Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy
Open accessAbstract
Glial cytoplasmic inclusions (GCIs), commonly observed as α-synuclein (α-syn)-positive aggregates within oligodendrocytes, are the pathological hallmark of multiple system atrophy. The origin of α-syn in GCIs is uncertain; there is little evidence of endogenous α-syn expression in oligodendrocyte lineage cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes (OLGs). Here, based on in vitro analysis using primary rat cell cultures, we elucidated that preformed fibrils (PFFs) generated from recombinant human α-syn trigger multimerization and an upsurge of endogenous α-syn in OPCs, which is attributable to insufficient autophagic proteolysis. RNA-seq analysis of OPCs revealed that α-syn PFFs interfered with the expression of proteins associated with neuromodulation and myelination. Furthermore, we detected cytoplasmic α-syn inclusions in OLGs through differentiation of OPCs pre-incubated with PFFs. Overall, our findings suggest the possibility of endogenous α-syn accumulation in OPCs that contributes to GCI formation and perturbation of neuronal/glial support in multiple system atrophy brains.
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Accumulation of SNCA inclusions in oligodendrocytes is exacerbated by autophagy inhibition, either pharmacologically with chloroquine or genetically by MIR101 overexpression.
“and the accumulation of these inclusions is exacerbated by autophagy inhibition, either pharmacologically with chloroquine or genetically by MIR101 overexpression [12,450,454].”
From Autophagy and ALS: mechanistic insights and therapeutic implications (2022) · cites this paper as [454]
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- Authors
- Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., Ono, Y., Mao, X., Quach, T. H., Iwai, K., Dawson, V. L., Dawson, T. M., & Takahashi, R.
- Affiliations
- Kyoto University (JP)
- Shiga University of Medical Science (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- KAN Research Institute (JP)
- Johns Hopkins University (US)
- Corresponding author
- Maki, Takakuni
- ORCID
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 10
- Issue
- 2
- Pages
- 356-365
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC5830961
- OpenAlex
- W2784225857
- Cited by
- 93
- References
- 24
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 17 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 20 · 2019: 16
- FWCI
- 7.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion, cc-by-nc-nd)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Funders
- School of Medicine, Johns Hopkins University
- Johns Hopkins Hospital
- Japan Society for the Promotion of Science (16K07056)
- National Institutes of Health
- Ministry of Education, Culture, Sports, Science and Technology
- Adrienne Helis Malvin Medical Research Foundation
- National Institute of Neurological Disorders and Stroke (P50 NS38377)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- alpha-synuclein, multiple system atrophy, glial cytoplasmic inclusions, oligodendrocyte precursor cells, oligodendrocytes, preformed fibrils, autophagy, myelination, neuromodulation, oligodendrocyte differentiation, neurodegeneration
- MeSH terms
- Oligodendrocyte Precursor Cells, Animals, Brain, Cell Differentiation, Inclusion Bodies, Humans, Neuroglia, Neurons, Oligodendroglia, Cell Culture Techniques, Multiple System Atrophy, Rats, alpha-Synuclein
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