Cited by 208Per- and polyfluoroalkyl substances researchPeroxisome Proliferator-Activated ReceptorsEffects and risks of endocrine disrupting chemicals

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In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays

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Evans, Nicola, Conley, Justin M., Cardon, Mary, Hartig, Phillip, Medlock-Kakaley, Elizabeth, Gray, L. Earl·2022·Toxicology and Applied Pharmacology

DOI 10.1016/j.taap.2022.116136PMC PMC9341220

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Abstract

Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, additional work is needed to characterize PFAS activity on PPAR gamma (PPARγ) and other nuclear receptors. We utilized in vitro assays with either human or rat PPARα or PPARγ ligand binding domains to evaluate 16 PFAS (HFPO-DA, HFPO-DA-AS, NBP2, PFMOAA, PFHxA, PFOA, PFNA, PFDA, PFOS, PFBS, PFHxS, PFOSA, EtPFOSA, and 4:2, 6:2 and 8:2 FTOH), 3 endogenous fatty acids (oleic, linoleic, and octanoic), and 3 pharmaceuticals (WY14643, clofibrate, and the metabolite clofibric acid). We also tested chemicals for human estrogen receptor (hER) transcriptional activation. Nearly all compounds activated both PPARα and PPARγ in both human and rat ligand binding domain assays, except for the FTOH compounds and PFOSA. Receptor activation and relative potencies were evaluated based on effect concentration 20% (EC 20), top percent of max fold induction (pmax top), and area under the curve (AUC). HFPO-DA and HFPO-DA-AS were the most potent (lowest EC 20, highest pmax top and AUC) of all PFAS in rat and human PPARα assays, being slightly less potent than oleic and linoleic acid, while NBP2 was the most potent in rat and human PPARγ assays. Only PFHxS, 8:2 and 6:2 FTOH exhibited hER agonism >20% pmax. In vitro measures of human and rat PPARα and PPARγ activity did not correlate with oral doses or serum concentrations of PFAS that induced increases in male rat liver weight from the National Toxicology Program 28-d toxicity studies. Data indicate that both PPARα and PPARγ activation may be molecular initiating events that contribute to the in vivo effects observed for many PFAS.

