Cited by 9Phytochemical Studies and BioactivitiesPhytochemistry and Biological ActivitiesNatural product bioactivities and synthesis

Two new phytoecdysteroids from Sphenocentrum jollyanum Pierre root

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Ajayi, Temitayo O., Srivedavyasasri, Radhakrishnan, Nyong, Emmanuel E., Odeniyi, Micheal A., Moody, Jones O., Ross, Samir A.·2019·Steroids

Abstract

The crude methanol extract of Sphenocentrum jollyanum root exhibited 98% and 80% antimicrobial activity against Aspergillus fumigatus Pinh and Vancomycin resistant enterococcus (VRE) at a concentration of 200 µg/mL, with IC 50 11.45 and 12.95 µg/mL, respectively. The ethyl acetate fraction of methanol extract showed in-vitro antimicrobial activity against A. fumigatus Pinh at 83% with IC 50 of <8 µg/mL. The phytochemical investigation of ethyl acetate fraction yielded six compounds, which were identified by their NMR, IR and MS spectral analyses as two new phytoecdysteroidal glycosides Sphenocentroside A (1), and Sphenocentroside B (2), and four known phytoecdysteroids: polypodoaurein (3), polypodine B (4), ecdysterone (5), and 20, 26-dihydroxyecdysone (6).

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Crossref · 10.1016/j.steroids.2019.108456

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Authors
Ajayi, T. O., Srivedavyasasri, R., Nyong, E. E., Odeniyi, M. A., Moody, J. O., & Ross, S. A.
Affiliations
  • University of Ibadan (NG)
  • University of Mississippi (US)
Corresponding author
Ross, Samir A.
Venue
Steroids
Publisher
Elsevier BV
Published
2019-10
Volume
150
Pages
108456
ISSN
0039-128X (ISSN-L)
OpenAlex
W2963409105
Cited by
9
References
23
Citations by year
2026: 2 · 2022: 4 · 2020: 2 · 2019: 1
FWCI
0.58
Type
journal article
Language
en
Open access
Locations
  • Steroids (acceptedVersion)
  • PubMed (publishedVersion)
Funders
  • American Association of University Women
  • U.S. Department of Agriculture
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
Keywords
Sphenocentrum jollyanum, phytoecdysteroids, polypodine B, 20-hydroxyecdysone, Aspergillus fumigatus, vancomycin-resistant enterococci, antimicrobial activity, root phytochemistry
MeSH terms
Anti-Bacterial Agents, Antifungal Agents, Aspergillus fumigatus, Dose-Response Relationship, Drug, Ecdysterone, Microbial Sensitivity Tests, Molecular Conformation, Plant Extracts, Stereoisomerism, Structure-Activity Relationship, Plant Roots, Menispermaceae, Vancomycin-Resistant Enterococci

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