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Cited by 23Protein Structure and DynamicsDrug Transport and Resistance MechanismsEnzyme Structure and Function

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Rational exploration of fold atlas for human solute carrier proteins

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Xie, Tengyu, Chi, Ximin, Huang, Bangdong, Ye, Fangfei, Zhou, Qiang, Huang, Jing·2022·Structure
DOI 10.1016/j.str.2022.05.015

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Abstract

The solute carrier (SLC) superfamily is the largest group of proteins responsible for the transmembrane transport of substances in human cells. It includes more than 400 members that are organized into 65 families according to their physiological function and sequence similarity. Different families of SLCs can adopt the same or different folds that determine the mechanism and reflect the evolutionary relationship between SLC members. Analysis of structural data in the literature before this work showed 13 different folds in the SLC superfamily covering 40 families and 343 members. To further study their mechanism, we systematically explored the SLC superfamily to look for more folds. Based on our results, at least three new folds are found for the SLC superfamily, one of which is in the choline-like transporter family (SLC44) and has been experimentally verified. Our work has laid a foundation and provided important insights for the systematic and comprehensive study of the structure and function of SLC.

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Metadata

Authors
Xie, T., Chi, X., Huang, B., Ye, F., Zhou, Q., & Huang, J.
Affiliations
Westlake University (CN)
Corresponding author
  • Zhou, Qiang
  • Huang, Jing
ORCID
Venue
Structure
Publisher
Elsevier BV
Published
2022-09
Volume
30
Issue
9
Pages
1321-1330.e5
ISSN
0969-2126 (ISSN-L)
DOI
10.1016/j.str.2022.05.015
OpenAlex
W4282562958
Cited by
23
References
7
Citations by year
2026: 3 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 3
FWCI
1.63
Type
journal article
Language
en
Open access
Licence
Locations
  • Structure (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (21803057, 31971123, 32022037, 32171247)
  • Ministry of Science and Technology of the People's Republic of China
  • Natural Science Foundation of Zhejiang Province (LR19B030001)
  • National Key Research and Development Program of China (2020YFA0509300)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Keywords
solute carrier proteins, protein folding, membrane transport, protein structure-function relationship, protein evolution
MeSH terms
Solute Carrier Proteins, Biological Transport, Humans, Membrane Transport Proteins

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