Cooperation of two mRNA-Binding proteins drives metabolic adaptation to iron deficiency

Puig, Sergi; Vergara, Sandra V.; Thiele, Dennis J.

doi:10.1016/j.cmet.2008.04.010

Cited by 135Iron Metabolism and DisordersRNA Research and SplicingFungal and yeast genetics research

Cooperation of two mRNA-Binding proteins drives metabolic adaptation to iron deficiency

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Puig, Sergi, Vergara, Sandra V., Thiele, Dennis J.·2008·Cell Metabolism

DOI 10.1016/j.cmet.2008.04.010PMC PMC2459314

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Abstract

Iron (Fe) is an essential cofactor for a wide range of cellular processes. We have previously demonstrated in yeast that Cth2 is expressed during Fe deficiency and promotes degradation of a battery of mRNAs leading to reprogramming of Fe-dependent metabolism and Fe storage. We report here that the Cth2-homologous protein Cth1 is transiently expressed during Fe deprivation and participates in the response to Fe deficiency through the degradation of mRNAs primarily involved in mitochondrially localized activities including respiration and amino acid biosynthesis. In parallel, wild-type cells, but not cth1Deltacth2Delta cells, accumulate mRNAs encoding proteins that function in glucose import and storage and store high levels of glycogen. In addition, Fe deficiency leads to phosphorylation of Snf1, an AMP-activated protein kinase family member required for the cellular response to glucose starvation. These studies demonstrate a metabolic reprogramming as a consequence of Fe starvation that is dependent on the coordinated activities of two mRNA-binding proteins.

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Under iron limitation, yeast cells lacking Cth2 display high mRNA levels of multiple ERG genes including ERG1, ERG7, ERG11 and DAP1.
“Under iron limitation, yeast cells lacking the iron-regulated RNA-binding protein Cth2 display high mRNA levels of multiple ERG genes including those of the first steps of the late stage of synthesis (ERG1, ERG7, ERG11 and DAP1) [116,118].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [118]

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Post-transcriptional regulation of gene expression in response to iron deficiency in Saccharomyces cerevisiae
Vergara, S. V. (2010) · DukeSpace (Duke University)

Authors: Puig, S., Vergara, S. V., & Thiele, D. J.
Affiliations: Universitat de València (ES)
Duke Medical Center (US)
Corresponding author: Puig, Sergi
Thiele, Dennis J.
ORCID: Puig, Sergi
Vergara, Sandra V.
Thiele, Dennis J.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2008-06
Volume: 7
Issue: 6
Pages: 555-564
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2008.04.010
PMC: PMC2459314
OpenAlex: W2041968919
Cited by: 135
References: 38
Citations by year: 2026: 3 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 11 · 2017: 8 · 2016: 8 · 2015: 4 · 2014: 7 · 2013: 12 · 2012: 13
FWCI: 5.84
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1872 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: University of Pittsburgh
National Institutes of Health
U.S. Public Health Service (FDK081304A)
National Institute of General Medical Sciences (GM 41840, R01GM041840)
National Institute of Diabetes and Digestive and Kidney Diseases (F31DK081304)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: iron deficiency, mRNA-binding proteins, mRNA degradation, metabolic reprogramming, Snf1, AMPK, glycogen storage, mitochondrial respiration, amino acid biosynthesis, Saccharomyces cerevisiae, iron starvation response
MeSH terms: Iron Deficiencies, Adaptation, Physiological, DNA-Binding Proteins, Metabolism, Phosphorylation, RNA, Messenger, Saccharomyces cerevisiae, Transcription Factors, RNA-Binding Proteins, Protein Serine-Threonine Kinases, Saccharomyces cerevisiae Proteins, Tristetraprolin

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Cooperation of two mRNA-Binding proteins drives metabolic adaptation to iron deficiency

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