Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities
Abstract
Two new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 1-10 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 8-10 exhibited cytotoxic activities with IC(50) values ranging from 3.4 to 6.6microM.
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Compound 181 showed no significant cytotoxic activity against MDA-MB-231 cells.
“Evaluated cytotoxicity against human breast adenocarcinoma MDA-MB-231 cell line and no significant activity have been observed”
From The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review (2021) · cites this paper as [128]
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- Authors
- Wu, J.-J., Cheng, K.-W., Zuo, X.-F., Wang, M.-F., Li, P., Zhang, L.-Y., Wang, H., & Ye, W.-C.
- Affiliations
- University of Hong Kong (HK)
- China Pharmaceutical University (CN)
- Jinan University (CN)
- Corresponding author
- Wang, Hao
- Ye, Wen-Cai
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 75
- Issue
- 10
- Pages
- 734-739
- ISSN
- 0039-128X (ISSN-L)
- OpenAlex
- W1980697875
- Cited by
- 25
- References
- 16
- Citations by year
- 2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Steroids (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Physical Sciences › Materials Science › Biomaterials › Phytochemistry and Bioactive Compounds
- Keywords
- Asparagus filicinus, steroidal saponins, 20-hydroxyecdysone, cytotoxicity, MDA-MB-231 cells, root constituents, natural product isolation, structure elucidation
- MeSH terms
- Cell Survival, Ecdysterone, Humans, Magnetic Resonance Spectroscopy, Plant Extracts, Saponins, Molecular Structure, Plant Roots, Asparagus Plant, Cell Line, Tumor
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