Impaired iron status in aging research

Xu, Jinze; Jia, Zhenhua; Knutson, Mitchell D.; Leeuwenburgh, Christiaan

doi:10.3390/ijms13022368

Cited by 103Iron Metabolism and DisordersTrace Elements in HealthNeurological diseases and metabolism

Impaired iron status in aging research

Open access

Xu, Jinze, Jia, Zhenhua, Knutson, Mitchell D., Leeuwenburgh, Christiaan·2012·International Journal of Molecular Sciences

DOI 10.3390/ijms13022368PMC PMC3292028

Open this paper in CoChat — free account Open PDF

Abstract

Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/ijms13022368

Cites

127 of 127 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Age-dependent accumulation of iron in various tissues occurs separately to the enrichment of senescent cells.
“Age-dependent accumulation of iron in various tissues has been reported to occur separately to the enrichment of senescent cells [11], [12], [16], [17], [18], [19].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [12]
Conceivably, senescent cells account for the increased iron observed in aged tissues and in organs affected by age-related pathologies.
“Conceivably, senescent cells account for the increased iron observed in aged tissues [11], [12] and similarly in organs affected by age-related pathologies [13], [14], [15].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [12]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
Reeves, P. G., Nielsen, F. H., & Fahey, G. C., Jr. (1993) · Journal of Nutrition · doi:10.1093/jn/123.11.1939 · Cited by 8,730 · see citing works
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T., & Kaplan, J. (2004) · Science · doi:10.1126/science.1104742 · Cited by 4,803 · see citing works
A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., & Loréal, O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008923200 · Cited by 1,697 · see citing works
A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation
McKie, A. T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T. J., Farzaneh, F., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80425-6 · Cited by 1,422 · see citing works
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., & Ganz, T. (2003) · Blood · doi:10.1182/blood-2002-10-3235 · Cited by 1,417 · see citing works
Dysmetabolic Hyperferritinemia: All Iron Overload Is Not Hemochromatosis
Makker, J. S., Hanif, A., Bajantri, B., & Chilimuri, S. S. (2015) · Case Reports in Gastroenterology · doi:10.1159/000373883 · Cited by 1,353 · see citing works
High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men
Salonen, J. T., Nyyssönen, K., Korpela, H., Tuomilehto, J., Seppänen, R., & Salonen, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.803 · Cited by 1,284 · see citing works
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
Donovan, A., Lima, C. A., Pinkus, J. L., Pinkus, G. S., Zon, L. I., Robine, S., & Andrews, N. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.003 · Cited by 1,275 · see citing works
Regulation of cellular iron metabolism
Wang, J., & Pantopoulos, K. (2011) · Biochemical Journal · doi:10.1042/bj20101825 · Cited by 986 · see citing works
Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence
Weindruch, R. H., & Walford, R. L. (1982) · Science · doi:10.1126/science.7063854 · Cited by 766 · see citing works
Gemcitabine: metabolism, mechanisms of action, and self-potentiation.
Plunkett, W. K., Huang, P., Xu, Y.-Z., Heinemann, V., Grunewald, R., & Gandhi, V. V. (1995) · PubMed · Cited by 753 · see citing works
Immunoassay for human serum hepcidin
Ganz, T., Olbina, G., Girelli, D., Nemeth, E., & Westerman, M. (2008) · Blood · doi:10.1182/blood-2008-02-139915 · Cited by 688 · see citing works
Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program
Turturro, A., Witt, W. W., Lewis, S. M., Hass, B. S., Lipman, R. D., & Hart, R. W. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.11.b492 · Cited by 668 · see citing works
Body iron metabolism and pathophysiology of iron overload
Kohgo, Y., Ikuta, K., Ohtake, T., Torimoto, Y., & Kato, J. (2008) · International Journal of Hematology · doi:10.1007/s12185-008-0120-5 · Cited by 616 · see citing works
The Role of Hepcidin in Iron Metabolism
Nemeth, E., & Ganz, T. (2009) · Acta Haematologica · doi:10.1159/000243791 · Cited by 607 · see citing works
Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export
Lei, P., Ayton, S., Finkelstein, D. I., Spoerri, L., Ciccotosto, G. D., Wright, D. K., Wong, B. X. W., Adlard, P. A., Cherny, R. A., Lam, L. Q., et al. (2012) · Nature Medicine · doi:10.1038/nm.2613 · Cited by 594 · see citing works
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells
Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606424103 · Cited by 577 · see citing works
Self-citation
Anemia Is Associated with Disability and Decreased Physical Performance and Muscle Strength in the Elderly
Penninx, B. W. J. H., Pahor, M., Cesari, M., Corsi, A. M., Woodman, R. C., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52208.x · Cited by 567 · see citing works
Role of iron in carcinogenesis: cancer as a ferrotoxic disease
Toyokuni, S. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2008.01001.x · Cited by 552 · see citing works
PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
Morgan, N. V., Westaway, S. K., Morton, J. E. V., Gregory, A., Gissen, P., Sonek, S., Cangül, H., Coryell, J. C., Canham, N. L. E., Nardocci, N., et al. (2006) · Nature Genetics · doi:10.1038/ng1826 · Cited by 532 · see citing works
Labile iron pool: the main determinant of cellular response to oxidative stress
Kruszewski, M. K. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.004 · Cited by 529 · see citing works
Inhibition of non-haem iron absorption in man by polyphenolic-containing beverages
Hurrell, R. F., Reddy, M., & Cook, J. D. (1999) · British Journal of Nutrition · doi:10.1017/s0007114599000537 · Cited by 490 · see citing works
Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia major patients with asymptomatic myocardial siderosis
Pennell, D. J. (2005) · Blood · doi:10.1182/blood-2005-07-2948 · Cited by 490 · see citing works
Prevalence of anaemia in older persons: systematic review
Gaskell, H., Derry, S., Moore, R. A., & McQuay, H. J. (2008) · BMC Geriatrics · doi:10.1186/1471-2318-8-1 · Cited by 489 · see citing works
On T2* Magnetic Resonance and Cardiac Iron
Carpenter, J., He, T., Kirk, P., Roughton, M., Anderson, L. J., de Noronha, S. V., Sheppard, M. N., Porter, J. B., Walker, J. M., Wood, J. C., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.007641 · Cited by 486 · see citing works
The UFAW Handbook on the Care and Management of Laboratory Animals.
(1958) · Archives of Ophthalmology · doi:10.1001/archopht.1958.00940081000029 · Cited by 451 · see citing works
Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta-thalassaemia
Anderson, L. J., Wonke, B., Prescott, E., Holden, S., Walker, J. M., & Pennell, D. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09740-4 · Cited by 431 · see citing works
Mitochondrial Dysfunction Leads to Nuclear Genome Instability via an Iron-Sulfur Cluster Defect
Veatch, J. R., McMurray, M. A., Nelson, Z. W., & Gottschling, D. E. (2009) · Cell · doi:10.1016/j.cell.2009.04.014 · Cited by 427 · see citing works
Untitled work
(1989) · PubMed · Cited by 421 · see citing works
Iron uptake and metabolism in the new millennium
Dunn, L., Rahmanto, Y. S., & Richardson, D. R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.12.003 · Cited by 419 · see citing works
Iron, Neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes
Zecca, L., Gallorini, M., Schünemann, V., Trautwein, A. X., Gerlach, M., Riederer, P., Vezzoni, P., & Tampellini, D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00186.x · Cited by 401 · see citing works