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Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting
Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., & Wahli, W. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6223 · Cited by 1,649
Half-Lives of PFOS, PFHxS and PFOA after End of Exposure to Contaminated Drinking Water
Li, Y., Fletcher, T., Mucs, D., Scott, K., Lindh, C. H., Tallving, P., & Jakobsson, K. (2018) · Occupational and Environmental Medicine · doi:10.1136/oemed-2017-104651 · Cited by 815
Integrated physiology and systems biology of PPARα
Kersten, S. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.02.002 · Cited by 701
Legacy and Emerging Perfluoroalkyl Substances Are Important Drinking Water Contaminants in the Cape Fear River Watershed of North Carolina
Sun, M., Arevalo, E., Strynar, M., Lindstrom, A., Richardson, M., Kearns, B., Pickett, A., Smith, C., & Knappe, D. R. U. (2016) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.6b00398 · Cited by 688
Differential Activation of Nuclear Receptors by Perfluorinated Fatty Acid Analogs and Natural Fatty Acids: A Comparison of Human, Mouse, and Rat Peroxisome Proliferator-Activated Receptor-α, -β, and -γ, Liver X Receptor-β, and Retinoid X Receptor-α
Heuvel, J. P. V., Thompson, J. T., Frame, S. R., & Gillies, P. J. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl014 · Cited by 489
Activation of Mouse and Human Peroxisome Proliferator-Activated Receptors (α, β/δ, γ) by Perfluorooctanoic Acid and Perfluorooctane Sulfonate
Takacs, M. L., & Abbott, B. D. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfl135 · Cited by 396
trans-Activation of PPARα and PPARγ by Structurally Diverse Environmental Chemicals
Maloney, E. K., & Waxman, D. J. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1999.8809 · Cited by 388
Identification of Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs) in Natural Waters Using Accurate Mass Time-of-Flight Mass Spectrometry (TOFMS)
Strynar, M., Dagnino, S., McMahen, R., Liang, S., Lindstrom, A., Andersen, E., McMillan, L., Thurman, M., Ferrer, I., & Ball, C. (2015) · Environmental Science & Technology · doi:10.1021/acs.est.5b01215 · Cited by 386
Comparative Analysis of Gene Regulation by the Transcription Factor PPARα between Mouse and Human
Rakhshandehroo, M., Hooiveld, G. J. E. J., Müller, M. M., & Kersten, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006796 · Cited by 317
Development and Characterization of a Cell Line That Stably Expresses an Estrogen-Responsive Luciferase Reporter for the Detection of Estrogen Receptor Agonist and Antagonists
Wilson, V. S. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh180 · Cited by 304
Activation of Mouse and Human Peroxisome Proliferator−Activated Receptor Alpha by Perfluoroalkyl Acids of Different Functional Groups and Chain Lengths
Wolf, C. J., Takacs, M. L., Schmid, J. E., Lau, C. S., & Abbott, B. D. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn166 · Cited by 302
Recently Detected Drinking Water Contaminants: GenX and Other Per‐ and Polyfluoroalkyl Ether Acids
Hopkins, Z. R., Sun, M., DeWitt, J. C., & Knappe, D. R. U. (2018) · Journal AWWA · doi:10.1002/awwa.1073 · Cited by 288
Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
Bjork, J. A., Butenhoff, J. L., & Wallace, K. B. (2011) · Toxicology · doi:10.1016/j.tox.2011.06.012 · Cited by 266
Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina
Kotlarz, N., McCord, J., Collier, D., Lea, C. S., Strynar, M., Lindstrom, A. B., Wilkie, A. A., Islam, J. Y., Matney, K., Tarte, P., et al. (2020) · Environmental Health Perspectives · doi:10.1289/ehp6837 · Cited by 261
Estrogen-Like Activity of Perfluoroalkyl Acids In Vivo and Interaction with Human and Rainbow Trout Estrogen Receptors In Vitro
Benninghoff, A. D., Bisson, W. H., Koch, D. C., Ehresman, D. J., Kolluri, S. K., & Williams, D. E. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq379 · Cited by 255
Activation of Human Nuclear Receptors by Perfluoroalkylated Substances (PFAS)
Behr, A.-C., Plinsch, C., Braeuning, A., & Buhrke, T. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2019.104700 · Cited by 235
PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling
Rosen, M. B., Das, K. P., Rooney, J. P., Abbott, B. D., Lau, C. S., & Corton, J. C. (2017) · Toxicology · doi:10.1016/j.tox.2017.05.013 · Cited by 217
Interspecies differences in perfluoroalkyl substances (PFAS) toxicokinetics and application to health-based criteria
