. D., & Frenette, P. S. (2014) · Blood

Neutrophil, Myeloperoxidase and Oxidative MechanismsHemoglobinopathies and Related Disorders

Cited by 354

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

Bogeska, R., Mikecin, A.-M., Kaschutnig, P., Fawaz, M., Büchler-Schäff, M., Le, D., Ganuza, M., Vollmer, A., Paffenholz, S. V., Asada, N., et al. (2022) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 299

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

Hanoun, M., Maryanovich, M., Arnal-Estapé, A., & Frenette, P. S. (2015) · Neuron

Cancer, Stress, Anesthesia, and Immune ResponseVagus Nerve Stimulation Research

Cited by 265

The hematopoietic stem cell niche: from embryo to adult

Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

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GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

Chang, J., Patton, J. T., Sarkar, A., Ernst, B., Magnani, J. L., & Frenette, P. S. (2010) · Blood

Hemoglobinopathies and Related DisordersCell Adhesion Molecules Research

Cited by 238

Brain motor and fear circuits regulate leukocytes during acute stress

Poller, W. C., Downey, J., Mooslechner, A. A., Khan, N., Li, L., Chan, C. T., McAlpine, C. S., Xu, C., Kahles, F., He, S., et al. (2022) · Nature

Stress Responses and CortisolCancer, Stress, Anesthesia, and Immune Response

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Bone marrow NG2+/Nestin+ mesenchymal stem cells drive DTC dormancy via TGF-β2

Nobre, A. R., Risson, E., Singh, D. K., Di Martino, J. S., Cheung, J. F., Wang, J., Johnson, J., Russnes, H. G., Bravo-Cordero, J. J., Birbrair, A., et al. (2021) · Nature Cancer

Cancer Cells and MetastasisMesenchymal stem cell research

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Neural regulation of bone and bone marrow

Maryanovich, M., Takeishi, S., & Frenette, P. S. (2018) · Cold Spring Harbor Perspectives in Medicine

Bone Metabolism and DiseasesCancer, Stress, Anesthesia, and Immune Response

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Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Nakahara, F., Borger, D. K., Wei, Q., Pinho, S., Maryanovich, M., Zahalka, A. H., Suzuki, M., Cruz, C. D., Wang, Z., Xu, C., et al. (2019) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

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MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

Wei, Q., Pinho, S., Dong, S., Pierce, H., Li, H., Nakahara, F., Xu, J., Xu, C., Boulais, P. E., Zhang, D., et al. (2021) · Nature Communications

Hematopoietic Stem Cell TransplantationUbiquitin and proteasome pathways

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