The role of glial autophagy in Alzheimer’s disease

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493 · see citing works

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

Cillà, S. D., Farruggio, S., Vujosevic, S., Raina, G., Filippini, D. A., Gatti, V., Clemente, N., Mary, D., Vezzola, D., Casini, G., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479441 · Cited by 5,154 · see citing works

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · cited 1× · see citing works

Autophagy: cellular and molecular mechanisms

Glick, D. R., Barth, S., & Macleod, K. F. (2010) · The Journal of Pathology · doi:10.1002/path.2697 · Cited by 3,815 · see citing works

Genomic analysis of reactive astrogliosis

Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works

Microglia in Alzheimer’s disease

Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935 · cited 1× · see citing works

A single–cell type transcriptomics map of human tissues

Karlsson, M., Zhang, C., Méar, L., Zhong, W., Digre, A., Katona, B., Sjöstedt, E., Butler, L., Odeberg, J., Dusart, P., et al. (2021) · Science Advances · doi:10.1126/sciadv.abh2169 · Cited by 1,768 · see citing works

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0332-9 · Cited by 1,740 · see citing works

Signals from the lysosome: a control centre for cellular clearance and energy metabolism

Settembre, C., Fraldi, A., Medina, D. L., & Ballabio, A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3565 · Cited by 1,689 · see citing works

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588 · see citing works

Microglia Biology: One Century of Evolving Concepts

Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525 · see citing works

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523 · see citing works

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0176-2 · Cited by 1,505 · see citing works

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425 · see citing works

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

Initiative, A. D. N., Shi, Y., Yamada, K., Liddelow, S. A., Smith, S. T., Zhao, L., Luo, W., Tsai, R. M., Spina, S., Grinberg, L. T., et al. (2017) · Nature · doi:10.1038/nature24016 · Cited by 1,220 · see citing works

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice.

Pickford, F., Masliah, E., Britschgi, M., Lucin, K. M., Narasimhan, R., Jaeger, P. A., Small, S., Spencer, B., Rockenstein, E., Levine, B., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33585 · Cited by 1,186 · see citing works

The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting

von Bartheld, C. S., Bahney, J., & Herculano‐Houzel, S. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.24040 · Cited by 1,063 · see citing works

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Spilman, P., Podlutskaya, N., Hart, M. J., Debnath, J., Gorostiza, O., Bredesen, D., Richardson, A., Strong, R., & Galvan, V. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009979 · Cited by 1,033 · see citing works

Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model

Zhang, P., Kishimoto, Y., Grammatikakis, I., Gottimukkala, K., Cutler, R. G., Zhang, S., Abdelmohsen, K., Bohr, V. A., Misra Sen, J., Gorospe, M., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0372-9 · Cited by 977 · see citing works

Microglia polarization from M1 to M2 in neurodegenerative diseases

Guo, S., Wang, H., & Yin, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.815347 · Cited by 920 · see citing works

Chaperone-mediated autophagy: a unique way to enter the lysosome world

Kaushik, S., & Cuervo, A. M. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.05.006 · Cited by 850 · see citing works

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

Jordão, M. J. C., Sankowski, R., Brendecke, S. M., Sagar, Locatelli, G., Tai, Y.-H., Tay, T. L., Schramm, E., Armbruster, S., Hagemeyer, N., et al. (2019) · Science · doi:10.1126/science.aat7554 · Cited by 843 · see citing works

TFEB at a glance

Napolitano, G., & Ballabio, A. (2016) · Journal of Cell Science · doi:10.1242/jcs.146365 · Cited by 836 · see citing works

Microglia: Immune and non-immune functions

Borst, K., Dumas, A. A., & Prinz, M. (2021) · Immunity · doi:10.1016/j.immuni.2021.09.014 · Cited by 804 · see citing works

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

Park, J., Wetzel, I., Marriott, I., Dréau, D., D’Avanzo, C., Kim, D. Y., Tanzi, R. E., & Cho, H. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0175-4 · Cited by 644 · see citing works

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Booth, H. D. E., Hirst, W. D., & Wade-Martins, R. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.04.001 · Cited by 633 · see citing works

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587 · see citing works

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

Jha, M. K., Jo, M., Kim, J.-H., & Suk, K. (2019) · The Neuroscientist · doi:10.1177/1073858418783959 · Cited by 579 · see citing works

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Choi, I., Zhang, Y., Seegobin, S. P., Pruvost, M., Wang, Q., Purtell, K., Zhang, B., & Yue, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-15119-w · Cited by 549 · see citing works

Mechanisms of Aβ Clearance and Degradation by Glial Cells

Ries, M., & Sastre, M. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00160 · Cited by 527 · see citing works

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

Bolmont, T., Haiss, F., Eicke, D., Radde, R., Mathis, C. A., Klunk, W. E., Kohsaka, S., Jucker, M., & Calhoun, M. E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4814-07.2008 · Cited by 526 · see citing works

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 525 · see citing works

The Lifespan and Turnover of Microglia in the Human Brain

Réu, P., Khosravi, A., Bernard, S., Mold, J. E., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Druid, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.004 · Cited by 515 · see citing works

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

Fakhoury, M. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170720095240 · Cited by 482 · see citing works

Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease

Braak, H., Sastre, M., & Del Tredici, K. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0244-3 · Cited by 462 · see citing works

Autophagy in neurodegenerative diseases: pathogenesis and therapy

Guo, F., Liu, X., Cai, H., & Le, W. (2017) · Brain Pathology · doi:10.1111/bpa.12545 · Cited by 443 · see citing works

Economic burden of Alzheimer disease and managed care considerations

Winston Wong, P. (2020) · The American Journal of Managed Care · doi:10.37765/ajmc.2020.88482 · Cited by 408 · see citing works

Role of LAMP-2 in Lysosome Biogenesis and Autophagy

Eskelinen, E., Illert, A. L., Tanaka, Y., Schwarzmann, G. O. H., Blanz, J., FIGURA, K. V., & Säftig, P. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-02-0114 · Cited by 365 · see citing works

Autophagy in Huntington disease and huntingtin in autophagy

Martin, D. D. O., Ladha, S., Ehrnhoefer, D. E., & Hayden, M. R. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.09.003 · Cited by 344 · see citing works

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience · doi:10.1038/nn.3668 · Cited by 333 · see citing works

TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation

Norden, D. M., Fenn, A. M., Dugan, A., & Godbout, J. P. (2014) · Glia · doi:10.1002/glia.22647 · Cited by 332 · see citing works

Autophagy and neurodegeneration

Frake, R. A., Ricketts, T., Menzies, F. M., & Rubinsztein, D. C. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73944 · Cited by 332 · see citing works

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia

Edgar, J. M., McLaughlin, M., Yool, D., Zhang, S.-C., Fowler, J. H., Montague, P., Barrie, J. A., McCulloch, M. C., Duncan, I. D., Garbern, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312012 · Cited by 328 · see citing works

Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

Gu, L., & Guo, Z. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12202 · Cited by 325 · see citing works

Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives

Béard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825816 · Cited by 309 · see citing works

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works

Genetic analysis of the human microglial transcriptome across brain regions, aging and disease pathologies

