Cited by 175Hormonal and reproductive studiesProstate Cancer Treatment and ResearchPharmacological Effects and Assays

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Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications

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Solomon, Zachary J., Mirabal, Jorge Rivera, Mazur, Daniel J., Kohn, Taylor P., Lipshultz, Larry I., Pastuszak, Alexander W.·2019·Sexual Medicine Reviews

DOI 10.1016/j.sxmr.2018.09.006PMC PMC6326857

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Abstract

INTRODUCTION: Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM's chemical structure. As a result, SARMs result in anabolic cellular activity while avoiding many of the side effects of currently available anabolic steroids. SARMs have been studied in the treatment of breast cancer and cachexia and have also been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs. AIM: To present the background, mechanisms, current and potential clinical applications, as well as risks and benefits of SARMs. METHODS: A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean muscle mass. Both basic research and clinical studies were included. MAIN OUTCOME MEASURE: To complete a review of peer-reviewed literature. RESULTS: Although there are currently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential uses for these compounds. Basic research has focused on the pharmacokinetics and pharmacodynamics of these agents, demonstrating good availability with a paucity of drug interactions. Early clinical studies have demonstrated potential uses for SARMs in the treatment of cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancer, with positive results. CONCLUSION: SARMs have numerous possible clinical applications, with promise for the safe use in the treatment of cachexia, BPH, hypogonadism, breast cancer, and prostate cancer. Solomon ZJ, Mirabal JR, Mazur DJ, et al. Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications. Sex Med Rev 2019;7:84-94.

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Authors: Solomon, Z. J., Mirabal, J. R., Mazur, D. J., Kohn, T. P., Lipshultz, L. I., & Pastuszak, A. W.
Affiliations: Baylor College of Medicine (US)
Urology Associates (US)
Johns Hopkins University (US)
Corresponding author: Pastuszak, Alexander W.
ORCID: Kohn, Taylor P.
Lipshultz, Larry I.
Pastuszak, Alexander W.
Venue: Sexual Medicine Reviews
Publisher: Oxford University Press (OUP)
Published: 2019-01
Volume: 7
Issue: 1
Pages: 84-94
ISSN: 2050-0513 (ISSN-L)
2050-0521
DOI: 10.1016/j.sxmr.2018.09.006
PMC: PMC6326857
OpenAlex: W2903095656
Cited by: 174
References: 61
Citations by year: 2026: 18 · 2025: 19 · 2024: 30 · 2023: 28 · 2022: 36 · 2021: 20 · 2020: 16 · 2019: 7
FWCI: 1.65
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Sexual Medicine Reviews (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases
Urology Care Foundation
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Pharmacological Effects and Assays
Keywords: selective androgen receptor modulators, androgen receptor, anabolic steroids, cancer cachexia, benign prostatic hyperplasia, hypogonadism, breast cancer, prostate cancer, sexual desire, lean muscle mass, pharmacokinetics, pharmacodynamics
MeSH terms: Androgens, Breast Neoplasms, Cachexia, Clinical Trials as Topic, Female, Humans, Hypogonadism, Male, Prostatic Neoplasms, Receptors, Androgen, Androgen Receptor Antagonists

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