The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Quercitrin protects skin from UVB-induced oxidative damage
Open accessAbstract
Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.
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Cites
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Manganese Superoxide Dismutase: Guardian of the Powerhouse
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Cited by
Review of Natural Compounds for Potential Skin Cancer Treatment
Chinembiri, T., Du Plessis, L., Gerber, M., Hamman, J., & Du Plessis, J. (2014) · Molecules · doi:10.3390/molecules190811679 · Cited by 270
Role of AhR/ARNT system in skin homeostasis
Furue, M., Takahara, M., Nakahara, T., & Uchi, H. (2014) · Archives of Dermatological Research · doi:10.1007/s00403-014-1481-7 · Cited by 175
Takei, K., Mitoma, C., Hashimoto‐Hachiya, A., Uchi, H., Takahara, M., Tsuji, G., Kido‐Nakahara, M., Nakahara, T., & Furue, M. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12717 · Cited by 81
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Self-citationFernández-García, E., Carvajal-Lérida, I., & Pérez-Gálvez, A. (2016) · Photochemical & Photobiological Sciences · doi:10.1039/c6pp00134c · Cited by 40
Metadata
- Authors
- Yin, Y., Li, W., Son, Y.-O., Sun, L., Lu, J., Kim, D., Wang, X., Yao, H., Wang, L., Pratheeshkumar, P., Hitron, A. J., Luo, J., Gao, N., Shi, X., & Zhang, Z.
- Venue
- Toxicology and Applied Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 269
- Issue
- 2
- Pages
- 89-99
- ISSN
- 0041-008X (ISSN-L)
- OpenAlex
- W2102157328
- Cited by
- 163
- References
- 9
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- green
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- Yin, Y., Li, W., Son, Y.-O., Sun, L., Lu, J., Kim, D., Wang, X., Yao, H., Wang, L., Pratheeshkumar, P., Hitron, A. J., Luo, J., Gao, N., Shi, X., & Zhang, Z. (2013). Quercitrin protects skin from UVB-induced oxidative damage. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2013.03.015
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