Lopes, K. D. P., Snijders, G. J. L., Humphrey, J., Allan, A., Sneeboer, M. A. M., Navarro, E., Schilder, B. M., Vialle, R. A., Parks, M., Missall, R., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-00976-y · Cited by 273 · see citing works

Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo

Angot, E., Steiner, J. A., Lema Tomé, C. M., Ekström, P., Mattsson, B., Björklund, A., & Brundin, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039465 · Cited by 270 · see citing works

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, S., Nikitidou, E., Brolin, R., Söderberg, L., Sehlin, D., Lannfelt, L., & Erlandsson, A. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0098-z · Cited by 267 · see citing works

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

Lee, J.-W., Nam, H., Kim, L. E., Jeon, Y., Min, H., Ha, S., Lee, Y., Kim, S.-Y., Lee, S. J., Kim, E.-K., et al. (2019) · Autophagy · doi:10.1080/15548627.2018.1556946 · Cited by 260 · see citing works

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

Motori, E., Puyal, J., Toni, N., Ghanem, A., Angeloni, C., Malaguti, M., Cantelli-Forti, G., Berninger, B., Conzelmann, K.-K., Götz, M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.005 · Cited by 249 · see citing works

The Role of Mitophagy in Innate Immunity

Gkikas, I., Palikaras, K., & Tavernarakis, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01283 · Cited by 244 · see citing works

Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models

Shin, J. Y., Park, H. J., Kim, H. N., Oh, S. H., Bae, J.-S., Ha, H.-J., & Lee, P. H. (2014) · Autophagy · doi:10.4161/auto.26508 · Cited by 243 · see citing works

Aberrant oligodendroglial–vascular interactions disrupt the blood–brain barrier, triggering CNS inflammation

Niu, J., Tsai, H., Hoi, K. K., Huang, N., Yu, G., Kim, K., Baranzini, S. E., Xiao, L., Chan, J. R., & Fancy, S. P. J. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0369-4 · Cited by 241 · see citing works

The Dual Role of Microglia in ALS: Mechanisms and Therapeutic Approaches

Geloso, M. C., Corvino, V., Marchese, E., Serrano, A., Michetti, F., & D’Ambrosi, N. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00242 · Cited by 239 · see citing works

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

Lindström, V., Gustafsson, G., Sanders, L. H., Howlett, E. H., Sigvardson, J., Kasrayan, A., Ingelsson, M., Bergström, J., & Erlandsson, A. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.04.009 · Cited by 233 · see citing works

Microglial Autophagy Defect Causes Parkinson Disease-like Symptoms by Accelerating Inflammasome Activation in Mice

Cheng, J., Liao, Y., Dong, Y., Hu, H., Yang, N., Kong, X., Li, S., Li, X., Guo, J., Qin, L., et al. (2020) · Autophagy · doi:10.1080/15548627.2020.1719723 · Cited by 233 · see citing works

Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing Aβ Generation and Amyloid Plaque Pathogenesis

Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E. R., Tripoli, D. L., Czerniewski, L. R., Ballabio, A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0705-15.2015 · Cited by 230 · see citing works

Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes

Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230 · see citing works

Astrocytic control of synaptic function

Papouin, T., Dunphy, J. M., Tolman, M., Foley, J., & Haydon, P. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0154 · Cited by 229 · see citing works

Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo

Yambire, K. F., Rostosky, C. M., Watanabe, T., Pacheu‐Grau, D., Torres-Odio, S., Sanchez-Guerrero, A., Senderovich, O., Meyron‐Holtz, E. G., Milošević, I., Frahm, J., et al. (2019) · eLife · doi:10.7554/elife.51031 · Cited by 229 · see citing works

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff-Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T., & Bu, G. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx155 · Cited by 221 · see citing works

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

Gomez‐Arboledas, A., Davila, J. C., Sanchez‐Mejias, E., Navarro, V., Nuñez‐Diaz, C., Sanchez‐Varo, R., Sanchez‐Mico, M. V., Trujillo‐Estrada, L., Fernandez‐Valenzuela, J. J., Vizuete, M., et al. (2018) · Glia · doi:10.1002/glia.23270 · Cited by 220 · see citing works

Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis

Iorio, R., Celenza, G., & Petricca, S. (2021) · Cells · doi:10.3390/cells11010030 · Cited by 218 · see citing works

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Herdy, J. R., Traxler, L., Agarwal, R. K., Karbacher, L., Schlachetzki, J. C. M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C. K., Mertens, J., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2022.11.010 · Cited by 208 · see citing works

Autophagy, heterophagy, microautophagy and crinophagy as the means for intracellular degradation

Marzella, L., Ahlberg, J., & Glaumann, H. (1981) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02912068 · Cited by 196 · see citing works

Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer’s disease

Park, J.-S., Kam, T.-I., Lee, S., Park, H., Oh, Y., Kwon, S.-H., Song, J.-J., Kim, D., Kim, H., Jhaldiyal, A., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01180-z · Cited by 192 · see citing works

Association Between Autophagy and Neurodegenerative Diseases

Fujikake, N., Shin, M., & Shimizu, S. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00255 · Cited by 190 · see citing works

Distinct roles for motor neuron autophagy early and late in the SOD1 ^G93A mouse model of ALS

Rudnick, N. D., Griffey, C. J., Guarnieri, P., Gerbino, V., Wang, X., Piersaint, J. A., Tapia, J. C., Rich, M. M., & Maniatis, T. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704294114 · Cited by 189 · see citing works

Role of Microglia and Astrocytes in Alzheimer’s Disease: From Neuroinflammation to Ca2+ Homeostasis Dysregulation

Di Benedetto, G., Burgaletto, C., Bellanca, C. M., Munafò, A., Bernardini, R., & Cantarella, G. (2022) · Cells · doi:10.3390/cells11172728 · Cited by 189 · see citing works

The role of myelin damage in Alzheimer’s disease pathology

Papuć, E., & Rejdak, K. (2020) · Archives of Medical Science · doi:10.5114/aoms.2018.76863 · Cited by 188 · see citing works

Astrocyte and Oligodendrocyte Cross-Talk in the Central Nervous System

Nutma, E., van Gent, D., Amor, S., & Peferoen, L. A. N. (2020) · Cells · doi:10.3390/cells9030600 · Cited by 184 · see citing works

Neuronal Cell Death in Alzheimers Disease and a Neuroprotective Factor, Humanin

Niikura, T., Tajima, H., & Kita, Y. (2006) · Current Neuropharmacology · doi:10.2174/157015906776359577 · Cited by 184 · see citing works

SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology

Bunton-Stasyshyn, R. K. A., Saccon, R. A., Fratta, P., & Fisher, E. (2014) · The Neuroscientist · doi:10.1177/1073858414561795 · Cited by 180 · see citing works

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration

Jin, M.-M., Wang, F., Qi, D., Liu, W.-W., Gu, C., Mao, C.-J., Yang, Y.-P., Zhao, Z., Hu, L.-F., & Liu, C.-F. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00378 · Cited by 180 · see citing works

Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration

Molina-Gonzalez, I., Holloway, R. K., Jiwaji, Z., Dando, O., Kent, S. A., Emelianova, K., Lloyd, A. F., Forbes, L. H., Mahmood, A., Skripuletz, T., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39046-8 · Cited by 176 · cited 1× · see citing works

