Cited by 74Artificial Intelligence in Healthcare and EducationArtificial Intelligence in EducationInnovations in Medical Education

Integrating ChatGPT in Orthopedic Education for Medical Undergraduates: Randomized Controlled Trial

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Gan, Wenyi, Ouyang, Jianfeng, Li, Hua, Xue, Zhaowen, Zhang, Yiming, Dong, Qiu, Huang, Jiadong, Zheng, Xiaofei +1 more·2024·Journal of Medical Internet Research

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Abstract

Background: ChatGPT is a natural language processing model developed by OpenAI, which can be iteratively updated and optimized to accommodate the changing and complex requirements of human verbal communication. Objective: The study aimed to evaluate ChatGPT’s accuracy in answering orthopedics-related multiple-choice questions (MCQs) and assess its short-term effects as a learning aid through a randomized controlled trial. In addition, long-term effects on student performance in other subjects were measured using final examination results. Methods: We first evaluated ChatGPT’s accuracy in answering MCQs pertaining to orthopedics across various question formats. Then, 129 undergraduate medical students participated in a randomized controlled study in which the ChatGPT group used ChatGPT as a learning tool, while the control group was prohibited from using artificial intelligence software to support learning. Following a 2-week intervention, the 2 groups’ understanding of orthopedics was assessed by an orthopedics test, and variations in the 2 groups’ performance in other disciplines were noted through a follow-up at the end of the semester. Results: ChatGPT-4.0 answered 1051 orthopedics-related MCQs with a 70.60% (742/1051) accuracy rate, including 71.8% (237/330) accuracy for A1 MCQs, 73.7% (330/448) accuracy for A2 MCQs, 70.2% (92/131) accuracy for A3/4 MCQs, and 58.5% (83/142) accuracy for case analysis MCQs. As of April 7, 2023, a total of 129 individuals participated in the experiment. However, 19 individuals withdrew from the experiment at various phases; thus, as of July 1, 2023, a total of 110 individuals accomplished the trial and completed all follow-up work. After we intervened in the learning style of the students in the short term, the ChatGPT group answered more questions correctly than the control group (ChatGPT group: mean 141.20, SD 26.68; control group: mean 130.80, SD 25.56; P=.04) in the orthopedics test, particularly on A1 (ChatGPT group: mean 46.57, SD 8.52; control group: mean 42.18, SD 9.43; P=.01), A2 (ChatGPT group: mean 60.59, SD 10.58; control group: mean 56.66, SD 9.91; P=.047), and A3/4 MCQs (ChatGPT group: mean 19.57, SD 5.48; control group: mean 16.46, SD 4.58; P=.002). At the end of the semester, we found that the ChatGPT group performed better on final examinations in surgery (ChatGPT group: mean 76.54, SD 9.79; control group: mean 72.54, SD 8.11; P=.02) and obstetrics and gynecology (ChatGPT group: mean 75.98, SD 8.94; control group: mean 72.54, SD 8.66; P=.04) than the control group. Conclusions: ChatGPT answers orthopedics-related MCQs accurately, and students using it excel in both short-term and long-term assessments. Our findings strongly support ChatGPT’s integration into medical education, enhancing contemporary instructional methods. Trial Registration: Chinese Clinical Trial Registry Chictr2300071774; https://www.chictr.org.cn/hvshowproject.html ?id=225740&v=1.0

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  • In Gan et al. (2024), ChatGPT-4 use raised unassisted 214-item orthopedics exam scores by 0.40 SD compared to conventional internet resources.

    “The ChatGPT group scored 0.40 SD higher on an unassisted 214-item orthopedics exam.”

    From Experimental Evidence on the Learning Impact of Generative AI (2026) · cites this paper as Gan et al. (2024)

    Methods > Intervention describes a 214-item orthopedics exam after the ChatGPT-4.0 and internet-review periods. Abstract > Results reports means of 141.20 and 130.80 with SDs of 26.68 and 25.56, yielding an approximately 0.40-SD difference. The copy does not establish that the exam was unassisted, and Results > The Accuracy of the 2 Groups gives a different ChatGPT-group mean (138.46). (LLM, conf=0.83)

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  1. [44]Al-Azri H Ratnapalan S Problem-based learning in continuing medical education: review of randomized controlled trials Can Fam Physician 2014 60 2 157 165 24522680 60/2/157 24522680 PMC3922562

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Authors
Gan, W., Ouyang, J., Li, H., Xue, Z., Zhang, Y., Dong, Q., Huang, J., Zheng, X., & Zhang, Y.
Affiliations
  • Jinan University (CN)
  • Beijing Jishuitan Hospital (CN)
Corresponding author
Zhang, Yiyi
Venue
Journal of Medical Internet Research
Published
2024-08-20
Volume
26
Pages
e57037
ISSN
1438-8871 (ISSN-L)
OpenAlex
W4401729352
Cited by
73
References
57
Citations by year
2026: 39 · 2025: 32 · 2024: 2
FWCI
6.82
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Medical Internet Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Jinan University
Topics
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Physical Sciences › Computer Science › Information Systems › Artificial Intelligence in Education
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Innovations in Medical Education
Keywords
ChatGPT, large language models, artificial intelligence in medical education, orthopaedic education, undergraduate medical students, multiple-choice question accuracy, student performance, transfer of learning, ChatGPT-4, ChatGPT-3.5
MeSH terms
Generative Artificial Intelligence, Education, Medical, Undergraduate, Educational Measurement, Female, Humans, Male, Natural Language Processing, Orthopedics, Students, Medical, Young Adult

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