Clinical and genetic delineation of neurodegeneration with brain iron accumulation
Gregory, A., Polster, B. J., & Hayflick, S. J. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.061929 · Cited by 364 · see citing works
Impact of Anemia on Mortality, Cognition, and Function in Community-Dwelling Elderly
Denny, S. D., Kuchibhatla, M. N., & Cohen, H. J. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.08.027 · Cited by 356 · see citing works
Age-related Iron Deposition in the Basal Ganglia: Quantitative Analysis in Healthy Subjects
Aquino, D., Bizzi, A., Grisoli, M., Garavaglia, B., Bruzzone, M. G., Nardocci, N., Savoiardo, M., & Chiapparini, L. (2009) · Radiology · doi:10.1148/radiol.2522081399 · Cited by 296 · see citing works
Association Between Body Iron Stores and the Risk of Acute Myocardial Infarction in Men
Tuomainen, T.-P., Punnonen, K., Nyyssönen, K., & Salonen, J. T. (1998) · Circulation · doi:10.1161/01.cir.97.15.1461 · Cited by 286 · see citing works
Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion
Schrag, M., Mueller, C., Oyoyo, U. E., Smith, M. A., & Kirsch, W. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.001 · Cited by 266 · see citing works
Anemia in the elderly: Current understanding and emerging concepts
Eisenstaedt, R. S., Penninx, B. W. J. H., & Woodman, R. C. (2006) · Blood Reviews · doi:10.1016/j.blre.2005.12.002 · Cited by 261 · see citing works
Micronutrient deficiencies and gender: social and economic costs.
Darnton-Hill, I., Webb, P., Harvey, P., Hunt, J., Dalmiya, N., Chopra, M., Ball, M., Bloem, M. W., & de Benoist, B. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.5.1198 · Cited by 245 · see citing works
The pathogenesis of Friedreich ataxia and the structure and function of frataxin
Pandolfo, M., & Pastore, A. (2009) · Journal of Neurology · doi:10.1007/s00415-009-1003-2 · Cited by 242 · see citing works
Impact of Anemia on Mortality, Cognition, and Function in Community-Dwelling Elderly
Gordon, M. S. (2007) · Yearbook of Oncology · doi:10.1016/s1040-1741(08)70286-0 · Cited by 232 · see citing works
Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging
Atamna, H., Killilea, D. W., Killilea, A. N., & Ames, B. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192585799 · Cited by 228 · see citing works
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
Galy, B., Ferring–Appel, D., Miñana, B., Bell, O., Janser, H., Muckenthaler, M. U., Schümann, K., & Hentze, M. W. (2005) · Blood · doi:10.1182/blood-2005-04-1365 · Cited by 222 · see citing works
Position Statement on Human Aging
Olshansky, S. J., Hayflick, L., & Carnes, B. A. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.8.b292 · Cited by 202 · see citing works
The role of iron in mitochondrial function
Levi, S., & Rovida, E. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.008 · Cited by 195 · see citing works
Iron in arterial plaque: A modifiable risk factor for atherosclerosis
Sullivan, J. L. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.06.005 · Cited by 176 · see citing works
Intracellular labile iron
Breuer, W., Shvartsman, M., & Cabantchik, Z. I. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.03.010 · Cited by 175 · see citing works
Aging of subcortical nuclei: Microstructural, mineralization and atrophy modifications measured in vivo using MRI
Cherubini, A., Péran, P., Caltagirone, C., Sabatini, U., & Spalletta, G. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.06.035 · Cited by 173 · see citing works
Heme, iron, and the mitochondrial decay of ageing.
Atamna, H. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.02.002 · Cited by 169 · see citing works
Dietary iron restriction or iron chelation protects from diabetes and loss of β-cell function in the obese (ob/ob lep−/−) mouse
Cooksey, R. C., Jones, D., Gabrielsen, S., Huang, J., Simcox, J., Luo, B., Soesanto, Y., Rienhoff, H. Y., Abel, E. D., & McClain, D. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00022.2010 · Cited by 168 · see citing works
The Regulation of Cellular Iron Metabolism
Chua, A. C. G., Graham, R. M., Trinder, D., & Olynyk, J. K. (2007) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360701428257 · Cited by 168 · see citing works
Redistribution of accumulated cell iron: a modality of chelation with therapeutic implications
Sohn, Y.-S., Breuer, W., Munnich, A., & Cabantchik, Z. I. (2008) · Blood · doi:10.1182/blood-2007-07-102335 · Cited by 167 · see citing works
Heme Deficiency Selectively Interrupts Assembly of Mitochondrial Complex IV in Human Fibroblasts
Atamna, H., Liu, J., & Ames, B. N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108362200 · Cited by 166 · see citing works
ZRT/IRT-like Protein 14 (ZIP14) Promotes the Cellular Assimilation of Iron from Transferrin
Zhao, N., Gao, J., Enns, C. A., & Knutson, M. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.143248 · Cited by 166 · see citing works
Self-citation
Ironing Out Cancer
Torti, S. V., & Torti, F. M. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3614 · Cited by 157 · see citing works
Iron Induced Oxidative Damage As a Potential Factor in Age-Related Macular Degeneration: The Cogan Lecture
Dunaief, J. L. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.06-0568 · Cited by 154 · see citing works
Oxidative Inactivation of Mitochondrial Aconitase Results in Iron and H2O2-Mediated Neurotoxicity in Rat Primary Mesencephalic Cultures
Cantu, D., Schaack, J. B., & Patel, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007095 · Cited by 142 · see citing works
Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy
Hofer, T., Marzetti, E., Xu, J., Seo, A. Y., Güleç, Ş., Knutson, M. D., Leeuwenburgh, C., & Dupont‐Versteegden, E. E. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.02.007 · Cited by 140 · see citing works
Self-citation
Iron accumulation in aging: modulation by dietary restriction
Cook, C. I., & Yu, B. P. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00005-0 · Cited by 137 · see citing works
Anemia in older persons: Etiology and evaluation
Price, E. A., Mehra, R., Holmes, T. H., & Schrier, S. L. (2011) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.11.004 · Cited by 135 · see citing works
Dysregulation of Iron Metabolism in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis
Oshiro, S., Morioka, M. S., & Kikuchi, M. (2011) · Advances in Pharmacological Sciences · doi:10.1155/2011/378278 · Cited by 134 · see citing works
Iron Accumulation with Age, Oxidative Stress and Functional Decline
Xu, J., Knutson, M. D., Carter, C. S., & Leeuwenburgh, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002865 · Cited by 128 · see citing works
Self-citation
The Effects of Overfeeding and Dietary Restriction on Sprague-Dawley Rat Survival and Early Pathology Biomarkers of Aging
Keenan, K. P., Smith, P. F., Hertzog, P. R., Soper, K. A., Ballam, G. C., & Clark, R. L. (1994) · Toxicologic Pathology · doi:10.1177/019262339402200308 · Cited by 126 · see citing works
Mitochondrial iron accumulation with age and functional consequences
Seo, A. Y., Xu, J., Servais, S., Hofer, T., Marzetti, E., Wohlgemuth, S. E., Knutson, M. D., Chung, H. Y., & Leeuwenburgh, C. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00418.x · Cited by 123 · see citing works
Self-citation
Does cellular iron dysregulation play a causative role in Parkinson’s disease?
Kaur, D., & Andersen, J. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.01.003 · Cited by 123 · see citing works
The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation
Whitnall, M., Rahmanto, Y. S., Šuťák, R., Xu, X., Becker, E., Mikhael, M., Ponka, P., & Richardson, D. R. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804261105 · Cited by 122 · see citing works