Pizzurro, D. M., Seeley, M., Kerper, L. E., & Beck, B. D. (2019) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2019.05.008 · Cited by 206
Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?
Fragki, S., Dirven, H. A. A. M., Fletcher, T., Grasl‐Kraupp, B., Gützkow, K. B., Hoogenboom, L. A. P., Kersten, S., Lindeman, B., Louisse, J., Peijnenburg, A., et al. (2021) · Critical Reviews in Toxicology · doi:10.1080/10408444.2021.1888073 · Cited by 196
Hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) alters maternal and fetal glucose and lipid metabolism and produces neonatal mortality, low birthweight, and hepatomegaly in the Sprague-Dawley rat
Conley, J. M., Lambright, C. S., Evans, N., McCord, J. P., Strynar, M. J., Hill, D., Medlock-Kakaley, E., Wilson, V. S., & Gray, L. E. (2020) · Environment International · doi:10.1016/j.envint.2020.106204 · Cited by 195
Self-citation
Differential Gene Regulation in Human Versus Rodent Hepatocytes by Peroxisome Proliferator-activated Receptor (PPAR) α
Lawrence, J. W., Li, Y., Chen, S., DeLuca, J. G., Berger, J. P., Umbenhauer, D. R., Moller, D. E., & Zhou, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103306200 · Cited by 190
Identification of Per- and Polyfluoroalkyl Substances in the Cape Fear River by High Resolution Mass Spectrometry and Nontargeted Screening
McCord, J., & Strynar, M. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b06017 · Cited by 183
PPARα and PPARγ dual agonists for the treatment of type 2 diabetes and the metabolic syndrome
Fiévet, C., Fruchart, J., & Staels, B. (2006) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.06.009 · Cited by 182
Adverse Maternal, Fetal, and Postnatal Effects of Hexafluoropropylene Oxide Dimer Acid (GenX) from Oral Gestational Exposure in Sprague-Dawley Rats
Conley, J. M., Lambright, C. S., Evans, N., Strynar, M. J., McCord, J. P., Mcintyre, B., Travlos, G. S., Cardon, M. C., Medlock-Kakaley, E., Hartig, P. C., et al. (2019) · Environmental Health Perspectives · doi:10.1289/ehp4372 · Cited by 176
Self-citation
trans-Activation of PPAR and Induction of PPAR Target Genes by Perfluorooctane-Based Chemicals
Shipley, J. M. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh130 · Cited by 168
Activation of mouse and human peroxisome proliferator-activated receptor-alpha (PPARα) by perfluoroalkyl acids (PFAAs): Further investigation of C4–C12 compounds
Wolf, C. J., Schmid, J. E., Lau, C. S., & Abbott, B. D. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.09.009 · Cited by 160
Risk Assessment of Per- and Polyfluoroalkyl Substance Mixtures: A Relative Potency Factor Approach
Bil, W., Zeilmaker, M., Fragki, S., Lijzen, J., Verbruggen, E., & Bokkers, B. (2020) · Environmental Toxicology and Chemistry · doi:10.1002/etc.4835 · Cited by 158
In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths
Buhrke, T., Kibellus, A., & Lampen, A. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.01.025 · Cited by 153
Peroxisome Proliferator Activated Receptors and Lipoprotein Metabolism
Kersten, S. (2007) · PPAR Research · doi:10.1155/2008/132960 · Cited by 149
Bioactivity profiling of per- and polyfluoroalkyl substances (PFAS) identifies potential toxicity pathways related to molecular structure
Houck, K. A., Patlewicz, G. Y., Richard, A. M., Williams, A. J., Shobair, M., Smeltz, M. G., Clifton, M. S., Wetmore, B. A., Medvedev, A. V., & Makarov, S. S. (2021) · Toxicology · doi:10.1016/j.tox.2021.152789 · Cited by 149
The opportunities and challenges of peroxisome proliferator-activated receptors ligands in clinical drug discovery and development
Hong, F., Xu, P., & Zhai, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082189 · Cited by 139
Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro
Behr, A., Lichtenstein, D., Braeuning, A., Lampen, A., & Buhrke, T. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.03.029 · Cited by 130
Gene Expression Changes Induced by PPAR Gamma Agonists in Animal and Human Liver
Rogue, A., Spire, C., Brun, M., Claude, N., & Guillouzo, A. (2010) · PPAR Research · doi:10.1155/2010/325183 · Cited by 127
Long-term effects of a binary mixture of perfluorooctane sulfonate (PFOS) and bisphenol A (BPA) in zebrafish (Danio rerio)
Keiter, S., Baumann, L., Färber, H. A., Holbech, H., Skutlarek, D., Engwall, M., & Braunbeck, T. A. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.04.003 · Cited by 127
Comparative Gene Expression Profiles Induced by PPARγ and PPARα/γ Agonists in Human Hepatocytes
Rogue, A., Lambert, C. B., Jossé, R., Anthérieu, S., Spire, C., Claude, N., & Guillouzo, A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018816 · Cited by 110
