Iron uptake and metabolism in the new millennium

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803

Hepcidin, a urinary antimicrobial peptide synthesized in the liver

Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168

Balancing Acts

Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., & Vaulont, S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.151179498 · Cited by 1,233

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., & Andrews, N. C. (1997) · Nature Genetics · doi:10.1038/ng0897-383 · Cited by 1,159

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026

Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

Ohgami, R. S., Campagna, D. R., Greer, E. L., Antiochos, B., McDonald, A., Chen, J., Sharp, J. J., Fujiwara, Y., Barker, J. E., & Fleming, M. D. (2005) · Nature Genetics · doi:10.1038/ng1658 · Cited by 775

Identification of an Intestinal Heme Transporter

Shayeghi, M., Latunde-Dada, G. O., Oakhill, J. S., Laftah, A. H., Takeuchi, K., Halliday, N., Khan, Y., Warley, A., McCann, F. E., Hider, R. C., et al. (2005) · Cell · doi:10.1016/j.cell.2005.06.025 · Cited by 755

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

Puccio, H., Simon, D., Cossée, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P., & Koenig, M. (2001) · Nature Genetics · doi:10.1038/84818 · Cited by 738

Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency

Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908355 · Cited by 2,083

Iron deficiency: an ominous sign in patients with systolic chronic heart failure

Jankowska, E. A., Rozentryt, P., Witkowska, A., Nowak, J., Hartmann, O., Ponikowska, B., Borodulin-Nadzieja, L., Banasiak, W., Polonski, L., Filippatos, G., et al. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq158 · Cited by 652

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Richardson, D. R., Lane, D. J. R., Becker, E. M., Huang, M. L.-H., Whitnall, M., Rahmanto, Y. S., Sheftel, A. D., & Ponka, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912925107 · Cited by 536

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554

Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

Ishii, K.-A., Fumoto, T., Iwai, K., Takeshita, S., Ito, M., Shimohata, N., Aburatani, H., Taketani, S., Lelliott, C. J., Vidal-Puig, A., et al. (2009) · Nature Medicine · doi:10.1038/nm.1910 · Cited by 410

Iron deficiency and heart failure: diagnostic dilemmas and therapeutic perspectives

Jankowska, E. A., von Haehling, S., Anker, S. D., Macdougall, I. C., & Ponikowski, P. (2013) · European Heart Journal · doi:10.1093/eurheartj/ehs224 · Cited by 399

Redox signaling and cancer: The role of “labile” iron

Galaris, D., Skiada, V., & Barbouti, A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.02.038 · Cited by 284

Iron Deficiency Predicts Impaired Exercise Capacity in Patients With Systolic Chronic Heart Failure

Jankowska, E. A., Rozentryt, P., Witkowska, A., Nowak, J., Hartmann, O., Ponikowska, B., Borodulin-Nadzieja, L., von Haehling, S., Doehner, W., Banasiak, W., et al. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.08.003 · Cited by 281

Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy

Pringle, K. G., Kind, K. L., Sferruzzi-Perri, A. N., Thompson, J. G., & Roberts, C. T. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp046 · Cited by 259

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

Huang, M. L.-H., Becker, E. M., Whitnall, M., Rahmanto, Y. S., Ponka, P., & Richardson, D. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906784106 · Cited by 212

Nramp1 phagocyte intracellular metal withdrawal defense

Cellier, M. F., Courville, P., & Campion, C. (2007) · Microbes and Infection · doi:10.1016/j.micinf.2007.09.006 · Cited by 203

Iron export through the transporter ferroportin 1 is modulated by the iron chaperone PCBP2

Yanatori, I., Richardson, D. R., Imada, K., & Kishi, F. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.721936 · Cited by 170

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

Foot, N. J., Dalton, H. E., Shearwin-Whyatt, L. M., Dorstyn, L., Tan, S.-S., Yang, B., & Kumar, S. (2008) · Blood · doi:10.1182/blood-2008-04-150953 · Cited by 143

Cooperation of two mRNA-Binding proteins drives metabolic adaptation to iron deficiency

