The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond
Open accessAbstract
During development and cellular differentiation, tissue and cell-specific programs mediate mitochondrial biogenesis in order to meet physiological needs. However, environmental and disease-associated factors can perturb mitochondrial activities requiring cells to adapt to protect mitochondria and maintain cellular homeostasis. Several mitochondria-to-nuclear signaling pathways, or retrograde responses, have been described, but the mechanisms by which mitochondrial stress or dysfunction is sensed to precisely coordinate the appropriate response has only recently begun to be understood. Recent studies of the mitochondrial unfolded protein response (UPRmt) indicate that the cell monitors mitochondrial protein import efficiency as an indicator of mitochondrial function. Here, we review how the cell evaluates mitochondrial function and regulates transcriptional induction of the UPRmt, adapts protein synthesis rates and activates mitochondrial autophagy to promote mitochondrial function and cell survival during stress.
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Metadata
- Authors
- Haynes, C. M., Fiorese, C. J., & Lin, Y.-F.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-07
- Volume
- 23
- Issue
- 7
- Pages
- 311-318
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2058373529
- Cited by
- 211
- References
- 27
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- green
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