Assessment of Chelatable Mitochondrial Iron by Using Mitochondrion‐Selective Fluorescent Iron Indicators with Different Iron‐Binding Affinities
Rauen, U., Springer, A., Weisheit, D., Petrat, F., Korth, H., de Groot, H., & Sustmann, R. (2007) · ChemBioChem · doi:10.1002/cbic.200600311 · Cited by 121 · see citing works
The Role of Heme and Iron-Sulfur Clusters in Mitochondrial Biogenesis, Maintenance, and Decay with Age
Atamna, H., Walter, P. B., & Ames, B. N. (2002) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2671 · Cited by 118 · see citing works
Volume and iron content in basal ganglia and thalamus
Péran, P., Cherubini, A., Luccichenti, G., Hagberg, G. E., Démonet, J., Rascol, O., Celsis, P., Caltagirone, C., Spalletta, G., & Sabatini, U. (2009) · Human Brain Mapping · doi:10.1002/hbm.20698 · Cited by 116 · see citing works
Microcalcifications in Early Intimal Lesions of Atherosclerotic Human Coronary Arteries
Roijers, R. B., Debernardi, N., Cleutjens, J. P. M., Schurgers, L. J., Mutsaers, P. H. A., & Vusse, G. J. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.02.004 · Cited by 113 · see citing works
Iron reduction by deferoxamine leads to amelioration of adiposity via the regulation of oxidative stress and inflammation in obese and type 2 diabetes KKAy mice
Tajima, S., Ikeda, Y., Sawada, K., Yamano, N., Horinouchi, Y., Kihira, Y., Ishizawa, K., Izawa-Ishizawa, Y., Kawazoe, K., Tomita, S., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00033.2011 · Cited by 112 · see citing works
Association Between Mild Anemia and Executive Function Impairment in Community‐Dwelling Older Women: The Women's Health and Aging Study II
Chaves, P. H. M., Carlson, M. C., Ferrucci, L., Guralnik, J. M., Semba, R. D., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00863.x · Cited by 104 · see citing works
A novel endotoxin-induced pathway: upregulation of heme oxygenase 1, accumulation of free iron, and free iron-mediated mitochondrial dysfunction
Duvigneau, J. C., Piskernik, C., Haindl, S., Kloesch, B., Hartl, R. T., Hüttemann, M., Lee, I., Ebel, T., Moldzio, R., Gemeiner, M., et al. (2008) · Laboratory Investigation · doi:10.1038/labinvest.3700691 · Cited by 101 · see citing works
Age-dependent and gender-specific changes in mouse tissue iron by strain
Hahn, P., Song, Y., Ying, G.-S., He, X., Beard, J., & Dunaief, J. L. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.06.006 · Cited by 98 · cited 1× · see citing works
“[13,57] reported age- and sex-dependent changes in tissue iron levels among C57BL/6, DBA/2J, and BALB/c mouse strains and”
Background
Nanoparticle and Iron Chelators as a Potential Novel Alzheimer Therapy
Liu, G., Men, P., Perry, G. L., & Smith, M. A. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-029-8_8 · Cited by 95 · see citing works
SIH—a novel lipophilic iron chelator—protects H9c2 cardiomyoblasts from oxidative stress-induced mitochondrial injury and cell death
Šimůnek, T., Boer, C., Bouwman, R. A., VLASBLOM, R., Versteilen, A. M. G., Štěrba, M., Geršl, V., Hrdina, R., Poňka, P., & DELANGE, J. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.05.008 · Cited by 91 · see citing works
Effect of open and closed formula rations on the performance of three strains of laboratory mice.
Knapka, J. J., Smith, K. P., & Judge, F. J. (1974) · PubMed · Cited by 88 · see citing works
Iron load and redox stress in skeletal muscle of aged rats
Altun, M., Edström, E., Spooner, E., Flores‐Moralez, A., Bergman, E., Tollet‐Egnell, P., Norstedt, G., Kessler, B. M., & Ulfhake, B. (2007) · Muscle & Nerve · doi:10.1002/mus.20808 · Cited by 87 · see citing works
Iron accumulation and lipid peroxidation in aging C57BL/6J mice
Massie, H. R., Aiello, V. R., & Banziger, V. (1983) · Experimental Gerontology · doi:10.1016/0531-5565(83)90038-4 · Cited by 86 · see citing works
Is stored iron safe?
Sullivan, J. L. (2004) · Journal of Laboratory and Clinical Medicine · doi:10.1016/j.lab.2004.10.006 · Cited by 82 · see citing works
Nutrient Intake and Anemia Risk in the Women's Health Initiative Observational Study
Thomson, C. A., Stanaway, J. D., Neuhouser, M. L., Snetselaar, L. G., Stefanick, M. L., Arendell, L. A., & Chen, Z. (2011) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2011.01.017 · Cited by 78 · see citing works
Age-related declines in hematopoietic reserve capacity.
Lipschitz, D. A. (1995) · PubMed · Cited by 78 · see citing works
Role of iron in oxidative stress in skeletal muscle atrophied by immobilization
Kondo, H., Miura, M., Kodama, J., Ahmed, S. M., & Itokawa, Y. (1992) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374844 · Cited by 76 · see citing works
SERUM FERRITIN AND AGEING
Casale, G., BONORA, C., MIGLIAVACCA, A., ZURITA, I. E., & de Nicola, P. (1981) · Age and Ageing · doi:10.1093/ageing/10.2.119 · Cited by 76 · see citing works
Iron Chelation Protects the Retinal Pigment Epithelial Cell Line ARPE-19 against Cell Death Triggered by Diverse Stimuli
Lukinova, N. I., Iacovelli, J., Dentchev, T., Wolkow, N., Hunter, A. A., Amado, D. A., Ying, G., Sparrow, J. R., & Dunaief, J. L. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2545 · Cited by 71 · see citing works
Discovery of 4-(4-(2-((5-Hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)(propyl)amino)ethyl)piperazin-1-yl)quinolin-8-ol and Its Analogues as Highly Potent Dopamine D2/D3 Agonists and as Iron Chelator: In Vivo Activity Indicates Potential Application in Symptomatic and Neuroprotective Therapy for Parkinson’s Disease
Ghosh, B., Antonio, T., Reith, M. E. A., & Dutta, A. K. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm901618d · Cited by 70 · see citing works
Hematopoiesis and aging III: Anemia and a blunted erythropoietic response to hemorrhage in aged mice
Boggs, D. R., & Patrene, K. D. (1985) · American Journal of Hematology · doi:10.1002/ajh.2830190403 · Cited by 67 · see citing works
Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment
Goncalves, S., Paupe, V., Dassa, E. P., & Rustin, P. (2008) · BMC Neurology · doi:10.1186/1471-2377-8-20 · Cited by 66 · see citing works
Descriptive analysis of the prevalence of anemia in a randomly selected sample of elderly people living at home: Some results of an italian multicentric study
İnelmen, E., D'Alessio, M., Gatto, M. R., Baggio, M. B., Jiménez, G. G., Bizzotto, M., & Enzi, G. (1994) · Aging Clinical and Experimental Research · doi:10.1007/bf03324220 · Cited by 65 · see citing works
Anemia in Frailty
Roy, C. N. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.08.005 · Cited by 65 · see citing works
The Fischer 344/NNiaHSd X Brown Norway/BiNia is a Better Model of Sarcopenia than the Fischer 344/NNiaHSd: a Comparative Analysis of Muscle Mass and Contractile Properties in Aging Male Rat Models
Rice, K. M., Linderman, J. K., Kinnard, R. S., & Blough, E. R. (2005) · Biogerontology · doi:10.1007/s10522-005-4808-0 · Cited by 60 · see citing works
Serum transferrin receptor in the evaluation of the iron status in elderly hospitalized patients with anemia
Joosten, E., van Loon, R., Billen, J., Blanckaert, N. J. C., Fabri, R., & Pelemans, W. (2001) · American Journal of Hematology · doi:10.1002/ajh.10014 · Cited by 59 · see citing works
DMT1 polymorphism and risk of Parkinson's disease.
He, Q., Du, T., Yu, X., Xie, A., Song, N., Kang, Q., Yu, J.-T., Tan, L., Xie, J.-X., & Jiang, H. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.001 · Cited by 57 · see citing works
Effect of age and caloric restriction on bleomycin-chelatable and nonheme iron in different tissues of C57BL/6 mice
Sohal, R. S., Wennberg-Kirch, E., Jaiswal, K. R., Kwong, L. K., & Forster, M. J. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00052-0 · Cited by 54 · see citing works