Comparison of in vitro estrogenic activity and estrogen concentrations in source and treated waters from 25 U.S. drinking water treatment plants
Conley, J. M., Evans, N., Mash, H. E., Rosenblum, L., Schenck, K. M., Glassmeyer, S. T., Furlong, E. T., Kolpin, D. W., & Wilson, V. S. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.02.093 · Cited by 110
Self-citation
Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses
Rosen, M. B., Thibodeaux, J. R., Wood, C. R., ZEHR, R. D. J., Schmid, J. E., & Lau, C. S. (2007) · Toxicology · doi:10.1016/j.tox.2007.06.095 · Cited by 108
Toxicokinetics of perfluorobutane sulfonate (PFBS), perfluorohexane-1-sulphonic acid (PFHxS), and perfluorooctane sulfonic acid (PFOS) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration
Huang, M. C., Dzierlenga, A. L., Robinson, V. G., Waidyanatha, S., DeVito, M. J., Eifrid, M. A., Granville, C. A., Gibbs, S. T., & Blystone, C. R. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.06.016 · Cited by 98
Fluorinated alkyl substances and technical mixtures used in food paper‐packaging exhibit endocrine‐related activity in vitro
Rosenmai, A. K., Taxvig, C., Svingen, T., Trier, X., van Vugt‐Lussenburg, B. M. A., Pedersen, M., Lesné, L., Jégou, B., & Vinggaard, A. M. (2016) · Andrology · doi:10.1111/andr.12190 · Cited by 97
A Reexamination of the PPAR-α Activation Mode of Action as a Basis for Assessing Human Cancer Risks of Environmental Contaminants
Guyton, K. Z., Chiu, W. A., Bateson, T. F., Jinot, J., Scott, C. S., Brown, R. C., & Caldwell, J. C. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0900758 · Cited by 89
Rapid Characterization of Human Serum Albumin Binding for Per- and Polyfluoroalkyl Substances Using Differential Scanning Fluorimetry
Jackson, T. W., Scheibly, C. M., Polera, M. E., & Belcher, S. M. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c01200 · Cited by 87
The impact of PPARα activation on whole genome gene expression in human precision cut liver slices
Janssen, A. W. F., Betzel, B., Stoopen, G. M., Berends, F. J., Janssen, I. M. C., Peijnenburg, A., & Kersten, S. (2015) · BMC Genomics · doi:10.1186/s12864-015-1969-3 · Cited by 85
Validation of quantitative measurements and semi-quantitative estimates of emerging perfluoroethercarboxylic acids (PFECAs) and hexfluoroprolyene oxide acids (HFPOAs)
McCord, J. P., Newton, S., & Strynar, M. J. (2018) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.03.047 · Cited by 85
Solvent Suitability for HFPO-DA (“GenX” Parent Acid) in Toxicological Studies
Liberatore, H. K., Jackson, S. R., Strynar, M. J., & McCord, J. P. (2020) · Environmental Science & Technology Letters · doi:10.1021/acs.estlett.0c00323 · Cited by 85
Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: Comparison to changes induced by exposure to perfluorooctanoic acid
Rosen, M. B., Schmid, J. E., Das, K. P., Wood, C. R., ZEHR, R. D. J., & Lau, C. S. (2009) · Reproductive Toxicology · doi:10.1016/j.reprotox.2009.01.007 · Cited by 79
Stability of per-and Polyfluoroalkyl substances in solvents relevant to environmental and toxicological analysis
Zhang, C., McElroy, A. C., Liberatore, H. K., Alexander, N. L. M., & Knappe, D. R. U. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.1c03979 · Cited by 78
Evaluating the additivity of perfluoroalkyl acids in binary combinations on peroxisome proliferator-activated receptor-α activation
Wolf, C. J., Rider, C. V., Lau, C., & Abbott, B. D. (2014) · Toxicology · doi:10.1016/j.tox.2013.12.002 · Cited by 69
Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration
Dzierlenga, A. L., Robinson, V. G., Waidyanatha, S., DeVito, M. J., Eifrid, M. A., Gibbs, S. T., Granville, C. A., & Blystone, C. R. (2019) · Xenobiotica · doi:10.1080/00498254.2019.1683776 · Cited by 69
Perfluorooctanoic Acid Induces Liver and Serum Dyslipidemia in Humanized PPARα Mice fed an American Diet
Schlezinger, J. J., Hyötyläinen, T., Sinioja, T., Boston, C. M., Puckett, H. M., Oliver, J., Heiger‐Bernays, W., & Webster, T. F. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115644 · Cited by 68
Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or GenX) and perfluorooctane sulfonate (PFOS)
Conley, J. M., Lambright, C. S., Evans, N., Medlock-Kakaley, E., Hill, D., McCord, J. P., Strynar, M. J., Wehmas, L. C., Hester, S., MacMillan, D. K., et al. (2021) · Environment International · doi:10.1016/j.envint.2021.107056 · Cited by 65
Self-citation
