The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta
Open accessAbstract
Defective placentation is the underlying cause of various pregnancy complications, such as severe intrauterine growth restriction and preeclampsia. However, studies on human placental development are hampered by the lack of a self-renewing in vitro model that would recapitulate formation of trophoblast progenitors and differentiated subtypes, syncytiotrophoblast (STB) and invasive extravillous trophoblast (EVT), in a 3D orientation. Hence, we established long-term expanding organoid cultures from purified first-trimester cytotrophoblasts (CTBs). Molecular analyses revealed that the CTB organoid cultures (CTB-ORGs) express markers of trophoblast stemness and proliferation and are highly similar to primary CTBs at the level of global gene expression. Whereas CTB-ORGs spontaneously generated STBs, withdrawal of factors for self-renewal induced trophoblast outgrowth, expressing the EVT progenitor marker NOTCH1, and provoked formation of adjacent, distally located HLA-G + EVTs. In summary, we established human CTB-ORGs that grow and differentiate under defined culture conditions, allowing future human placental disease modeling.
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Cites
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Cited by
Pre-eclampsia: pathophysiology and clinical implications
Burton, G. J., Redman, C. W., Roberts, J. M., & Moffett, A. (2019) · BMJ · doi:10.1136/bmj.l2381 · Cited by 1,250
Development of the human placenta
Turco, M. Y., & Moffett, A. (2019) · Development · doi:10.1242/dev.163428 · Cited by 698
Spatial multiomics map of trophoblast development in early pregnancy
Arutyunyan, A., Roberts, K., Troulé, K., Wong, F. C. K., Sheridan, M. A., Kats, I., Garcia-Alonso, L., Velten, B., Hoo, R., Ruiz-Morales, E. R., et al. (2023) · Nature · doi:10.1038/s41586-023-05869-0 · Cited by 303
Sex at the interface: the origin and impact of sex differences in the developing human placenta
Braun, A. E., Mitchel, O. R., Gonzalez, T. L., Sun, T., Flowers, A. E., Pisarska, M. D., & Winn, V. D. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00459-7 · Cited by 94
Understanding the Chemical Exposome During Fetal Development and Early Childhood: A Review
Krausová, M., Braun, D., Buerki-Thurnherr, T., Gundacker, C., Schernhammer, E., Wisgrill, L., & Warth, B. (2023) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051922-113350 · Cited by 61
Metadata
- Authors
- Haider, S., Meinhardt, G., Saleh, L., Kunihs, V., Gamperl, M., Kaindl, U., Ellinger, A., Burkard, T. R., Fiala, C., Pollheimer, J., Mendjan, S., Latos, P. A., & Knöfler, M.
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 11
- Issue
- 2
- Pages
- 537-551
- ISSN
- 2213-6711 (ISSN-L)
- OpenAlex
- W2887483703
- Cited by
- 417
- References
- 59
- FWCI
- 30.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta. https://app.cochat.ai/papers/10.1016/j.stemcr.2018.07.004
- The paper
- Haider, S., Meinhardt, G., Saleh, L., Kunihs, V., Gamperl, M., Kaindl, U., Ellinger, A., Burkard, T. R., Fiala, C., Pollheimer, J., Mendjan, S., Latos, P. A., & Knöfler, M. (2018). Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta. Stem Cell Reports. https://doi.org/10.1016/j.stemcr.2018.07.004
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