Iron Withholding: A Defense Against Disease
Weinberg, E. D., & Judith Miklossy, A. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13409 · Cited by 53 · see citing works
Iron as a target of chemoprevention for longevity in humans
Toyokuni, S. (2011) · Free Radical Research · doi:10.3109/10715762.2011.564170 · Cited by 53 · see citing works
The Laboratory Rat
Koolhaas, J. M. (2010) · doi:10.1002/9781444318777.ch22 · Cited by 50 · see citing works
Chelation of Mitochondrial Iron Prevents Seizure-Induced Mitochondrial Dysfunction and Neuronal Injury
Liang, L., Jarrett, S. G., & Patel, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3016-08.2008 · Cited by 50 · see citing works
Iron Status and Stores Decline with Age in Lewis Rats
Ahluwalia, N., Gordon, M. A., Handte, G., Mahlon, M. W., Li, N.-Q., Beard, J. L., Weinstock, D., & Ross, A. C. (2000) · Journal of Nutrition · doi:10.1093/jn/130.9.2378 · Cited by 48 · see citing works
Plantaris muscle of aged rats demonstrates iron accumulation and altered expression of iron regulation proteins
Jung, S. H., DeRuisseau, L. R., Kavazis, A. N., & DeRuisseau, K. C. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2007.039453 · Cited by 47 · see citing works
Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy
Xu, J., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, S. E., Knutson, M. D., Judge, A. R., Dupont‐Versteegden, E. E., Marzetti, E., & Leeuwenburgh, C. (2011) · Experimental Gerontology · doi:10.1016/j.exger.2011.10.011 · Cited by 47 · see citing works
Self-citation
Iron and intestinal immunity
Cherayil, B. J., Ellenbogen, S., & Shanmugam, N. K. N. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834a4cd1 · Cited by 45 · see citing works
Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry
Leverence, R., Mason, A. B., & Kaltashov, I. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914898107 · Cited by 45 · see citing works
Relationship between brain R2 and liver and serum Iron concentrations in elderly men
House, M. J., Pierre, T. G. S., Milward, E. A., Bruce, D. G., & Olynyk, J. K. (2010) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22263 · Cited by 42 · see citing works
Hemopoiesis and Aging
Balducci, L., Hardy, C. L., & Lyman, G. H. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-387-23962-6_6 · Cited by 42 · see citing works
Intracellular and Extracellular Labile Iron Pools
Cabantchik, Z. I., Kakhlon, O., Epsztejn, S., Zanninelli, G., & Breuer, W. V. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0593-8_4 · Cited by 39 · see citing works
Hematologic and serum electrolyte values of the C57BL-6J male mouse in maturity and senescence.
Ce, F., & Foster (1973) · PubMed · Cited by 36 · see citing works
Implications of altered iron homeostasis for age-related macular degeneration
Błasiak, J. (2010) · Frontiers in bioscience · doi:10.2741/3804 · Cited by 34 · see citing works
Iron balance in the mouse.
Sorbie, J., & VALBERG, L. S. (1974) · PubMed · Cited by 26 · see citing works
Comparison of erythropoietic response to androgen in young and old senescence accelerated mice
Saitoh, T., Morimoto, K., Kumagai, T., Tsuboi, I., Aikawa, S., & Horie, T. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00032-9 · Cited by 26 · see citing works
Non-protein bound iron release during chemotherapy in cancer patients
Weijl, N. I., Elsendoorn, T. J., Moison, R. M. W., Lentjes, E. G. W. M., Brand, R., Berger, H. M., & Osanto, S. (2004) · Clinical Science · doi:10.1042/cs20030271 · Cited by 24 · see citing works
Aging is an organ-specific process: changes in homeostasis of iron and redox proteins in the rat
Bulvik, B. E., Berenshtein, E., Konijn, A. M., Grinberg, L. N., Vinokur, V., Eliashar, R., & Chevion, M. (2011) · AGE · doi:10.1007/s11357-011-9268-7 · Cited by 23 · see citing works
The anemia of ageing is not associated with increased plasma hepcidin levels
Lee, P. L., Gelbart, T., Waalen, J., & Beutler, E. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.06.005 · Cited by 22 · see citing works
Deferasirox Decreases Age-Associated Iron Accumulation in the Aging F344XBN Rat Heart and Liver
Arvapalli, R. K., Paturi, S., Laurino, J. P., Katta, A., Kakarla, S. K., Gadde, M. K., Wu, M., Rice, K. M., Walker, E. M., Wehner, P. S., et al. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9068-9 · Cited by 21 · see citing works
Modification of age-induced changes in heme and hemoproteins by testosterone in male rats
Bitar, M. S., & Weiner, M. (1983) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(83)90029-5 · Cited by 20 · see citing works
Pathology and tumor incidence in aged Lewis and BN rats
Feldman, J. D., & Woda, B. A. (1980) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(80)90045-8 · Cited by 20 · see citing works
Serum Iron, Transferrin Saturation, Ferritin, and Dietary Data in Age-Related Macular Degeneration
Richer, S., Rudy, D., Statkute, L., Karofty, K., & Frankowski, J. (2002) · American Journal of Therapeutics · doi:10.1097/00045391-200201000-00006 · Cited by 17 · see citing works
Effect of age and dietary protein level on tissue mineral levels in female rats
Takeda, T., Kimura, M., Yokoi, K., & Itokawa, Y. (1996) · Biological Trace Element Research · doi:10.1007/bf02785320 · Cited by 16 · see citing works
Aortic Aging in the Fischer 344 / NNiaHSd × Brown Norway / BiNia Rat
Rice, K. M., Wu, M., & Blough, E. R. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08r02cp · Cited by 15 · see citing works
Poor Iron Status Is More Prevalent in Hispanic Than in Non-Hispanic White Older Adults in Massachusetts
Seaverson, E. L. D., Buell, J. S., Fleming, D. J., Bermúdez, O. I., Potischman, N. A., Wood, R. J., Chasan‐Taber, L., & Tucker, K. L. (2007) · Journal of Nutrition · doi:10.1093/jn/137.2.414 · Cited by 13 · see citing works
A mathematical model of erythropoiesis suggests an altered plasma volume control as cause for anemia in aged mice
Loeffler, M., & Pantel, K. (1990) · Experimental Gerontology · doi:10.1016/0531-5565(90)90036-2 · Cited by 12 · see citing works
Anemia in Postmenopausal Women: Dietary Inadequacy or Nondietary Factors?
Tussing-Humphreys, L. M., & Braunschweig, C. L. (2011) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2011.01.006 · Cited by 11 · see citing works
Hematopoiesis and aging v. a decline in hematocrit occurs in all aging female b6d2f1mice
Boggs, D. R., & Patrene, K. D. (1986) · Experimental Aging Research · doi:10.1080/03610738608259449 · Cited by 11 · see citing works
Modulation of age-related alterations of iron, ferritin, and lipid peroxidation in rat brain synaptosomes.
Choi, J., Kim, D.-W., & Yu, B. (1998) · PubMed · Cited by 11 · see citing works
Prohepcidin and iron metabolism parameters in the obese elderly patients with anemia
Przybyszewska, J., Żekanowska, E., Kędziora–Kornatowska, K., Boińska, J., Cichon, R., & Porzych, K. (2010) · The journal of nutrition health & aging · doi:10.1007/s12603-010-0320-6 · Cited by 10 · see citing works
Low frequency of elevated serum transferrin saturation in elderly subjects
Franzini, C., Berlusconi, A., Favarelli, C., & Brambilla, S. (2000) · Clinica Chimica Acta · doi:10.1016/s0009-8981(00)00273-4 · Cited by 5 · see citing works
Impact of different diagnostic thresholds and the anaemia–ferritin–transferrin receptor model on the prevalence of anaemia and impaired iron status in older people
Tull, K. I., Hirani, V., Ali, A., Chua, E., & Mindell, J. S. (2009) · Age and Ageing · doi:10.1093/ageing/afp102 · Cited by 5 · see citing works
[Serum prohepcidin and other iron metabolism parameters in healthy adults].
Żekanowska, E., Boińska, J., Kwapisz, J., Kędziora–Kornatowska, K., Porzych, K., & Ratajczak, M. (2011) · PubMed · Cited by 1 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