A Demonstration of the Uncertainty in Predicting the Estrogenic Activity of Individual Chemicals and Mixtures From anIn VitroEstrogen Receptor Transcriptional Activation Assay (T47D-KBluc) to theIn VivoUterotrophic Assay Using Oral Exposure
Conley, J. M., Hannas, B. R., Furr, J., Wilson, V. S., & Gray, L. E. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw134 · Cited by 55
Self-citation
Predicting the effects of per- and polyfluoroalkyl substance mixtures on peroxisome proliferator-activated receptor alpha activity in vitro
Nielsen, G. H., Heiger‐Bernays, W., Schlezinger, J. J., & Webster, T. F. (2021) · Toxicology · doi:10.1016/j.tox.2021.153024 · Cited by 53
Fluorotelomer alcohols induce hepatic vitellogenin through activation of the estrogen receptor in male medaka (Oryzias latipes)
Ishibashi, H., Yamauchi, R., Matsuoka, M., Kim, J.-W., Hirano, M., Yamaguchi, A., Tominaga, N., & Arizono, K. (2008) · Chemosphere · doi:10.1016/j.chemosphere.2008.01.065 · Cited by 52
Relationship between peroxisome proliferator‐activated receptor alpha activity and cellular concentration of 14 perfluoroalkyl substances in HepG2 cells
Rosenmai, A. K., Ahrens, L., Godec, T. L., Lundqvist, J., & Oskarsson, A. (2017) · Journal of Applied Toxicology · doi:10.1002/jat.3515 · Cited by 52
Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
Dixon, D., Reed, C. E., Moore, A. B., Gibbs-Flournoy, E. A., Hines, E. P., Wallace, E. A., Stanko, J. P., Lu, Y., Jefferson, W. N., Newbold, R. R., et al. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.10.011 · Cited by 50
The Glitazars Paradox: Cardiotoxicity of the Metabolically Beneficial Dual PPARα and PPARγ Activation
Kalliora, C., & Drosatos, K. (2020) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000891 · Cited by 43
Failure to Confirm Estrogenic Activity for Benzoic Acid and Clofibrate: Implications for Lists of Endocrine-Disrupting Agents
Ashby, J., Lefevre, P. A., Odum, J., Tinwell, H., Kennedy, S., Beresford, N., & Sumpter, J. P. (1997) · Regulatory Toxicology and Pharmacology · doi:10.1006/rtph.1997.1158 · Cited by 39
Testing for departures from additivity in mixtures of perfluoroalkyl acids (PFAAs)
Carrico, C. K., Watkins, A. M., Wolf, C. J., Abbott, B. D., Lau, C. S., & Gennings, C. (2013) · Toxicology · doi:10.1016/j.tox.2013.02.016 · Cited by 35
Toxicokinetics of 8:2 fluorotelomer alcohol (8:2-FTOH) in male and female Hsd:Sprague Dawley SD rats after intravenous and gavage administration
Huang, M. C., Robinson, V. G., Waidyanatha, S., Dzierlenga, A. L., DeVito, M. J., Eifrid, M. A., Gibbs, S. T., & Blystone, C. R. (2019) · Toxicology Reports · doi:10.1016/j.toxrep.2019.08.009 · Cited by 35
NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane Sulfonic Acid, Perfluorohexane Sulfonate Potassium Salt, and Perfluorooctane Sulfonic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
(NTP), N. T. P. (2019) · doi:10.22427/ntp-tox-96 · Cited by 23
Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid
Yao, P., Ehresman, D. J., Rae, J. M. C., Chang, S., Frame, S. R., Butenhoff, J. L., Kennedy, G. L., & Peters, J. M. (2014) · Toxicology · doi:10.1016/j.tox.2014.10.008 · Cited by 22
Evaluation of the Reproductive and Developmental Toxicity of a Fluoroalkylethanol Mixture
Mylchreest, E., Ladics, G. S., Munley, S. M., Buck, R. C., & Stadler, J. C. (2005) · Drug and Chemical Toxicology · doi:10.1081/dct-52518 · Cited by 22
Comparative gene expression profiles induced by PPARγ and PPARα/γ agonists in rat hepatocytes
Rogue, A., Renaud, M. P., Claude, N., Guillouzo, A., & Spire, C. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.04.005 · Cited by 20
NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
(NTP), N. T. P. (2019) · doi:10.22427/ntp-tox-97 · Cited by 20
The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics
Dixit, G., & Prabhu, A. (2021) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2021.104723 · Cited by 18
Stimulatory Effect of Clofibrate on the Action of Estradiol in the Mammary Gland but Not in the Uterus of Rats
Xu, S. S., Zhu, B. T., Cai, M. X., & Conney, A. H. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29510-0 · Cited by 15
Comparison of full-length versus ligand binding domain constructs in cell-free and cell-based peroxisome proliferator-activated receptor alpha assays
Berbaum, J., & Harrison, R. K. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.01.007 · Cited by 7
Uterotropic effect of clofibrate and phenylbutazone in immature female rats.
Chandra, D., Thulasimany, M., & Biswas, A. R. (1983) · PubMed · Cited by 3
Clofibrate.
(1996) · PubMed Central · Cited by 3