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease

Qin, Y., Qiu, J., Wang, P., Liu, J., Zhao, Y., Jiang, F., & Lou, H. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.010 · Cited by 173 · see citing works

Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading

Xu, Y., Propson, N. E., Du, S., Xiong, W., & Zheng, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023418118 · Cited by 171 · see citing works

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

Kiani Shabestari, S., Morabito, S., Danhash, E. P., McQuade, A., Sanchez, J. R., Miyoshi, E., Chadarevian, J. P., Claes, C., Coburn, M. A., Hasselmann, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110961 · Cited by 167 · see citing works

SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity

Berdyński, M., Miszta, P., Safranow, K., Andersen, P., Morita, M., Filipek, S., Żekanowski, C., & Kuźma-Kozakiewicz, M. (2022) · Scientific Reports · doi:10.1038/s41598-021-03891-8 · Cited by 162 · see citing works

α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease

Tu, H., Yuan, B., Hou, X., Zhang, X., Pei, C., Ma, Y., Yang, Y., Fan, Y., Qin, Z., Liu, C., et al. (2021) · Aging Cell · doi:10.1111/acel.13522 · Cited by 152 · see citing works

Microglial autophagy–associated phagocytosis is essential for recovery from neuroinflammation

Berglund, R., Guerreiro-Cacais, A. O., Adzemovic, M. Z., Zeitelhofer, M., Lund, H., Ewing, E., Ruhrmann, S., Nutma, E., Parsa, R., Thessen-Hedreul, M., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abb5077 · Cited by 149 · see citing works

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

Lall, D., Lorenzini, I., Mota, T. A., Bell, S., Mahan, T. E., Ulrich, J. D., Davtyan, H., Rexach, J. E., Muhammad, A. K. M. G., Shelest, O., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.020 · Cited by 147 · see citing works

The importance of microglia in the development of the vasculature in the central nervous system

Arnold, T., & Betsholtz, C. (2013) · Vascular Cell · doi:10.1186/2045-824x-5-4 · Cited by 146 · see citing works

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune functionPreprint

Akay, L. A., Effenberger, A. H., & Tsai, L. (2021) · Genes & Development · doi:10.1101/gad.344218.120 · Cited by 142 · see citing works

Impaired Autophagy in APOE4 Astrocytes

Simonovitch, S., Schmukler, E., Bespalko, A., Iram, T., Frenkel, D., Holtzman, D. M., Masliah, E., Michaelson, D. M., & Pinkas-Kramarski, R. (2016) · Journal of Alzheimer's Disease · doi:10.3233/jad-151101 · Cited by 136 · see citing works

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

Mahan, T. E., Wang, C., Bao, X., Choudhury, A., Ulrich, J. D., & Holtzman, D. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00516-0 · Cited by 134 · see citing works

Disruption of oligodendrocyte progenitor cells is an early sign of pathology in the triple transgenic mouse model of Alzheimer's disease

Vanzulli, I., Papanikolaou, M., De-La-Rocha, I. C., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A., Rodríguez, J. J., & Butt, A. M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.016 · Cited by 130 · see citing works

Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

Festa, B. P., Siddiqi, F. H., Jimenez-Sanchez, M., Won, H., Rob, M., Djajadikerta, A., Stamatakou, E., & Rubinsztein, D. C. (2023) · Neuron · doi:10.1016/j.neuron.2023.04.006 · Cited by 129 · see citing works

Role of Oligodendrocyte Dysfunction in Demyelination, Remyelination and Neurodegeneration in Multiple Sclerosis

Dulamea, A. O. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-47861-6_7 · Cited by 128 · see citing works

Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

Schmukler, E., Solomon, S., Simonovitch, S., Goldshmit, Y., Wolfson, E., Michaelson, D. M., & Pinkas-Kramarski, R. (2020) · Cell Death & Disease · doi:10.1038/s41419-020-02776-4 · Cited by 125 · see citing works

Implication of cerebral astrocytes in major depression: A review of fine neuroanatomical evidence in humans

O’Leary, L. A., & Mechawar, N. (2021) · Glia · doi:10.1002/glia.23994 · Cited by 122 · see citing works

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs

Parcon, P. A., Balasubramaniam, M., Ayyadevara, S., Jones, R. A., Liu, L., Shmookler Reis, R. J., Barger, S. W., Mrak, R. E., & Griffin, W. S. T. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.07.754 · Cited by 122 · see citing works

TRPV1 sustains microglial metabolic reprogramming in Alzheimer's disease

Lu, J., Zhou, W., Dou, F., Wang, C., & Yu, Z. (2021) · The EMBO Reports · doi:10.15252/embr.202052013 · Cited by 121 · see citing works

Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease

Fairley, L. H., Wong, J. H., & Barron, A. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624538 · Cited by 120 · see citing works

Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination

Bankston, A. N., Forston, M. D., Howard, R. M., Andres, K. R., Smith, A. E., Ohri, S. S., Bates, M. L., Bunge, M. B., & Whittemore, S. R. (2019) · Glia · doi:10.1002/glia.23646 · Cited by 112 · see citing works

Celastrol enhances transcription factor EB (TFEB)-mediated autophagy and mitigates Tau pathology: Implications for Alzheimer's disease therapy

Yang, C., Su, C.-F., Iyaswamy, A., Krishnamoorthi, S. K., Zhu, Z., Yang, S., Tong, B. C., Liu, J., Sreenivasmurthy, S. G., Guan, X., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.01.017 · Cited by 112 · see citing works

The contribution of glial cells to Huntington's disease pathogenesis

Wilton, D. K., & Stevens, B. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104963 · Cited by 112 · see citing works

Oligodendrocytes and Microglia: Key Players in Myelin Development, Damage and Repair

Kalafatakis, I., & Karagogeos, D. (2021) · Biomolecules · doi:10.3390/biom11071058 · Cited by 111 · see citing works

Microglial autophagy is impaired by prolonged exposure to β-amyloid peptides: evidence from experimental models and Alzheimer’s disease patients

Pomilio, C., Gorojod, R. M., Riudavets, M., Vinuesa, A., Presa, J., Gregosa, A., Bentivegna, M., Alaimo, A., Alcon, S. P., Sevlever, G., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00161-9 · Cited by 109 · see citing works

Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

Lundquist, M. R., Goncalves, M. D., Loughran, R. M., Possik, E., Vijayaraghavan, T., Yang, A., Pauli, C., Ravi, A., Verma, A., Yang, Z., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.03.037 · Cited by 106 · see citing works

Central role of glucocorticoid receptors in Alzheimer's disease and depression

Canet, G., Chevallier, N., Zussy, C., Desrumaux, C., & Givalois, L. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00739 · Cited by 106 · see citing works

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

Narayan, P. S., Holmström, K. M., Kim, D.-H., Whitcomb, D. J., Wilson, M. R., George‐Hyslop, P. S., Wood, N. W., Dobson, C. M., Cho, K., Abramov, A. Y., et al. (2014) · Biochemistry · doi:10.1021/bi401606f · Cited by 104 · see citing works

Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration

Noori, A., Mezlini, A. M., Hyman, B. T., Serrano-Pozo, A., & Das, S. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105225 · Cited by 98 · see citing works