[74]Nutrient requirements of the mouse Nutrient Requirements of Laboratory Animals 4th ed Subcommittee on Laboratory Animal Nutrition; Commitee on Animal Nutrition, Board on Agriculture, National Research Council National Academy Press Washington, DC, USA 1995 90

Sorted by citations

The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease
Zucca, F. A., Segura-Aguilar, J., Ferrari, E., Muñoz, P., Paris, I., Sulzer, D., Sarna, T., Casella, L., & Zecca, L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.012 · Cited by 659 · see citing works
Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation
Huat, T. J., Camats‐Perna, J., Newcombe, E. A., Valmas, N., Kitazawa, M., & Medeiros, R. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.01.018 · Cited by 483 · see citing works
Ferroptosis and Its Role in Diverse Brain Diseases
Weiland, A., Wang, Y., Wu, W., Lan, X., Han, X., Li, Q., & Wang, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1403-3 · Cited by 469 · see citing works
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis
Masaldan, S., Clatworthy, S. A. S., Gamell, C., Meggyesy, P. M., Rigopoulos, A.-T., Haupt, S., Haupt, Y., Denoyer, D., Adlard, P. A., Bush, A. I., et al. (2018) · Redox Biology · doi:10.1016/j.redox.2017.08.015 · Cited by 452 · see citing works
Fluorescent, MRI, and colorimetric chemical sensors for the first-row d-block metal ions
Zhu, H., Fan, J., Wang, B., & Peng, X. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00285g · Cited by 438 · see citing works
Iron in Neurodegeneration – Cause or Consequence?
Ndayisaba, A., Kaindlstorfer, C., & Wenning, G. K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00180 · Cited by 298 · see citing works
A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells
Hirayama, T., Okuda, K., & Nagasawa, H. (2012) · Chemical Science · doi:10.1039/c2sc21649c · Cited by 297 · see citing works
Serum copper to zinc ratio: Relationship with aging and health status
Malavolta, M., Piacenza, F., Basso, A., Giacconi, R., Costarelli, L., & Mocchegiani, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.01.004 · Cited by 227 · see citing works
Iron imbalance in neurodegeneration
Levi, S., Ripamonti, M., Moro, A. S., & Cozzi, A. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02399-z · Cited by 214 · see citing works
Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology
Yang, J., Griffin, A. S., Qiang, Z., & Ren, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01243-0 · Cited by 211 · see citing works
Detection of metal ions in biological systems: A review
Zheng, X., Cheng, W., Ji, C., Zhang, J., & Yin, M. (2020) · Reviews in Analytical Chemistry · doi:10.1515/revac-2020-0118 · Cited by 181 · see citing works
Iron homeostasis and organismal aging
Zeidan, R. S., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101510 · Cited by 150 · see citing works
Self-citation
Iron overload: Effects on cellular biochemistry
Nogueira, L. S., Oliveira, M. M., Pessoa, M. T., & Barbosa, L. A. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.11.029 · Cited by 144 · see citing works
Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods
Kaur, D., Rasane, P., Singh, J., Kaur, S., Kumar, V., Mahato, D. K., Dey, A., Dhawan, K., & Kumar, S. (2019) · Current Aging Science · doi:10.2174/1874609812666190521110548 · Cited by 134 · see citing works
Appraising the Role of Iron in Brain Aging and Cognition: Promises and Limitations of MRI Methods
Daugherty, A. M., & Raz, N. (2015) · Neuropsychology Review · doi:10.1007/s11065-015-9292-y · Cited by 131 · see citing works
Multifaceted deregulation of gene expression and protein synthesis with age
Anisimova, A. S., Meerson, M., Gerashchenko, M. V., Kulakovskiy, I. V., Dmitriev, S. E., & Gladyshev, V. N. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2001788117 · Cited by 131 · see citing works
Therapeutic inhibition of ferroptosis in neurodegenerative disease
Ryan, S. K., Ugalde, C. L., Rolland, A., Skidmore, J., Devos, D., & Hammond, T. R. (2023) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.07.007 · Cited by 122 · see citing works
Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis
Chang, V. C., Cotterchio, M., & Khoo, E. (2019) · BMC Cancer · doi:10.1186/s12885-019-5642-0 · Cited by 111 · see citing works
2-Hydroxy-1-naphthaldehyde: A versatile building block for the development of sensors in supramolecular chemistry and molecular recognition
Das, A. K., & Goswami, S. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.01.068 · Cited by 94 · see citing works
Twisted intramolecular charge transfer (TICT) based fluorescent probes and imaging agents
Wu, Y., Wang, H.-M., Hu, X., Zang, Y., Li, J. X., Han, H., He, X., Lewis, S. E., Ismail, H. M., & James, T. D. (2025) · Chemical Society Reviews · doi:10.1039/d3cs01118f · Cited by 95 · see citing works
Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma
Suresh, S., Ankul Singh, S., Rushendran, R., Vellapandian, C., & Prajapati, B. G. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1303111 · Cited by 93 · see citing works
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
Mansfield, L., Ramponi, V., Gupta, K., Stevenson, T., Mathew, A. B., Barinda, A. J., Herbstein, F., & Morsli, S. (2024) · npj Aging · doi:10.1038/s41514-024-00181-1 · Cited by 91 · see citing works
Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging ( MRI ) microbleeds
Janaway, B. M., Simpson, J. E., Hoggard, N., Highley, J. R., Forster, G., Drew, D., Gebril, O. H., Matthews, F. E., Brayne, C., Wharton, S. B., et al. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12062 · Cited by 83 · see citing works
Aging is associated with increased brain iron through cortex-derived hepcidin expression
Sato, T., Shapiro, J. S., Chang, H.-C., Miller, R. A., & Ardehali, H. (2021) · eLife · doi:10.7554/elife.73456 · Cited by 76 · see citing works
Emerging Disease-Modifying Therapies in Neurodegeneration With Brain Iron Accumulation (NBIA) Disorders
Iankova, V., Karin, I., Klopstock, T., & Schneider, S. A. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.629414 · Cited by 73 · see citing works
Age-Related Changes and Sex-Related Differences in Brain Iron Metabolism
Kezele, T. G., & Ćurko‐Cofek, B. (2020) · Nutrients · doi:10.3390/nu12092601 · Cited by 72 · see citing works
Aging-related changes in the iron status of skeletal muscle
DeRuisseau, K. C., Park, Y.-M., DeRuisseau, L. R., Cowley, P. M., Fazen, C. H., & Doyle, R. P. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.011 · Cited by 69 · see citing works
Reaction-based turn-on fluorescent probes with magnetic responses for Fe 2+ detection in live cells
Maiti, S. K., Aydın, Z., Zhang, Y., & Guo, M. (2015) · Dalton Transactions · doi:10.1039/c4dt03792h · Cited by 57 · see citing works
The Potential of Ferroptosis-Targeting Therapies for Alzheimer’s Disease: From Mechanism to Transcriptomic Analysis
Majerníková, N., den Dunnen, W. F. A., & Dolga, A. M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.745046 · Cited by 55 · see citing works
Iron and Ferroptosis More than a Suspect: Beyond the Most Common Mechanisms of Neurodegeneration for New Therapeutic Approaches to Cognitive Decline and Dementia
Cerasuolo, M., Meo, I. D., Auriemma, M. C., Trojsi, F., Maiorino, M. I., Cirillo, M., Esposito, F., Polito, R., Colangelo, A. M., Paolisso, G., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119637 · Cited by 47 · see citing works
Mitochondrial superoxide mediates labile iron level: evidence from Mn-SOD-transgenic mice and heterozygous knockout mice and isolated rat liver mitochondria
Ibrahim, W. H., Habib, H. M., Kamal, H., Clair, D. K. S., & Chow, C. K. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.06.026 · Cited by 43 · see citing works
Selection of an optimal set of biomarkers and comparative analyses of biological age estimation models in Korean females
Jee, H., & Park, J. (2017) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2017.01.005 · Cited by 40 · see citing works
Soluble Fe release from iron-bearing clay mineral particles in acid environment and their oxidative potential
