Testing anabolic activity, potency and mechanisms of action of the phyto-derived beta 2 agonist higenamine

mTOR Signaling in Growth, Metabolism, and Disease

Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works

Glucocorticoid-Induced Skeletal Muscle Atrophy

Schakman, O., Kalista, S., Barbé, C., Loumaye, A., & Thissen, J. P. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.05.036 · Cited by 705 · see citing works

Distinct anabolic signalling responses to amino acids in C2C12 skeletal muscle cells

Atherton, P. J., Smith, K., Etheridge, T., Rankin, D., & Rennie, M. J. (2010) · Amino Acids · doi:10.1007/s00726-009-0377-x · Cited by 323 · see citing works

Selective Androgen Receptor Modulators: Current Knowledge and Clinical Applications

Solomon, Z. J., Mirabal, J. R., Mazur, D. J., Kohn, T. P., Lipshultz, L. I., & Pastuszak, A. W. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.09.006 · Cited by 174 · see citing works

Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy

Basualto-Alarcón, C., Jorquera, G., Altamirano, F. J., Jaimovich, E., & Estrada, M. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31828cf5f3 · Cited by 147 · see citing works

Comparison of the Pharmacological Effects of a Novel Selective Androgen Receptor Modulator, the 5α-Reductase Inhibitor Finasteride, and the Antiandrogen Hydroxyflutamide in Intact Rats: New Approach for Benign Prostate Hyperplasia

Gao, W., Kearbey, J. D., Nair, V. A., Chung, K., Parlow, A. F., Miller, D. D., & Dalton, J. T. (2004) · Endocrinology · doi:10.1210/en.2004-0627 · Cited by 124 · see citing works

Clenbuterol

Prather, I. D., BROWN, D. E., NORTH, P., & Wilson, J. R. (1995) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199508000-00003 · Cited by 114 · see citing works

Applications of Higenamine in pharmacology and medicine

Zhang, N., Lian, Z., Peng, X., Li, Z., & Zhu, H. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.12.033 · Cited by 113 · see citing works

Systemic administration of β2‐adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses

Ryall, J. G., Sillence, M. N., & Lynch, G. S. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706669 · Cited by 109 · see citing works

Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone.

Parr, M. K., Zhao, P., Haupt, O., Ngueu, S. T., Hengevoss, J., Fritzemeier, K. H., Piechotta, M., Schlörer, N., Muhn, P., Zheng, W., et al. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300806 · Cited by 106 · see citing works

Ecdysteroids: A novel class of anabolic agents?

Parr, M., Botrè, F., Naß, A., Hengevoss, J., Diel, P., & Wolber, G. (2014) · Biology of Sport · doi:10.5604/20831862.1144420 · Cited by 95 · see citing works

Creatine increases IGF‐I and myogenic regulatory factor mRNA in C2C12 cells

Louis, M., Beneden, R. V., Dehoux, M., Thissen, J. P., & Francaux, M. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01504-7 · Cited by 84 · see citing works

Chronic β2‐adrenoceptor agonist treatment alters muscle proteome and functional adaptations induced by high intensity training in young men

Hostrup, M., Onslev, J., Jacobson, G. A., Wilson, R., & Bangsbo, J. (2017) · The Journal of Physiology · doi:10.1113/jp274970 · Cited by 54 · see citing works

Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine

Cohen, P. A., Travis, J. C., Vanhee, C., Ohana, D., & Venhuis, B. J. (2021) · Clinical Toxicology · doi:10.1080/15563650.2021.1894333 · Cited by 54 · see citing works

A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects

Feng, S., Jiang, J., Hu, P., Zhang, J., Liu, T., Zhao, Q., & Li, B.-L. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.114 · Cited by 52 · see citing works

Anabolic and lipolytic actions of beta2‐agonists in humans and antidoping challenges

Hostrup, M., Jacobson, G. A., Jessen, S., & Lemminger, A. K. (2020) · Drug Testing and Analysis · doi:10.1002/dta.2728 · Cited by 52 · see citing works

Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy

Zhiyin, L., Jinliang, C., Qiunan, C., Yunfei, Y., & Xiao, Q. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111590 · Cited by 46 · see citing works

Functional Characterization of the β-Adrenergic Receptor Subtypes Expressed by CA1 Pyramidal Cells in the Rat Hippocampus

Hillman, K. L., Doze, V. A., & Porter, J. E. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.084947 · Cited by 43 · see citing works

β2-Adrenoceptor-Mediated Tracheal Relaxation Induced by Higenamine fromNandina domesticaThunberg

Tsukiyama, M., Ueki, T., Yasuda, Y., Kikuchi, H., Akaishi, T., Okumura, H., & Abe, K. (2009) · Planta Medica · doi:10.1055/s-0029-1185743 · Cited by 36 · see citing works

Comparison of the Protective Effect of Formoterol and of Salmeterol against Exercise-Induced Bronchospasm when Given Immediately before a Cycloergometric Test

Ferrari, M., Segattini, C., Zanon, R., Bertaiola, M., Balestreri, F., Brotto, E., & Cascio, V. L. (2002) · Respiration · doi:10.1159/000066458 · Cited by 32 · see citing works

Can β2-agonists have an ergogenic effect on strength, sprint or power performance? Systematic review and meta-analysis of RCTs

Riiser, A., Stensrud, T., Stang, J. S., & Andersen, L. B. (2020) · British Journal of Sports Medicine · doi:10.1136/bjsports-2019-100708 · Cited by 32 · see citing works

A cell-based assay to assess the persistence of action of agonists acting at recombinant human β2 adrenoceptors

Summerhill, S., Stroud, T., Nagendra, R., Huguet, C., & Trevethick, M. A. (2008) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2008.06.003 · Cited by 31 · see citing works

Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a β2-adrenoceptor-independent mechanism

McCormick, C., Alexandre, L., Thompson, J., & Mutungi, G. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00592.2010 · Cited by 24 · see citing works

Clinical safety assessment of oral higenamine supplementation in healthy, young men

Bloomer, R., Schriefer, J., & Gunnels, T. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327114565490 · Cited by 24 · see citing works

Role of Higenamine in Heart Diseases: A Mini-Review

Wen, J., Li, M., Zhang, W., Wang, H., Bai, Y., Hao, J., Liu, C., Deng, K., & Zhao, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.798495 · Cited by 24 · see citing works

Anabolic Activity of a Soy Extract and Three Major Isoflavones in C2C12 Myotubes

Zheng, W., Hemker, M., Xie, M., Soukup, S., & Diel, P. (2018) · Planta Medica · doi:10.1055/a-0598-4812 · Cited by 23 · see citing works

Anabolic Effect of the Traditional Chinese Medicine Compound Tanshinone IIA on Myotube Hypertrophy Is Mediated by Estrogen Receptor

Zhao, P., Soukup, S. T., Hegevoss, J., Ngueu, S. T., Kulling, S. E., & Diel, P. R. (2015) · Planta Medica · doi:10.1055/s-0035-1545883 · Cited by 21 · see citing works

β2‐Adrenoceptor agonist activity of higenamine

Hudzik, T. J., Patel, M., & Brown, A. J. (2020) · Drug Testing and Analysis · doi:10.1002/dta.2992 · Cited by 21 · see citing works

Combinatory in vitro effects of the β2-agonists salbutamol and formoterol in skeletal muscle cells

Piribauer, M., Jiang, L., Kostov, T., Parr, M., Steidel, S., Bizjak, D. A., Steinacker, J. M., & Diel, P. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.02.007 · Cited by 10 · see citing works

Androgen- and estrogen-receptor mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites in yeast based assays

Keiler, A. M., Zierau, O., Wolf, S., Diel, P. R., Schänzer, W., Vollmer, G., Machalz, D., Wolber, G., & Parr, M. K. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.04.026 · Cited by 9 · see citing works

Evaluation of the bronchodilating activity and the tolerability of broxaterol administered as a solution by inhalation.

Ferrari, M., Olivieri, M., Biasin, C., Pisati, R., Lodola, E., & Cascio, V. L. (1993) · PubMed · Cited by 1 · see citing works

The three-dimensional culture of L929 and C2C12 cells based on SPI-SA interpenetrating network hydrogel scaffold with excellent mechanical properties

Ma, C.-M., Gao, X., Yang, Y., Bian, X., Wang, B., Liu, X.-F., Wang, Y., Su, D., Zhang, G., Qu, L.-Z., et al. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1329183 · Cited by 32 · see citing works

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

Thevis, M., Kuuranne, T., & Geyer, H. (2023) · Drug Testing and Analysis · doi:10.1002/dta.3602 · Cited by 13 · see citing works

Advance in Detection Technique of Lean Meat Powder Residues in Meat Using SERS: A Review

Guo, Q., Peng, Y., Qin, J., Chao, K., Zhao, X., & Yin, T. (2023) · Molecules · doi:10.3390/molecules28227504 · Cited by 9 · see citing works

Examination of the anabolic activity and mechanisms of action of the combination of Diosgenin and Ecdysterone in C2C12 myotubes

Kostov, T., Diel, P., & Isenmann, E. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.10.005 · Cited by 7 · see citing works

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Thevis, M., Kuuranne, T., & Geyer, H. (2026) · Drug Testing and Analysis · doi:10.1002/dta.70033 · Cited by 5 · see citing works

Electrochemiluminescent detection of doping drugs in sports using metal-organic frameworks (MOFs)

Xie, B., & Zhang, F. (2024) · International Journal of Electrochemical Science · doi:10.1016/j.ijoes.2024.100552 · Cited by 3 · see citing works

How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study

Dissemond, J., Havers, T., Held, S., Geisler, S., Kostov, T., Diel, P., Türschmann, S., Parr, M. K., & Isenmann, E. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2540408 · Cited by 2 · see citing works

Metabolism of coclaurine into the WADA-banned substance higenamine: a doping-relevant analytical evaluation of Kampo extracts

Sakamoto, S., Osaki, K., Abe, H., Tayama, Y., Tsuruta, A., Nuntawong, P., Koyanagi, S., Yodsurang, V., & Morimoto, S. (2025) · Journal of Natural Medicines · doi:10.1007/s11418-025-01940-4 · Cited by 1 · see citing works

β2‐Adrenoceptor agonist activity of higenamine

Hudzik, T. J., Patel, M., & Brown, A. J. (2020) · Drug Testing and Analysis · doi:10.1002/dta.2992 · Cited by 21 · see citing works

Ability of higenamine and related compounds to enhance glucose uptake in L6 cells

Kato, E., Kimura, S., & Kawabata, J. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.10.011 · Cited by 19 · see citing works

Combinatory in vitro effects of the β2-agonists salbutamol and formoterol in skeletal muscle cells

Piribauer, M., Jiang, L., Kostov, T., Parr, M., Steidel, S., Bizjak, D. A., Steinacker, J. M., & Diel, P. (2023) · Toxicology Letters · doi:10.1016/j.toxlet.2023.02.007 · Cited by 10 · see citing works

A novel β2-AR agonist, Higenamine, induces β-arrestin-biased signaling

Zhang, N., Zhu, H., Li, Z., & Dong, E. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2008-1 · Cited by 5 · see citing works

Synthesis of Higenamine and its Cardiovascular Effects in Rabbit: Evidence for ${\beta}-Adrenoceptor$ agonist

Chang, K.-C., Lim, J.-K., & Park, C. (1986)