Cited by 25Phytochemical Studies and BioactivitiesNatural product bioactivities and synthesisPhytochemistry and Bioactive Compounds

Steroidal saponins and ecdysterone from Asparagus filicinus and their cytotoxic activities

Wu, Jia-Jun, Cheng, Ka-Wing, Zuo, Xiao-Feng, Wang, Ming-Fu, Li, Ping, Zhang, Lu-Yong, Wang, Hao, Ye, Wen-Cai·2010·Steroids

Abstract

Two new spirostanoides, filiasparosides E (1) and F (2), one new furostanoside, filiasparoside G (3), and one new ecdysterone, stachysterone A-20, 22-acetonide (4), together with six known steroidal saponins, asparagusin A (5), filiasparoside A (6), filiasparoside B (7), aspafilioside A (8), aspafilioside B (9), and filiasparoside C (10) were isolated from the roots of Asparagus filicinus Buch.-Ham. Their structures were elucidated on the basis of spectroscopic and chemical evidence. Compounds 1-10 were investigated for their cytotoxicities against human breast adenocarcinoma MDA-MB-231 cell line and compounds 8-10 exhibited cytotoxic activities with IC(50) values ranging from 3.4 to 6.6microM.

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Crossref · 10.1016/j.steroids.2010.05.002

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16 of 16 references verified0 citation errors · 0 not checkable

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Authors
Wu, J.-J., Cheng, K.-W., Zuo, X.-F., Wang, M.-F., Li, P., Zhang, L.-Y., Wang, H., & Ye, W.-C.
Affiliations
  • University of Hong Kong (HK)
  • China Pharmaceutical University (CN)
  • Jinan University (CN)
Corresponding author
  • Wang, Hao
  • Ye, Wen-Cai
Venue
Steroids
Publisher
Elsevier BV
Published
2010-10
Volume
75
Issue
10
Pages
734-739
ISSN
0039-128X (ISSN-L)
OpenAlex
W1980697875
Cited by
25
References
16
Citations by year
2023: 4 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 2 · 2016: 1 · 2015: 2 · 2013: 1 · 2012: 1
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Locations
  • Steroids (publishedVersion)
  • PubMed (publishedVersion)
  • The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
  • Physical Sciences › Materials Science › Biomaterials › Phytochemistry and Bioactive Compounds
Keywords
Asparagus filicinus, steroidal saponins, 20-hydroxyecdysone, cytotoxicity, MDA-MB-231 cells, root constituents, natural product isolation, structure elucidation
MeSH terms
Cell Survival, Ecdysterone, Humans, Magnetic Resonance Spectroscopy, Plant Extracts, Saponins, Molecular Structure, Plant Roots, Asparagus Plant, Cell Line, Tumor

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