Xie, T., Lü, S., Zeng, J., Rao, L., Wang, X., Win, M. S., Zhang, D., Lu, H. M., Liu, X., & Wang, Q. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138650 · Cited by 40 · see citing works
Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review
Behl, S., Mehta, S., & Pandey, M. K. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.586209 · Cited by 37 · see citing works
Aging-dependent changes in rat heart mitochondrial glutaredoxins—Implications for redox regulation
Gao, X., Qanungo, S., Pai, H. V., Starke, D. W., Steller, K. M., Fujioka, H., Lesnefsky, E. J., Kerner, J., Rosca, M. G., Hoppel, C. L., et al. (2013) · Redox Biology · doi:10.1016/j.redox.2013.10.010 · Cited by 36 · see citing works
Dissociation between iron accumulation and ferritin upregulation in the aged substantia nigra: attenuation by dietary restriction
Walker, T. A., Michaelides, C., Ekonomou, A., Geraki, K., Parkes, H. G., Suessmilch, M., Herlihy, A. H., Crum, W. R., & So, P. (2016) · Aging · doi:10.18632/aging.101069 · Cited by 34 · see citing works
Rebalancing the unbalanced aged immune system – A special focus on zinc
Baarz, B. R., & Rink, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101541 · Cited by 35 · see citing works
A differentially selective probe for trivalent chemosensor upon single excitation with cell imaging application: potential applications in combinatorial logic circuit and memory devices
Das, D., Alam, R., Katarkar, A., & Ali, M. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c8pp00381e · Cited by 30 · see citing works
Is Iron Accumulation a Possible Risk Factor for Sarcopenia?
Zhao, G. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1332-z · Cited by 27 · see citing works
The interplay between cell death and senescence in cancer
Shimizu, K., Inuzuka, H., & Tokunaga, F. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.001 · Cited by 25 · see citing works
Rhodamine 6G-based efficient chemosensor for trivalent metal ions (Al 3+ , Cr 3+ and Fe 3+ ) upon single excitation with applications in combinational logic circuits and memory devices
Das, D., Alam, R., & Ali, M. (2021) · The Analyst · doi:10.1039/d1an01788h · Cited by 24 · see citing works
Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice
Winn, N. C., Wolf, E. M., Cottam, M. A., Bhanot, M., & Hasty, A. H. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00116.2021 · Cited by 20 · see citing works
PKA modulates iron trafficking in the striatum via small GTPase, Rhes
Choi, B., Bang, S., Chen, Y., Cheah, J. H., & Kim, S. F. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.043 · Cited by 20 · see citing works
Long-term aerobic exercise increases redox-active iron through nitric oxide in rat hippocampus
Chen, Q., & Xiao, D.-S. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.10.009 · Cited by 20 · see citing works
Cardiac iron metabolism during aging – Role of inflammation and proteolysis
Walter, S., Mertens, C., Muckenthaler, M. U., & Ott, C. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111869 · Cited by 19 · see citing works
Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression
Zhang, Y., Feng, X., Zhang, J., & Chen, X. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-19-1104 · Cited by 18 · see citing works
Rapid and Live-Cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry
Thamarath, S. S., Tee, C. A., Neo, S. H., Yang, D., Othman, R. B., Boyer, L. A., & Han, J. (2023) · Stem Cells Translational Medicine · doi:10.1093/stcltm/szad014 · Cited by 19 · see citing works
Ferroptosis in Glaucoma: A Promising Avenue for Therapy
Zhu, J., Chen, H., Wu, J., Li, S., Lin, W., Wang, N., & Bai, L. (2024) · Advanced Biology · doi:10.1002/adbi.202300530 · Cited by 19 · see citing works
Iron in Frontotemporal Lobar Degeneration: A New Subcortical Pathological Pathway?
Gazzina, S., Premi, E., Zanella, I., Biasiotto, G., Archetti, S., Cosseddu, M., Scarpini, E. A., Galimberti, D., Serpente, M., Gasparotti, R., et al. (2015) · Neurodegenerative Diseases · doi:10.1159/000440843 · Cited by 18 · see citing works
Restless Legs Syndrome and Other Common Sleep-Related Movement Disorders
García-Malo, C., Romero-Peralta, S., & Garcı́a-Borreguero, D. (2020) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000000886 · Cited by 18 · see citing works
Iron status and oxidative stress in the aged rabbit heart
Lapenna, D., Ciofani, G., Pierdomenico, S. D., Giamberardino, M. A., & Porreca, E. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.11.016 · Cited by 17 · see citing works
Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis
Jamnongkan, W., Thanee, M., Yongvanit, P., Loilome, W., Thanan, R., Kimawaha, P., Boonmars, T., Silakit, R., Namwat, N., & Techasen, A. (2018) · PeerJ · doi:10.7717/peerj.4281 · Cited by 17 · see citing works
Factors associated with serum ferritin levels and iron excess: results from the EPIC-EurGast study
Iglesias‐Vázquez, L., Arija, V., Aranda, N., Aglago, E. K., Cross, A. J., Schulze, M. B., Pacheco, D. A. Q., Kuhn, T. E., Weiderpass, E., Tumino, R., et al. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02625-w · Cited by 16 · see citing works
Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress
Bloomer, S. A., Han, O., Kregel, K. C., & Brown, K. E. (2013) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2013.07.002 · Cited by 15 · see citing works
Investigation of the magnetic susceptibility properties of fresh and fixed mouse heart, liver, skeletal muscle and brain tissue
Klohs, J., & Hirt, A. M. (2021) · Physica Medica · doi:10.1016/j.ejmp.2021.06.014 · Cited by 14 · see citing works
Iron accumulation with age alters metabolic pattern and circadian clock gene expression through the reduction of AMP-modulated histone methylation
Liu, J., Zhao, Y., Ding, Z., Zhao, Y., Chen, T., Ge, W., & Zhang, J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101968 · Cited by 14 · see citing works
Developing a simple and water soluble thiophene-functionalized Ru(II)-polypyridyl complex for ferric ion detection
Kumar, S., Arora, A., Kaushal, J., Oswal, P., Kumar, A., & Kumar, P. (2019) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2019.107500 · Cited by 14 · see citing works
Recent developments in the creation of a single molecular sensing tool for ternary iron (III), chromium (III), aluminium (III) ionic species: A review
Saha, S., & Alam, R. (2022) · Luminescence · doi:10.1002/bio.4399 · Cited by 14 · see citing works
Predicting lifespan-extending chemical compounds for C. elegans with machine learning and biologically interpretable features
Ribeiro, C., Farmer, C., de Magalhães, J. P., & Freitas, A. A. (2023) · Aging · doi:10.18632/aging.204866 · Cited by 12 · see citing works
Iron content affects age group differences in associative learning-related fMRI activity
Petok, J. R., Merenstein, J. L., & Bennett, I. J. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120478 · Cited by 11 · see citing works
Dissolution factors and oxidative potential of acid soluble irons from chlorite mineral particles
Xie, T., Lü, S., Rao, L., Zhang, L., Wang, X., Wang, W., & Wang, Q. (2021) · Atmospheric Environment · doi:10.1016/j.atmosenv.2021.118436 · Cited by 10 · see citing works
Ribosome profiling reveals the role of yeast RNA-binding proteins Cth1 and Cth2 in translational regulation
Barlit, H., Romero, A. M., Gülhan, A., Patnaik, P. K., Tyshkovskiy, A., Martínez‐Pastor, M. T., Gladyshev, V. N., Puig, S., & Labunskyy, V. M. (2024) · iScience · doi:10.1016/j.isci.2024.109868 · Cited by 9 · see citing works
Impaired enzymatic reactive aldehyde-detoxifying capacity and glutathione peroxidase activity in the aged human arterial tissue
Lapenna, D., Ciofani, G., Obletter, G., Pierdomenico, S. D., Cipollone, F., Cotellese, R., Cieri, M., & Porreca, E. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2018.11.013 · Cited by 9 · see citing works
TSEREBRALNYYE NARUSHENIYA OBMENA ZHELEZA KAK OSNOVA RAZVITIYA I PROGRESSIROVANIYA NEYRODEGENERATIVNYKH ZABOLEVANIY
Litvinenko, I., Вячеславович, К. И., & Trufanov, A. G. (2018) · Bulletin of the Russian Military Medical Academy · doi:10.32863/1682-7392-2018-3-63-68-77 · Cited by 7 · see citing works
