A conversation with ChatGPT on the role of computational systems biology in stem cell research
Open accessAbstract
Welcome to this special issue of Stem Cell Reports on computational systems biology. As a computationalists at heart, we are going to adhere to the advice that Larry Wall (the creator of the Perl programming language) gave to budding programmers: “ […] develop the three great virtues of a programmer: laziness, impatience, and hubris.” In the normal world, these traits are typically considered vices. However, in the world of programming, they are considered virtues because they encourage writing code instead of performing repetitive tasks manually (laziness), documenting the code and program so that people do not harass you with incessant and perhaps inane questions (impatience), and fixing and updating the program rather than letting your reputation be tarnished by buggy or outdated code (hubris).
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ChatGPT utility extends to improvement in language and better ability to express and communicate research ideas and results, ultimately speeding up the publication process with faster availability of research results.
“Moreover, the utility of ChatGPT extends to involve an improvement in language and a better ability to express and communicate research ideas and results, ultimately speeding up the publication process with the faster availability of research results [23,25,29,40,48,63,66].”
From ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns (2023) · cites this paper as [29]
In “A conversation with ChatGPT on the role of computational systems biology in stem cell research” (page unavailable), the authors say ChatGPT helped articulate ideas for their editorial and could save researchers time by generating content. The paper does not say it improves language or speeds publication and the availability of results. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSuperficial, inaccurate, or incorrect content was frequently cited as a shortcoming of ChatGPT use in scientific writing.
“First, superficial, inaccurate, or incorrect content was frequently cited as a shortcoming of ChatGPT use in scientific writing [14,28,29,40,60].”
From ChatGPT Utility in Healthcare Education, Research, and Practice: Systematic Review on the Promising Perspectives and Valid Concerns (2023) · cites this paper as [29]
In the editorial’s closing discussion (page unavailable), the authors say many ChatGPT responses lacked depth and insight, supporting the description of superficial content. They do not say the content was inaccurate or incorrect, or establish that these shortcomings were frequently cited in scientific writing. (LLM, conf=0.86)
Experimental — accuracy not yet measured
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- Authors
- Cahan, P., & Treutlein, B.
- Affiliations
- Johns Hopkins University (US)
- ETH Zurich (CH)
- Corresponding author
- Cahan, Patrick
- Treutlein, Barbara
- Venue
- Stem Cell Reports
- Publisher
- Elsevier BV
- Published
- 2023-01
- Volume
- 18
- Issue
- 1
- Pages
- 1-2
- ISSN
- 2213-6711 (ISSN-L)
- PMC
- PMC9860153
- OpenAlex
- W4315477395
- Cited by
- 125
- References
- 0
- Citations by year
- 2026: 3 · 2025: 21 · 2024: 35 · 2023: 66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc-nd)
- ETH Zürich Research Collection
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- computational systems biology, stem cell research, ChatGPT, artificial intelligence in biology
- MeSH terms
- Communication, Computational Biology, Systems Biology, Stem Cell Research
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