Neuron-astrocyte transmitophagy is altered in Alzheimer's disease

Lampinen, R., Belaya, I., Saveleva, L., Liddell, J. R., Rait, D., Huuskonen, M. T., Giniatullina, R., Sorvari, A., Soppela, L., Mikhailov, N., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105753 · Cited by 97 · see citing works

Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies

Rocha, N. P., Ribeiro, F. M., Furr-Stimming, E. E., & Teixeira, A. L. (2016) · Mediators of Inflammation · doi:10.1155/2016/8653132 · Cited by 95 · see citing works

Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy

Kaji, S., Maki, T., Kinoshita, H., Uemura, N., Ayaki, T., Kawamoto, Y., Furuta, T., Urushitani, M., Hasegawa, M., Kinoshita, Y., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.12.001 · Cited by 93 · see citing works

Astrocyte-Derived CCL2 is Associated with M1 Activation and Recruitment of Cultured Microglial Cells

He, M., Dong, H., Huang, Y., Lu, S., Zhang, S., Qian, Y., & Jin, W. (2016) · Cellular Physiology and Biochemistry · doi:10.1159/000443040 · Cited by 92 · see citing works

Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age

Mills, W. A., Woo, A. M., Jiang, S., Martin, J., Surendran, D., Bergstresser, M., Kimbrough, I. F., Eyo, U. B., Sofroniew, M. V., & Sontheimer, H. W. (2022) · Nature Communications · doi:10.1038/s41467-022-29475-2 · Cited by 91 · see citing works

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

Zhang, Y., & Zhao, J. (2015) · DNA and Cell Biology · doi:10.1089/dna.2014.2738 · Cited by 88 · see citing works

Microglial morphology in Alzheimer’s disease and after Aβ immunotherapy

Franco-Bocanegra, D., Gourari, Y., McAuley, C., Chatelet, D. S., Johnston, D. A., Nicoll, J. A. R., & Boche, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-95535-0 · Cited by 85 · see citing works

Brain region‐specific amyloid plaque‐associated myelin lipid loss, APOE deposition and disruption of the myelin sheath in familial Alzheimer’s disease mice

Kaya, I., Jennische, E., Lange, S., Baykal, A. T., Malmberg, P., & Fletcher, J. S. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14999 · Cited by 84 · see citing works

Autophagy in traumatic brain injury: a new target for therapeutic intervention

Zhang, L., & Wang, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00190 · Cited by 82 · see citing works

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Chavarría, C., Rodríguez-Bottero, S., Quijano, C., Cassina, P., & Souza, J. M. (2018) · Biochemical Journal · doi:10.1042/bcj20180297 · Cited by 82 · see citing works

Mouse resident microglia: Isolation and characterization of immunoregulatory properties with naïve CD4 and CD8 T‐cells

Havenith, C. E. G., Askew, D., & Walker, W. S. G. (1998) · Glia · doi:10.1002/(sici)1098-1136(199804)22:4 · Cited by 80 · see citing works

Aβ oligomers promote oligodendrocyte differentiation and maturation via integrin β1 and Fyn kinase signaling

Quintela-López, T., Ortiz-Sanz, C., Serrano-Regal, M. P., Gaminde-Blasco, A., Valero, J., Baleriola, J., Sánchez-Gómez, M. V., Matute, C., & Alberdi, E. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1636-8 · Cited by 80 · see citing works

Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity

Collins-Praino, L. E., Francis, Y. I., Griffith, E. Y., Wiegman, A. F., Urbach, J., Lawton, A., Honig, L. S., Cortes, E., Vonsattel, J. P. G., Canoll, P. D., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0083-0 · Cited by 79 · see citing works

Presenilin-1 Mutation Sensitizes Oligodendrocytes to Glutamate and Amyloid Toxicities, and Exacerbates White Matter Damage and Memory Impairment in Mice

Pak, K. J., Chan, S. L., & Mattson, M. P. (2003) · NeuroMolecular Medicine · doi:10.1385/nmm:3:1:53 · Cited by 77 · see citing works

Atp13a2 Deficiency Aggravates Astrocyte‐Mediated Neuroinflammation via NLRP 3 Inflammasome Activation

Qiao, C., Yin, N., Gu, H., Zhu, J., Ding, J., Lu, M., & Hu, G. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12514 · Cited by 77 · see citing works

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain

Norden, D. M., Trojanowski, P. J., Walker, F. R., & Godbout, J. P. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.04.014 · Cited by 73 · see citing works

Alpha-synuclein fibrils recruit TBK1 and OPTN to lysosomal damage sites and induce autophagy in microglial cells

Bussi, C., Ramos, J. M. P., Arroyo, D. S., Gallea, J. I., Ronchi, P., Kolovou, A., Wang, J. M., Florey, O., Celej, M. S., Schwab, Y., et al. (2018) · Journal of Cell Science · doi:10.1242/jcs.226241 · Cited by 72 · see citing works

Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation

Lu, S., Guo, Y.-S., Liang, P., Zhang, S., Yin, S., Yin, Y., Wang, X., Ding, F., Gu, X., & Zhou, J. (2019) · Translational Neurodegeneration · doi:10.1186/s40035-018-0143-7 · Cited by 70 · see citing works

Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death

Aber, E. R., Griffey, C. J., Davies, T., Li, A. M., Yang, Y. J., Croce, K. R., Goldman, J. E., Grutzendler, J., Canman, J. C., & Yamamoto, A. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111480 · Cited by 70 · see citing works

Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury

Saraswat Ohri, S., Bankston, A. N., Mullins, S. A., Liu, Y., Andres, K. R., Beare, J. E., Howard, R. M., Burke, D. A., Riegler, A. S., Smith, A. E., et al. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0679-17.2018 · Cited by 70 · see citing works

Slow degradation in phagocytic astrocytes can be enhanced by lysosomal acidification

Lööv, C., Mitchell, C. H., Simonsson, M., & Erlandsson, A. (2015) · Glia · doi:10.1002/glia.22873 · Cited by 69 · see citing works

Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin Mutant

Smith, C. M., Mayer, J. A., & Duncan, I. D. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0233-13.2013 · Cited by 69 · see citing works

Human Traumatic Brain Injury Results in Oligodendrocyte Death and Increases the Number of Oligodendrocyte Progenitor Cells

Flygt, J., Gumucio, A., Ingelsson, M., Skoglund, K., Holm, J., Alafuzoff, I. I., & Marklund, N. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw025 · Cited by 67 · see citing works

Autophagy‐related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex

Wang, S., Li, B., Qiao, H., Lv, X., Liang, Q., Shi, Z., Xia, W., Ji, F., & Jiao, J. (2014) · EMBO Reports · doi:10.15252/embr.201338343 · Cited by 66 · see citing works

Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide

Li, W., Tang, Y., Fan, Z., Meng, Y. J., Yang, G., Luo, J., & Ke, Z. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-27 · Cited by 64 · see citing works

Overexpression of α‐synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis

Erustes, A. G., Stefani, F. Y., Terashima, J. Y., Stilhano, R. S., Monteforte, P. T., Pereira, G. J. S., Han, S. W., Calgarotto, A. K., Hsu, Y., Ureshino, R. P., et al. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24092 · Cited by 64 · see citing works

