The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
ALIX and the multivesicular endosome: ALIX in Wonderland
Abstract
In yeast and mammalian cells, endosomal sorting complexes required for transport (ESCRT) assist in sorting ubiquitinated proteins into intralumenal vesicles (ILVs) of multivesicular endosomes (MVEs) for degradation in the lysosome/vacuole. In mammalian cells, ESCRTs also drive other topologically identical membrane deformation processes, including cytokinesis, exosome release, and virus budding. Although the ESCRT-associated protein ALIX regulates these mammalian cell-specific functions, it was believed to be dispensable for receptor sorting into ILVs, unlike its yeast homolog Bro1. Despite these differences, recent evidence suggests ALIX and Bro1 share common properties in cargo sorting and ILV formation. We review these commonalities and discuss the role of ALIX in operating 'behind the mirror' during ILV back-fusion with the limiting membrane. We also propose models of how ALIX and some ESCRTs regulate the back-fusion process.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“LBPA is also functionally involved in membrane degradation by recruiting the programmed cell death-6-interacting protein (PDCD6IP) (45, 46).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [46]
In the citing paper
“PDCD6IP also binds in a Ca2+-dependent manner to endophilins, which influence the endosomal membrane shape (bending) probably through interaction with dynamin via SH3 domains (46).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [46]
Citations
Cites
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
Trajković, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., & Simons, M. (2008) · Science · doi:10.1126/science.1153124 · Cited by 3,760
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes
Baietti, M. F., Zhang, Z., Mortier, E., Melchior, A., Degeest, G., Geeraerts, A., Ivarsson, Y., Depoortere, F., Coomans, C., Vermeiren, E., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2502 · Cited by 1,899
Henne, W. M., Buchkovich, N. J., & Emr, S. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.05.015 · Cited by 1,586
Ebola virus entry requires the cholesterol transporter Niemann–Pick C1
Carette, J. E., Raaben, M., Wong, A., Herbert, A. S., Obernosterer, G., Mulherkar, N., Kuehne, A. I., Kranzusch, P. J., Griffin, A. M., Ruthel, G. T., et al. (2011) · Nature · doi:10.1038/nature10348 · Cited by 1,327
Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228
Hydration forces between phospholipid bilayers
Rand, R. P., & Parsegian, V. A. (1989) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(89)90010-5 · Cited by 1,125
ExoCarta 2012: database of exosomal proteins, RNA and lipids
Mathivanan, S., Fahner, C. J., Reid, G. E., & Simpson, R. J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr828 · Cited by 1,096
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
Gillooly, D. J., Morrow, I. C., Lindsay, M., Gould, R., Bryant, N. J., Gaullier, J., Parton, R. G., & Stenmark, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4577 · Cited by 1,031
The Golgi apparatus (complex)-(1954-1981)-from artifact to center stage.