What matters in aging is signaling for responsiveness
Park, S. C., Lee, Y., Cho, K. A., Kim, S. Y., Lee, Y., Lee, S.-R., & Lim, I. K. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108560 · Cited by 7 · see citing works
Inter-organ regulation of haem homeostasis
Pitt, J. N., & Kaeberlein, M. R. (2017) · Nature Cell Biology · doi:10.1038/ncb3568 · Cited by 7 · see citing works
Light and heavy ferritin chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy
Vulinović, M. P., Turčić, P., Micek, V., & Ljubojević, M. (2022) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/aiht-2022-73-3621 · Cited by 6 · see citing works
On a New Paradigm of the Development of Neurodegenerative Diseases by the Example of Alzheimer’s Disease and Parkinson’s Disease
Litvinenko, I., & Lobzin, V. Y. (2022) · Advances in Gerontology · doi:10.1134/s2079057022040117 · Cited by 5 · see citing works
Associations Between Hemoglobin and Serum Iron Levels and the Risk of Mortality Among Patients with Coronary Artery Disease
Li, Q., Pan, Z., Zeng, Y., Wang, X., Li, D., Yin, T., Chen, Q., & Ling, W. (2024) · Nutrients · doi:10.3390/nu17010139 · Cited by 5 · see citing works
WITHDRAWN: Can Traditional Chinese Medicine provide insights into controlling the COVID-19 pandemic: Serpentinization-induced lithospheric long-wavelength magnetic anomalies in Proterozoic bedrocks in a weakened geomagnetic field mediate the aberrant transformation of biogenic molecules in COVID-19 via magnetic catalysis
Bility, M. T., Agarwal, Y., Ho, S. G., Castronova, I., Beatty, C., Biradar, S., Narala, V., Periyapatna, N., Chen, Y., & Nachega, J. B. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.142830 · Cited by 6 · see citing works
Retracted
The interplay between the myeloperoxidase-hypochlorous acid system, heme oxygenase, and free iron in inflammatory diseases
Biernat, M. M., Camp, O. G., Moussa, D. N., Awonuga, A. O., & Abu‐Soud, H. M. (2025) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2025.112927 · Cited by 4 · see citing works
Iron Metabolism in Neuromyelitis Optica Patients
Zhang, L., Hong, Z., Chen, X., Tan, S., Lin, Y., Wang, Y., Sun, S., Cai, W., & Lu, Z. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.09.051 · Cited by 4 · see citing works
Defining the Neuropathological Aggresome across in Silico, in Vitro, and ex Vivo Experiments
Gomes, G.-N. W., & Levine, Z. A. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.0c09193 · Cited by 4 · see citing works
Exploring age-related iron dysregulation: effects on longevity, body size, and behavior in C. elegans
Zeidan, R. S., Ebea, P. O., Sykes, S., Evripidou, N., Pan, E., Markovich, Z., Sheng, Y., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112826 · Cited by 3 · see citing works
Self-citation
Deferoxamine halt rotenone-induced Parkinson’s like symptoms in experimental rats: biochemical, neuroinflammatory, neurotransmitters, and histological evidence
Awasthi, A., Gupta, G. D., & Singh, S. (2025) · Drug and Chemical Toxicology · doi:10.1080/01480545.2025.2495361 · Cited by 2 · see citing works
Iron Metabolism in Aging
Silvestri, L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801816-3.00037-6 · Cited by 2 · see citing works
The disorder of the iron metabolism as a possible mechanism for the development of neurodegeneration after new coronavirus infection of SARS-CoV-2
Litvinenko, I., & Вячеславович, К. И. (2021) · Russian Military Medical Academy Reports · doi:10.17816/rmmar83609 · Cited by 2 · see citing works
Oxidants and Antioxidants Levels for Elderly Male People
Al-Helaly, L. A., & Saleh, M. A. (2014) · Mağallaẗ ʻulūm al-rāfidayn · doi:10.33899/rjs.2014.131368 · Cited by 2 · see citing works
Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint
Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.19.572293 · Cited by 2 · see citing works
Beyin Homeostazında Bakır, Demir, Çinko Elementlerinin Parkinson Hastalığı ile İlişkisi
YATKIN, G., GÜLTEKİN, S. K., ALBAYRAK, İ. G., & Arslan, B. A. (2022) · Doğu Fen Bilimleri Dergisi · doi:10.57244/dfbd.1073262 · Cited by 1 · see citing works
Plasma Ferritin Concentrations in the General Population: A Cross-Sectional Analysis of Anthropometric, Metabolic, and Dietary Correlates
Övermöhle, C., Waniek, S., Rimbach, G. H., Weber, K. S., & Lieb, W. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.03.008 · Cited by 1 · see citing works
Iron hypothesis of cardiovascular disease: still controversial.
Aursulesei, V. O., Cozma, A., & Krasniqi, A. (2014) · The Medical-Surgical Journal · Cited by 1 · see citing works
Iron content affects age group differences in associative learning-related fMRI activityPreprint
Petok, J. R., Merenstein, J. L., & Bennett, I. J. (2023) · doi:10.31234/osf.io/v7m6g · Cited by 1 · see citing works
Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint
Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2024) · eLife · doi:10.7554/elife.94988.1 · Cited by 1 · see citing works
PREVALENCIA DE ANEMIA EN ESTUDIANTES INGRESANTES A LA UNIVERSIDAD NACIONAL MAYOR DE SAN MARCOS DEL PERÚ
Rosales-Rimache, J. A., Baldeón, J. A., Timaná, J. D. M. A., & Sánchez, M. O. (2012) · Americanae (AECID Library)
Peer Review #1 of "Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis (v0.1)"
(2018) · PeerJ · doi:10.7287/peerj.4281v0.1/reviews/1
Peer Review #2 of "Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis (v0.2)"
(2018) · PeerJ · doi:10.7287/peerj.4281v0.2/reviews/2
Peer Review #2 of "Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis (v0.1)"
(2018) · PeerJ · doi:10.7287/peerj.4281v0.1/reviews/2
Peer Review #1 of "Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis (v0.2)"
(2018) · PeerJ · doi:10.7287/peerj.4281v0.2/reviews/1
Genome-wide ribosome profiling uncovers the role of iron in the control of protein translationPreprint
Barlit, H., Romero, A. M., Gülhan, A., Patnaik, P. K., Tyshkovskiy, A., Martínez‐Pastor, M. T., Gladyshev, V. N., Puig, S., & Labunskyy, V. M. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.22.509115
Predicting Lifespan-Extending Chemical Compounds with Machine Learning and Biologically Interpretable FeaturesPreprint
Ribeiro, C., Farmer, C., de Magalhães, J. P., & Freitas, A. A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.20.517230
Prophylactic Effects of DL-β Hydroxybutyrate against Hepatic Cellular Senescence Induced by D-galactose or γ-irradiation via Partial Modulation of Antioxidants and Trace Elements in Male Rats
Habieb, M. E., Mohamed, M. A. E. H., Gamal, D. M. E., Hawas, A. M., & Mohamed, T. M. (2023) · Egyptian Journal of Radiation Sciences and Applications · doi:10.21608/ejrsa.2023.187973.1148
A Novel Triphenylamine Isoflurone-Based Fluorescent Probe for the Detection of Cu2+ and Fe3+Preprint
tianxiaoyong, X., Xu, H., Zhang, K., Zhang, Y., Wang, N., Wang, H., & Guang, S. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4512711
Iron content affects age group differences in associative learning-related fMRI activityPreprint
Petok, J. R., Merenstein, J. L., & Bennett, I. J. (2023) · doi:10.31234/osf.io/vwxbt
Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agentPreprint
Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2024) · eLife · doi:10.7554/elife.94988
eLife Assessment: Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agent
Weyemi, U. (2024) · eLife · doi:10.7554/elife.94988.1.sa3
Author Response: Large pan-cancer cell screen coupled to (phospho-)proteomics underscores high-dose vitamin C as a potent anti-cancer agent
Vallés‐Martí, A., Böttger, F., Yau, E., Tejjani, K., Meijs, L. A. M., Sharma, S., Mumtaz, M., Large, T. Y. S. L., Erozenci, L. A., Dekker, D., et al. (2024) · eLife · doi:10.7554/elife.94988.1.sa4
The Associations of Iron Accumulation and Cognitive Impairment in Alzheimer’s Disease in Kerbala Governate, Iraq
Al-Razaq, Z. N. A., Hameed, R. M., Odda, A. H., & Alhaideri, A. F. (2026) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_1454_23
A double-edged sword: iron regulation in alveolar lung epithelial repair
Mbaekwe, U., Kenny, S., Cloonan, S. M., & Kliment, C. R. (2026) · JCI Insight · doi:10.1172/jci.insight.199953