Research works printed but not linked: 1

IARC, 1996, Clofibrate, IARC Monograph, 66, 391

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Neurotoxic Effects of Mixtures of Perfluoroalkyl Substances (PFAS) at Environmental and Human Blood Concentrations
Ríos-Bonilla, K. M., Aga, D. S., Lee, J., König, M., Qin, W., Cristobal, J. R., Atilla‐Gokcumen, G. E., & Escher, B. I. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.4c06017 · Cited by 69
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See all 208

Authors: Evans, N., Conley, J. M., Cardon, M., Hartig, P., Medlock-Kakaley, E., & Gray, L. E.
Affiliations: Environmental Protection Agency (US)
Corresponding author: Conley, Justin M.
ORCID: Evans, Nicola
Conley, Justin M.
Medlock-Kakaley, Elizabeth
Gray, L. Earl
Venue: Toxicology and Applied Pharmacology
Publisher: Elsevier BV
Published: 2022-08
Volume: 449
Pages: 116136
ISSN: 0041-008X (ISSN-L)
DOI: 10.1016/j.taap.2022.116136
PMC: PMC9341220
OpenAlex: W4283375803
Cited by: 208
References: 72
Citations by year: 2026: 53 · 2025: 73 · 2024: 51 · 2023: 29 · 2022: 2
FWCI: 13.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Toxicology and Applied Pharmacology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Topics: Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Keywords: per- and polyfluoroalkyl substances, PPARα, PPARγ, estrogen receptor, nuclear receptor activation, HFPO-DA, fatty acids, clofibric acid, clofibrate, Wy-14,643, PFOS, PFHxS, molecular initiating events, liver weight, endocrine disruptors
MeSH terms: Animals, Fatty Acids, Female, Fluorocarbons, Ligands, Male, Receptors, Estrogen, PPAR alpha, PPAR gamma, Rats

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In vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays

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