The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights
Open accessAbstract
As part of a high-throughput structural analysis of SARS-coronavirus (SARS-CoV) proteins, we have solved the structure of the non-structural protein 9 (nsp9). This protein, encoded by ORF1a, has no designated function but is most likely involved with viral RNA synthesis. The protein comprises a single β-barrel with a fold previously unseen in single domain proteins. The fold superficially resembles an OB-fold with a C-terminal extension and is related to both of the two subdomains of the SARS-CoV 3C-like protease (which belongs to the serine protease superfamily). nsp9 has, presumably, evolved from a protease. The crystal structure suggests that the protein is dimeric. This is confirmed by analytical ultracentrifugation and dynamic light scattering. We show that nsp9 binds RNA and interacts with nsp8, activities that may be essential for its function(s).
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Metadata
- Authors
- Sutton, G., Fry, E., Carter, L., Sainsbury, S., Walter, T., Nettleship, J., Berrow, N., Owens, R., Gilbert, R., Davidson, A., Siddell, S., Poon, L. L. M., Diprose, J., Alderton, D., Walsh, M., Grimes, J. M., & Stuart, D. I.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 12
- Issue
- 2
- Pages
- 341-353
- ISSN
- 0969-2126 (ISSN-L)
- OpenAlex
- W2092033589
- Cited by
- 256
- References
- 49
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sutton, G., Fry, E., Carter, L., Sainsbury, S., Walter, T., Nettleship, J., Berrow, N., Owens, R., Gilbert, R., Davidson, A., Siddell, S., Poon, L. L. M., Diprose, J., Alderton, D., Walsh, M., Grimes, J. M., & Stuart, D. I. (2004). The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights. Structure. https://doi.org/10.1016/j.str.2004.01.016
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