The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—Generation of reactive oxygen species and cell damage
Open accessAbstract
Nano-sized titanium dioxide (TiO2) is among the top five widely used nanomaterials for various applications. In this study, we determine the phototoxicity of TiO2 nanoparticles (nano-TiO2) with different molecular sizes and crystal forms (anatase and rutile) in human skin keratinocytes under UVA irradiation. Our results show that all nano-TiO2 particles caused phototoxicity, as determined by the MTS assay and by cell membrane damage measured by the lactate dehydrogenase (LDH) assay, both of which were UVA dose- and nano-TiO2 dose- dependent. The smaller the particle size of nano-TiO2 the higher the cell damage. The rutile form of nano-TiO2 showed less phototoxicity than anatase nano-TiO2. The level of photocytotoxicity and cell membrane damage is mainly dependent on the level of reactive oxygen species (ROS) production. Using polyunsaturated lipids in plasma membranes and human serum albumin as model targets, and employing electron spin resonance (ESR) oximetry and immuno-spin trapping as unique probing methods, we demonstrated that UVA irradiation of nano-TiO2 can induce significant cell damage, mediated by lipid and protein peroxidation. These overall results suggest that nano-TiO2 is phototoxic to human skin keratinocytes, and that this phototoxicity is mediated by ROS generated during UVA irradiation.
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Cites
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., & Fusenig, N. E. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.3.761 · Cited by 4,170
Explaining the Enhanced Photocatalytic Activity of Degussa P25 Mixed-Phase TiO 2 Using EPR
Hurum, D. C., Agrios, A. G., Gray, K. A., Rajh, T., & Thurnauer, M. C. (2003) · The Journal of Physical Chemistry B · doi:10.1021/jp0273934 · Cited by 2,015
Tanaka, M., Yamamoto, Y., Misawa, E., Nabeshima, K., Saito, M., Yamauchi, K., Abe, F., & Furukawa, F. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000454718 · Cited by 1,092
Cited by
He, W., Kim, H.-K., Wamer, W. G., Melka, D., Callahan, J. H., & Yin, J.-J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja410800y · Cited by 850
Self-citationTitanium Dioxide Nanoparticles – Prospects and Applications in Medicine
Ziental, D., Czarczynska-Goslinska, B., Mlynarczyk, D. T., Glowacka-Sobotta, A., Stanisz, B., Goslinski, T., & Sobotta, L. (2020) · doi:10.20944/preprints202002.0271.v1 · Cited by 721
Toxicity and mechanisms of action of titanium dioxide nanoparticles in living organisms
Hou, J., Wang, L., Wang, C., Zhang, S., Liu, H., Li, S., & Wang, X. (2019) · Journal of Environmental Sciences · doi:10.1016/j.jes.2018.06.010 · Cited by 369
Titanium Dioxide in the Service of the Biomedical Revolution
Rajh, T., Dimitrijevic, N. M., Bissonnette, M., Koritarov, T., & Konda, V. (2014) · Chemical Reviews · doi:10.1021/cr500029g · Cited by 293
Jansen, R., Osterwalder, U., Wang, S. Q., Burnett, M., & Lim, H. W. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.08.022 · Cited by 224
Metadata
- Authors
- Yin, J.-J., Liu, J., Ehrenshaft, M., Roberts, J. E., Fu, P. P., Mason, R. P., & Zhao, B.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 263
- Issue
- 1
- Pages
- 81-88
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W1990550498
- Cited by
- 251
- References
- 3
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Yin, J.-J., Liu, J., Ehrenshaft, M., Roberts, J. E., Fu, P. P., Mason, R. P., & Zhao, B. (2012). Phototoxicity of nano titanium dioxides in HaCaT keratinocytes—Generation of reactive oxygen species and cell damage. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2012.06.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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