Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids
Open accessAbstract
Human induced pluripotent stem cell (hiPSC)-derived hair-bearing skin organoids offer exciting new possibilities for modeling diseases like epidermolysis bullosa (EB). These inherited diseases affect 1 in 30,000 people worldwide and result from perturbed expression and/or structure of components of the epidermal-dermal junction (EDJ). To establish whether hiPSC-derived skin organoids might be able to capture salient features of EB, it is thus important to characterize their EDJ. Here, we report successful generation of hair-bearing skin organoids from two hiPSC lines that exhibited fully stratified interfollicular epidermis. Using immunofluorescence and electron microscopy, we showed that basal keratinocytes in organoids adhere to laminin-332 and type IV collagen-rich basement membrane via type I hemidesmosomes and integrin β1-based adhesion complexes. Importantly, we demonstrated that EDJs in organoids are almost devoid of type VII collagen, a fibril that mediates anchorage of the epidermis to dermis. This should be considered when using skin organoids for EB modeling.
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hiPSC-derived skin organoids have hair follicles, pigmentation, dermal stratification, appendage patterning, and innervation.
“Recent advances in human induced pluripotent stem cell (hiPSC) technology have enabled the generation of skin organoids (SKO) with hair follicles, pigmentation, dermal stratification, appendage patterning, and innervation.[ 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ]”
From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [31]
Previous human SKO models were devoid of vascularization and immune cells.
“Previous human SKO models were devoid of vascularization and immune cells.[ 25 , 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 59 ]”
From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [31]
The Introduction and Results and discussion describe the organoids’ epidermal-dermal junction and cell types, but do not state whether previous skin organoid models lacked vascularization or immune cells. Searches for vascularization, endothelial cells, and immune cells found no passage addressing both claimed absences; a reference to endothelialized skin equivalents does not establish them. (LLM, conf=0.72)
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- Authors
- Ramovs, V., Janssen, H., Fuentes, I., Pitaval, A., Rachidi, W., Chuva de Sousa Lopes, S. M., Freund, C., Gidrol, X., Mummery, C. L., & Raymond, K.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Universidad del Desarrollo (CL)
- Inserm (FR)
- Leiden University (NL)
- Corresponding author
- Raymond, Karine
- ORCID
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 17
- Issue
- 6
- Pages
- 1279-1288
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC9213820
- OpenAlex
- W4280560580
- Cited by
- 44
- References
- 29
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 13 · 2023: 7 · 2022: 4
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Novo Nordisk Fonden (NNF21CC0073729)
- DEBRA International
- Institut National de la Santé et de la Recherche Médicale
- DEBRA Austria
- Leids Universitair Medisch Centrum
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- basement membrane zone, epidermolysis bullosa, type VII collagen, laminin-5, basement membrane, basal keratinocytes, disease modeling
- MeSH terms
- Epidermis, Epidermolysis Bullosa, Humans, Organoids, Skin, Keratinocytes, Induced Pluripotent Stem Cells
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