The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification
Open accessAbstract
Homing endonucleases are microbial DNA-cleaving enzymes that mobilize their own reading frames by generating double strand breaks at specific genomic invasion sites. These proteins display an economy of size, and yet recognize long DNA sequences (typically 20 to 30 basepairs). They exhibit a wide range of fidelity at individual nucleotide positions, in a manner that is strongly influenced by host constraints on the coding sequence of the targeted gene. The activity of these proteins leads to site-specific recombination events that can result in the insertion, deletion, mutation or correction of DNA sequences. Over the past 15 years the crystal structures of representatives from several homing endonuclease families have been solved, and methods have been described to create variants of these enzymes that cleave novel DNA targets. Engineered homing endonucleases proteins are now being used to generate targeted genomic modifications for a variety of biotech and medical applications.
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Cites
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes
Roberts, R. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg274 · Cited by 755
Phylogenomic analysis of the GIY-YIG nuclease superfamily
Dunin-Horkawicz, S., Feder, M., & Bujnicki, J. M. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-98 · Cited by 133
Argast, G. M., Stephens, K. M., Emond, M. J., & Monnat, R. J. (1998) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.1886 · Cited by 127 · cited 1×
“Additional interdependence between adjacent basepair substitutions increases this estimate to at least 1 in 109 (Argast et al., 1998; Arnould et al., 2006; Ashworth et al., 2010; Scalley-Kim et al., 2007).”
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Cited by
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
Anzalone, A. V., Koblan, L. W., & Liu, D. R. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0561-9 · Cited by 2,237
Therapeutic genome editing: prospects and challenges
Cox, D. B. T., Platt, R. J., & Zhang, F. (2015) · Nature Medicine · doi:10.1038/nm.3793 · Cited by 1,336
TAL effectors: customizable proteins for DNA targeting
Bogdanove, A. J., & Voytas, D. F. (2011) · Science · doi:10.1126/science.1204094 · Cited by 984
Delivery technologies for genome editing
Yin, H., Kauffman, K. J., & Anderson, D. G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.280 · Cited by 597
Genome Engineering with Targetable Nucleases
Carroll, D. (2014) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060713-035418 · Cited by 568
Metadata
- Authors
- Stoddard, B. L.
- Venue
- Structure
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 19
- Issue
- 1
- Pages
- 7-15
- ISSN
- 0969-2126 (ISSN-L)
- OpenAlex
- W2061948650
- Cited by
- 346
- References
- 3
- FWCI
- 12.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stoddard, B. L. (2011). Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification. Structure. https://doi.org/10.1016/j.str.2010.12.003
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