The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Iron metabolism and toxicity
Abstract
Iron is an essential nutrient with limited bioavailability. When present in excess, iron poses a threat to cells and tissues, and therefore iron homeostasis has to be tightly controlled. Iron's toxicity is largely based on its ability to catalyze the generation of radicals, which attack and damage cellular macromolecules and promote cell death and tissue injury. This is lucidly illustrated in diseases of iron overload, such as hereditary hemochromatosis or transfusional siderosis, where excessive iron accumulation results in tissue damage and organ failure. Pathological iron accumulation in the liver has also been linked to the development of hepatocellular cancer. Here we provide a background on the biology and toxicity of iron and the basic concepts of iron homeostasis at the cellular and systemic level. In addition, we provide an overview of the various disorders of iron overload, which are directly linked to iron's toxicity. Finally, we discuss the potential role of iron in malignant transformation and cancer.
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“The same group demonstrated the ferroxidase activity of yeast frataxin (233) [similar to that of ferritin H, which oxidizes Fe2+ to Fe3+ (178)].”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [233]
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Cites
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
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“This modification is required for the recognition of HIF-1a by the von Hippel–Lindau protein (pVHL), which is a component of an E3 ubiquitin ligase complex (Ivan et al., 2001; Jaakkola et al., 2001).”
BackgroundA novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
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The ferritins: molecular properties, iron storage function and cellular regulation
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“Hepcidin expression is increased in inflammation (Nemeth et al., 2004) and secondary iron overload (Adamsky et al.”
BackgroundA conserved family of prolyl-4-hydroxylases that modify HIF
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Hepcidin, a urinary antimicrobial peptide synthesized in the liver
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1 of the 101 references couldn’t be matched to a known paper.
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Excited-state intramolecular proton-transfer (ESIPT) based fluorescence sensors and imaging agents
Sedgwick, A. C., Wu, L., Han, H., Bull, S. D., He, X., James, T. D., Sessler, J. L., Tang, B. Z., Tian, H., & Yoon, J. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00185e · Cited by 1,589
Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
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Anticancer Activity of Metal Complexes: Involvement of Redox Processes
Jungwirth, U., Kowol, C. R., Keppler, B. K., Hartinger, C. G., Berger, W., & Heffeter, P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3663 · Cited by 568
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526
Metadata
- Authors
- Papanikolaou, G., & Pantopoulos, K.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Jewish General Hospital (CA)
- Corresponding author
- Pantopoulos, K.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 202
- Issue
- 2
- Pages
- 199-211
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2077328361
- Cited by
- 1,070
- References
- 101
- Citations by year
- 2026: 35 · 2025: 46 · 2024: 59 · 2023: 71 · 2022: 62 · 2021: 52 · 2020: 52 · 2019: 140 · 2018: 48 · 2017: 44 · 2016: 48 · 2015: 63 · 2014: 53 · 2013: 57 · 2012: 44
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Toxicology and Applied Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- iron metabolism, iron homeostasis, iron toxicity, iron overload, hereditary hemochromatosis, oxidative stress, free radicals, hepatocellular carcinoma, malignant transformation, iron bioavailability
- MeSH terms
- Animals, Free Radicals, Humans, Iron, Liver, Oxidative Stress, Iron Overload
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