Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

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Friedreich's Ataxia: Autosomal Recessive Disease Caused by an Intronic GAA Triplet Repeat Expansion

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IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

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Hepcidin, a urinary antimicrobial peptide synthesized in the liver

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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

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A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

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Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

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Function and biogenesis of iron-sulphur proteins

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Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

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Clinical and Genetic Abnormalities in Patients with Friedreich's Ataxia

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p16INK4a induces an age-dependent decline in islet regenerative potential

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Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia

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<i>Nramp</i> <i>2</i> is mutated in the anemic Belgrade ( <i>b</i> ) rat: Evidence of a role for Nramp2 in endosomal iron transport

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Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin

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Ferritins: A family of molecules for iron storage, antioxidation and more

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The labile iron pool: characterization, measurement, and participation in cellular processes1 1This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.

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Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells

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Frataxin is Reduced in Friedreich Ataxia Patients and is Associated with Mitochondrial Membranes

Campuzano, V., Montermini, L., Lutz, Y., Cova, L., Hindelang, C., Jiralerspong, S., Trottier, Y., Kish, S. J., Faucheux, B. A., Trouillas, P., et al. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1771 · Cited by 739 · see citing works

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

Puccio, H., Simon, D., Cossée, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P., & Koenig, M. (2001) · Nature Genetics · doi:10.1038/84818 · Cited by 738 · see citing works

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

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The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

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Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

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Mitoferrin is essential for erythroid iron assimilation

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Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis

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Identification of the iron-responsive element for the translational regulation of human ferritin mRNA

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Tissue-Specific Regulation of Iron Metabolism and Heme Synthesis: Distinct Control Mechanisms in Erythroid Cells

Ponka, P. (1997) · Blood · doi:10.1182/blood.v89.1.1 · Cited by 544 · see citing works

Regulation of hepcidin transcription by interleukin-1 and interleukin-6

Lee, P. L., Peng, H., Gelbart, T., Wang, L., & Beutler, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409808102 · Cited by 542 · see citing works

Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol

Richardson, D. R., Lane, D. J. R., Becker, E. M., Huang, M. L.-H., Whitnall, M., Rahmanto, Y. S., Sheftel, A. D., & Ponka, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912925107 · Cited by 536 · see citing works

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works

Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin

Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, F., & Wessling-Resnick, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409409102 · Cited by 479 · see citing works

Suppression of hepcidin during anemia requires erythropoietic activity

Pak, M., Lopez, M. A., Gabayan, V., Ganz, T., & Rivera, S. (2006) · Blood · doi:10.1182/blood-2006-06-028787 · Cited by 472 · see citing works

Grx5 Is a Mitochondrial Glutaredoxin Required for the Activity of Iron/Sulfur Enzymes

Rodrı́guez-Manzaneque, M. T., Tamarit, J., Bellı́, G., Ros, J., & Herrero, E. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-10-0517 · Cited by 464 · see citing works

An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis

Salahudeen, A. A., Thompson, J. W., Ruiz, J. C., Ma, H.-W., Kinch, L. N., Li, Q., Grishin, N. V., & Bruick, R. K. (2009) · Science · doi:10.1126/science.1176326 · Cited by 432 · see citing works

Control of iron homeostasis by an iron-regulated ubiquitin ligase

Vashisht, A. A., Zumbrennen, K. B., Huang, X., Powers, D. N., Durazo, A., Sun, D., Bhaskaran, N., Persson, A., Uhlen, M., Sangfelt, O., et al. (2009) · Science · doi:10.1126/science.1176333 · Cited by 429 · see citing works

Iron uptake and metabolism in the new millennium

Dunn, L., Rahmanto, Y. S., & Richardson, D. R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.12.003 · Cited by 419 · see citing works

Selective iron chelation in Friedreich ataxia: biologic and clinical implications

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Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

Meyron‐Holtz, E. G., Ghosh, M. C., Iwai, K., LaVaute, T., Brazzolotto, X., Berger, U. V., Land, W., Ollivierre‐Wilson, H., Grinberg, A., Love, P., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600041 · Cited by 408 · see citing works

Mutation of a Putative Mitochondrial Iron Transporter Gene (ABC7) in X-Linked Sideroblastic Anemia and Ataxia (XLSA/A)

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A human mitochondrial ferritin encoded by an intronless gene

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Hepcidin is decreased in TFR2 hemochromatosis

Nemeth, E., Roetto, A., Garozzo, G., Ganz, T., & Camaschella, C. (2004) · Blood · doi:10.1182/blood-2004-08-3042 · Cited by 396 · see citing works

Molecular bases of cellular iron toxicity12 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.

Eaton, J. W., & Qian, M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00772-4 · Cited by 389 · cited 1× · see citing works

Low molecular weight intracellular iron transport compounds

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Iron–sulfur cluster biogenesis and human disease

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Frataxin Acts as an Iron Chaperone Protein to Modulate Mitochondrial Aconitase Activity

Bulteau, A.-L., O’Neill, H. A., Kennedy, M. C., Ikeda‐Saito, M., Isaya, G., & Szweda, L. I. (2004) · Science · doi:10.1126/science.1098991 · Cited by 372 · see citing works

Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis.

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Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms

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A mouse model of juvenile hemochromatosis

Huang, F. W. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25049 · Cited by 363 · see citing works

Human erythroid 5‐aminolevulinate synthase: promoter analysis and identification of an iron‐responsive element in the mRNA.

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Identification of a mammalian mitochondrial porphyrin transporter

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Iron−Sulfur Cluster Biosynthesis. Characterization of Frataxin as an Iron Donor for Assembly of [2Fe-2S] Clusters in ISU-Type Proteins

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Molecular control of iron transport

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Identification of a novel iron‐responsive element in murine and human erythroid delta‐aminolevulinic acid synthase mRNA.

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The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload

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Iron-dependent regulation of the divalent metal ion transporter

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Transferrin, biochemistry, physiology and clinical significance

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Crystal structure of protoporphyrinogen IX oxidase: a key enzyme in haem and chlorophyll biosynthesis

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Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis

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Iron trafficking in the mitochondrion: novel pathways revealed by disease

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Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation

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Frataxin-mediated Iron Delivery to Ferrochelatase in the Final Step of Heme Biosynthesis

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The ABC transporter Atm1p is required for mitochondrial iron homeostasis

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Decreased Liver Hepcidin Expression in the Hfe Knockout Mouse

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Direct interorganellar transfer of iron from endosome to mitochondrion

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Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis

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Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS

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Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia

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A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

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Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia

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Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts

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Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

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Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages

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Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1)

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Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

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Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

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Formation of iron–sulfur clusters in bacteria: an emerging field in bioinorganic chemistry

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Human ferrochelatase is an iron-sulfur protein

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Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

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Splice Mutation in the Iron-Sulfur Cluster Scaffold Protein ISCU Causes Myopathy with Exercise Intolerance

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The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron–sulfur cluster biogenesis

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Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia

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Iron–sulfur proteins in health and disease

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