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Estfanous, S. Z. K., Daily, K. P., Eltobgy, M. M., Deems, N. P., Anne, M. N. K., Krause, K., Badr, A., Hamilton, K., Carafice, C., Hegazi, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705581 · Cited by 63 · see citing works

Activation of PPARα enhances astroglial uptake and degradation of β-amyloid

Raha, S., Ghosh, A., Dutta, D., Patel, D. R., & Pahan, K. (2021) · Science Signaling · doi:10.1126/scisignal.abg4747 · Cited by 63 · see citing works

Autophagy in Multiple Sclerosis: Two Sides of the Same Coin

Misrielal, C., Mauthe, M., Reggiori, F., & Eggen, B. J. L. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.603710 · Cited by 54 · see citing works

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72 -ALS iPSC-derived microglia contributes to neurodegeneration

Banerjee, P., Mehta, A. R., Nirujogi, R. S., Cooper, J. D., James, O. G., Nanda, J., Longden, J., Burr, K., McDade, K., Salzinger, A., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq0651 · Cited by 54 · see citing works

ApoE4 attenuates autophagy via FoxO3a repression in the brain

Sohn, H.-Y., Kim, S.-I., Park, J.-Y., Park, S.-H., Koh, Y. H., Kim, J., & Jo, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-97117-6 · Cited by 54 · see citing works

Accelerated Dystrophy and Decay of Oligodendrocyte Precursor Cells in the APP/PS1 Model of Alzheimer’s-Like Pathology

Chacon-De-La-Rocha, I., Fryatt, G., Rivera, A. D., Verkhratsky, A., Raineteau, O., Gomez-Nicola, D., & Butt, A. M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.575082 · Cited by 52 · see citing works

Good, bad, and neglectful: Astrocyte changes in neurodegenerative disease

Jiwaji, Z., & Hardingham, G. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.02.020 · Cited by 51 · see citing works

Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α‐synuclein in oligodendroglial cells

Pukaß, K., Goldbaum, O., & Richter‐Landsberg, C. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13256 · Cited by 49 · see citing works

Oxidative Stress Promotes Uptake, Accumulation, and Oligomerization of Extracellular α-Synuclein in Oligodendrocytes

Pukaß, K., & Richter‐Landsberg, C. (2013) · Journal of Molecular Neuroscience · doi:10.1007/s12031-013-0154-x · Cited by 48 · see citing works

Microglial overexpression of fALS-linked mutant SOD1 induces SOD1 processing impairment, activation and neurotoxicity and is counteracted by the autophagy inducer trehalose

Massenzio, F., Peña‐Altamira, E., Petralla, S., Virgili, M., Zuccheri, G., Miti, A., Polazzi, E., Mengoni, I., Piffaretti, D., & Monti, B. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.10.013 · Cited by 45 · see citing works

Growth Factors and Astrocytes Metabolism: Possible Roles for Platelet Derived Growth Factor

Cabezas, R., Ávila-Rodriguez, M., Vega-Vela, N. E., Echeverrı́a, V., González, J., Hidalgo‐Lanussa, O., dos Santos, A. B., Aliev, G. M., & Barreto, G. E. (2015) · Medicinal Chemistry · doi:10.2174/1573406411666151019120444 · Cited by 43 · see citing works

FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology

Du, S., Jin, F., Maneix, L., Gedam, M., Xu, Y., Catic, A., Wang, M. C., & Zheng, H. (2021) · Aging Cell · doi:10.1111/acel.13432 · Cited by 42 · see citing works

Apoptotic neurons and amyloid-beta clearance by phagocytosis in Alzheimer's disease: Pathological mechanisms and therapeutic outlooks

Tajbakhsh, A., Read, M. I., Barreto, G. E., Ávila-Rodriguez, M., Hayat, S. M. G., & Sahebkar, A. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173873 · Cited by 41 · see citing works

Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes

Granatiero, V., Sayles, N. M., Savino, A. M., Konràd, C., Kharas, M. G., Kawamata, H., & Manfredi, G. (2021) · Autophagy · doi:10.1080/15548627.2021.1899682 · Cited by 41 · see citing works

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

Chandrasekaran, A., Dittlau, K. S., Corsi, G. I., Haukedal, H., Doncheva, N. T., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Zhang, Y., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.09.013 · Cited by 41 · see citing works

Microglia‐specific knock‐out of NF‐κB / IKK2 increases the accumulation of misfolded α‐synuclein through the inhibition of p62/ sequestosome ‐1‐dependent autophagy in the rotenone model of Parkinson's disease

Rocha, S. M., Kirkley, K. S., Chatterjee, D., Aboellail, T., Smeyne, R. J., & Tjalkens, R. B. (2023) · Glia · doi:10.1002/glia.24385 · Cited by 40 · see citing works

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Chen, W., He, B., Tong, W., Zeng, J., & Zheng, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00298 · Cited by 37 · see citing works

Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy

Wang, M., Zhang, X., Liu, H., Ma, W., Zhang, M., Zhang, Y., Li, X., Dou, M., Jing, Y., Chu, Y., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.08.006 · Cited by 37 · see citing works

Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain

Ferreira, S., Pitman, K. A., Wang, S., Summers, B. S., Bye, N., Young, K. M., & Cullen, C. L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24672 · Cited by 36 · see citing works

Downregulation of ATP6V1A Involved in Alzheimer’s Disease via Synaptic Vesicle Cycle, Phagosome, and Oxidative Phosphorylation

Zhou, Z., Bai, J., Zhong, S., Zhang, R., Kang, K., Zhang, X., Xu, Y., Zhao, C., & Zhao, M. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5555634 · Cited by 36 · see citing works

Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension

Eide, P. K., Hasan‐Olive, M. M., Hansson, H., & Enger, R. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24743 · Cited by 35 · see citing works

Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

Fernandes, M. G. F., Luo, J. X. X., Cui, Q., Perlman, K., Pernin, F., Yaqubi, M., Hall, J. A., Dudley, R., Srour, M., Couturier, C., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01557-1 · Cited by 34 · see citing works

Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models

Mavroeidi, P., Arvanitaki, F., Vetsi, M., Becker, S., Vlachakis, D., Jensen, P. H., Stefanis, L., & Xilouri, M. (2022) · Autophagy · doi:10.1080/15548627.2021.2016256 · Cited by 34 · see citing works

Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins

Fote, G., Geller, N. R., Efstathiou, N. E., Hendricks, N. G., Vavvas, D. G., Reidling, J. C., Thompson, L. M., & Steffan, J. S. (2022) · Journal of Cell Science · doi:10.1242/jcs.258687 · Cited by 33 · see citing works

The effect of A1 and A2 reactive astrocyte expression on hydrocephalus shunt failure

Khodadadei, F., Arshad, R., Morales, D. M., Gluski, J. M., Marupudi, N. I., McAllister, J. P., Limbrick, D. D., & Harris, C. A. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00367-3 · Cited by 33 · see citing works

The Effects of Alpha-Linolenic Acid on the Secretory Activity of Astrocytes and β Amyloid-Associated Neurodegeneration in Differentiated SH-SY5Y Cells: Alpha-Linolenic Acid Protects the SH-SY5Y cells against β Amyloid Toxicity

Litwiniuk, A., Domańska, A., Chmielowska, M., Martyńska, L., Bik, W., & Kalisz, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8908901 · Cited by 33 · see citing works

SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden

Yilmaz, R., Müller, K., Brenner, D., Volk, A. E., Borck, G., Hermann, A., Meitinger, T., Strom, T. M., Danzer, K. M., Ludolph, A. C., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.10.018 · Cited by 30 · see citing works

Nuclear factor ? B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations

Sako, W., Ito, H., Yoshida, M., Koizumi, H., Kamada, M., Fujita, K., Hashizume, Y., Izumi, Y., & Kaji, R. (2012) · Clinical Neuropathology · doi:10.5414/np300493 · Cited by 30 · see citing works

Autophagy Mediates Astrogenesis in Adult Hippocampal Neural Stem Cells

Ha, S., Jeong, S.-H., Yi, K., Chu, J. J.-M., Kim, S., Kim, E., & Yu, S. (2019) · Experimental Neurobiology · doi:10.5607/en.2019.28.2.229 · Cited by 29 · see citing works

White Matter and Neuroprotection in Alzheimer’s Dementia

Lorenzini, L., Fernández, M., Baldassarro, V. A., Bighinati, A., Giuliani, A., Calzà, L., & Giardino, L. (2020) · Molecules · doi:10.3390/molecules25030503 · Cited by 29 · see citing works

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Chavda, V. K., Singh, K., Patel, V., Mishra, M., & Mishra, A. K. (2022) · Brain Sciences · doi:10.3390/brainsci12010075 · Cited by 29 · see citing works

Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X7R

Beltran-Lobo, P., Reid, M. J., Jiménez-Sánchez, M., Verkhratsky, A., Perez‐Nievas, B. G., & Noble, W. J. (2022) · Essays in Biochemistry · doi:10.1042/ebc20220079 · Cited by 28 · see citing works

Roles for H+/K+‐ ATPase and zinc transporter 3 in cAMP ‐mediated lysosomal acidification in bafilomycin A1 ‐treated astrocytes

Lee, H., & Koh, J. (2020) · Glia · doi:10.1002/glia.23952 · Cited by 27 · see citing works

Autophagic degradation of CNS myelin maintains axon integrity

Ktena, N., Kaplanis, S. I., Kolotuev, I., Georgilis, A., Stavroulaki, V., Kallergi, E., Nikoletopoulou, V., Karagogeos, D., & Savvaki, M. (2022) · Cell Stress · doi:10.15698/cst2022.12.274 · Cited by 26 · see citing works

Neuronal expression of pathological tau accelerates oligodendrocyte progenitor cell differentiation

Ossola, B., Zhao, C., Compston, A., Pluchino, S., Franklin, R. J. M., & Spillantini, M. G. (2015) · Glia · doi:10.1002/glia.22940 · Cited by 24 · see citing works

Autophagy‐Mediated Inflammatory Cytokine Secretion in Sporadic ALS Patient iPSC‐Derived Astrocytes

BaofengFeng, Amponsah, A. E., Guo, R., Liu, X., Zhang, J., Du, X., Zhou, Z., He, J., Ma, J., & Cui, H. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6483582 · Cited by 24 · see citing works

Cilostazol restores autophagy flux in bafilomycin A1-treated, cultured cortical astrocytes through lysosomal reacidification: roles of PKA, zinc and metallothionein 3

Kim, H., Seo, B.-R., Kim, H., & Koh, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-66292-3 · Cited by 22 · see citing works

Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures

Alam, M. M., Zhao, X., Liao, Y., Mathur, R., McCallum, S. E., Mazurkiewicz, J. E., Adamo, M. A., Feustel, P. J., Belin, S., Poitelon, Y., et al. (2021) · eNeuro · doi:10.1523/eneuro.0183-20.2021 · Cited by 21 · see citing works

Reduced mitochondria membrane potential and lysosomal acidification are associated with decreased oligomeric Aβ degradation induced by hyperglycemia: A study of mixed glia cultures

Huang, Y., Hsu, S.-M., Shie, F., Shiao, Y., Chao, L.-J., Chen, H., Yao, H.-H., Chien, M. A., Lin, C., & Tsay, H.-J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0260966 · Cited by 17 · see citing works

Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes

Wakida, N. M., Lau, A., Nguyen, J., Cruz, G. M. S., Fote, G., Steffan, J. S., Thompson, L. M., & Berns, M. W. (2022) · Journal of Huntington s Disease · doi:10.3233/jhd-210502 · Cited by 15 · see citing works

Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels

Prtenjača, N., Rob, M., Alam, M. S., Markovinović, A., Stuani, C., Buratti, E., & Munitić, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126829 · Cited by 14 · see citing works

Role of NCKAP1 in the Defective Phagocytic Function of Microglia-Like Cells Derived from Rapidly Progressing Sporadic ALS

Noh, M., Kwon, M., Oh, K., Nahm, M., Park, J., Kim, Y.-E., Ki, C., Jin, H. K., Bae, J., & Kim, S. H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03339-2 · Cited by 14 · see citing works

NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

Pereira, C. A. S., Medaglia, N. D. C., Ureshino, R. P., Bincoletto, C., Antonioli, M., Fimia, G. M., Piacentini, M., Pereira, G. J. S., Erustes, A. G., & Smaili, S. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065593 · Cited by 14 · see citing works

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease

Jewett, M. A. S., Dickson, E., Brolin, K. A., Negrini, M., Jiménez-Ferrer, I., & Swanberg, M. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00222 · Cited by 9 · see citing works

Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies.

Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138 · see citing works

Reactive gliosis in traumatic brain injury: a comprehensive review

Amlerova, Z., Chmelová, M., Anděrová, M., & Vargová, L. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1335849 · Cited by 86 · see citing works

Targeting autophagy in Alzheimer’s disease: Animal models and mechanisms

Zhang, X.-W., 澳门大学中华医药研究院中药质量研究国家重点实验室, 澳. 凼. 9., State Key Laboratory of Quality Research in Chinese Medicine, I. O. C. M. S., Zhu, X.-X., Tang, D.-S., Lu, J.-H., 佛山大学广东省动物分子设计与精准育种重点实验室, 广., & Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, G. E. T. C. O. G. P. (2023) · Zoological Research · doi:10.24272/j.issn.2095-8137.2023.294 · Cited by 77 · see citing works

H4K12 lactylation-regulated NLRP3 is involved in cigarette smoke-accelerated Alzheimer-like pathology through mTOR-regulated autophagy and activation of microglia

Wang, H., Xia, H., Bai, J., Wang, Z., Wang, Y., Lin, J., Cheng, C., Chen, W., Zhang, J., Zhang, Q., et al. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.137310 · Cited by 49 · see citing works

The complex relationship between gut microbiota and Alzheimer’s disease: A systematic review

Zhou, X.-P., Sun, L.-B., Liu, W., Zhu, W.-M., Li, L.-C., Song, X., Xing, J.-P., & Gao, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102637 · Cited by 50 · see citing works

The potential influence of melatonin on mitochondrial quality control: a review

Lei, X., Xu, Z., Huang, L., Huang, Y., Tu, S., Xu, L., & Liu, D. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1332567 · Cited by 36 · see citing works

Lysosomal acidification impairment in astrocyte-mediated neuroinflammation

Zeng, J., Indajang, J., Pitt, D., & Lo, C. H. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03410-w · Cited by 38 · see citing works

Unravelling neuronal death mechanisms: The role of cytokines and chemokines in immune imbalance in Alzheimer’s disease progression

Kumari, S., Dhapola, R., Sharma, P., Paidlewar, M., Vellingiri, B., Medhi, B., & HariKrishnaReddy, D. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102883 · Cited by 34 · see citing works

Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention

Jia, B., Xu, Y., & Zhu, X. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102711 · Cited by 27 · see citing works

Macrophages and autophagy: partners in crime

Vitaliti, A., Reggio, A., & Palma, A. (2024) · The FEBS Journal · doi:10.1111/febs.17305 · Cited by 23 · see citing works

Targeting secretory autophagy in solid cancers: mechanisms, immune regulation and clinical insights

Li, X., & Zhao, H. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00603-0 · Cited by 23 · see citing works

Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease

Jury-Garfe, N., Redding-Ochoa, J., You, Y., Martínez, P., Karahan, H., Chimal-Juárez, E., Johnson, T. S., Zhang, J., Resnick, S., Kim, J., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-024-02775-1 · Cited by 22 · see citing works

Efficacy and molecular mechanisms of hesperidin in mitigating Alzheimer's disease: A systematic review

Han, X., Zhang, Y., Zhang, L., Zhang, L., & Wang, Y. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117144 · Cited by 22 · see citing works

Beneficial versus Detrimental Effects of Complement–Microglial Interactions in Alzheimer’s Disease

Ayyubova, G., & Fazal, N. (2024) · Brain Sciences · doi:10.3390/brainsci14050434 · Cited by 20 · see citing works

A ROS-Responsive nanoparticle for nuclear gene delivery and autophagy restoration in Parkinson's disease therapy

Zhai, L., Gao, Y., Yang, H., Wang, H., Liao, B., Cheng, Y., Liu, C., Che, J., Xia, K., Zhang, L., et al. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123345 · Cited by 17 · see citing works

Autophagy in alzheimer disease pathogenesis and its therapeutic values

Angst, G., Jia, N., Esqueda, L. T., Fan, Y., Cai, Q., & Wang, C. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2471677 · Cited by 19 · see citing works

Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance

Dematteis, G., Gong, C., Malecka, J., Tonelli, E., Genazzani, A. A., Tapella, L., Eleuteri, A. M., Lim, D., & Bonfili, L. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01793-9 · Cited by 14 · see citing works

Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management

Singh, B., Mahajan, S., Abdella, S., Khan, R., & Garg, S. (2025) · Medicinal Research Reviews · doi:10.1002/med.70013 · Cited by 14 · see citing works

AdipoRon promotes amyloid‐β clearance through enhancing autophagy via nuclear GAPDH‐induced sirtuin 1 activation in Alzheimer's disease

Sun, F., Wang, J., Meng, L., Zhou, Z., Xu, Y., Yang, M., Li, Y., Jiang, T., Liu, B., & Yan, H. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16400 · Cited by 15 · see citing works

Exploring the interplay of glucose metabolism, insulin resistance, and neurodegenerative pathologies: insights from streptozotocin and hypoglycaemic in vitro models

Grünblatt, E., Ohki, C. M. Y., Schmitt-Böhrer, G. A., Riederer, P. F., & Walitza, S. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02891-6 · Cited by 13 · see citing works

Deletion of Gadd45a Expression in Mice Leads to Cognitive and Synaptic Impairment Associated with Alzheimer’s Disease Hallmarks

Griñán‐Ferré, C., Jarné‐Ferrer, J., Bellver‐Sanchís, A., Ribalta‐Vilella, M., Barroso, E., Salvador, J. M., Jurado-Aguilar, J., Palomer, X., Vázquez‐Carrera, M., & Pallàs, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052595 · Cited by 10 · see citing works

Autophagy and apoptosis in Alzheimer’s disease-associated neurons

Cui, J., & Cui, Z. (2025) · Discover Neuroscience · doi:10.1186/s13064-025-00210-z · Cited by 10 · see citing works

Dissecting PANoptosis in the Nervous System: A Unified Cell-Death Mechanism Driving Neuroimmune Activation and Chronic Neuroinflammation

Goel, F., Singh, P., & Nand, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06031-3 · Cited by 9 · see citing works

Beyond Support Cells: Astrocytic Autophagy as a Central Regulator of CNS Homeostasis and Neurodegenerative Diseases

Lee, J. H., Chang, W. S., Min, S. S., Song, D., & Yoo, H. (2025) · Cells · doi:10.3390/cells14171342 · Cited by 8 · see citing works

Potential of phytochemicals in the treatment of Alzheimer disease by modulating lysosomal dysfunction: a systematic review

Yuan, M., Nguyen, T. T. T., Gibb, A. J., Xian, Y., & Xu, H. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01204-z · Cited by 8 · see citing works

Neuropathological links between T2DM and LOAD: systematic review and meta-analysis

Lemche, E., Hortobágyi, T., Kiecker, C. M., & Turkheimer, F. (2025) · Physiological Reviews · doi:10.1152/physrev.00040.2024 · Cited by 8 · see citing works

Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease

Ferreira, F. D. S., de Mattos, J. L. A., da Silva, P. H. F., da Costa, C. A., Ognibene, D. T., Resende, Â. C., & de Bem, G. F. (2025) · Plants · doi:10.3390/plants14132010 · Cited by 7 · see citing works

Unrevealing role of TLRs/NLRP receptors in halting Alzheimer's neuroinflammation: Current progress and existing therapies

Upadhayay, S. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116285 · Cited by 7 · see citing works

Histone Deacetylation in Alzheimer’s Diseases (AD); Hope or Hype

Ateya, N. H., Al-Taie, S. F., Jasim, S. A., Uthirapathy, S., Chaudhary, K., Rani, P., Kundlas, M., Naidu, K. S., Amer, N. A., & Ahmed, J. K. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01670-0 · Cited by 7 · see citing works

Alpha-, Beta-, and Gamma-Secretase, Amyloid Precursor Protein, and Tau Protein Genes in the Hippocampal CA3 Subfield in an Ischemic Model of Alzheimer’s Disease with Survival up to 2 Years

Czuczwar, S. J., Kocki, J., Miziak, B., Bogucki, J., Bogucka‐Kocka, A., & Pluta, R. M. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231333 · Cited by 7 · see citing works

The Role of Stem Cell Therapies in the Treatment of Neurodegenerative Diseases

Jayaprakash, B., Savira, M., Mahmood, A. A. R., & Prasanna, M. (2024) · Current Stem Cell Research & Therapy · doi:10.2174/011574888x313112240510160102 · Cited by 6 · see citing works

Role of astrocytes in Alzheimer's disease pathogenesis and the impact of exercise-induced remodeling

Shao, J., Deng, Q., Feng, S., Wu, C., Liu, X., & Yang, L. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150418 · Cited by 5 · see citing works

Delving into Autophagy: Utilizing Natural Bioactive Compounds to Combat Alzheimer's Disease

Singh, A., Mazumder, A., Das, S., Kanda, A., Mishra, R., & Chaitanya, M. (2024) · Current Bioactive Compounds · doi:10.2174/0115734072311552240718112619 · Cited by 4 · see citing works