Puig, S., Vergara, S. V., & Thiele, D. J. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.04.010 · Cited by 135

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

Zhang, Z., Zhang, F., Guo, X., An, P., Tao, Y., & Wang, F. (2012) · Hepatology · doi:10.1002/hep.25746 · Cited by 123

Iron overload signature in chrysotile-induced malignant mesothelioma

Jiang, L., Akatsuka, S., Nagai, H., Chew, S., Ohara, H., Okazaki, Y., Yamashita, Y., Yoshikawa, Y., Yasui, H., Ikuta, K., et al. (2012) · The Journal of Pathology · doi:10.1002/path.4075 · Cited by 104

Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

Huang, M. L.-H., Lane, D. J. R., & Richardson, D. R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3921 · Cited by 103

Impaired iron status in aging research

Xu, J., Jia, Z., Knutson, M. D., & Leeuwenburgh, C. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13022368 · Cited by 103

Compartmentalization of iron between mitochondria and the cytosol and its regulation

Mühlenhoff, U., Hoffmann, B., Richter, N., Rietzschel, N., Spantgar, F., Stehling, O., Uzarska, M. A., & Lill, R. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.05.003 · Cited by 95

Increased Body Iron Stores Are Associated With Poor Outcome After Thrombolytic Treatment in Acute Stroke

Millan, M., Sobrino, T., Castellanos, M., Nombela, F., Arenillas, J. F., Riva, E., Cristobo, I., García, M. M., Vivancos, J., Serena, J., et al. (2007) · Stroke · doi:10.1161/01.str.0000251798.25803.e0 · Cited by 92

Intravenous iron supplementation in distance runners with low or suboptimal ferritin

GARVICAN, L. A., SAUNDERS, P. U., CARDOSO, T., MACDOUGALL, I. C., LOBIGS, L. M., FAZAKERLEY, R., FALLON, K. E., ANDERSON, B., ANSON, J. M., THOMPSON, K. G., et al. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182a53594 · Cited by 91

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

Yanatori, I., Richardson, D. R., Toyokuni, S., & Kishi, F. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.776021 · Cited by 69

Transferrin-mediated iron sequestration suggests a novel therapeutic strategy for controlling Nosema disease in the honey bee, Apis mellifera

Rodríguez-García, C., Heerman, M. C., Cook, S. C., Evans, J. D., DeGrandi-Hoffman, G., Banmeke, O., Zhang, Y., Huang, S., Hamilton, M., & Chen, Y. P. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009270 · Cited by 50

Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1

Núñez, M. T., Tapia, V., Rojas, A., Aguirre, P., Gómez, F., & Nualart, F. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00168.2009 · Cited by 44

Joint Model of Iron and Hepcidin During the Menstrual Cycle in Healthy Women

Angeli, A., Lainé, F., Lavenu, A., Ropert, M., Lacut, K., Gissot, V., Sacher-Huvelin, S., Jezequel, C., Moignet, A., Laviolle, B., et al. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9875-4 · Cited by 40

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

Lok, H. C., Sahni, S., Jansson, P. J., Kovacevic, Z., Hawkins, C. L., & Richardson, D. R. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.763714 · Cited by 36

N‐tert‐butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration

Voloboueva, L. A., Killilea, D. W., Atamna, H., & Ames, B. N. (2007) · The FASEB Journal · doi:10.1096/fj.07-8396com · Cited by 33

Heme‐dependent autophosphorylation of a heme sensor kinase, ChrS, from Corynebacterium diphtheriae reconstituted in proteoliposomes

Ito, Y., Nakagawa, S., Komagata, A., Ikeda-Saito, M., Shiro, Y., & Nakamura, H. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.06.001 · Cited by 28

Flow cytometric estimation of ‘labile iron pool’ in human white blood cells reveals a positive association with ageing

Doulias, P.-T., Vlachou, C., Boudouri, C., Kanavaros, P., Siamopoulos, K. C., & Galaris, D. (2008) · Free Radical Research · doi:10.1080/10715760801911649 · Cited by 21