Farquhar, M. G., & Palade, G. E. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.91.3.77s · Cited by 999
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–323 of 323
Tourchinets, A. M., & Yakovlev, A. A. (2023) · Нейрохимия · doi:10.31857/s1027813323040222
Extracellular vesicle mobility in collagen I hydrogels is influenced by RGD-binding integrinsPreprint
Tam, N. W., Becker, A., Mangiarotti, A., Cipitria, A., & Dimova, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.29.596426
Czernisz, É. S. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2018.tde-28062024-145337
Cell-Derived Exosome-Based Materials for Biomedical Applications
Ghosh, D., Rudra, D. S., & Pal, U. (2024) · Springer eBooks · doi:10.1007/978-3-031-56363-8_35
Chang, J., Alenizi, S., Milioli, H. H., Lay, W., Pounraj, S., Li, Y., Shiferaw, M. S., Beheshti, E. H., & Kovačević, Ž. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.15.682724
Nourafshan, N., Sarab, G. A., Mesbahzadeh, B., & Sayadi, M. (2025) · Medical Oncology · doi:10.1007/s12032-025-03147-9
Wu, L., Yang, S., Li, H., Zhang, Y., Feng, L., Zhang, C., Wei, J., Gu, X., 徐国彤, Wang, Z., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26552569
Exploring the potential of extracellular vesicles as therapeutic protein delivery vectors
Saux, S. L. (2019) · theses.fr (ABES) · doi:10.70675/4c1c1220ze70dz4948z9cddz682d3502dce2
Mécanismes de tri et voies de transport intracellulaire des protéines de la membrane du lysosome
Ecard, J. (2019) · theses.fr (ABES) · doi:10.70675/b7bc8be7zf58cz46aczb856zd4face7b7c97
Netrin-1 in extracellular vesicles : a new secretory pathway
Fiore, S. (2019) · theses.fr (ABES) · doi:10.70675/d67eb9cdz25f4z4d1czbf7czf70e76f70396
Dumontet, E. (2020) · theses.fr (ABES) · doi:10.70675/12155076z603ez4c55zbedfz05c58338e7ad
Intérêt de l'étude des HSP70-exosomes dans le diagnostic et le suivi du cancer
Chanteloup, G. (2020) · theses.fr (ABES) · doi:10.70675/ae1cca2az7e99z41aazbb58z8b3f455c016a
Role of extracellular vesicles in type 1 diabetes
Giri, K. R. (2020) · theses.fr (ABES) · doi:10.70675/0b17ca8bz26a4z454bz9cd6zfce0f6d3ddaf
Mechanisms of Extracellular Vesicle Cargo Delivery
Askarian‐Amiri, S. (2023) · theses.fr (ABES) · doi:10.70675/7fc22cfaz56eez4b3aza652z01d13ba8b908
Burn-associated metabolic dysfunction: could extracellular vesicles play a role?
Farahat, M., Dadashizadeh, G., Ricciuti, Z., Pappas, A., & Jeschke, M. G. (2026) · Clinical Science · doi:10.1042/cs20260147 · Cited by 1
The Pathology of Viral Infections
Veenstra, T. D. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-3-032-22340-1_6
Chang, J., Alenizi, S., Milioli, H. H., Lay, W., Pounraj, S., Li, Y., Sisay, M., Hosseini-Beheshti, E., & Kovačević, Ž. (2026) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70334 · Cited by 2
Xu, B., Yang, H., Chen, K. X., Wang, L., Fan, J., 杜垬, Guo, W., Ruan, R. R., Yan, X., Yin, Y., et al. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108979
Hao, J., Wang, Y., Ma, Y., Liu, S., Gong, Y., & Xu, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27157013
Uehara, Y., Nagao, H., Tobimatsu, A., Kawada, K., Shiode, S., Kawada-Horitani, E., Obata, Y., Fukuda, S., Fujishima, Y., Kita, S., et al. (2026) · Science Advances · doi:10.1126/sciadv.aei1333
Metadata
- Authors
- Bissig, C., & Gruenberg, J.
- Affiliations
- University of Geneva (CH)
- ORCID
- Gruenberg, Jean
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 24
- Issue
- 1
- Pages
- 19-25
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2154203178
- Cited by
- 323
- References
- 66
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 29 · 2023: 19 · 2022: 20 · 2021: 29 · 2020: 35 · 2019: 28 · 2018: 33 · 2017: 18 · 2016: 36 · 2015: 24 · 2014: 15
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- Alix, multivesicular endosomes, ESCRT, intralumenal vesicles, ubiquitin-dependent protein degradation, membrane deformation, limiting membrane, exosome secretion, viral budding, cytokinesis
- MeSH terms
- Animals, Calcium-Binding Proteins, Cell Membrane, Humans, Cell Cycle Proteins, Protein Transport, Transport Vesicles, Saccharomyces cerevisiae Proteins, Endosomal Sorting Complexes Required for Transport, Multivesicular Bodies, Ubiquitinated Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