Review Impaired Iron Status in Aging Research
Jia, J. X. Z. (2012)
Iron Metabolism in Aging and Age-Related Diseases
Tian, Y., Tian, Y., Yuan, Z., Zeng, Y., Wang, S., Fan, X., Yang, D., & Yang, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073612 · Cited by 104 · see citing works
Outside Front Cover
(2021) · Journal of Molecular Biology · doi:10.1016/s0022-2836(21)00135-2
Iron homeostasis and organismal aging
Zeidan, R. S., Han, S. M., Leeuwenburgh, C., & Xiao, R. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101510 · Cited by 150 · see citing works
Self-citation
The emerging role of iron dyshomeostasis in the mitochondrial decay of aging
Xu, J., Marzetti, E., Seo, A. Y., Kim, J., Prolla, T. A., & Leeuwenburgh, C. (2010) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2010.04.007 · Cited by 77 · see citing works
Self-citation

Authors: Xu, J., Jia, Z., Knutson, M. D., & Leeuwenburgh, C.
Affiliations: University of Florida (US)
Corresponding author: Xu, Jinze
Leeuwenburgh, Christiaan
ORCID: Jia, Zhenhua
Knutson, Mitchell D.
Leeuwenburgh, Christiaan
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2012-02-22
Volume: 13
Issue: 2
Pages: 2368-2386
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms13022368
PMC: PMC3292028
OpenAlex: W2144968983
Cited by: 103
References: 127
Citations by year: 2026: 5 · 2025: 4 · 2024: 10 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 10 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 2
FWCI: 0.96
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: American Heart Association
University of Florida (P30 AG028740)
National Institutes of Health (UL1TR000064, DK080706)
National Institute on Aging (R01AG017994, P30AG028740)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080706)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: iron metabolism, iron dyshomeostasis, aging, age-related diseases, iron chelation, iron storage, rodent models, cellular and molecular mechanisms
MeSH terms: Aging, Animals, Disease Models, Animal, Health Status, Humans, Iron, Mitochondria, Rodentia, Iron Metabolism Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impaired iron status in aging research

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks