The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast
Open accessAbstract
Controversy surrounds reports describing the derivation of human trophoblast cells from placentas and embryonic stem cells (ESC), partly due to the difficulty in identifying markers that define cells as belonging to the trophoblast lineage. We have selected criteria that are characteristic of primary first-trimester trophoblast: a set of protein markers, HLA class I profile, methylation of ELF5, and expression of microRNAs (miRNAs) from the chromosome 19 miRNA cluster (C19MC). We tested these criteria on cells previously reported to show some phenotypic characteristics of trophoblast: bone morphogenetic protein (BMP)-treated human ESC and 2102Ep, an embryonal carcinoma cell line. Both cell types only show some, but not all, of the four trophoblast criteria. Thus, BMP-treated human ESC have not fully differentiated to trophoblast. Our study identifies a robust panel, including both protein and non-protein-coding markers that, in combination, can be used to reliably define cells as characteristic of early trophoblast.
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Cites
NIH Image to ImageJ: 25 years of image analysis
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Self-citation
Cited by
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Self-citationA single-cell survey of the human first-trimester placenta and decidua
Suryawanshi, H., Morozov, P., Straus, A., Sahasrabudhe, N., Max, K. E. A., Garzia, A., Kustagi, M., Tuschl, T., & Williams, Z. (2018) · Science Advances · doi:10.1126/sciadv.aau4788 · Cited by 441
Haider, S., Meinhardt, G., Saleh, L., Kunihs, V., Gamperl, M., Kaindl, U., Ellinger, A., Burkard, T. R., Fiala, C., Pollheimer, J., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.07.004 · Cited by 417
Establishment of porcine and human expanded potential stem cells
Gao, X., Nowak-Imialek, M., Chen, X., Chen, D., Herrmann, D., Ruan, D., Chen, A. C. H., Eckersley-Maslin, M. A., Ahmad, S., Lee, Y. L., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0333-2 · Cited by 389
In vitro reconstitution of epigenetic reprogramming in the human germ line
Murase, Y., Yokogawa, R., Yabuta, Y., Nagano, M., Katou, Y., Mizuyama, M., Kitamura, A., Puangsricharoen, P., Yamashiro, C., Hu, B., et al. (2024) · Nature · doi:10.1038/s41586-024-07526-6 · Cited by 80
Metadata
- Authors
- Lee, C. Q. E., Gardner, L., Turco, M., Zhao, N., Murray, M. J., Coleman, N., Rossant, J., Hemberger, M., & Moffett, A.
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 6
- Issue
- 2
- Pages
- 257-272
- ISSN
- 2213-6711 (ISSN-L)
- OpenAlex
- W2265249939
- Cited by
- 292
- References
- 3
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lee, C. Q. E., Gardner, L., Turco, M., Zhao, N., Murray, M. J., Coleman, N., Rossant, J., Hemberger, M., & Moffett, A. (2016). What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2016.01.006
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