The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Forcing form and function: biomechanical regulation of tumor evolution
Open accessAbstract
Cancer cells exist in a constantly evolving tissue microenvironment of diverse cell types within a proteinaceous extracellular matrix. As tumors evolve, the physical forces within this complex microenvironment change, with pleiotropic effects on both cell- and tissue-level behaviors. Recent work suggests that these biomechanical factors direct tissue development and modulate tissue homeostasis, and, when altered, critically influence tumor evolution. In this review, we discuss the biomechanical regulation of cell and tissue homeostasis from the molecular, cellular and tissue levels, including how modifications of this physical dialogue could contribute to cancer etiology. Because of the broad impact of biomechanical factors on cell and tissue functions, an understanding of tumor evolution from the biomechanical perspective should improve risk assessment, clinical diagnosis and the efficacy of cancer treatment.
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Cites
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Cited by
The extracellular matrix: A dynamic niche in cancer progression
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Self-citationExtracellular Matrix Degradation and Remodeling in Development and Disease
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Dynamic molecular processes mediate cellular mechanotransduction
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Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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Metadata
- Authors
- Yu, H., Mouw, J. K., & Weaver, V. M.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 21
- Issue
- 1
- Pages
- 47-56
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2166460268
- Cited by
- 321
- References
- 14
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Yu, H., Mouw, J. K., & Weaver, V. M. (2011). Forcing form and function: biomechanical regulation of tumor evolution. Trends in Cell Biology. https://doi.org/10.1016/j.tcb.2010.08.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