The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer’s disease

Tang, L., Liu, F., Sun, X., Yang, J., Liu, Y., Pan, X., Hao, L., Lou, F., & Su, J. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04160-7 · Cited by 5 · see citing works

Rescuing lysosomal/autophagic defects via nanoapproach: implications for lysosomal/autophagic defect-related diseases

Huang, X.-Y., Fang, Y., Song, J., Hao, Y., Cai, Y., Wei, P., & Zhang, N. (2025) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2400186 · Cited by 3 · see citing works

The emerging role and therapeutic targeting of autophagy-lysosome pathway in the pathogenesis of Parkinson’s disease

Shimizu, T., Isik, S., Kamath, N., & Yue, Z. (2026) · Translational Neurodegeneration · doi:10.1186/s40035-026-00555-3 · Cited by 3 · see citing works

LncRNA-driven programmed cell death networks: new therapeutic targets for neurological disorders

Xiong, Z., Sun, C., & Huang, S. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1635119 · Cited by 3 · see citing works

Antiretroviral Drugs Impact Autophagy Differently in Primary Human Astrocytes

Cheney, L., McDermott, G., Guzik, H. M., & Berman, J. W. (2025) · Cells · doi:10.3390/cells14231904 · Cited by 3 · see citing works

Alzheimer’s Disease: Pathological Mechanism and Treatment

Duan, W. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2024.19345 · Cited by 2 · see citing works

Di Huang Yi Zhi Fang improves cognitive function in APP/PS1 mice by inducing neuronal mitochondrial autophagy through the PINK1-parkin pathway

Zhang, L., An, H., Zhen, R.-R., Zhang, T., Ding, M.-R., Zhang, M., Sun, Y., & Gu, C. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877241299832 · Cited by 1 · see citing works

The protective effect of fluoxetine on hippocampal oligodendrocytes in AD mice: a potential mechanism involving S100BPreprint

Zhang, Y., Jiang, L. H., Tang, Y. C., Chen, W., & Chao, F. (2023) · Research Square · doi:10.21203/rs.3.rs-3713955/v1

Autophagy-Based Treatment Approaches in Neuropsychological Diseases

Kadıçeşme, Ş. Y. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-5908-2.ch002

PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD

Lanza, M., Basilotta, R., Caccamo, A., Casili, G., Repici, A., Oddo, S., & Esposito, E. (2025) · Cells · doi:10.3390/cells14181474

TEMPOL alleviated tau pathology and cognitive deficits induced by P301S-tau

Li, X., Liu, R., He, Y., Yang, X., Li, T., & Feng, Y. (2025) · Neuroscience Letters · doi:10.1016/j.neulet.2025.138465

Sevoflurane Exposure Exacerbates Memory Impairment and Pathological Manifestation by Inhibiting AKT /m TOR ‐Mediated Autophagy in P 301 L Tau Transgenic Mice

He, K., Zhang, Z., Li, Y., Xiong, W., Xing, Y., Gao, W., Kong, W., Chen, L., Yang, X., & Dai, Z. (2025) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.70694

Astrocyte autophagy-pyroptosis crosstalk in Alzheimer’s: insights from knowledge graphs

Liu, T., Huang, Z., & Qin, H.-Y. (2026) · BMC Neurology · doi:10.1186/s12883-026-04793-w

Neurosteroid-Mediated Neuroprotection via mTORC1/AMPK/BDNF Signaling Pathway in Alzheimer’s Disease

Khobrani, M. A., Al‐kuraishy, H. M., Hussein, N. R., Mustafa, A. M., & Batiha, G. E. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05918-5

Lysosome-targeted near-infrared fluorescent probes for monitoring aβ plaques in vivo and aβ monomers dynamic degradation in vitro

Gong, H., Li, Z., Zhao, Y., Wang, Z., & Luo, W. (2026) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2026.128160

Proteomics of post mortem brains in early‐ and late‐onset Alzheimer's disease: Unraveling differential Aβ effects and potential AD biomarkers

Thanou, E., Ganz, A. B., Pita-Illobre, D., Koopmans, F., Hoozemans, J. J. M., Rozemüller, A. J. M., Holstege, H. H., SMIT, A. B., & Li, K. W. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71662

Machine learning-driven plasma proteomics identifies MBP/PSMD10 panel for stratification of mild-to-moderate clinical Alzheimer's disease

Han, X.-H., Yang, Y., Wang, T., Zhu, Y., Chai, W., Rao, J., Yang, P., Liu, Z.-Q., Fang, S.-S., Qu, X.-H., et al. (2026) · Current Proteomics · doi:10.1016/j.curpro.2026.100143

Subchronic diethyl phthalate exposure aggravates Alzheimer-like phenotypes in 5XFAD mice: Partial attenuation by Akt activation

Zhao, J., Zhang, S., Gao, D., Xie, L., Wang, Y., & Peng, D. (2026) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2026.112116

Hippocampal AdipoR1 regulates the microglial response and delays disease progression in a mouse model of Alzheimer’s disease

Li, J., Jiang, L., 晁凤蕾, Zhang, L., 胡春年, Zhou, Y., Wang, S., Pan, Q., Luo, Y., Tang, J., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03907-7

Ganoderma lucidum for Alzheimer's disease: A neuroinflammatory and oxidative stress perspective

Gao, J., 张文杰, Yang, F., Peng, G., Zhang, T., Dong, T., & Wang, J. (2026) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2026.122442

Astrocytic timekeepers and their influence on brain waste clearance in Alzheimer's disease

Koenders, C. L., Chiu, R. K., Medeiros-Furquim, T., & Bergink, S. (2026) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2026.100155

CCA, a cassane diterpene from Caesalpinia bonduc ameliorates cognition impairment in Alzheimer’s disease mice by regulating neuroinflammation and autophagy

Zhou, J., Zhang, W., Yang, Y., Jin, Y., Li, X., Wang, Y., Lu, H., Gao, H., & Jiang, X. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61228-9

Molecular Regulation Mechanism of Microglial Autophagy in the Pathology of Alzheimer's Disease

Ou-Yang, P., Cai, Z., & Zhang, Z.-H. (2023) · Aging and Disease · doi:10.14336/ad.2023.0106 · Cited by 21 · see citing works

Pharmacological modulation of autophagy for Alzheimer's disease therapy: Opportunities and obstacles

Deng, Z., Dong, Y., Zhou, X., Lu, J.-H., & Yue, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.009 · Cited by 58 · see citing works

Advancements in autophagy perturbations in Alzheimer’s disease: Molecular aspects and therapeutics

Dhapola, R., Kumari, S., Sharma, P., Vellingiri, B., & HariKrishnaReddy, D. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149494 · Cited by 17 · see citing works

Autophagy Dysfunction in Alzheimer’s Disease: Mechanistic Insights and New Therapeutic Opportunities

Di Meco, A., Curtis, M. E., Lauretti, E., & Praticò, D. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.008 · Cited by 133 · see citing works

Autophagy in alzheimer disease pathogenesis and its therapeutic values

Angst, G., Jia, N., Esqueda, L. T., Fan, Y., Cai, Q., & Wang, C. (2025) · Autophagy Reports · doi:10.1080/27694127.2025.2471677 · Cited by 19 · see citing works