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Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

Verheyen, An, Diels, Annick, Reumers, Joke, Van Hoorde, Kirsten, Van den Wyngaert, Ilse, van Outryve d’Ydewalle, Constantin, De Bondt, An, Kuijlaars, Jacobine, De Muynck, Louis, De Hoogt, Ronald, Bretteville, Alexis, Jaensch, Steffen, Buist, Arjan, Cabrera-Socorro, Alfredo, Wray, Selina, Ebneth, Andreas, Roevens, Peter, Royaux, Ines, Peeters, Pieter J.·2018·Stem Cell Reports
DOI 10.1016/j.stemcr.2018.06.022PMC PMC6093179
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  • Mature neurons derived from MAPT IVS10+16 hiPSCs with 120-day differentiation recapitulate FTD hallmarks: 4R/3R Tau unbalance, neurodegenerative and neurodevelopmental phenotypes, and impaired neuronal excitability.

    “Mature neurons derived from 10 + 16 hiPSCs with 120-day-long differentiation protocol are obtained to recapitulate several FTD hallmarks: 4R/3R Tau unbalance, neurodegenerative and neurodevelopmental phenotypes [48] and impaired neuronal excitability [49, 50].”

    From miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal Dementia (2025) · cites this paper as [48]

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Research works printed but not linked: 40

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Metadata

Authors
Verheyen, A., Diels, A., Reumers, J., Van Hoorde, K., Van den Wyngaert, I., van Outryve d’Ydewalle, C., De Bondt, A., Kuijlaars, J., De Muynck, L., De Hoogt, R., Bretteville, A., Jaensch, S., Buist, A., Cabrera-Socorro, A., Wray, S., Ebneth, A., Roevens, P., Royaux, I., & Peeters, P. J.
Venue
Stem Cell Reports
Publisher
Elsevier BV
Published
2018-08
Volume
11
Issue
2
Pages
363-379
ISSN
2213-6711
DOI
10.1016/j.stemcr.2018.06.022
PMC
PMC6093179
Cited by
69
References
3
Language
en
Update notices
erratum (2019-08-13)
Licence
Funders
Innovative Medicines Initiative (115582, 115439)

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