The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives
Abstract
Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing. There is a huge body of evidence on the relation between exposure to pesticides and elevated rate of chronic diseases such as different types of cancers, diabetes, neurodegenerative disorders like Parkinson, Alzheimer, and amyotrophic lateral sclerosis (ALS), birth defects, and reproductive disorders. There is also circumstantial evidence on the association of exposure to pesticides with some other chronic diseases like respiratory problems, particularly asthma and chronic obstructive pulmonary disease (COPD), cardiovascular disease such as atherosclerosis and coronary artery disease, chronic nephropathies, autoimmune diseases like systemic lupus erythematous and rheumatoid arthritis, chronic fatigue syndrome, and aging. The common feature of chronic disorders is a disturbance in cellular homeostasis, which can be induced via pesticides' primary action like perturbation of ion channels, enzymes, receptors, etc., or can as well be mediated via pathways other than the main mechanism. In this review, we present the highlighted evidence on the association of pesticide's exposure with the incidence of chronic diseases and introduce genetic damages, epigenetic modifications, endocrine disruption, mitochondrial dysfunction, oxidative stress, endoplasmic reticulum stress and unfolded protein response (UPR), impairment of ubiquitin proteasome system, and defective autophagy as the effective mechanisms of action.
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Cites
Autophagy in the Pathogenesis of Disease
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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
ER stress and neurodegenerative diseases
Lindholm, D., Wootz, H., & Korhonen, L. (2006) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401778 · Cited by 882
Mitochondrial Dysfunction in Neurodegenerative Diseases
Johri, A., & Beal, M. F. (2012) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192138 · Cited by 806
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Epigenetic Transgenerational Actions of Endocrine Disruptors
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Geographic differences in semen quality of fertile U.S. males.
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Cited by
An extensive review on the consequences of chemical pesticides on human health and environment
Rani, L., Thapa, K., Kanojia, N., Sharma, N., Singh, S., Grewal, A. S., Srivastav, A. L., & Kaushal, J. (2021) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2020.124657 · Cited by 1,427
Clark, M., & Tilman, D. (2017) · Environmental Research Letters · doi:10.1088/1748-9326/aa6cd5 · Cited by 989
Wastewater-based epidemiology biomarkers: Past, present and future
Choi, P. M., Tscharke, B. J., Donner, E., O'Brien, J. W., Grant, S. C., Kaserzon, S. L., Mackie, R., O'Malley, E., Crosbie, N. D., Thomas, K. V., et al. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.06.004 · Cited by 486
Handford, C. E., Elliott, C. T., & Campbell, K. (2015) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.1635 · Cited by 408
Pesticides, Environmental Pollution, and Health
Özkara, A., Akyil, D., & Konuk, M. (2016) · Environmental Health Risk - Hazardous Factors to Living Species · doi:10.5772/63094 · Cited by 284
Metadata
- Authors
- Mostafalou, S., & Abdollahi, M.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 268
- Issue
- 2
- Pages
- 157-177
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2127163848
- Cited by
- 1,261
- References
- 13
- FWCI
- 94.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mostafalou, S., & Abdollahi, M. (2013). Pesticides and human chronic diseases: Evidences, mechanisms, and perspectives. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2013.01.025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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